857
Views
47
CrossRef citations to date
0
Altmetric
Reviews

Novel C-C chemokine receptor 2 antagonists in metabolic disease: a review of recent developments

, MD, , MD, , MD & , MD
Pages 745-756 | Published online: 06 Apr 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ke Chen, Hui Gao & Yongchang Yao. (2022) Prospects of cell chemotactic factors in bone and cartilage tissue engineering. Expert Opinion on Biological Therapy 22:7, pages 883-893.
Read now
Nathalie Esser, Nicolas Paquot & André J Scheen. (2015) Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opinion on Investigational Drugs 24:3, pages 283-307.
Read now
Syeda M Kabir, Eun-Sook Lee & Deok-Soo Son. (2014) Chemokine network during adipogenesis in 3T3-L1 cells. Adipocyte 3:2, pages 97-106.
Read now
Percy H Carter. (2013) Progress in the discovery of CC chemokine receptor 2 antagonists, 2009 – 2012. Expert Opinion on Therapeutic Patents 23:5, pages 549-568.
Read now

Articles from other publishers (43)

Manish Pal Singh, Rashita Makkar, Tapan Behl & Kamla Pathak. 2023. Recent Developments in Anti-Inflammatory Therapy. Recent Developments in Anti-Inflammatory Therapy 69 79 .
Sourav Roy, Dipty Rani Bhowmik, Rahima Begum, Mohammad Tohidul Amin, Md Aminul Islam, Firoz Ahmed & Mohammad Salim Hossain. (2022) Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice. Prostaglandins & Other Lipid Mediators 162, pages 106664.
Crossref
Qingpu Zhang, Chunjing Zhu, Xiaojing Li, Yulin Shi & Zhongli Zhang. (2020) CCR2 downregulation attenuates spinal cord injury by suppressing inflammatory monocytes. Synapse 75:5.
Crossref
Haibo Mei, Jianlin Han, Sarah White, Daniel J. Graham, Kunisuke Izawa, Tatsunori Sato, Santos Fustero, Nicholas A. Meanwell & Vadim A. Soloshonok. (2020) Tailor‐Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals. Chemistry – A European Journal 26:50, pages 11349-11390.
Crossref
Hanieh Safari, William J. Kelley, Eiji SaitoNicholas KaczorowskiLauren CarethersLonnie D. SheaOmolola Eniola-Adefeso. (2020) Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases. Science Advances 6:24.
Crossref
Luigi Adamo, Cibele Rocha-Resende, Sumanth D. Prabhu & Douglas L. Mann. (2020) Reappraising the role of inflammation in heart failure. Nature Reviews Cardiology 17:5, pages 269-285.
Crossref
Shiori Sugawara, Masamichi Shinoda, Yoshinori Hayashi, Hiroto Saito, Sayaka Asano, Asako Kubo, Ikuko Shibuta, Akihiko Furukawa, Akira Toyofuku & Koichi Iwata. (2019) Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain. International Journal of Molecular Sciences 20:24, pages 6360.
Crossref
Ramyar Azizi, Mohammad Sadegh Soltani-Zangbar, Golshan sheikhansari, Zahra Pourmoghadam, Amir Mehdizadeh, Mahdi Mahdipour, Siamak Sandoghchian, Shahla Danaii, Ladan Koushaein, Hossein Samadi Kafil & Mehdi Yousefi. (2019) Metabolic syndrome mediates inflammatory and oxidative stress responses in patients with recurrent pregnancy loss. Journal of Reproductive Immunology 133, pages 18-26.
Crossref
Michael G. Yang, Zili Xiao, Robert J. Cherney, Andrew J. Tebben, Douglas G. Batt, Gregory D. Brown, Jing Chen, Mary Ellen Cvijic, Marta Dabros, John V. Duncia, Michael Galella, Daniel S. Gardner, Purnima Khandelwal, Soo S. Ko, Mary F. Malley, Ruowei Mo, Jian Pang, Anne V. Rose, Joseph B. SantellaIIIIII, Hong Shi, Anurag Srivastava, Sarah C. Traeger, Bei Wang, Songmei Xu, Rulin Zhao, Joel C. Barrish, Sandhya Mandlekar, Qihong Zhao & Percy H. Carter. (2019) Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672. ACS Medicinal Chemistry Letters 10:3, pages 300-305.
