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Farzana Alam, Seung Rim Hwang, Taslim A. Al-Hilal, Seung Woo Chung, Hak-Soo Kim, Boo-Hyun Kang, Hu-Song Zhang, Seo-Ho Shin, Joo-Young Lee, Min-Soo Kang, Geum-Hee Kwon, Ok-Cheol Jeon, Sang Yoon Kim & Youngro Byun. (2016) Safety studies on intravenous infusion of a potent angiogenesis inhibitor: taurocholate-conjugated low molecular weight heparin derivative LHT7 in preclinical models. Drug Development and Industrial Pharmacy 42:8, pages 1247-1257.
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Vito Ferro. (2013) Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses. Expert Opinion on Therapeutic Targets 17:8, pages 965-975.
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Steven D Rosen & Hassan Lemjabbar-Alaoui. (2010) Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opinion on Therapeutic Targets 14:9, pages 935-949.
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Articles from other publishers (71)
Ana M. Gomez, Juan Ventura, Clara Uriel & Jose Cristobal Lopez. (2023) Synthesis of carbohydrate–BODIPY hybrids. Pure and Applied Chemistry 95:9, pages 945-954.
Crossref
Crossref
Joseph Wakpal, Vishaka Pathiranage, Alice R. Walker & Hien M. Nguyen. (2023) Rational Design and Expedient Synthesis of Heparan Sulfate Mimetics from Natural Aminoglycosides for Structure and Activity Relationship Studies. Angewandte Chemie International Edition 62:32.
Crossref
Crossref
Joseph Wakpal, Vishaka Pathiranage, Alice R. Walker & Hien M. Nguyen. (2023) Rational Design and Expedient Synthesis of Heparan Sulfate Mimetics from Natural Aminoglycosides for Structure and Activity Relationship Studies. Angewandte Chemie 135:32.
Crossref
Crossref
Yuzhao Zhang & Lina Cui. (2023) Discovery and development of small-molecule heparanase inhibitors. Bioorganic & Medicinal Chemistry 90, pages 117335.
Crossref
Crossref
Yiyuan Yang, Fengyan Yuan, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Fen Xiao, Qiao Liu, Jie Liu, Yujing Zhang & Xing Yu. (2023) Potential roles of heparanase in cancer therapy: Current trends and future direction. Journal of Cellular Physiology 238:5, pages 896-917.
Crossref
Crossref
John Hogwood, Barbara Mulloy, Rebeca Lever, Elaine Gray & Clive P. Page. (2023) Pharmacology of Heparin and Related Drugs: An Update. Pharmacological Reviews 75:2, pages 328-379.
Crossref
Crossref
Zhi-Ming Zeng, Ning Mo, Jie Zeng, Fu-Chao Ma, Yan-Feng Jiang, Hua-Sheng Huang, Xi-Wen Liao, Guang-Zhi Zhu, Jie Ma & Tao Peng. (2022) Advances in postoperative adjuvant therapy for primary liver cancer. World Journal of Gastrointestinal Oncology 14:9, pages 1604-1621.
Crossref
Crossref
Fengyan Yuan, Yiyuan Yang, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Yujing Zhang & Xing Yu. (2022) Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential. Frontiers in Chemistry 10.
Crossref
Crossref
Samet KOCABAY, Mehmet Abdullah ALAGÖZ, Hıncal Gökhan BAKIR & Birnur AKKAYA. (2022) In Silico Studies of Synthetic Sulfatide as a Potential Drug Candidate Against Covid-19. Cumhuriyet Science Journal 43:2, pages 238-245.
Crossref
Crossref
Ravi S. Loka, Zhenfeng Song, Eric T. Sletten, Yasmin Kayal, Israel Vlodavsky, Kezhong Zhang & Hien M. Nguyen. (2022) Heparan Sulfate Mimicking Glycopolymer Prevents Pancreatic β Cell Destruction and Suppresses Inflammatory Cytokine Expression in Islets under the Challenge of Upregulated Heparanase. ACS Chemical Biology 17:6, pages 1387-1400.
Crossref
Crossref
Ronja Wieboldt & Heinz Läubli. (2022) Glycosaminoglycans in cancer therapy. American Journal of Physiology-Cell Physiology 322:6, pages C1187-C1200.
