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Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms

, MD & , PharmD
Pages 661-668 | Published online: 30 Apr 2008

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Muhammad Usman Munir, Arsalan Ahmed, Muhammad Usman & Sajal Salman. (2020) Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes. International Journal of Nanomedicine 15, pages 7329-7358.
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Rong Zhang, Ning Dong, Yonglu Huang, Hongwei Zhou, Miaomiao Xie, Edward Wai-Chi Chan, Yanyan Hu, Jiachang Cai & Sheng Chen. (2018) Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract. Emerging Microbes & Infections 7:1, pages 1-11.
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Elizabeth B Hirsch & Vincent H Tam. (2010) Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes. Expert Review of Pharmacoeconomics & Outcomes Research 10:4, pages 441-451.
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Articles from other publishers (33)

Hannah Krivić, Sebastian Himbert & Maikel C. Rheinstädter. (2022) Perspective on the Application of Erythrocyte Liposome-Based Drug Delivery for Infectious Diseases. Membranes 12:12, pages 1226.
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Hannah Krivić, Sebastian Himbert, Ruthie Sun, Michal Feigis & Maikel C. Rheinstädter. (2022) Erythro-PmBs: A Selective Polymyxin B Delivery System Using Antibody-Conjugated Hybrid Erythrocyte Liposomes. ACS Infectious Diseases 8:10, pages 2059-2072.
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Yajuan Su, Jaime T. Yrastorza, Mitchell Matis, Jenna Cusick, Siwei Zhao, Guangshun Wang & Jingwei Xie. (2022) Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment. Advanced Science 9:29.
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Guanhao Zheng, Jiaqi Cai, Shenghui Zhou, Ning Du, Hao Bai, Juan He & Xiaolan Bian. (2022) Risk of polymyxin B-induced acute kidney injury with a non adjusted dose versus adjusted dose based on renal function. Personalized Medicine 19:4, pages 307-314.
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Tomohiro Kagi, Rio Naganuma, Aya Inoue, Takuya Noguchi, Shuhei Hamano, Yuto Sekiguchi, Gi-Wook Hwang, Yusuke Hirata & Atsushi Matsuzawa. (2021) The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages. The Journal of Antibiotics 75:1, pages 29-39.
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Shu Chen, Pingping Zhang, Liyin Xiao, Ying Liu, Kuihai Wu, Guoying Ni, Hejie Li, Tianfang Wang, Xiaolian Wu, Guoqiang Chen & Xiaosong Liu. (2021) Caerin 1.1 and 1.9 Peptides from Australian Tree Frog Inhibit Antibiotic-Resistant Bacteria Growth in a Murine Skin Infection Model. Microbiology Spectrum 9:1.
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Hui Zhang, Ge Zhang, Jingjia Zhang, Simeng Duan, Yue Kang, Qiwen Yang & Yingchun Xu. (2020) Antimicrobial Activity of Colistin Against Contemporary (2015 – 2017) P. aeruginosa and A. baumannii Isolates From a Chinese Surveillance Program. Frontiers in Microbiology 11.
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Maria Helena Rigatto, Diego R. Falci & Alexandre P. Zavascki. 2019. Polymyxin Antibiotics: From Laboratory Bench to Bedside. Polymyxin Antibiotics: From Laboratory Bench to Bedside 197 218 .
Ramakrishnan Sitaraman. (2018) Prokaryotic horizontal gene transfer within the human holobiont: ecological-evolutionary inferences, implications and possibilities. Microbiome 6:1.
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Jenna Covelli, Donna Ruszaj, Robert Straubinger, Jian Li & Gauri G. Rao. (2017) The development and validation of a simple liquid chromatography–tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices. Journal of Chromatography B 1065-1066, pages 112-118.
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Masoumeh Navidinia, Mehdi Goudarzi, Samira Molaei Rameshe, Zahra Farajollahi, Pedram Ebadi Asl, Saeed Zaka khosravi & Mohammad Reza Mounesi. (2017) Molecular Characterization of Resistance Genes in MDR-ESKAPE Pathogens. Journal of Pure and Applied Microbiology 11:2, pages 779-792.
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Mathieu Heulot, Nicolas Jacquier, Sébastien Aeby, Didier Le Roy, Thierry Roger, Evgeniya Trofimenko, David Barras, Gilbert Greub & Christian Widmann. (2017) The Anticancer Peptide TAT-RasGAP317−326 Exerts Broad Antimicrobial Activity. Frontiers in Microbiology 8.
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Kim H. Hee, Yee K.J. Leaw, Jun L. Ong & Lawrence S. Lee. (2017) Development and validation of liquid chromatography tandem mass spectrometry method quantitative determination of polymyxin B1, polymyxin B2, polymyxin B3 and isoleucine-polymyxin B1 in human plasma and its application in clinical studies. Journal of Pharmaceutical and Biomedical Analysis 140, pages 91-97.
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Pooja Manchandani, Jian Zhou, Kimberly R. Ledesma, Luan D. Truong, Diana S.-L. Chow, Jason L. Eriksen & Vincent H. Tam. (2016) Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model. Antimicrobial Agents and Chemotherapy 60:2, pages 1029-1034.
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Fatoumata Tambadou, Thibault Caradec, Anne-Laure Gagez, Antoine Bonnet, Valérie Sopéna, Nicolas Bridiau, Valérie Thiéry, Sandrine Didelot, Cyrille Barthélémy & Romain Chevrot. (2015) Characterization of the colistin (polymyxin E1 and E2) biosynthetic gene cluster. Archives of Microbiology 197:4, pages 521-532.