Crossref
Maki Komiyama, Rieko Takanabe, Koh Ono, Sayaka Shimada, Hiromichi Wada, Hajime Yamakage, Noriko Satoh-Asahara, Tatsuya Morimoto, Akira Shimatsu, Yuko Takahashi & Koji Hasegawa. (2017) Association between monocyte chemoattractant protein-1 and blood pressure in smokers. Journal of International Medical Research 46:3, pages 965-974.
Crossref
Ji Hye Huh, Hong Min Kim, Eun Soo Lee, Mi Hye Kwon, Bo Ra Lee, Hyun-Jeong Ko & Choon Hee Chung. (2018) Dual CCR2/5 Antagonist Attenuates Obesity-Induced Insulin Resistance by Regulating Macrophage Recruitment and M1/M2 Status. Obesity 26:2, pages 378-386.
Crossref
Su Ji Jeong, John G. Cooper, Igal Ifergan, Tammy L. McGuire, Dan Xu, Zoe Hunter, Sripadh Sharma, Derrick McCarthy, Stephen D. Miller & John A. Kessler. (2017) Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice. Neurobiology of Disease 108, pages 73-82.
Crossref
Zhenhua Ren, Xin Wang, Fanmuyi Yang, Mei Xu, Jacqueline A. Frank, Haiping Wang, Siying Wang, Zun-ji Ke & Jia Luo. (2017) Ethanol-induced damage to the developing spinal cord: The involvement of CCR2 signaling. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:11, pages 2746-2761.
Crossref
William F. CarsonIVIV, Sarah E. Salter-Green, Melissa M. Scola, Amrita Joshi, Katherine A. Gallagher & Steven L. Kunkel. (2017) Enhancement of macrophage inflammatory responses by CCL2 is correlated with increased miR-9 expression and downregulation of the ERK1/2 phosphatase Dusp6. Cellular Immunology 314, pages 63-72.
Crossref
Sho Yasunaga, Miku Domen, Kosuke Nishi, Ayumu Kadota & Takuya Sugahara. (2016) Nobiletin suppresses monocyte chemoattractant protein-1 (MCP-1) expression by regulating MAPK signaling in 3T3-L1 cells. Journal of Functional Foods 27, pages 406-415.
Crossref
Kae Won Cho, Brian F. Zamarron, Lindsey A. Muir, Kanakadurga Singer, Cara E. Porsche, Jennifer B. DelProposto, Lynn Geletka, Kevin A. Meyer, Robert W. O’Rourke & Carey N. Lumeng. (2016) Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance. The Journal of Immunology 197:9, pages 3650-3661.
Crossref
Eun Sin Du, Hong Sik Moon, Soo-Jeong Lim, Sun Young Chang & So Hee Kim. (2016) High performance liquid chromatographic determination of YJC-10592, a new chemokine receptor 2 (CCR-2) antagonist, in biological samples. Journal of Pharmaceutical Investigation 46:5, pages 495-504.
Crossref
Eun Sin Du, Hong Sik Moon, Soo-Jeong Lim & So Hee Kim. (2016) Pharmacokinetics of YJC-10592, a novel chemokine receptor 2 (CCR-2) antagonist, in rats. Archives of Pharmacal Research 39:6, pages 833-842.
Crossref
Kinning Poon & Sarah F. Leibowitz. (2016) Consumption of Substances of Abuse during Pregnancy Increases Consumption in Offspring: Possible Underlying Mechanisms. Frontiers in Nutrition 3.
Crossref
Settu Saravanan & Leelevinothan Pari. (2016) Protective effect of thymol on high fat diet induced diabetic nephropathy in C57BL/6J mice. Chemico-Biological Interactions 245, pages 1-11.
Crossref
Pintu Maity, Debasish Kundu & Brindaban C. Ranu. (2015) Nickel-Copper-Catalyzed C( sp 2 )N Cross-Coupling of Cyclic and Bridged Amides: An Access to Cyclic Enamides and Alkenyl Vince Lactams . Advanced Synthesis & Catalysis 357:16-17, pages 3617-3626.
