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Investigational melatonin receptor agonists

Pages 747-764 | Published online: 21 Apr 2010

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Alessia Carocci, Alessia Catalano & Maria Stefania Sinicropi. (2014) Melatonergic drugs in development. Clinical Pharmacology: Advances and Applications 6, pages 127-137.
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Alberto Dominguez-Rodriguez. (2012) Melatonin in cardiovascular disease. Expert Opinion on Investigational Drugs 21:11, pages 1593-1596.
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Ludovit Paulis, Fedor Simko & Moshe Laudon. (2012) Cardiovascular effects of melatonin receptor agonists. Expert Opinion on Investigational Drugs 21:11, pages 1661-1678.
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D Alan Lankford. (2011) Tasimelteon for insomnia. Expert Opinion on Investigational Drugs 20:7, pages 987-993.
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Marco Mor, Silvia Rivara, Daniele Pala, Annalida Bedini, Gilberto Spadoni & Giorgio Tarzia. (2010) Recent advances in the development of melatonin MT1 and MT2 receptor agonists. Expert Opinion on Therapeutic Patents 20:8, pages 1059-1077.
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Rüdiger Hardeland. (2021) Divergent Importance of Chronobiological Considerations in High- and Low-dose Melatonin Therapies. Diseases 9:1, pages 18.
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Dongmei Chen, Tao Zhang & Tae Ho Lee. (2020) Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases. Biomolecules 10:8, pages 1158.
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Jana Tchekalarova, Violina T. Angelova, Nadezhda Todorova, Pavlina Andreeva-Gateva & Miroslav Rangelov. (2019) Evaluation of the anticonvulsant effect of novel melatonin derivatives in the intravenous pentylenetetrazol seizure test in mice. European Journal of Pharmacology 863, pages 172684.
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Ronan Rocaboy, Ioannis Anastasiou & Olivier Baudoin. (2019) Redox‐Neutral Coupling between Two C(sp 3 )−H Bonds Enabled by 1,4‐Palladium Shift for the Synthesis of Fused Heterocycles . Angewandte Chemie International Edition 58:41, pages 14625-14628.
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Ronan Rocaboy, Ioannis Anastasiou & Olivier Baudoin. (2019) Redox‐Neutral Coupling between Two C(sp 3 )−H Bonds Enabled by 1,4‐Palladium Shift for the Synthesis of Fused Heterocycles . Angewandte Chemie 131:41, pages 14767-14770.
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Si-Yue Chen, Chang-An Geng, Yun-Bao Ma, Xiao-Yan Huang, Xiao-Tong Yang, Li-Hua Su, Xiao-Feng He, Tian-Ze Li, Zhen-Tao Deng, Zhen Gao, Xue-Mei Zhang & Ji-Jun Chen. (2019) Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships. Bioorganic & Medicinal Chemistry 27:15, pages 3299-3306.
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Yaoyao Xia, Siyuan Chen, Sijing Zeng, Yuanyuan Zhao, Congrui Zhu, Baichuan Deng, Guoqiang Zhu, Yulong Yin, Wence Wang, Rüdiger Hardeland & Wenkai Ren. (2019) Melatonin in macrophage biology: Current understanding and future perspectives. Journal of Pineal Research 66:2, pages e12547.
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Brian Raymer & Samit K. Bhattacharya. (2018) Lead-like Drugs: A Perspective. Journal of Medicinal Chemistry 61:23, pages 10375-10384.
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Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 481 535 .
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SumraWajid Abbasi, Saad Raza, Syed Sikander Azam, Klaus R. Liedl & Julian E. Fuchs. (2016) Interaction mechanisms of a melatonergic inhibitor in the melatonin synthesis pathway. Journal of Molecular Liquids 221, pages 507-517.
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Ya-Mei He, Hong-Hui Deng, Mei-Hong Shi, Bello Musa Bodinga, Hua-Li Chen, Zeng-Sheng Han, Zhong-Liang Jiang & Qing-Wang Li. (2016) Melatonin modulates the functions of porcine granulosa cells via its membrane receptor MT2 in vitro. Animal Reproduction Science 172, pages 164-172.
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Paula Mosińska, Katarzyna Socała, Dorota Nieoczym, Moshe Laudon, Martin Storr, Jakub Fichna & Piotr Wlaź. (2016) Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice. Behavioural Brain Research 307, pages 199-207.
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Rüdiger Hardeland. (2016) Melatonergic Treatment: Focus on Metabolism and Chronobiology. Focus on Sciences 2:1, pages 1-10.
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Rüdiger Hardeland. 2016. Inflammation, Aging, and Oxidative Stress. Inflammation, Aging, and Oxidative Stress 345 376 .
Izaskun Buendia, Vanessa Gómez-Rangel, Laura González-Lafuente, Esther Parada, Rafael León, Isabel Gameiro, Patrycja Michalska, Moshe Laudon, Javier Egea & Manuela G. López. (2015) Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models. Neuropharmacology 99, pages 187-195.
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Rüdiger Hardeland. 2014. Melatonin. Melatonin 11 18 .
Darius. P. Zlotos, Ralf Jockers, Erika Cecon, Silvia Rivara & Paula A. Witt-Enderby. (2013) MT 1 and MT 2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential . Journal of Medicinal Chemistry 57:8, pages 3161-3185.
