Advanced search
Publication Cover
Expert Opinion on Investigational Drugs Volume 19, 2010 - Issue 6
Submit an article Journal homepage
1,233
Views
71
CrossRef citations to date
0
Altmetric
Reviews

New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders

Noriaki Manabe Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Charlton 8-110, 200 First St. SW, Rochester, MN 55905, USA +1 507 266 2305; [email protected]
, MD PhD,
Banny S Wong Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Charlton 8-110, 200 First St. SW, Rochester, MN 55905, USA +1 507 266 2305; [email protected]
, MD &
Michael Camilleri Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Charlton 8-110, 200 First St. SW, Rochester, MN 55905, USA +1 507 266 2305; [email protected]
, MD
Pages 765-775 | Published online: 21 Apr 2010

Citations (71)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Binjie Wang, Xiaoyang Sun, Shixiao Wang, Ping Guo, Shujuan Li, Meiyu Zhang, Longshan Zhao & Xiaohui Chen. (2018) Comparative pharmacokinetics of (S)-MP3950, a novel 5-HT4 receptor agonist, in normal and atropine-induced gastrointestinal motility disorders rats. Xenobiotica 48:8, pages 824-830.
Read now
Gabrio Bassotti, Dario Gambaccini & Massimo Bellini. (2016) Velusetrag for the treatment of chronic constipation. Expert Opinion on Investigational Drugs 25:8, pages 985-990.
Read now
James Langworthy, Henry P Parkman & Ron Schey. (2016) Emerging strategies for the treatment of gastroparesis. Expert Review of Gastroenterology & Hepatology 10:7, pages 817-825.
Read now
Ramakrishna Nirogi, Shankar Reddy Gagginapally, Anil K. Shinde & Abdul Rasheed Mohammed. (2016) Synthesis of GR 125487, a selective 5-HT4 receptor antagonist. Synthetic Communications 46:12, pages 1036-1043.
Read now
Paula Mosińska, Maciej Salaga & Jakub Fichna. (2016) Novel investigational drugs for constipation-predominant irritable bowel syndrome: a review. Expert Opinion on Investigational Drugs 25:3, pages 275-286.
Read now
Mark Malamood, Henry Parkman & Ron Schey. (2015) Current advances in treatment of gastroparesis. Expert Opinion on Pharmacotherapy 16:13, pages 1997-2008.
Read now
Baharak Moshiree, Jose Barboza & Nicholas Talley. (2013) An update on current pharmacotherapy options for dyspepsia. Expert Opinion on Pharmacotherapy 14:13, pages 1737-1753.
Read now
Roland Staud. (2011) Sodium oxybate for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy 12:11, pages 1789-1798.
Read now

Articles from other publishers (63)

Meng Li, Ning Gao, Shaoli Wang, Yufeng Guo & Zhen Liu. (2023) A global bibliometric and visualized analysis of the status and trends of gastroparesis research. European Journal of Medical Research 28:1.
Crossref
Sarvee Moosavi, Yang Won Min, Melissa Wong & Ali Rezaie. (2023) Gastroparesis in pregnancy. American Journal of Obstetrics and Gynecology 228:4, pages 382-394.
Crossref
Johny Bajgai, Mihyun Lee, Yeon-Gyu Jang, Kiwon Lee, Subham Sharma, Yun Ju Jeong, Hong Jun Park, Seong Hoon Goh, Cheol-Su Kim, Hyun Il Kim & Kyu-Jae Lee. (2023) Effects of Drinking Electrolyzed Alkaline-Reduced Water on Functional Dyspepsia: A Randomized, Double-Blind, Controlled Prospective Trial. Processes 11:3, pages 968.
Crossref
Priya Bisht, Neha Dagar, Nitesh Kumar, Ravichandiran Velayutham & Somasundaram Arumugam. (2023) Potential Targets in Constipation Research: A Review. Current Drug Targets 24:3, pages 247-260.