Crossref
David P. BurgnerMatthew A. SabinCostan G. MagnussenMichael CheungMika Kähönen, Terho LehtimäkiNina Hutri-KähönenEero JokinenTomi LaitinenLeena TaittonenPäivi TossavainenTerence DwyerJorma S.A. Viikari, Olli T. Raitakari & Markus Juonala. (2015) Infection-Related Hospitalization in Childhood and Adult Metabolic Outcomes. Pediatrics 136:3, pages e554-e562.
Crossref
Percy H. Carter, Gregory D. Brown, Robert J. Cherney, Douglas G. Batt, Jing Chen, Cheryl M. Clark, Mary Ellen Cvijic, John V. Duncia, Soo S. Ko, Sandhya Mandlekar, Ruowei Mo, David J. Nelson, Jian Pang, Anne V. Rose, Joseph B. SantellaIIIIII, Andrew J. Tebben, Sarah C. Traeger, Songmei Xu, Qihong Zhao & Joel C. Barrish. (2015) Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5. ACS Medicinal Chemistry Letters 6:4, pages 439-444.
Crossref
Maris Vilums, Annelien J.M. Zweemer, Farhana Barmare, Anouk M.F. van der Gracht, Dave C.T. Bleeker, Zhiyi Yu, Henk de Vries, Raymond Gross, Jeremy Clemens, Paul Krenitsky, Johannes Brussee, Dean Stamos, John Saunders, Laura H. Heitman & Adriaan P. IJzerman. (2015) When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. European Journal of Medicinal Chemistry 93, pages 121-134.
Crossref
Michael P. Winters, Christopher A. Teleha, Fu-An Kang, David McComsey, John C. O’Neill, Cuifen Hou, Thomas Kirchner, Ping Wang, Dana Johnson & Zhihua Sui. (2014) The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2. Bioorganic & Medicinal Chemistry Letters 24:9, pages 2137-2140.
Crossref
Hye Sook Min, Jung Eun Kim, Mi Hwa Lee, Hye Kyoung Song, Mi Jin Lee, Ji Eun Lee, Hyun Wook Kim, Jin Joo Cha, Young Youl Hyun, Jee Young Han, Dae Ryong Cha & Young Sun Kang. (2014) Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet. Kidney Research and Clinical Practice 33:1, pages 33-44.
Crossref
Daniel R. GettsRachael L. TerryMeghann Teague GettsCeline DeffrasnesMarcus MüllerCaryn van VredenThomas M. AshhurstBelal ChamiDerrick McCarthyHuiling WuJin MaAaron MartinLonnie D. ShaePaul WittingGeoffrey S. KansasJoachim KühnWali HafeziIain L. CampbellDavid ReillyJana SayLouise BrownMelanie Y. WhiteStuart J. CordwellSteven J. ChadbanEdward B. ThorpShisan BaoStephen D. MillerNicholas J. C. King. (2014) Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles. Science Translational Medicine 6:219.
Crossref
Francoise Bachelerie, Adit Ben-Baruch, Amanda M. Burkhardt, Christophe Combadiere, Joshua M. Farber, Gerard J. Graham, Richard Horuk, Alexander Hovard Sparre-Ulrich, Massimo Locati, Andrew D. Luster, Alberto Mantovani, Kouji Matsushima, Philip M. Murphy, Robert Nibbs, Hisayuki Nomiyama, Christine A. Power, Amanda E. I. Proudfoot, Mette M. Rosenkilde, Antal Rot, Silvano Sozzani, Marcus Thelen, Osamu Yoshie & Albert Zlotnik. (2014) International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors. Pharmacological Reviews 66:1, pages 1-79.
Crossref
Bianca K. Itariu & Thomas M. Stulnig. 2014. Inflammation, Advancing Age and Nutrition. Inflammation, Advancing Age and Nutrition 157 164 .
Brian Callaghan & Eva Feldman. (2013) The metabolic syndrome and neuropathy: Therapeutic challenges and opportunities. Annals of Neurology 74:3, pages 397-403.
