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Expert Opinion on Investigational Drugs Volume 19, 2010 - Issue 12
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Drug Evaluations

Delayed release phosphatidylcholine as new therapeutic drug for ulcerative colitis – a review of three clinical trials

Wolfgang Stremmel University Hospital Heidelberg, Department of Gastroenterology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany +49 6221 568705; +49 6221 564116; wolfgang_stremmel@med. uni-heidelberg.de
, MD,
Anja Hanemann University Hospital Heidelberg, Department of Gastroenterology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany +49 6221 568705; +49 6221 564116; wolfgang_stremmel@med. uni-heidelberg.de
, MS,
Annika Braun University Hospital Heidelberg, Department of Gastroenterology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany +49 6221 568705; +49 6221 564116; wolfgang_stremmel@med. uni-heidelberg.de
, MD,
Sabine Stoffels University Hospital Heidelberg, Department of Gastroenterology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany +49 6221 568705; +49 6221 564116; wolfgang_stremmel@med. uni-heidelberg.de
, MD,
Max Karner University Hospital Heidelberg, Department of Gastroenterology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany +49 6221 568705; +49 6221 564116; wolfgang_stremmel@med. uni-heidelberg.de
, MD,
Sahar Fazeli University Hospital Heidelberg, Department of Gastroenterology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany +49 6221 568705; +49 6221 564116; wolfgang_stremmel@med. uni-heidelberg.de
, MD &
Robert Ehehalt University Hospital Heidelberg, Department of Gastroenterology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany +49 6221 568705; +49 6221 564116; wolfgang_stremmel@med. uni-heidelberg.de
, MD show all
Pages 1623-1630 | Published online: 25 Nov 2010

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Dong-Hai Lin, Chong-Zhi Wang, Li-Fang Qin, Xin-Xin Xie, Jun-Teng Wang, Maojian Gu, Eryn McEntee & Chun-Su Yuan. (2014) Bioavailability of oral methylnaltrexone increases with a phosphatidylcholine-based formulation. Drug Development and Industrial Pharmacy 40:2, pages 186-191.
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Ping Zhou, Jing Zhang, Yudi Xu, Peng Zhang, Zhihao Zhang, Yongqing Xiao & Ying Liu. (2024) Bidirectional regulation effect of rhubarb as laxative and astringent by metabolomics studies. Journal of Ethnopharmacology 320, pages 117348.
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Axel Dignass, Wolfgang Stremmel, Marek Horyński, Oleksandr Poyda, Peter Armerding, Klaus Fellermann, Jost Langhorst, Tanja Kuehbacher, Peter Uebel, Juergen Stein, Gottfried Novacek, Elena Avalueva, Oleksandr Oliinyk, Peter Hasselblatt, Andrey Dorofeyev, Heidrun Heinemann, Ralph Mueller, Roland Greinwald & Walter Reinisch. (2023) Modified-Release Phosphatidylcholine (LT-02) for Ulcerative Colitis: Two Double-Blind, Randomized, Placebo-Controlled Trials. Clinical Gastroenterology and Hepatology.
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Mohammed A. Hussein, Heba M. Abo-Salem, Ahmed M. Moro, Ebtsam A. Abdel-Wahab, Ali A Ali & Shaimaa A. Abdelkawy. (2022) Pulmonary Phospholipid Components as Promising Natural Inhibitors against COVID-19 Mpro; Molecular Docking Analysis Based Study. Asian Journal of Chemistry 34:9, pages 2191-2197.
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Jesus K Yamamoto-Furusho & Norma N Parra-Holguín. (2021) Emerging therapeutic options in inflammatory bowel disease. World Journal of Gastroenterology 27:48, pages 8242-8261.
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Ivo Laidmäe, Andres Meos, Irja Alainezhad Kjærvik, Sveinung G. Ingebrigtsen, Nataša Škalko-Basnet, Kalle Kirsimäe, Tavo Romann, Urmas Joost, Vambola Kisand & Karin Kogermann. (2021) Electrospun Amphiphilic Nanofibers as Templates for In Situ Preparation of Chloramphenicol-Loaded Liposomes. Pharmaceutics 13:11, pages 1742.
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Peng Wu, Zhengquan Huang, Jinjun Shan, Zichen Luo, Nongshan Zhang, Songjiang Yin, Cunsi Shen, Runlin Xing, Wei Mei, Yancheng Xiao, Bo Xu, Jun Mao & Peimin Wang. (2020) Interventional effects of the direct application of “Sanse powder” on knee osteoarthritis in rats as determined from lipidomics via UPLC-Q-Exactive Orbitrap MS. Chinese Medicine 15:1.
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Georgia Tsaousi, George Stavrou, Kyriakos Fotiadis, Katerina Kotzampassi & George Kolios. (2019) Implementation of phospholipids as pharmacological modalities for postoperative adhesions prevention. European Journal of Pharmacology 842, pages 189-196.
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Neeraj Narula, David T Rubin & Bruce E Sands. (2016) Novel Therapies in Inflammatory Bowel Disease: An Evaluation of the Evidence. The American Journal of Gastroenterology Supplements 3:3, pages 38-44.
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Stephen M. Vindigni, Timothy L. Zisman, David L. Suskind & Christopher J. Damman. (2016) The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions. Therapeutic Advances in Gastroenterology 9:4, pages 606-625.
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Riccardo Ghidoni, Anna Caretti & Paola Signorelli. (2015) Role of Sphingolipids in the Pathobiology of Lung Inflammation. Mediators of Inflammation 2015, pages 1-19.
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Lawrence N. Diebel & David M. Liberati. (2014) Reinforcement of the Intestinal Mucus Layer Protects Against Clostridium difficile Intestinal Injury In Vitro. Journal of the American College of Surgeons 219:3, pages 460-468.
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Katharina Leucht, Anne Fischbeck, Michaela Caj, Gerhard Liebisch, Eva Hartlieb, Petr Benes, Michael Fried, Hans-Ulrich Humpf, Gerhard Rogler & Martin Hausmann. (2014) Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells. Molecular Nutrition & Food Research 58:4, pages 782-798.
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. 2014. Intestinal Microbiota in Health and Disease. Intestinal Microbiota in Health and Disease 229 237 .
Jürgen Schölmerich. (2014) Trichuris suis Ova, Lecithin and Other Fancy Molecules. Digestive Diseases 32:Suppl. 1, pages 67-73.
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M. Gersemann, J. Wehkamp & E. F. Stange. (2012) Innate immune dysfunction in inflammatory bowel disease. Journal of Internal Medicine 271:5, pages 421-428.
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Florian Rieder, Thomas Karrasch, Shomron Ben-Horin, Anja Schirbel, Robert Ehehalt, Jan Wehkamp, Colin de Haar, Dominique Velin, Giovanni Latella, Franco Scaldaferri, Gerhard Rogler, Peter Higgins & Miquel Sans. (2012) Results of the 2nd Scientific Workshop of the ECCO (III): Basic mechanisms of intestinal healing. Journal of Crohn's and Colitis 6:3, pages 373-375.
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