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Original Research

Naloxone as part of a prolonged release oxycodone/naloxone combination reduces oxycodone-induced slowing of gastrointestinal transit in healthy volunteers

, PhD, , , , , , , , & show all
Pages 427-439 | Published online: 14 Mar 2011

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Antti Valtola, James D. Morse, Pawel Florkiewicz, Heidi Hautajärvi, Pasi Lahtinen, Tadeusz Musialowicz, Brian J. Anderson, Veli-Pekka Ranta & Hannu Kokki. (2020) Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients – a randomized trial. Journal of Drug Assessment 9:1, pages 117-128.
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Gineke Koopmans-Klein, Michel F.M. Wagemans, Hans C.H. Wartenberg, Yvonne J.B. Van Megen & Frank J.P.M. Huygen. (2016) The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot study. Expert Review of Gastroenterology & Hepatology 10:4, pages 547-553.
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Gineke Koopmans, Karen Simpson, Javier De Andrés, Eberhard Albert Lux, Michel Wagemans & Yvonne Van Megen. (2014) Fixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxatives. Current Medical Research and Opinion 30:11, pages 2389-2396.
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Sebastiano Mercadante & Antonello Giarratano. (2013) Combined oral prolonged-release oxycodone and naloxone in chronic pain management. Expert Opinion on Investigational Drugs 22:1, pages 161-166.
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Gill E Mundin, Kevin J Smith, Jana Mysicka, Gerhard Heun, Mathias Krämer, Udo Hahn & Christian Leuner. (2012) Validated in vitro/in vivo correlation of prolonged-release oxycodone/naloxone with differing dissolution rates in relation to gastrointestinal transit times. Expert Opinion on Drug Metabolism & Toxicology 8:12, pages 1495-1503.
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Articles from other publishers (27)