Crossref
Crossref
Juan Ventura, Clara Uriel, Ana M. Gómez & J. Cristobal López. (2022) Access to n-pentenyl tetra- and pentasaccharide analogues of the antitumor drug PI-88 based on 1,2-methyl orthoester glycosyl donors. Carbohydrate Research 516, pages 108557.
Crossref
Crossref
Alfredo Rus, Victor M. Bolanos-Garcia, Agatha Bastida & Paula Morales. (2022) Identification of Novel Potential Heparanase Inhibitors Using Virtual Screening. Catalysts 12:5, pages 503.
Crossref
Crossref
Theodore E. Warkentin. (2022) Platelet-activating anti-PF4 disorders: An overview. Seminars in Hematology 59:2, pages 59-71.
Crossref
Crossref
Yiwei Huang, Yuyun Song, Jichen Li, Changning Lv, Zhe-Sheng Chen & Zhijun Liu. (2022) Receptors and ligands for herpes simplex viruses: Novel insights for drug targeting. Drug Discovery Today 27:1, pages 185-195.
Crossref
Crossref
Eric T. Sletten, José Danglad-Flores, Sabrina Leichnitz, A. Abragam Joseph & Peter H. Seeberger. (2022) Expedited synthesis of mannose-6-phosphate containing oligosaccharides. Carbohydrate Research 511, pages 108489.
Crossref
Crossref
Mohit Chhabra, Gareth G. Doherty, Nicholas W. See, Neha S. Gandhi & Vito Ferro. (2021) From Cancer to COVID‐19: A Perspective on Targeting Heparan Sulfate‐Protein Interactions. The Chemical Record 21:11, pages 3087-3101.
Crossref
Crossref
Hyun Young Woo, So Young Yoo & Jeong Heo. (2021) Peretinoin, an Acyclic Retinoid, for the Secondary Prevention of Hepatocellular Carcinoma. Molecules 26:2, pages 295.
Crossref
Crossref
Rajwinder Kaur, Pran Kishore Deb, Vishal Diwan & Balraj Saini. (2021) Heparanase Inhibitors in Cancer Progression: Recent Advances. Current Pharmaceutical Design 27:1, pages 43-68.
Crossref
Crossref
Sanyong Zhu, Jiayi Li, Ravi S. Loka, Zhenfeng Song, Israel Vlodavsky, Kezhong Zhang & Hien M. Nguyen. (2020) Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides. Journal of Medicinal Chemistry 63:8, pages 4227-4255.
Crossref
Crossref
A. Sainio & H. Järveläinen. (2020) Extracellular matrix-cell interactions: Focus on therapeutic applications. Cellular Signalling 66, pages 109487.
Crossref
Crossref
David Green. 2020. The Heparins. The Heparins
35
55
.
Charmaine J. Simeonovic, Sarah K. Popp, Debra J. Brown, Fei-Ju Li, Antony R. A. Lafferty, Craig Freeman & Christopher R. Parish. 2020. Heparanase. Heparanase
607
630
.
Giuseppe Giannini, Gianfranco Battistuzzi & Silvia Rivara. 2020. Heparanase. Heparanase
567
603
.
Mohit Chhabra & Vito Ferro. 2020. Heparanase. Heparanase
473
491
.
David Lesur, Gilbert Duhirwe & José Kovensky. (2019) High resolution MALDI-TOF-MS and MS/MS: Application for the structural characterization of sulfated oligosaccharides. European Journal of Mass Spectrometry 25:5, pages 428-436.
Crossref
Crossref
Chakrabhavi Dhananjaya Mohan, Swetha Hari, Habbanakuppe D. Preetham, Shobith Rangappa, Uri Barash, Neta Ilan, S. Chandra Nayak, Vijai K. Gupta, Basappa, Israel Vlodavsky & Kanchugarakoppal S. Rangappa. (2019) Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds. iScience 15, pages 360-390.
Crossref
Crossref
Eric Boittier, Neha Gandhi, Vito Ferro & Deirdre Coombe. (2019) Cross-Species Analysis of Glycosaminoglycan Binding Proteins Reveals Some Animal Models Are “More Equal” than Others. Molecules 24:5, pages 924.