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Michelle Basler, Alexander Jetter, Daniel Fink, Burkhardt Seifert, Gerd A. Kullak-Ublick & Andreas Trojan. (2014) Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature. Breast Care 9:3, pages 182-187.
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Xuan Zhang, Zhilong Wang, Qingqing Huang, Yu Luo, Xin Xie & Wei Lu. (2014) Design, synthesis, and biological evaluation of a new class of MT 2 -selective agonists . RSC Adv. 4:49, pages 25871-25874.
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Darius P. Zlotos. 2014. Melatonin and Melatonergic Drugs in Clinical Practice. Melatonin and Melatonergic Drugs in Clinical Practice 97 116 .
King Chan & Yung Wong. (2013) A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity. International Journal of Molecular Sciences 14:9, pages 18385-18406.
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Jaime M. Monti, Ahmed S. BaHammam, Seithikurippu R. Pandi-Perumal, Vivien Bromundt, D. Warren Spence, Daniel P. Cardinali & Gregory M. Brown. (2013) Sleep and circadian rhythm dysregulation in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 43, pages 209-216.
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Seithikurippu R. Pandi-Perumal, Ahmed S. BaHammam, Gregory M. Brown, D. Warren Spence, Vijay K. Bharti, Charanjit Kaur, Rüdiger Hardeland & Daniel P. Cardinali. (2012) Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes. Neurotoxicity Research 23:3, pages 267-300.
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Elmar Peschke, Ina Bähr & Eckhard Mühlbauer. (2013) Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon. International Journal of Molecular Sciences 14:4, pages 6981-7015.
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Rüdiger Hardeland. (2013) Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus—Consequences to Melatonin Dysfunction. International Journal of Molecular Sciences 14:3, pages 5817-5841.
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Reinhard Oertel, Lisa Goltz & Wilhelm Kirch. (2013) Determination of the novel melatonin agonist Neu-P11 in plasma samples by liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 74, pages 66-70.
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R. Oertel, L. Goltz & W. Kirch. (2013) Elucidation of Neu-P11 metabolism in urine of volunteers by liquid chromatography–tandem mass spectrometry. Journal of Chromatography A 1278, pages 69-75.
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T. Partonen. 2013. Encyclopedia of Sleep. Encyclopedia of Sleep 118 121 .
Shou-min Xi, San-qiang Li & Wei-dong Yin. (2012) Topical Application of Melatonin Analogue Neu-P11 Reduces Intraocular Pressure in Normotensive Rabbit. Topical Application of Melatonin Analogue Neu-P11 Reduces Intraocular Pressure in Normotensive Rabbit.
Rüdiger Hardeland, Juan Antonio Madrid, Dun‐Xian Tan & Russel J. Reiter. (2011) Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling. Journal of Pineal Research 52:2, pages 139-166.
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Rüdiger Hardeland. (2012) Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction. The Scientific World Journal 2012, pages 1-18.
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Jeffrey M. Ellenbogen & Edward F. Pace-Schott. (2011) Drug-induced sleep: theoretical and practical considerations. Pflügers Archiv - European Journal of Physiology 463:1, pages 177-186.
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Randi Hagerman, Julie Lauterborn, Jacky Au & Elizabeth Berry-Kravis. 2012. Modeling Fragile X Syndrome. Modeling Fragile X Syndrome 297 335 .
Tatsuki Koike, Takafumi Takai, Yasutaka Hoashi, Masaharu Nakayama, Yohei Kosugi, Masato Nakashima, Shin-ichi Yoshikubo, Keisuke Hirai & Osamu Uchikawa. (2011) Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8,9-Dihydrofuro[3,2- c ]pyrazolo[1,5- a ]pyridines as Melatonin Receptor (MT 1 /MT 2 ) Ligands . Journal of Medicinal Chemistry 54:12, pages 4207-4218.
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Tatsuki Koike, Yasutaka Hoashi, Takafumi Takai, Masaharu Nakayama, Nobuhito Yukuhiro, Takashi Ishikawa, Keisuke Hirai & Osamu Uchikawa. (2011) 1,6-Dihydro-2 H -indeno[5,4- b ]furan Derivatives: Design, Synthesis, and Pharmacological Characterization of a Novel Class of Highly Potent MT 2 -Selective Agonists . Journal of Medicinal Chemistry 54:9, pages 3436-3444.
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Guiying Li, Hao Zhou, Yu Jiang, Holger Keim, Sidney W. Topiol, Suresh B. Poda, Yong Ren, Gamini Chandrasena & Darío Doller. (2011) Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands. Bioorganic & Medicinal Chemistry Letters 21:4, pages 1236-1242.
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David Heckman, Mohamed I. Attia, Mira A. M. Behnam, Amal M. Y. Mohsen, Christian Markl, Justin Julius, Shalini Sethi, Paula A. Witt-Enderby & Darius P. Zlotos. (2011) 2-[(1,3-Dihydro-2H-isoindol-2-yl)methyl]melatonin – a novel MT2-selective melatonin receptor antagonist. MedChemComm 2:10, pages 991.
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Elmar Peschke & Eckhard Mühlbauer. (2010) New evidence for a role of melatonin in glucose regulation. Best Practice & Research Clinical Endocrinology & Metabolism 24:5, pages 829-841.
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