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Drug Evaluations

Berberine: a potential phytochemical with multispectrum therapeutic activities

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Pages 1297-1307 | Published online: 13 Sep 2010

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Maryam Mahdavi Siuki, Nafiseh Fazel Nasab, Elham Barati, Maryam Nezafat Firizi, Tahereh Jalilvand & Hasan Namdar Ahmadabad. (2018) The protective effect of berberine against lipopolysaccharide-induced abortion by modulation of inflammatory/immune responses. Immunopharmacology and Immunotoxicology 40:4, pages 333-337.
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Mohammad Adil, Amit D. Kandhare, Gautami Dalvi, Pinaki Ghosh, Shivakumar Venkata, Kiran S. Raygude & Subhash L. Bodhankar. (2016) Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Renal Failure 38:6, pages 996-1006.
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Francesco Di Pierro, Nicola Villanova, Federica Agostini, Rebecca Marzocchi, Valentina Soverini & Giulio Marchesini. (2012) Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes, Metabolic Syndrome and Obesity 5, pages 213-217.
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Arrigo F. G. Cicero & Elisa Tartagni. (2012) Antidiabetic Properties of Berberine: From Cellular Pharmacology to Clinical Effects. Hospital Practice 40:2, pages 56-63.
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Simona Moscatiello, Raffaella Di Luzio, Anna Simona Sasdelli & Giulio Marchesini. (2011) Managing the combination of nonalcoholic fatty liver disease and metabolic syndrome. Expert Opinion on Pharmacotherapy 12:17, pages 2657-2672.
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Ying Guo, Feng Li, Xiaochao Ma, Xingguo Cheng, Honghao Zhou & Curtis D. Klaassen. (2011) CYP2D plays a major role in berberine metabolism in liver of mice and humans. Xenobiotica 41:11, pages 996-1005.
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Zengsheng Lu, Beihui He, Zhiyun Chen, Maoxiang Yan & Liyan Wu. (2020) Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway. BMC Immunology 21:1.
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Seyed‐Morteza Ehteshamfar, Masoume Akhbari, Jalil Tavakol Afshari, Motahareh Seyedi, Banafsheh Nikfar, Abbas Shapouri‐Moghaddam, Erfan Ghanbarzadeh & Amir Abbas Momtazi‐Borojeni. (2020) Anti‐inflammatory and immune‐modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation. Journal of Cellular and Molecular Medicine 24:23, pages 13573-13588.
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Rutusmita Mishra, Sandip Nathani, Ritu Varshney, Debabrata Sircar & Partha Roy. (2020) Berberine reverses epithelial-mesenchymal transition and modulates histone methylation in osteosarcoma cells. Molecular Biology Reports 47:11, pages 8499-8511.
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Hongying Kuang, Yuwei Duan, Dan Li, Yanwen Xu, Wenxia Ai, Wei Li, Ying Wang, Sha Liu, Mushan Li, Xiaoqiu Liu & Manqi Shao. (2020) The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome. PLOS ONE 15:8, pages e0235404.
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Jian Chen, Xiaofei Huang, Cheng Tao, Li Wang, Zide Chen, Xinping Li, Qiang Zeng, Min Ma, Ren Zhang & Zhengzhi Wu. (2020) Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo. Cancer Chemotherapy and Pharmacology 86:1, pages 151-161.
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Hui Liu, Leiming You, Jun Wu, Mengfan Zhao, Rui Guo, Haili Zhang, Rina Su, Qin Mao, Di Deng & Yu Hao. (2020) Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS. Journal of Leukocyte Biology 108:1, pages 253-266.
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Maria Zych, Weronika Wojnar, Magdalena Kielanowska, Joanna Folwarczna & Ilona Kaczmarczyk-Sedlak. (2020) Effect of Berberine on Glycation, Aldose Reductase Activity, and Oxidative Stress in the Lenses of Streptozotocin-Induced Diabetic Rats In Vivo—A Preliminary Study. International Journal of Molecular Sciences 21:12, pages 4278.
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Qiang-Song Wang, Kefeng Li, Li-Na Gao, Ye Zhang, Ke-Ming Lin & Yuan-Lu Cui. (2020) Intranasal delivery of berberine via in situ thermoresponsive hydrogels with non-invasive therapy exhibits better antidepressant-like effects . Biomaterials Science 8:10, pages 2853-2865.
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Pan Xiong, Li Niu, Sam Talaei, Hamed Kord-Varkaneh, Cain C.T. Clark, Mihnea-Alexandru Găman, Jamal Rahmani, Masoumeh Dorosti, Seyed Mohammad Mousavi, Meysam Zarezadeh, Hossein Taghizade-Bilondi & Jitao Zhang. (2020) The effect of berberine supplementation on obesity indices: A dose– response meta-analysis and systematic review of randomized controlled trials. Complementary Therapies in Clinical Practice 39, pages 101113.
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Weijian Mai, Yangzhi Xu, Jiahui Xu, Dan Zhao, Liangying Ye, Ganxiang Yu, Zhilei Wang, Qianting Lu, Jiaen Lin, Tao Yang, Chengxin Gu, Shiming Liu, Yun Zhong & Hui Yang. (2020) Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis. Frontiers in Pharmacology 11.
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Mohammad Reza Amini, Fatemeh Sheikhhossein, Sina Naghshi, Farhang Djafari, Mohammadreza Askari, Hossein Shahinfar, Maryam Safabakhsh, Alireza Jafari & Sakineh Shab-Bidar. (2020) Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine 49, pages 102337.
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Furong Zhong, Ling Huang, Luming Qi, Yuntong Ma & Zhuyun Yan. (2020) Full-length transcriptome analysis of Coptis deltoidea and identification of putative genes involved in benzylisoquinoline alkaloids biosynthesis based on combined sequencing platforms. Plant Molecular Biology 102:4-5, pages 477-499.
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Alexander BertuccioliSara MoricoliStefano AmatoriMarco Bruno Luigi RocchiGiorgia ViciDavide Sisti. (2020) Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis. Journal of Medicinal Food 23:2, pages 101-113.
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Li Xu, Yujie Zhang, Xianmin Xue, Jie Liu, Zeng-Shan Li, Guang-Yu Yang, Ying Song, Yan Pan, Yueyun Ma, Sijun Hu, Aidong Wen, Yanyan Jia, Luz Maria Rodriguez, Mary Beth Tull, Kelly Benante, Seema A. Khan, Ying Cao, Borko Jovanovic, Ellen Richmond, Asad Umar, Raymond Bergan & Kaichun Wu. (2020) A Phase I Trial of Berberine in Chinese with Ulcerative Colitis. Cancer Prevention Research 13:1, pages 117-126.
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Sonali Dash, Manish Kumar & Nidhi Pareek. (2020) Enhanced antibacterial potential of berberine via synergism with chitosan nanoparticles. Materials Today: Proceedings 31, pages 640-645.
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Ammara Shamim, Haq Nawaz, Muhammad Asif Hanif, Muhammad Idrees Jilani & Ubirajara Lanza Júnior. 2020. Medicinal Plants of South Asia. Medicinal Plants of South Asia 645 655 .
Liangzhen Xie, Duojia Zhang, Hongli Ma, Hui He, Qing Xia, Wenjuan Shen, Hui Chang, Yingying Deng, Qi Wu, Jing Cong, Chi Chiu Wang & Xiaoke Wu. (2019) The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-14.
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