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Expert Opinion on Investigational Drugs Volume 17, 2008 - Issue 8
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Review

New drugs in development for the treatment of endometriosis

Luigi Fedele Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]; Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, MD,
Edgardo Somigliana Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]
, MD PhD,
Giada Frontino Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]; Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, MD,
Laura Benaglia Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]; Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, MD &
Paola Vigano Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, PhD
Pages 1187-1202 | Published online: 10 Jul 2008

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Norbert Schmees & Hilmar Weinmann. (2009) Recent patent trends in the field of progesterone receptor agonists and modulators. Expert Opinion on Therapeutic Patents 19:11, pages 1521-1534.
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Sun-Wei Guo. (2008) Emerging drugs for endometriosis. Expert Opinion on Emerging Drugs 13:4, pages 547-571.
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Articles from other publishers (25)

Augusto Pereira, Manuel Herrero-Trujillano, Gema Vaquero, Lucia Fuentes, Sofia Gonzalez, Agustin Mendiola & Tirso Perez-Medina. (2022) Clinical Management of Chronic Pelvic Pain in Endometriosis Unresponsive to Conventional Therapy. Journal of Personalized Medicine 12:1, pages 101.
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Laurin Burla, Dimitrios Rafail Kalaitzopoulos, Julian Matthias Metzler, David Scheiner & Patrick Imesch. (2021) Popularity of endocrine endometriosis drugs and limited alternatives in the present and foreseeable future: A survey among 1420 affected women. European Journal of Obstetrics & Gynecology and Reproductive Biology 262, pages 232-238.
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Alexandre Vallée, Jean-Noël Vallée, Alain Le Blanche & Yves Lecarpentier. (2021) PPARγ Agonists: Emergent Therapy in Endometriosis. Pharmaceuticals 14:6, pages 543.
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Alexandra Sabrina Kohl Schwartz, Elvira Gross, Kirsten Geraedts, Martina Rauchfuss, Monika Maria Wölfler, Felix Häberlin, Stephanie von Orelli, Markus Eberhard, Patrick Imesch, Bruno Imthurn & Brigitte Leeners. (2019) The use of home remedies and complementary health approaches in endometriosis. Reproductive BioMedicine Online 38:2, pages 260-271.
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Silvana R. Ferreira, Leandro M. Vélez, Maria F. Heber, Giselle A. Abruzzese & Alicia B. Motta. (2019) Prenatal androgen excess alters the uterine peroxisome proliferator-activated receptor (PPAR) system. Reproduction, Fertility and Development 31:8, pages 1401.
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Jin Song, Zehui Wu, Beau Wangtrakuldee, Seok Rye Choi, Zhihao Zha, Karl Ploessl, Robert H Mach & Hank Kung. (2016) 4-(((4-Iodophenyl)methyl)-4 H -1,2,4-triazol-4-ylamino)-benzonitrile: A Potential Imaging Agent for Aromatase . Journal of Medicinal Chemistry 59:20, pages 9370-9380.
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Ozlem Ulas Erten, Tuğba Altun Ensari, Berna Dilbaz, Huseyin Cakiroglu, Sadiman Kıykac Altinbas, Muzaffer Çaydere & Umit Goktolga. (2016) Vitamin C is effective for the prevention and regression of endometriotic implants in an experimentally induced rat model of endometriosis. Taiwanese Journal of Obstetrics and Gynecology 55:2, pages 251-257.
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Anat Biegon. (2016) In vivo visualization of aromatase in animals and humans. Frontiers in Neuroendocrinology 40, pages 42-51.
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Anat Biegon, David L. Alexoff, Sung Won Kim, Jean Logan, Deborah Pareto, David Schlyer, Gene-Jack Wang & Joanna S. Fowler. (2015) Aromatase Imaging with [ N -Methyl- 11 C]Vorozole PET in Healthy Men and Women . Journal of Nuclear Medicine 56:4, pages 580-585.