Tianzhuo Zhang, Zhijie Yue, Ling Yu, Shuo Li, Yining Xie, Jin Wei, Mengge Wu, Honglei Liu & Hongyu Tan. (2023) S-ketamine promotes postoperative recovery of gastrointestinal function and reduces postoperative pain in gynecological abdominal surgery patients: a randomized controlled trial. BMC Surgery 23:1.
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Hong-Yang Chen, Zi-Ning Wang, Wei-Yi Zhang & Tao Zhu. (2022) Advances in the clinical application of oxycodone in the perioperative period. World Journal of Clinical Cases 10:16, pages 5156-5164.
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Anna Ozaki, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuma Takeda, Yuki Kasai, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Takayuki Kato, Akihiro Suzuki, Yasushi Honda, Yuji Ogawa, Akiko Fuyuki, Kento Imajo, Takuma Higurashi, Masato Yoneda, Masataka Taguri, Hiroto Ishiki, Noritoshi Kobayashi, Satoru Saito, Yasushi Ichikawa & Atsushi Nakajima. (2022) Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial. Cancers 14:9, pages 2112.
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Michael Camilleri. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 76 99 .
Roberto De Giorgio, Furio Massimino Zucco, Giuseppe Chiarioni, Sebastiano Mercadante, Enrico Stefano Corazziari, Augusto Caraceni, Patrizio Odetti, Raffaele Giusti, Franco Marinangeli & Carmine Pinto. (2021) Management of Opioid-Induced Constipation and Bowel Dysfunction: Expert Opinion of an Italian Multidisciplinary Panel. Advances in Therapy 38:7, pages 3589-3621.
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Ana Fernández-Montes, Guillermo de Velasco, Santiago Aguín, Cristina Farriols, María Guirado-Risueño, Vanessa G. Jerviz-Guía, María Victoria Baeza-Nadal, Rodolfo Chicas-Sett, José Luis Fírvida, Francisco García-Navalón, Patricia Martín, Carmen Perezagua-Marín, Dulce Rodríguez, Joan Santamaría, Tamara Saurí & Manuel Cobo. (2021) Insights into the Use of Peripherally Acting μ-Opioid Receptor Antagonists (PAMORAs) in Oncologic Patients: from Scientific Evidence to Real Clinical Practice. Current Treatment Options in Oncology 22:3.
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Esben Bolvig Mark, Mette Winther Klinge, Debbie Grønlund, Jakob Lykke Poulsen, Vincent Schlageter, S. Mark Scott, Klaus Krogh & Asbjørn Mohr Drewes. (2019) Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system: Effect of opioids. Neurogastroenterology & Motility 32:3.
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Xiaomei Leng, Fengxiao Zhang, Shanglong Yao, Xisheng Weng, Kaizhi Lu, Gouzhong Chen, Ming Huang, Yuguang Huang, Xiaofeng Zeng, Michael Hopp & Guodong Lu. (2020) Prolonged-Release (PR) Oxycodone/Naloxone Improves Bowel Function Compared with Oxycodone PR and Provides Effective Analgesia in Chinese Patients with Non-malignant Pain: A Randomized, Double-Blind Trial. Advances in Therapy 37:3, pages 1188-1202.
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Anne Leuppi-Taegtmeyer, Urs Duthaler, Felix Hammann, Yasmin Schmid, Michael Dickenmann, Patricia Amico, Andreas W Jehle, Stefan Kalbermatter, Christoph Lenherr, Henriette E Meyer zu Schwabedissen, Manuel Haschke, Matthias E Liechti & Stephan Krähenbühl. (2019) Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions. Nephrology Dialysis Transplantation 34:4, pages 692-702.
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K. van Malderen, H. Halawi & M. Camilleri. (2018) Insights on efficacious doses of PAMORAs for patients on chronic opioid therapy or opioid-naïve patients. Neurogastroenterology & Motility 30:5, pages e13250.
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Lee-anne Chapple & Adam Deane. (2018) From dysmotility to virulent pathogens. Current Opinion in Critical Care 24:2, pages 118-123.
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Marc P. Schneider, Lukas M. Löffel, Marc A. Furrer, Fiona C. Burkhard, Bettina Kleeb, Michele Curatolo & Patrick Y. Wuethrich. (2017) Can early oral prolonged-release oxycodone with or without naloxone reduce the duration of epidural analgesia after cystectomy? A 3-arm, randomized, double-blind, placebo-controlled trial. Pain 159:3, pages 560-567.
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Jakob L Poulsen, Esben B Mark, Christina Brock, Jens B Frøkjær, Klaus Krogh & Asbjørn M Drewes. (2018) Colorectal Transit and Volume During Treatment With Prolonged-release Oxycodone/Naloxone Versus Oxycodone Plus Macrogol 3350. Journal of Neurogastroenterology and Motility 24:1, pages 119-127.
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Thorsten Nickel. (2018) Critical Scrutiny Needed. Deutsches Ärzteblatt international.
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Michael Camilleri, Anthony Lembo & David A. Katzka. (2017) Opioids in Gastroenterology: Treating Adverse Effects and Creating Therapeutic Benefits. Clinical Gastroenterology and Hepatology 15:9, pages 1338-1349.
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Stefan Müller-Lissner, Gabrio Bassotti, Benoit Coffin, Asbjørn Mohr Drewes, Harald Breivik, Elon Eisenberg, Anton Emmanuel, Françoise Laroche, Winfried Meissner & Bart Morlion. (2016) Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline. Pain Medicine, pages pnw255.
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Asbjørn M. Drewes, Pia Munkholm, Magnus Simrén, Harald Breivik, Ulf E. Kongsgaard, Jan G. Hatlebakk, Lars Agreus, Maria Friedrichsen & Lona L. Christrup. (2016) Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction–Recommendations of the Nordic Working Group. Scandinavian Journal of Pain 11:1, pages 111-122.
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Alfred D. Nelson & Michael Camilleri. (2016) Opioid-induced constipation: advances and clinical guidance. Therapeutic Advances in Chronic Disease 7:2, pages 121-134.
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Michael W. Jann. 2016. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents 351 372 .
Claudia Trenkwalder, K Ray Chaudhuri, Pablo Martinez-Martin, Olivier Rascol, Reinhard Ehret, Martin Vališ, Maria Sátori, Anna Krygowska-Wajs, Maria J Marti, Karen Reimer, Alexander Oksche, Mark Lomax, Julia DeCesare & Michael Hopp. (2015) Prolonged-release oxycodone–naloxone for treatment of severe pain in patients with Parkinson's disease (PANDA): a double-blind, randomised, placebo-controlled trial. The Lancet Neurology 14:12, pages 1161-1170.
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Borja Mugabure Bujedo. (2015) Treatment of Failed Back Surgery Syndrome in a Forty-Three-Year-Old Man With High-Dose Oxycodone/Naloxone. Anesthesiology and Pain Medicine 5:2.
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Mona Darwish, Ronghua Yang, William Tracewell, Philmore RobertsonJr.Jr. & Mary Bond. (2015) Single- and Multiple-dose Pharmacokinetics of a Hydrocodone Bitartrate Extended-release Tablet Formulated With Abuse-deterrence Technology in Healthy, Naltrexone-blocked Volunteers. Clinical Therapeutics 37:2, pages 390-401.
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Bart Morlion, Katri Elina Clemens & Will Dunlop. (2014) Quality of Life and Healthcare Resource in Patients Receiving Opioids for Chronic Pain: A Review of the Place of Oxycodone/Naloxone. Clinical Drug Investigation 35:1, pages 1-11.
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M. Blagden, J. Hafer, H. Duerr, M. Hopp & B. Bosse. (2014) Long‐term evaluation of combined prolonged‐release oxycodone and naloxone in patients with moderate‐to‐severe chronic pain: pooled analysis of extension phases of two Phase III trials. Neurogastroenterology & Motility 26:12, pages 1792-1801.
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Anne Z. DePriest & Katie Miller. (2014) Oxycodone/Naloxone: Role in Chronic Pain Management, Opioid-Induced Constipation, and Abuse Deterrence. Pain and Therapy 3:1, pages 1-15.
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Celeste B. Burness & Gillian M. Keating. (2014) Oxycodone/Naloxone Prolonged-Release: A Review of Its Use in the Management of Chronic Pain While Counteracting Opioid-Induced Constipation. Drugs 74:3, pages 353-375.
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