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Expert Opinion on Investigational Drugs Volume 17, 2008 - Issue 5
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Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis

Malini Bajpai Department of Pharmacology, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot No-20, Sector-18, Gurgaon-122001-Haryana, India +91 124 2342001 10, ext: 5256; +91 124 [email protected]
, PhD,
Puneet Chopra Department of Pharmacology, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot No-20, Sector-18, Gurgaon-122001-Haryana, India +91 124 2342001 10, ext: 5256; +91 124 [email protected]
, PhD,
Sunanda G Dastidar Department of Pharmacology, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot No-20, Sector-18, Gurgaon-122001-Haryana, India +91 124 2342001 10, ext: 5256; +91 124 [email protected]
, PhD &
Abhijit Ray Department of Pharmacology, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot No-20, Sector-18, Gurgaon-122001-Haryana, India +91 124 2342001 10, ext: 5256; +91 124 [email protected]
, PhD
Pages 641-659 | Published online: 30 Apr 2008

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Jorge Morales-Torres. (2012) The status of fostamatinib in the treatment of rheumatoid arthritis. Expert Review of Clinical Immunology 8:7, pages 609-615.
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Paolo Ruzza, Barbara Biondi & Andrea Calderan. (2009) Therapeutic prospect of Syk inhibitors. Expert Opinion on Therapeutic Patents 19:10, pages 1361-1376.
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Neil P. Grimster, Lakshmaiah Gingipalli, Bernard Barlaam, Qibin Su, XiaoLan Zheng, David Watson, Haixia Wang, Iain Simpson, Andy Pike, Amber Balazs, Scott Boiko, Timothy P. Ikeda, Anna C. Impastato, Natalie H. Jones, Sameer Kawatkar, Paul Kemmitt, Scott Lamont, Joe Patel, Jon Read, Ujjal Sarkar, Li Sha, Ronald C. Tomlinson, Haiyun Wang, David M. Wilson, Troy E. Zehnder, Lianghe Wang, Peng Wang, Frederick W. Goldberg, Wenlin Shao, Stephen Fawell, Hannah Dry, James E. Dowling & Scott D. Edmondson. (2020) Optimization of a series of potent, selective and orally bioavailable SYK inhibitors. Bioorganic & Medicinal Chemistry Letters 30:19, pages 127433.
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Stanley Cohen. 2017. Kelley and Firestein's Textbook of Rheumatology. Kelley and Firestein's Textbook of Rheumatology 1044 1060 .
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Sang Jae Lee, Jang-Sik Choi, Byeong-Gu Han, Hyoun Sook Kim, Ho-Juhn Song, Jaekyoo Lee, Seungyoon Nam, Sung-Ho Goh, Jung-Ho Kim, Jong Sung Koh & Byung Il Lee. (2016) Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs. The FEBS Journal 283:19, pages 3613-3625.
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Alba Llop-Guevara, Mónica Porras, Carla Cendón, Irene Di Ceglie, Francesco Siracusa, Federica Madarena, Vagelis Rinotas, Lluís Gómez, Peter L. van Lent, Eleni Douni, Hyun Dong Chang, Thomas Kamradt & Juan Román. (2015) Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice. Arthritis Research & Therapy 17:1.
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Jianlin Qiao, Mohammad Al-Tamimi, Ross I. Baker, Robert K. Andrews & Elizabeth E. Gardiner. (2015) The platelet Fc receptor, FcγRIIa. Immunological Reviews 268:1, pages 241-252.
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Jang-Sik Choi, Hae-jun Hwang, Se-Won Kim, Byung Il Lee, Jaekyoo Lee, Ho-Juhn Song, Jong Sung Koh, Jung-Ho Kim & Phil Ho Lee. (2015) Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 25:20, pages 4441-4446.