Crossref
Crossref
Ravi S. Loka, Eric T. Sletten, Uri Barash, Israel Vlodavsky & Hien M. Nguyen. (2018) Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice. ACS Applied Materials & Interfaces 11:1, pages 244-254.
Crossref
Crossref
Stefano Elli, Eduardo Stancanelli, Paul N Handley, Anthony Carroll, Elena Urso, Marco Guerrini & Vito Ferro. (2018) Structural and conformational studies of the heparan sulfate mimetic PI-88. Glycobiology 28:10, pages 731-740.
Crossref
Crossref
Shifaza Mohamed & Deirdre Coombe. (2017) Heparin Mimetics: Their Therapeutic Potential. Pharmaceuticals 10:4, pages 78.
Crossref
Crossref
Paul N. Handley, Anthony Carroll & Vito Ferro. (2017) New structural insights into the oligosaccharide phosphate fraction of Pichia ( Hansenula ) holstii NRRL Y2448 phosphomannan. Carbohydrate Research 446-447, pages 68-75.
Crossref
Crossref
Nicolas Poupard, Hugo Groult, Justine Bodin, Nicolas Bridiau, St?phanie Bordenave-Juchereau, Fr?d?ric Sannier, Jean?-Marie Piot, Ingrid Fruitier-Arnaudin & Thierry Maugard. (2017) Production of heparin and ?-carrageenan anti-heparanase derivatives using a combination of physicochemical depolymerization and glycol splitting. Carbohydrate Polymers 166, pages 156-165.
Crossref
Crossref
Nicolas Poupard, Pamela Badarou, Fabienne Fasani, Hugo Groult, Nicolas Bridiau, Frédéric Sannier, Stéphanie Bordenave-Juchereau, Claudine Kieda, Jean-Marie Piot, Catherine Grillon, Ingrid Fruitier-Arnaudin & Thierry Maugard. (2017) Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent. Marine Drugs 15:5, pages 134.
Crossref
Crossref
Maryam Tahmasebi Birgani & Vinicio Carloni. (2017) Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy. International Journal of Molecular Sciences 18:2, pages 405.
Crossref
Crossref
Ryan J. Weiss, Jeffrey D. Esko & Yitzhak Tor. (2017) Targeting heparin and heparan sulfate protein interactions. Organic & Biomolecular Chemistry 15:27, pages 5656-5668.
Crossref
Crossref
Ravi S. Loka, Fei Yu, Eric T. Sletten & Hien M. Nguyen. (2017) Design, synthesis, and evaluation of heparan sulfate mimicking glycopolymers for inhibiting heparanase activity. Chemical Communications 53:65, pages 9163-9166.
Crossref
Crossref
Kishore Kumar Jella & Zhentian Li. 2017. Role of Transcription Factors in Gastrointestinal Malignancies. Role of Transcription Factors in Gastrointestinal Malignancies
449
463
.
Israel Vlodavsky, Preeti Singh, Ilanit Boyango, Lilach Gutter-Kapon, Michael Elkin, Ralph D. Sanderson & Neta Ilan. (2016) Heparanase: From basic research to therapeutic applications in cancer and inflammation. Drug Resistance Updates 29, pages 54-75.
Crossref
Crossref
Dániel Eszenyi, Attila Mándi, Mihály Herczeg, Attila Bényei, István Komáromi & Anikó Borbás. (2016)
Synthesis of
C
-2- and
C
-3-Sulfonatomethyl
O
- and
S
-Glycosides by Horner-Wadsworth-Emmons Olefination
. European Journal of Organic Chemistry 2016:22, pages 3884-3893.
Crossref
Crossref
Silvia Rivara, Ferdinando M Milazzo & Giuseppe Giannini. (2016) Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases. Future Medicinal Chemistry 8:6, pages 647-680.
Crossref
Crossref
Angélica Maciel Gomes, Dovile Sinkeviciute, Hinke A. B. Multhaupt, Atsuko Yoneda & John R. Couchman. (2016) Syndecan Heparan Sulfate Proteoglycans: Regulation, Signaling and Impact on Tumor Biology. Trends in Glycoscience and Glycotechnology 28:163, pages J77-J88.
