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Expert Opinion on Investigational Drugs Volume 20, 2011 - Issue 1
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Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective

Paul A Lapchak Cedars-Sinai Medical Center, Department of Neurology, Davis Research Building, D-2091, 110 N. George Burns Road, Los Angeles, CA 90048, USA +1 310 248 8188; +1 310 423 0148; [email protected]
, PhD FAHA
Pages 13-22 | Published online: 15 Dec 2010

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Ranjana Himalian, Sandeep Kumar Singh & Mahendra Pratap Singh. (2022) Ameliorative Role of Nutraceuticals on Neurodegenerative Diseases Using the Drosophila melanogaster as a Discovery Model to Define Bioefficacy. Journal of the American Nutrition Association 41:5, pages 511-539.
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Zhi-Qiang Liu, Shan-Shan Xing & Wei Zhang. (2013) Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion. The Journal of Spinal Cord Medicine 36:2, pages 147-152.
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Altaf S Darvesh, Richard T Carroll, Anupam Bishayee, Nicholas A Novotny, Werner J Geldenhuys & Cornelis J Van der Schyf. (2012) Curcumin and neurodegenerative diseases: a perspective. Expert Opinion on Investigational Drugs 21:8, pages 1123-1140.
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Rui Zhou, Feifei Guo, Changpei Xiang, Yi Zhang, Hongjun Yang & Jingjing Zhang. (2021) Systematic Study of Crucial Transcription Factors of Coptidis rhizoma Alkaloids against Cerebral Ischemia-Reperfusion Injury . ACS Chemical Neuroscience 12:13, pages 2308-2319.
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Jun Zhong, Rong-Wei Li, Ju Wang, Ying Wang, Hong-Fei Ge, Ji-Shu Xian, Hua Feng & Liang Tan. (2021) Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke. Neural Regeneration Research 16:2, pages 312.
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Meiying Xin, Yulei Hao, Ge Huang, Xu Wang, Zhen Liang, Jing Miao, Di Ma & Jiachun Feng. (2020) The efficacy and safety of salvianolic acids on acute cerebral infarction treatment. Medicine 99:23, pages e20059.
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Hong-xuan Feng, Chun-pu Li, Shuang-jie Shu, Hong Liu & Hai-yan Zhang. (2018) A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo. Acta Pharmacologica Sinica 40:2, pages 160-169.
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Kewal K. JainKewal K. Jain. 2019. The Handbook of Neuroprotection. The Handbook of Neuroprotection 175 280 .
Mingchao Zhou, Shanshan Ling, Hongxia Chen & Ruihuan Pan. (2017) Inhibition of notch signaling pathways contribute to neuroprotection effect by the combination of astragalus membranaceus and ligustrazine in rat model after thrombolysis of cerebral ischaemia. Inhibition of notch signaling pathways contribute to neuroprotection effect by the combination of astragalus membranaceus and ligustrazine in rat model after thrombolysis of cerebral ischaemia.
Zongjian Liu, Yuanyuan Ran, Shuo Huang, Shaohong Wen, Wenxiu Zhang, Xiangrong Liu, Zhili Ji, Xiaokun Geng, Xunming Ji, Huishan Du, Rehana K. Leak & Xiaoming Hu. (2017) Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization. Frontiers in Aging Neuroscience 9.
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Cai-Ping Wang, Yun-Wei Shi, Miao Tang, Xiao-Chuan Zhang, Yun Gu, Xin-Miao Liang, Zhi-Wei Wang & Fei Ding. (2016) Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats. Molecular Neurobiology 54:3, pages 2126-2142.
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Jiahui Chang, Xiaoquan Yao, Haiyan Zou, Lei Wang, Yue Lu, Qiuxia Zhang & Hui Zhao. (2016) BDNF/PI3K/Akt and Nogo-A/RhoA/ROCK signaling pathways contribute to neurorestorative effect of Houshiheisan against cerebral ischemia injury in rats. Journal of Ethnopharmacology 194, pages 1032-1042.
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Mei-Yin Chien, Cheng-Hung Chuang, Chang-Ming Chern, Kou-Tong Liou, Der-Zen Liu, Yu-Chang Hou & Yuh-Chiang Shen. (2016) Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice. Free Radical Biology and Medicine 99, pages 508-519.
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Wei Li, Nijasri C. Suwanwela & Suthiluk Patumraj. (2016) Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R. Microvascular Research 106, pages 117-127.
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Qun E, Miao Tang, XiaoChuan Zhang, YunWei Shi, DanDan Wang, Yun Gu, ShiYing Li, XinMiao Liang, ZhiWei Wang & CaiPing Wang. (2015) Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells . Cell Biology International 39:12, pages 1418-1424.
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Anil Kumar & Arti Singh. (2015) A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions. Frontiers in Pharmacology 6.