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Gebhard Thoma, Alexander B. Smith, Maurice J. van Eis, Eric Vangrevelinghe, Joachim Blanz, Reiner Aichholz, Amanda Littlewood-Evans, Christian C. Lee, Hong Liu & Hans-Günter Zerwes. (2015) Discovery and Profiling of a Selective and Efficacious Syk Inhibitor. Journal of Medicinal Chemistry 58:4, pages 1950-1963.
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Xianghong Chen, Erika A. Eksioglu, John D. Carter, Nicole Fortenbery, Sarah S. Donatelli, Junmin Zhou, Jinhong Liu, Lili Yang, Danielle Gilvary, Julie Djeu & Sheng Wei. (2015) Inactivation of DAP12 in PMN Inhibits TREM1-Mediated Activation in Rheumatoid Arthritis. PLOS ONE 10:2, pages e0115116.
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Jihye Ryu, Jeyoung Woo, Jimin Shin, Hyunju Ryoo, Younyoung Kim & Chaeyoung Lee. (2014) Profile of Differential Promoter Activity by Nucleotide Substitution at GWAS Signals For Multiple Sclerosis. Medicine 93:28, pages e281.
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Ming Jiang, Renping Liu, Ying Chen, Qisheng Zheng, Saijun Fan & Peixun Liu. (2014) A Combined Experimental and Computational Study of Vam3, a Derivative of Resveratrol, and Syk Interaction. International Journal of Molecular Sciences 15:9, pages 17188-17203.
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Robert L. Geahlen. (2014) Getting Syk: spleen tyrosine kinase as a therapeutic target. Trends in Pharmacological Sciences 35:8, pages 414-422.
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Yue Lu, Xian Li, Young Na Park, Okyun Kwon, Donggen Piao, Young-Chae Chang, Cheorl-Ho Kim, Eunkyung Lee, Jong Keun Son & Hyeun Wook Chang. (2014) Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway. Biomolecules & Therapeutics 22:3, pages 193-199.
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Gebhard Thoma, Joachim Blanz, Peter Bühlmayer, Peter Drückes, Matthias Kittelmann, Alexander B. Smith, Maurice van Eis, Eric Vangrevelinghe, Hans-Günter Zerwes, Jianwei (John) Che, Xiaohui He, Yunho Jin, Christian C. Lee, Pierre-Yves Michellys, Tetsuo Uno & Hong Liu. (2014) Syk inhibitors with high potency in presence of blood. Bioorganic & Medicinal Chemistry Letters 24:10, pages 2278-2282.
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Matthew C. Lucas, Niala Bhagirath, Eric Chiao, David M. Goldstein, Johannes C. Hermann, Pei-Yuan Hsu, Stephan Kirchner, Joshua J. Kennedy-Smith, Andreas Kuglstatter, Christine Lukacs, John Menke, Linghao Niu, Fernando Padilla, Ying Peng, Liudmila Polonchuk, Aruna Railkar, Michelle Slade, Michael Soth, Daigen Xu, Preeti Yadava, Calvin Yee, Mingyan Zhou & Cheng Liao. (2014) Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors. Journal of Medicinal Chemistry 57:6, pages 2683-2691.
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J. Michael Bradshaw. (2010) The Src, Syk, and Tec family kinases: Distinct types of molecular switches. Cellular Signalling 22:8, pages 1175-1184.
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Huan-Zhang Xie, Lin-Li Li, Ji-Xia Ren, Jun Zou, Li Yang, Yu-Quan Wei & Sheng-Yong Yang. (2009) Pharmacophore modeling study based on known Spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorganic & Medicinal Chemistry Letters 19:7, pages 1944-1949.
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Emily Tsang, Anthony M. Giannetti, David Shaw, Marie Dinh, Joyce K.Y. Tse, Shaan Gandhi, Hoangdung Ho, Sandra Wang, Eva Papp & J. Michael Bradshaw. (2008) Molecular Mechanism of the Syk Activation Switch. Journal of Biological Chemistry 283:47, pages 32650-32659.
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