Crossref
Ting Cai, Shao-peng Zheng, Xiao Shi, Ling-zhi Yuan, Hai Hu, Bai Zhou, Shi-lang Xiao & Fen Wang. (2022) Therapeutic effect of fecal microbiota transplantation on chronic unpredictable mild stress-induced depression. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Sijie Huang, Peiyu Xu, Dan-Dan Shen, Icaro A. Simon, Chunyou Mao, Yangxia Tan, Huibing Zhang, Kasper Harpsøe, Huadong Li, Yumu Zhang, Chongzhao You, Xuekui Yu, Yi Jiang, Yan Zhang, David E. Gloriam & H. Eric Xu. (2022) GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Molecular Cell 82:14, pages 2681-2695.e6.
Crossref
Charlotte Uldahl Jansen & Katrine M. Qvortrup. 2022. Serotonin and the CNS - New Developments in Pharmacology and Therapeutics. Serotonin and the CNS - New Developments in Pharmacology and Therapeutics.
Bettina Lengger, Emma E. Hoch-Schneider, Christina N. Jensen, Tadas Jakočiu̅nas, Anja A. Petersen, Thomas M. Frimurer, Emil D. Jensen & Michael K. Jensen. (2022) Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast. ACS Sensors 7:5, pages 1323-1335.
Crossref
Dae Young Lee & Hee Eun Kang. (2022) Pharmacokinetics of DA-6886, A New 5-HT4 Receptor Agonist, in Rats. Pharmaceutics 14:4, pages 702.
Crossref
Victor Chedid, Justin Brandler, Kayla Arndt, Priya Vijayvargiya, Xiao Jing Wang, Duane Burton, W. Scott Harmsen, Jenifer Siegelman, Chunlin Chen, Yinzhong Chen, Cristina Almansa, George Dukes & Michael Camilleri. (2021) Randomised study: effects of the 5‐HT 4 receptor agonist felcisetrag vs placebo on gut transit in patients with gastroparesis . Alimentary Pharmacology & Therapeutics 53:9, pages 1010-1020.
Crossref
Kara G. Margolis, John F. Cryan & Emeran A. Mayer. (2021) The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology 160:5, pages 1486-1501.
Crossref
Henry P. Parkman. 2021. Gastroparesis. Gastroparesis 323 339 .
Azher Arafah, Muneeb U. Rehman, Tahir Maqbool Mir, Adil Farooq Wali, Rayeesa Ali, Wajhul Qamar, Rehan Khan, Ajaz Ahmad, Syed Sameer Aga, Saeed Alqahtani & Nada M. Almatroudi. (2020) Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms. Plants 9:12, pages 1784.
Crossref
Lokesh Agrawal, Mustafa Korkutata, Sunil Kumar Vimal, Manoj Kumar Yadav, Sanjib Bhattacharyya & Takashi Shiga. (2020) Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut. Neuropharmacology 166, pages 107969.
Crossref
Emily A. Yasi, Aurelia A. Allen, Widianti Sugianto & Pamela Peralta-Yahya. (2019) Identification of Three Antimicrobials Activating Serotonin Receptor 4 in Colon Cells. ACS Synthetic Biology 8:12, pages 2710-2717.
Crossref
Rachel M. Gwynne & Joel C. Bornstein. (2019) Luminal 5‐HT 4 receptors—A successful target for prokinetic actions . Neurogastroenterology & Motility 31:10.
Crossref
Xiao Wang, Chen Zhang, Mingyue Zheng, Fei Gao, Jinming Zhang & Fang Liu. (2019) Metabolomics Analysis of L-Arginine Induced Gastrointestinal Motility Disorder in Rats Using UPLC-MS After Magnolol Treatment. Frontiers in Pharmacology 10.
Crossref
Narek Israelyan & Kara Gross Margolis. (2019) Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Pharmacological Research 140, pages 115-120.
Crossref
Beom Jin Kim & Braden Kuo. (2019) Gastroparesis and Functional Dyspepsia: A Blurring Distinction of Pathophysiology and Treatment. Journal of Neurogastroenterology and Motility 25:1, pages 27-35.
Crossref
Muhammed MajeedShaheen MajeedKalyanam NagabhushanamSivakumar ArumugamAnurag PandeMahesh PaschapurFurqan Ali. (2018) Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Journal of Medicinal Food 21:11, pages 1120-1128.