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Yuh-Chiang Shen, Chung-Kuang Lu, Kuo-Tong Liou, Yu-Chang Hou, Yun-Lan Lin, Yea-Hwey Wang, Hsing-Jen Sun, Ko-Hsun Liao & Hsei-Wei Wang. (2015) Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses. Journal of Ethnopharmacology 173, pages 370-382.
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Aiguo Wu, Emily E. Noble, Ethika Tyagi, Zhe Ying, Yumei Zhuang & Fernando Gomez-Pinilla. (2015) Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:5, pages 951-961.
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Alessio Alfieri & Giovanni E. Mann. 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease 365 379 .
Chang-Ming Chern, Yea-Hwey Wang, Kuo-Tong Liou, Yu-Chang Hou, Chien-Chih Chen & Yuh-Chiang Shen. (2014) 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke. Biochemical Pharmacology 87:3, pages 502-514.
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Youngmin Bu, Kyungjin Lee, Hyuk-Sang Jung & Sang-Kwan Moon. (2013) Therapeutic effects of traditional herbal medicine on cerebral ischemia: A perspective of vascular protection. Chinese Journal of Integrative Medicine 19:11, pages 804-814.
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Yu-Chang Hou, Chung-Kuang Lu, Yea-Hwey Wang, Chang-Ming Chern, Kuo-Tong Liou, Hsei-Wei Wang & Yuh-Chiang Shen. (2013) Unique Mechanisms of Sheng Yu Decoction (聖愈湯 Shèng Yù Tang) on Ischemic Stroke Mice Revealed by an Integrated Neurofunctional and Transcriptome Analysis. Journal of Traditional and Complementary Medicine 3:4, pages 240-249.
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Paul A. Lapchak, John H. Zhang & Linda J. Noble-Haeusslein. (2012) RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research. Translational Stroke Research 4:3, pages 279-285.
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Mansour S. Al Moundhri, Suhail Al-Salam, Ahmed Al Mahrouqee, S. Beegam & Badreldin H. Ali. (2012) The Effect of Curcumin on Oxaliplatin and Cisplatin Neurotoxicity in Rats: Some Behavioral, Biochemical, and Histopathological Studies. Journal of Medical Toxicology 9:1, pages 25-33.
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Langston T. Holly, Donald Blaskiewicz, Aiguo Wu, Cameron Feng, Zhe Ying & Fernando Gomez-Pinilla. (2012) Dietary therapy to promote neuroprotection in chronic spinal cord injury. Journal of Neurosurgery: Spine 17:2, pages 134-140.
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Gunter P. Eckert, Kathrin Renner, Schamim H. Eckert, Janett Eckmann, Stephanie Hagl, Reham M. Abdel-Kader, Christopher Kurz, Kristina Leuner & Walter E. Muller. (2012) Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease. Molecular Neurobiology 46:1, pages 136-150.
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Tuba Esatbeyoglu, Patricia Huebbe, Insa M. A. Ernst, Dawn Chin, Anika E. Wagner & Gerald Rimbach. (2012) Curcumin-From Molecule to Biological Function. Angewandte Chemie International Edition 51:22, pages 5308-5332.
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Tuba Esatbeyoglu, Patricia Huebbe, Insa M. A. Ernst, Dawn Chin, Anika E. Wagner & Gerald Rimbach. (2012) Curcumin – vom Molekül zur biologischen Wirkung. Angewandte Chemie 124:22, pages 5402-5427.
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Chang-Ming Chern, Jyh-Fei Liao, Yea-Hwey Wang & Yuh-Chiang Shen. (2012) Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice. Free Radical Biology and Medicine 52:9, pages 1634-1647.
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Fernanda M. F. Roleira, Elisiário J. Tavares-da-Silva, Jorge Garrido & Fernanda Borges. 2012. Translational Stroke Research. Translational Stroke Research 117 143 .
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Yuhao SunMinchao DaiYongting WangWenjing WangQingfang SunGuo-Yuan YangLiuguan Bian. (2011) Neuroprotection and Sensorimotor Functional Improvement by Curcumin after Intracerebral Hemorrhage in Mice. Journal of Neurotrauma 28:12, pages 2513-2521.
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Hsei-Wei Wang, Kuo-Tong Liou, Yea-Hwey Wang, Chung-Kuang Lu, Yun-Lian Lin, I-Jung Lee, Sheng-Teng Huang, Yuan-Hau Tsai, Yi-Chieh Cheng, Hung-Jui Lin & Yuh-Chiang Shen. (2011) Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. Journal of Ethnopharmacology 138:1, pages 22-33.
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Paul A. Lapchak. (2011) Emerging Therapies: Pleiotropic Multi-target Drugs to Treat Stroke Victims. Translational Stroke Research 2:2, pages 129-135.
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