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Lorraine A Draper, Paul D Cotter, Colin Hill & R Paul Ross. (2013) The two peptide lantibiotic lacticin 3147 acts synergistically with polymyxin to inhibit Gram negative bacteria. BMC Microbiology 13:1.
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Jie He, Kamilia Abdelraouf, Kimberly R. Ledesma, Diana S.-L. Chow & Vincent H. Tam. (2013) Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model. International Journal of Antimicrobial Agents 42:6, pages 559-564.
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Georgina Cox & Gerard D. Wright. (2013) Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions. International Journal of Medical Microbiology 303:6-7, pages 287-292.
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Thomas V. Magee, Matthew F. Brown, Jeremy T. Starr, David C. Ackley, Joseph A. Abramite, Jiri Aubrecht, Andrew Butler, Jared L. Crandon, Fadia Dib-Hajj, Mark E. Flanagan, Karl Granskog, Joel R. Hardink, Michael D. Huband, Rebecca Irvine, Michael Kuhn, Karen L. Leach, Bryan Li, Jian Lin, David R. Luke, Shawn H. MacVane, Alita A. Miller, Sandra McCurdy, James M. McKimJr.Jr., David P. Nicolau, Thuy-Trinh Nguyen, Mark C. Noe, John P. O’Donnell, Scott B. Seibel, Yue Shen, Antonia F. Stepan, Andrew P. Tomaras, Paul C. Wilga, Li Zhang, Jinfeng Xu & Jinshan Michael Chen. (2013) Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections. Journal of Medicinal Chemistry 56:12, pages 5079-5093.
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J. He, S. Gao, M. Hu, D. S.- L. Chow & V. H. Tam. (2013) A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies. Journal of Antimicrobial Chemotherapy 68:5, pages 1104-1110.
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Kamilia Abdelraouf, Jie He, Kimberly R. Ledesma, Ming Hu & Vincent H. Tam. (2012) Pharmacokinetics and Renal Disposition of Polymyxin B in an Animal Model. Antimicrobial Agents and Chemotherapy 56:11, pages 5724-5727.
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Kamilia Abdelraouf, Kirk H. Braggs, Taijun Yin, Luan D. Truong, Ming Hu & Vincent H. Tam. (2012) Characterization of Polymyxin B-Induced Nephrotoxicity: Implications for Dosing Regimen Design. Antimicrobial Agents and Chemotherapy 56:9, pages 4625-4629.
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Marius Henkel, Markus M. Müller, Johannes H. Kügler, Roberta B. Lovaglio, Jonas Contiero, Christoph Syldatk & Rudolf Hausmann. (2012) Rhamnolipids as biosurfactants from renewable resources: Concepts for next-generation rhamnolipid production. Process Biochemistry 47:8, pages 1207-1219.
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Vincent H. Tam, Henry Cao, Kimberly R. Ledesma & Ming Hu. (2011) In Vitro Potency of Various Polymyxin B Components . Antimicrobial Agents and Chemotherapy 55:9, pages 4490-4491.
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Christine M. Salvatore, Kamilia Abdelraouf, Deyin D. Hsing & Vincent H. Tam. (2011) Pharmacokinetics of Polymyxin B in an Infant With Multidrug-resistant Klebsiella pneumoniae Bacteremia. Pediatric Infectious Disease Journal 30:6, pages 537-539.
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Azza Elemam, Joseph Rahimian & Mehmet Doymaz. (2010) In Vitro Evaluation of Antibiotic Synergy for Polymyxin B-Resistant Carbapenemase-Producing Klebsiella pneumoniae . Journal of Clinical Microbiology 48:10, pages 3558-3562.
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Jie HeDeborah A. FigueroaTze-Peng LimDiana S. Chow & Vincent H. Tam. (2010) Stability of polymyxin B sulfate diluted in 0.9% sodium chloride injection and stored at 4 or 25 °C. American Journal of Health-System Pharmacy 67:14, pages 1191-1194.
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William F. Wade & George A. O’Toole. (2010) Antibodies and immune effectors: shaping Gram-negative bacterial phenotypes. Trends in Microbiology 18:6, pages 234-239.
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Jie He, Kimberly R. Ledesma, Wai-Ying Lam, Deborah A. Figueroa, Tze-Peng Lim, Diana S.-L. Chow & Vincent H. Tam. (2010) Variability of polymyxin B major components in commercial formulations. International Journal of Antimicrobial Agents 35:3, pages 308-310.
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Jason Kindrachuk, Anastasia Nijnik & R.E.W. Hancock. 2010. Comprehensive Natural Products II. Comprehensive Natural Products II 175 216 .
KuoYuan Hwa, Di-Shuan Chiang & Chen-Wen Yao. (2009) Target Identification of an Antibacterial Compound from Data Mining of 2-D Gel Images. Target Identification of an Antibacterial Compound from Data Mining of 2-D Gel Images.
Matthew E. Falagas, Evridiki K. Vouloumanou & Petros I. Rafailidis. (2009) Systemic colistin use in children without cystic fibrosis: a systematic review of the literature. International Journal of Antimicrobial Agents 33:6, pages 503.e1-503.e13.
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Hemamali J. Warshakoon, Mark R. Burns & Sunil A. David. (2009) Structure-Activity Relationships of Antimicrobial and Lipoteichoic Acid-Sequestering Properties in Polyamine Sulfonamides. Antimicrobial Agents and Chemotherapy 53:1, pages 57-62.
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