Crossref
Yoonjin Nam, Young Sil Min & Uy Dong Sohn. (2018) Recent advances in pharmacological research on the management of irritable bowel syndrome. Archives of Pharmacal Research 41:10, pages 955-966.
Crossref
Narek Israelyan & Kara Gross Margolis. (2018) Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Pharmacological Research 132, pages 1-6.
Crossref
Yongwoo Jang, Eun-Kyung Kim & Won-Sik Shim. (2018) Phytotherapeutic effects of the fruits of Poncirus trifoliata (L.) Raf. on cancer, inflammation, and digestive dysfunction . Phytotherapy Research 32:4, pages 616-624.
Crossref
Eun Jeong Jeong, Soo Yong Chung, Han Na Hong, Se-Woong Oh & Jae Young Sim. (2018) The novel, potent and highly selective 5-HT 4 receptor agonist YH12852 significantly improves both upper and lower gastrointestinal motility . British Journal of Pharmacology 175:3, pages 485-500.
Crossref
Z. Hussain, Y. J. Lee, H. Yang, E. J. Jeong, J. Y. Sim & H. Park. (2017) YH12852, a potent and highly selective 5-HT 4 receptor agonist, significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus . Neurogastroenterology & Motility 29:10, pages e13094.
Crossref
Tianming Wang, Zhen Yang, Naiming Zhou, Lina Sun, Zhenming Lv & Changwen Wu. (2017) Identification and functional characterisation of 5-HT4 receptor in sea cucumber Apostichopus japonicus (Selenka). Scientific Reports 7:1.
Crossref
Henry I. Jacoby. 2017. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu & Chien-Lin Chen. (2016) Effects of prucalopride on esophageal secondary peristalsis in humans. Clinical and Translational Gastroenterology 7:11, pages e202.
Crossref
Zhi Sun, Lihua Zuo, Jian Kang, Lin Zhou, Mengmeng Jia, Zeyun Li, Zhiheng Yang, Xiaojian Zhang & Zhenfeng Zhu. (2016) Development and validation of a sensitive UHPLC–MS/MS method for quantitation of prucalopride in rat plasma and its application to pharmacokinetics study. Journal of Chromatography B 1033-1034, pages 328-333.
Crossref
Xin Chang, Shuai Wang, Yong-rui Bao, Tian-jiao Li, Xiao-meng Yu & Xian-sheng Meng. (2016) Multicomponent, multitarget integrated adjustment – Metabolomics study of Qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine. Journal of Ethnopharmacology 189, pages 14-21.
Crossref
Natalie Terry & Kara Gross Margolis. 2017. Gastrointestinal Pharmacology. Gastrointestinal Pharmacology 319 342 .
A. S. Youssef, H. P. Parkman & S. Nagar. (2015) Drug‐drug interactions in pharmacologic management of gastroparesis. Neurogastroenterology & Motility 27:11, pages 1528-1541.
Crossref
Ramakrishna Nirogi, Abdul Rasheed Mohammed, Anil K. Shinde, Narsimha Bogaraju, Shankar Reddy Gagginapalli, Srinivasa Rao Ravella, Laxman Kota, Gopinadh Bhyrapuneni, Nageswara Rao Muddana, Vijay Benade, Raghava Chowdary Palacharla, Pradeep Jayarajan, Ramkumar Subramanian & Vinod Kumar Goyal. (2015) Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease. European Journal of Medicinal Chemistry 103, pages 289-301.
Crossref
Andres Acosta & Michael Camilleri. (2015) Prokinetics in Gastroparesis. Gastroenterology Clinics of North America 44:1, pages 97-111.
Crossref
Scott L. Friedman, Eamonn M. M. Quigley, Keith A. Sharkey, Joseph J. Y. Sung & David C. Whitcomb. (2014) The past 10 years of gastroenterology and hepatology—reflections and predictions. Nature Reviews Gastroenterology & Hepatology 11:11, pages 692-700.
Crossref
Xiaofang Zhang, Bojun Yuan, Yu Mao, Xiaoyu Dai, Xiaodong Zhang & Guocai Lu. (2014) Acute and subchronic toxicities of QX100626, a 5-HT4 receptor agonist, in rodents and Beagle dogs. Regulatory Toxicology and Pharmacology 70:1, pages 379-391.