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Satoru Matsuda, Mayumi Kobayashi & Yasuko Kitagishi. (2013) Expression and Function of PPARs in Placenta. PPAR Research 2013, pages 1-7.
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Edgardo Somigliana, Paola Vigano, Laura Benaglia, Andrea Busnelli, Paolo Vercellini & Luigi Fedele. (2012) Adhesion Prevention in Endometriosis: A Neglected Critical Challenge. Journal of Minimally Invasive Gynecology 19:4, pages 415-421.
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Mahaut Leconte, Bruno Borghese, Charles Chapron & Bertrand Dousset. (2012) Localisations digestives de l?endom?triose. La Presse M?dicale 41:4, pages 358-366.
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CHRISTIANE OTTO, JENNY SCHKOLDOW, ELISABETH KRAHL, IRIS FUCHS & HANNES-FRIEDRICH ULBRICH. (2012) Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis. Experimental and Therapeutic Medicine 3:3, pages 410-414.
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Kathrin Schwager, Frank Bootz, Patrick Imesch, Manuela Kaspar, Eveline Trachsel & Dario Neri. (2011) The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model. Human Reproduction 26:9, pages 2344-2352.
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Mahaut Leconte, Carole Nicco, Charlotte Ngô, Christiane Chéreau, Sandrine Chouzenoux, Wioleta Marut, Jean Guibourdenche, Sylviane Arkwright, Bernard Weill, Charles Chapron, Bertrand Dousset & Frédéric Batteux. (2011) The mTOR/AKT Inhibitor Temsirolimus Prevents Deep Infiltrating Endometriosis in Mice. The American Journal of Pathology 179:2, pages 880-889.
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P. Stratton & K. J. Berkley. (2010) Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Human Reproduction Update 17:3, pages 327-346.
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Pamela Stratton & Karen J. Berkley. 2011. Endometriosis. Endometriosis 230 239 .
P. Vercellini, P. Crosignani, E. Somigliana, P. Vigano, M. P. Frattaruolo & L. Fedele. (2010) 'Waiting for Godot': a commonsense approach to the medical treatment of endometriosis. Human Reproduction 26:1, pages 3-13.
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Anat Biegon, Sung Won Kim, David L. Alexoff, Millard Jayne, Pauline Carter, Barbara Hubbard, Payton King, Jean Logan, Lisa Muench, Deborah Pareto, David Schlyer, Colleen Shea, Frank Telang, Gene-Jack Wang, Youwen Xu & Joanna S. Fowler. (2010) Unique distribution of aromatase in the human brain: In vivo studies with PET and [N-methyl-11C]vorozole. Synapse 64:11, pages 801-807.
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Z. Melis Altan, Deborah Denis, David Kagan, Eric M. Grund, Stephen S. Palmer & Selvaraj G. Nataraja. (2010) A Long-Acting Tumor Necrosis Factor α-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis. Journal of Pharmacology and Experimental Therapeutics 334:2, pages 460-466.
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E. Somigliana, P. Vercellini, P. Vigano'L. Benaglia, P. G. Crosignani & L. Fedele. (2010) Non-invasive diagnosis of endometriosis: the goal or own goal?. Human Reproduction 25:8, pages 1863-1868.
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Xinmei Zhang, Bangchun Lu, Xiufeng Huang, Hong Xu, Caiyun Zhou & Jun Lin. (2010) Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids. Fertility and Sterility 94:2, pages 730-737.
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Isabel C. Green, Sarah L. Cohen, Dayna Finkenzeller & Paul J. Christo. (2010) Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?. Current Pain and Headache Reports 14:1, pages 22-32.
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Qionghua Chen, Weidong Zhou, Demin Pu, Zhiyong Li, Qiansheng Huang & Qingxi Chen. (2009) The inhibitory effect of 15-R-LXA4 on experimental endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology 145:2, pages 200-204.
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Fernando M. Reis, Débora M. Morsch, Ana L. Rocha, Márcia M. Carneiro & Poli M. Spritzer. (2018) The Early Genes c-fos and c-jun: Potential Targets to Modulate Estrogen Action in Endometriosis?. Journal of Endometriosis 1:1, pages 30-35.
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