Crossref
Crossref
Angélica Maciel Gomes, Dovile Sinkeviciute, Hinke A. B. Multhaupt, Atsuko Yoneda & John R. Couchman. (2016) Syndecan Heparan Sulfate Proteoglycans: Regulation, Signaling and Impact on Tumor Biology. Trends in Glycoscience and Glycotechnology 28:163, pages E79-E90.
Crossref
Crossref
Oussama Achour, Nicolas Poupard, Nicolas Bridiau, Stephanie Bordenave Juchereau, Fred?ric Sannier, Jean-Marie Piot, Ingrid Fruitier Arnaudin & Thierry Maugard. (2016) Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization. Carbohydrate Polymers 135, pages 316-323.
Crossref
Crossref
HuaPing Li, HuaLi Li, HongJie Qu, MingZhu Zhao, Bo Yuan, MingHua Cao & JinQuan Cui. (2015) Suramin inhibits cell proliferation in ovarian and cervical cancer by downregulating heparanase expression. Cancer Cell International 15:1.
Crossref
Crossref
Wei Gao, Heungnam Kim & Mitchell Ho. (2015) Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells. PLOS ONE 10:9, pages e0137664.
Crossref
Crossref
Carolina M. Vicente, Marcelo A. Lima, Edwin A. Yates, Helena B. Nader & Leny Toma. (2015) Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases. Molecular Cancer Research 13:3, pages 510-523.
Crossref
Crossref
Hassan Lemjabbar-Alaoui, Andrew McKinney, Yi-Wei Yang, Vy M. Tran & Joanna J. Phillips. 2015. Glycosylation and Cancer. Glycosylation and Cancer
305
344
.
N. E. Ustyuzhanina, M. I. Bilan, N. A. Ushakova, A. I. Usov, M. V. Kiselevskiy & N. E. Nifantiev. (2014) Fucoidans: Pro- or antiangiogenic agents?. Glycobiology 24:12, pages 1265-1274.
Crossref
Crossref
Wei Gao, Heungnam Kim, Mingqian Feng, Yen Phung, Charles P. Xavier, Jeffrey S. Rubin & Mitchell Ho. (2014) Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology 60:2, pages 576-587.
Crossref
Crossref
Edward Hammond, Ashwani Khurana, Viji Shridhar & Keith Dredge. (2014) The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics. Frontiers in Oncology 4.
Crossref
Crossref
Chun-Jen Liu. (2014) Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence. World Journal of Gastroenterology 20:32, pages 11384.
Crossref
Crossref
Amal Seffouh, Fabian Milz, Cédric Przybylski, Cédric Laguri, Arie Oosterhof, Sébastien Bourcier, Rabia Sadir, Elodie Dutkowski, Régis Daniel, Toin H. Kuppevelt, Thomas Dierks, Hugues Lortat‐Jacob & Romain R. Vivès. (2013)
HSulf sulfatases catalyze processive and oriented 6‐
O
‐desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity
. The FASEB Journal 27:6, pages 2431-2439.
Crossref
Crossref
Hui-Li Chu, Hua Mao, Wei Feng, Jing-wen Liu & Yue Geng. (2013) Effects of sulfated polysaccharide from Masson pine (Pinus massoniana) pollen on the proliferation and cell cycle of HepG2 cells. International Journal of Biological Macromolecules 55, pages 104-108.
Crossref
Crossref
Seung Woo Chung, Myungjin Lee, Sang Mun Bae, Jooho Park, Ok Cheol Jeon, Hui Sun Lee, Han Choe, Han Sung Kim, Beom Suk Lee, Rang-Woon Park, Sang Yoon Kim & Youngro Byun. (2012) Potentiation of anti-angiogenic activity of heparin by blocking the ATIII-interacting pentasaccharide unit and increasing net anionic charge. Biomaterials 33:35, pages 9070-9079.
Crossref
Crossref
Elizabeth Yuriev & Paul RamslandNeha Gandhi & Ricardo Mancera. 2012. Structural Glycobiology. Structural Glycobiology
259
296
.
Keun Hur, Tae‐Su Han, Eun‐Jung Jung, Jieun Yu, Hyuk‐Joon Lee, Woo Ho Kim, Ajay Goel & Han‐Kwang Yang. (2012) Up‐regulated expression of sulfatases (SULF1 and SULF2) as prognostic and metastasis predictive markers in human gastric cancer. The Journal of Pathology 228:1, pages 88-98.