Crossref
Michael F. Wangler, Claudia Gonzaga-Jauregui, Tomasz Gambin, Samantha Penney, Timothy Moss, Atul Chopra, Frank J. Probst, Fan Xia, Yaping Yang, Steven Werlin, Ieva Eglite, Liene Kornejeva, Carlos A. Bacino, Dustin Baldridge, Jeff Neul, Efrat Lev Lehman, Austin Larson, Joke Beuten, Donna M. Muzny, Shalini Jhangiani, Richard A. Gibbs, James R. Lupski & Arthur Beaudet. (2014) Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin (ACTG2) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome. PLoS Genetics 10:3, pages e1004258.
Crossref
Natsumi Aoki, Hiroyuki Watanabe, Kazuya Okada, Kazuyuki Aoki, Takuma Imanishi, Daisuke Yoshida, Ryosuke Ishikawa & Shigenobu Shibata. (2014) Involvement of 5-HT3 and 5-HT4 Receptors in the Regulation of Circadian Clock Gene Expression in Mouse Small Intestine. Journal of Pharmacological Sciences 124:2, pages 267-275.
Crossref
Martina Böttner, Martina Barrenschee, Ines Hellwig, Jonas Harde, Jan-Hendrik Egberts, Thomas Becker, Dimitri Zorenkov & Thilo Wedel. (2013) The enteric serotonergic system is altered in patients with diverticular disease. Gut 62:12, pages 1753-1762.
Crossref
Jean-David Zeitoun & Vincent de Parades. (2013) Constipation chronique chez l’adulte. La Presse Médicale 42:9, pages 1176-1185.
Crossref
Yongwoo Jang, Su-Won Kim, Jungeun Oh, Gyu-Sang Hong, Eun-Kyoung Seo, Uhtaek Oh & Won-Sik Shim. (2013) Ghrelin receptor is activated by naringin and naringenin, constituents of a prokinetic agent Poncirus fructus. Journal of Ethnopharmacology 148:2, pages 459-465.
Crossref
Soo Jung ParkEun Ju ChoiYoung Hoon YoonHyojin Park. (2013) The Effects of Prucalopride on Postoperative Ileus in Guinea Pigs. Yonsei Medical Journal 54:4, pages 845.
Crossref
D.T. Beattie, D.L. Higgins, M.P. Ero, S.M. Amagasu, R.G. Vickery, K. Kersey, A. Hopkins & J.A.M. Smith. (2013) An in vitro investigation of the cardiovascular effects of the 5-HT4 receptor selective agonists, velusetrag and TD-8954. Vascular Pharmacology 58:1-2, pages 150-156.
Crossref
Gérard Amarenco & Agnès SenéjouxA. Senéjoux. 2013. Pathologies des toilettes. Pathologies des toilettes 225 234 .
Emmanuelle Dubost, Noé Dumas, Christine Fossey, Rosa Magnelli, Sabrina Butt-Gueulle, Céline Ballandonne, Daniel H. Caignard, Fabienne Dulin, Jana Sopkova de-Oliveira Santos, Philippe Millet, Yves Charnay, Sylvain Rault, Thomas Cailly & Frederic Fabis. (2012) Synthesis and Structure–Affinity Relationships of Selective High-Affinity 5-HT 4 Receptor Antagonists: Application to the Design of New Potential Single Photon Emission Computed Tomography Tracers . Journal of Medicinal Chemistry 55:22, pages 9693-9707.
Crossref
Feng Li, You-Min Lin, Sushil K. Sarna & Xuan-Zheng Shi. (2012) Cellular mechanism of mechanotranscription in colonic smooth muscle cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 303:5, pages G646-G656.
Crossref
Reza A. Hejazi, Richard W. McCallum & Irene Sarosiek. (2012) Prokinetics in Diabetic Gastroparesis. Current Gastroenterology Reports 14:4, pages 297-305.