Crossref
Dominic G. Hildebrand, Eva Alexander, Sebastian Hörber, Simon Lehle, Kerstin Obermayer, Niels-Arne Münck, Oliver Rothfuss, Julia-Stefanie Frick, Masami Morimatsu, Ingo Schmitz, Johannes Roth, Jan M. Ehrchen, Frank Essmann & Klaus Schulze-Osthoff. (2013) IκBζ Is a Transcriptional Key Regulator of CCL2/MCP-1. The Journal of Immunology 190:9, pages 4812-4820.
Crossref
J A Alvarez, S M Zughaier, J Law, L Hao, H Wasse, T R Ziegler & V Tangpricha. (2013) Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease. European Journal of Clinical Nutrition 67:3, pages 264-269.
Crossref
Carey N. Lumeng. (2013) Innate immune activation in obesity. Molecular Aspects of Medicine 34:1, pages 12-29.
Crossref
J. Joven, A. Rull, E. Rodriguez-Gallego, J. Camps, M. Riera-Borrull, A. Hernández-Aguilera, V. Martin-Paredero, A. Segura-Carretero, V. Micol, C. Alonso-Villaverde & J.A. Menéndez. (2013) Multifunctional targets of dietary polyphenols in disease: A case for the chemokine network and energy metabolism. Food and Chemical Toxicology 51, pages 267-279.
Crossref
Rohit Singh & Robert Vince. (2012) 2-Azabicyclo[2.2.1]hept-5-en-3-one: Chemical Profile of a Versatile Synthetic Building Block and its Impact on the Development of Therapeutics. Chemical Reviews 112:8, pages 4642-4686.
Crossref
John G. Cumming, Justin F. Bower, David Waterson, Alan Faull, Philip J. Poyser, Paul Turner, Benjamin McDermott, Andrew D. Campbell, Julian Hudson, Michael James, Jon Winter & Christine Wood. (2012) The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity. Bioorganic & Medicinal Chemistry Letters 22:12, pages 3895-3899.
Crossref
Percy H. Carter, Gregory D. Brown, Sarah R. King, Matthew E. Voss, Andrew J. Tebben, Robert J. Cherney, Sandhya Mandlekar, Yvonne C. Lo, Gengjie Yang, Persymphonie B. Miller, Peggy A. Scherle, Qihong Zhao & Carl P. Decicco. (2012) Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone. Bioorganic & Medicinal Chemistry Letters 22:9, pages 3311-3316.
Crossref
Michael G. Yang, Zili Xiao, Qing Shi, Robert J. Cherney, Andrew J. Tebben, George V. De Lucca, Joseph B. SantellaIIIIII, Ruowei Mo, Mary Ellen Cvijic, Qihong Zhao, Joel C. Barrish & Percy H. Carter. (2012) Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2). Bioorganic & Medicinal Chemistry Letters 22:3, pages 1384-1387.
Crossref
Pappachan E. KolattukudyJianli Niu. (2012) Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway. Circulation Research 110:1, pages 174-189.
Crossref
Ryo Yamasaki, LiPing Liu, Jessica Lin & Richard M. Ransohoff. (2012) Role of CCR2 in immunobiology and neurobiology. Clinical and Experimental Neuroimmunology 3:1, pages 16-29.
Crossref
Alaa S. Awad, Gilbert R. Kinsey, Konstantine Khutsishvili, Ting Gao, W. Kline Bolton & Mark D. Okusa. (2011) Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury. American Journal of Physiology-Renal Physiology 301:6, pages F1358-F1366.
Crossref
Gren Z. Wang, Pamela A. Haile, Tom Daniel, Benjamin Belot, Andrew Q. Viet, Krista B. Goodman, Deyou Sha, Sarah E. Dowdell, Norbert Varga, Xuan Hong, Subhas Chakravorty, Christine Webb, Carla Cornejo, Alan Olzinski, Roberta Bernard, Christopher Evans, Amanda Emmons, Jacques Briand, Chun-Wa Chung, Ruben Quek, Dennis Lee, Peter J. Gough & Clark A. Sehon. (2011) CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood. Bioorganic & Medicinal Chemistry Letters 21:24, pages 7291-7294.
Crossref
Dario A. Gutierrez, Arion Kennedy, Jeb S. Orr, Emily K. Anderson, Corey D. Webb, William K. Gerrald & Alyssa H. Hasty. (2011) Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity. Diabetes 60:11, pages 2820-2829.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.