Crossref
Crossref
Xiaoyan Liu, Hong Fang, Hongchao Chen, Xiaoling Jiang, Deren Fang, Yan Wang & Dingxian Zhu. (2012) An Artificial miRNA against HPSE Suppresses Melanoma Invasion Properties, Correlating with a Down-Regulation of Chemokines and MAPK Phosphorylation. PLoS ONE 7:6, pages e38659.
Crossref
Crossref
Vito Ferro, Ligong Liu, Ken D. Johnstone, Norbert Wimmer, Tomislav Karoli, Paul Handley, Jessica Rowley, Keith Dredge, Cai Ping Li, Edward Hammond, Kat Davis, Laura Sarimaa, Job Harenberg & Ian Bytheway. (2012) Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis. Journal of Medicinal Chemistry 55:8, pages 3804-3813.
Crossref
Crossref
Neha S Gandhi, Craig Freeman, Christopher R Parish & Ricardo L Mancera. (2012) Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-d-glucuronidase (heparanase). Glycobiology 22:1, pages 35-55.
Crossref
Crossref
Anna Lundin, Tomas Bergstr?m, Carla R. Andrighetti-Fr?hner, Loubna Bendrioua, Vito Ferro & Edward Trybala. (2012) Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate. Antiviral Research 93:1, pages 101-109.
Crossref
Crossref
David Planer, Shulamit Metzger, Eyal Zcharia, Isaiah D. Wexler, Israel Vlodavsky & Tova Chajek-Shaul. (2011) Role of Heparanase on Hepatic Uptake of Intestinal Derived Lipoprotein and Fatty Streak Formation in Mice. PLoS ONE 6:4, pages e18370.
Crossref
Crossref
Kirsty A. Allen, Rosemary L. Brown, Gillian Norris, Peter C. Tyler, Derek K. Watt & Olga V. Zubkova. (2010) Syntheses of novel azasugar-containing mimics of heparan sulfate fragments as potential heparanase inhibitors. Carbohydrate Research 345:13, pages 1831-1841.
Crossref
Crossref
Carmen Ruiz Velasco, Sylvia Colliec-Jouault, Françoise Redini, Dominique Heymann & Marc Padrines. (2010) Proteoglycans on bone tumor development. Drug Discovery Today 15:13-14, pages 553-560.
Crossref
Crossref
Elizabeth Lau & Richard U Margolis. (2010) Inhibitors of slit protein interactions with the heparan sulphate proteoglycan glypican-1: Potential agents for the treatment of spinal cord injury. Clinical and Experimental Pharmacology and Physiology 37:4, pages 417-421.
Crossref
Crossref
Ken D. Johnstone, Tomislav Karoli, Ligong Liu, Keith Dredge, Elizabeth Copeman, Cai Ping Li, Kat Davis, Edward Hammond, Ian Bytheway, Edmund Kostewicz, Francis C. K. Chiu, David M. Shackleford, Susan A. Charman, William N. Charman, Job Harenberg, Thomas J. Gonda & Vito Ferro. (2010) Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth. Journal of Medicinal Chemistry 53:4, pages 1686-1699.
Crossref
Crossref
Pingping Ma, Yan Luo, Xiaobo Zhu, Tao Li, Jie Hu & Shibo Tang. (2010) Retinal heparanase expression in streptozotocin-induced diabetic rats. Canadian Journal of Ophthalmology 45:1, pages 46-51.
Crossref
Crossref
. (2010) Current World Literature. Current Opinion in Obstetrics & Gynecology 22:1, pages 87-93.
Crossref
Crossref
Catherine Kirn-Safran, Mary C. Farach-Carson & Daniel D. Carson. (2009) Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans. Cellular and Molecular Life Sciences 66:21, pages 3421-3434.
Crossref
Crossref
Andrew Beenken & Moosa Mohammadi. (2009) The FGF family: biology, pathophysiology and therapy. Nature Reviews Drug Discovery 8:3, pages 235-253.
Crossref
Crossref
Pingping Ma, Yan Luo, Xiaobo Zhu, Hongjie Ma, Jie Hu & Shibo Tang. (2009) Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. Biochemical and Biophysical Research Communications 380:2, pages 402-406.
Crossref
Crossref