Crossref
Y.‐M. Lin, F. Li & X.‐Z. Shi. (2012) Mechano‐transcription of COX‐2 is a common response to lumen dilation of the rat gastrointestinal tract. Neurogastroenterology & Motility 24:7, pages 670.
Crossref
B. E. Lacy, N. J. Talley, G. R. LockeIIIIII, E. P. Bouras, J. K. DiBaise, H. B. El‐Serag, B. P. Abraham, C. W. Howden, P. Moayyedi & C. Prather. (2012) Review article: current treatment options and management of functional dyspepsia. Alimentary Pharmacology & Therapeutics 36:1, pages 3-15.
Crossref
Henry P. Parkman, Anurag Mishra, Michael Jacobs, Murali Pathikonda, Priyanka Sachdeva, John Gaughan & Evgeny Krynetskiy. (2012) Clinical Response and Side Effects of Metoclopramide. Journal of Clinical Gastroenterology 46:6, pages 494-503.
Crossref
Daniel D. Long, Scott R. Armstrong, David T. Beattie, Seok-Ki Choi, Paul R. Fatheree, Roland A.L. Gendron, Adam A. Goldblum, Patrick P. Humphrey, Daniel G. Marquess, Jeng-Pyng Shaw, Jacqueline A.M. Smith, S. Derek Turner & Ross G. Vickery. (2012) Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: Clinical compound TD-2749. Bioorganic & Medicinal Chemistry Letters 22:14, pages 4849-4853.
Crossref
Michael Camilleri & Carlo Di Lorenzo. (2012) Brain-Gut Axis. Journal of Pediatric Gastroenterology & Nutrition 54:4, pages 446-453.
Crossref
M Camilleri. (2011) Pharmacology of the New Treatments for Lower Gastrointestinal Motility Disorders and Irritable Bowel Syndrome. Clinical Pharmacology & Therapeutics 91:1, pages 44-59.
Crossref
Juan F Gallegos-Orozco, Amy E Foxx-Orenstein, Susan M Sterler & Jean M Stoa. (2012) Chronic Constipation in the Elderly. American Journal of Gastroenterology 107:1, pages 18-25.
Crossref
Jackie D. Wood. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 671 688 .
Henry P. Parkman. 2012. Gastroparesis. Gastroparesis 257 278 .
J. -D. Zeitoun & V. de Parades. (2011) Constipation de transit : les traitements ayant fait la preuve de leur efficacitéSlow-transit constipation: evidence-based treatments. Côlon & Rectum 5:4, pages 239-245.
Crossref
Evelien K.V. Priem & Romain A. Lefebvre. (2011) Investigation of neurogenic excitatory and inhibitory motor responses and their control by 5-HT4 receptors in circular smooth muscle of pig descending colon. European Journal of Pharmacology 667:1-3, pages 365-374.
Crossref
S. Scott Bowersox, Luke K. Lightning, Satish Rao, Monica Palme, Dave Ellis, Renee Coleman, Adrian M. Davies, Padmapriya Kumaraswamy & Pascal Druzgala. (2011) Metabolism and Pharmacokinetics of Naronapride (ATI-7505), a Serotonin 5-HT 4 Receptor Agonist for Gastrointestinal Motility Disorders . Drug Metabolism and Disposition 39:7, pages 1170-1180.
Crossref
Donato F. Altomare & Simona Giuratrabocchetta. (2011) Defecación inducida por electro-estimulación en el estreñimiento: ¿vamos en la dirección adecuada?. Cirugía Española 89:5, pages 267-268.
Crossref
Joël Bockaert, Sylvie Claeysen, Valérie Compan & Aline Dumuis. (2011) 5-HT4 receptors, a place in the sun: act two. Current Opinion in Pharmacology 11:1, pages 87-93.
Crossref
Donato F. Altomare & Simona Giuratrabocchetta. (2011) Electrical induced defecation in constipation: Are we running the right way?. Cirugía Española (English Edition) 89:5, pages 267-268.
Crossref
Paul Enck, Florian Junne, Sibylle Klosterhalfen, Stephan Zipfel & Ute Martens. (2010) Therapy options in irritable bowel syndrome. European Journal of Gastroenterology & Hepatology, pages 1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.