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Adenosine receptor targeting in health and disease

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Pages 1591-1609 | Published online: 22 Oct 2011

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Estefanía Díaz-Del Cerro & Mónica De la Fuente. (2023) Positive effects of pulsed electromagnetic fields on behavior, immune function, and oxidative and inflammatory state in old mice. Electromagnetic Biology and Medicine 42:2, pages 51-66.
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Flaminia Bardanzellu, Melania Puddu, Diego Giampietro Peroni & Vassilios Fanos. (2021) The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome. Expert Review of Proteomics 18:7, pages 571-606.
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Endre Sulyok, Balint Farkas & Jozsef Bodis. (2023) Pathomechanisms of Prenatally Programmed Adult Diseases. Antioxidants 12:7, pages 1354.
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Wiwin Is Effendi & Tatsuya Nagano. (2023) A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression. International Journal of Molecular Sciences 24:5, pages 4428.
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Filippo Prencipe, Tatiana Da Ros, Eleonora Cescon, Ilenia Grieco, Margherita Persico, Giampiero Spalluto & Stephanie Federico. 2023.
Tejinder Kaur, Brenna Weadick, Thomas A. Mace, Kajal Desai, Hannah Odom & Rajgopal Govindarajan. (2022) Nucleoside transporters and immunosuppressive adenosine signaling in the tumor microenvironment: Potential therapeutic opportunities. Pharmacology & Therapeutics 240, pages 108300.
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Xuesong Wang, Gerard J. P. van Westen, Adriaan P. IJzerman & Laura H. Heitman. 2022. GPCRs as Therapeutic Targets. GPCRs as Therapeutic Targets 631 676 .
Abid Mahmood & Jamshed Iqbal. (2022) Purinergic receptors modulators: An emerging pharmacological tool for disease management. Medicinal Research Reviews 42:4, pages 1661-1703.
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Jinan Wang, Apurba Bhattarai, Hung N. Do, Sana Akhter & Yinglong Miao. (2022) Molecular Simulations and Drug Discovery of Adenosine Receptors. Molecules 27:7, pages 2054.
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Rongfeng Zou, Xueying Wang, Shu Li, H. C. Stephen Chan, Horst Vogel & Shuguang Yuan. (2021) The role of metal ions in G protein‐coupled receptor signalling and drug discovery. WIREs Computational Molecular Science 12:2.
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Dan Zhang & Xuanjun Zhang. (2021) Bioinspired Solid‐State Nanochannel Sensors: From Ionic Current Signals, Current, and Fluorescence Dual Signals to Faraday Current Signals. Small 17:43.
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Edward Beamer, Manvitha Kuchukulla, Detlev Boison & Tobias Engel. (2021) ATP and adenosine—Two players in the control of seizures and epilepsy development. Progress in Neurobiology 204, pages 102105.
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Qiaoyun Wu, Jie Chen, Jingjing Yue, Xinwang Ying, Ye Zhou, Xiaolong Chen, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Kecheng Zhou & Songhe Jiang. (2021) Electroacupuncture improves neuronal plasticity through the A2AR/cAMP/PKA signaling pathway in SNL rats. Neurochemistry International 145, pages 104983.
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Aida Menéndez Méndez, Jonathon Smith & Tobias Engel. (2020) Neonatal Seizures and Purinergic Signalling. International Journal of Molecular Sciences 21:21, pages 7832.
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Kyungmi Kim, Wonyeong Jeong, In Gu Jun & Jong Yeon Park. (2020) Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy. Korean Journal of Anesthesiology 73:5, pages 434-444.
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Flaminia Bardanzellu, Melania Puddu, Diego Giampietro Peroni & Vassilios Fanos. (2020) The Human Breast Milk Metabolome in Overweight and Obese Mothers. Frontiers in Immunology 11.
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Alexander D. Verin, Robert Batori, Anita Kovacs-Kasa, Mary Cherian-Shaw, Sanjiv Kumar, Istvan Czikora, Vijaya Karoor, Derek Strassheim, Kurt R. Stenmark & Evgenia V. Gerasimovskaya. (2020) Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms. American Journal of Physiology-Cell Physiology 319:1, pages C183-C193.
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Hariharakrishnan Chidambaram & Subashchandrabose Chinnathambi. (2020) G-Protein Coupled Receptors and Tau-different Roles in Alzheimer’s Disease. Neuroscience 438, pages 198-214.
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Wiwin Is Effendi, Tatsuya Nagano, Kazuyuki Kobayashi & Yoshihiro Nishimura. (2020) Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases. Cells 9:3, pages 785.
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Yun-Cheng Lv, An-Bo Gao, Jing Yang, Li-Yuan Zhong, Bo Jia, Shu-Hui Ouyang, Le Gui, Tian-Hong Peng, Sha Sun & FranciscoS Cayabyab. (2020) Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons. Neural Regeneration Research 15:4, pages 712.
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Pran Kishore Deb, Sarah Falah Kokaz, Sara Nidal Abed, Balakumar Chandrasekaran, Wafa Hourani, Abdulmuttaleb Yousef Jaber, Raghu Prasad Mailavaram, Puneet Kumar & Katharigatta N. Venugopala. 2020. Frontiers in Pharmacology of Neurotransmitters. Frontiers in Pharmacology of Neurotransmitters 325 359 .
Bijo Mathew, Della G. T. Parambi, Githa E. Mathew, Md. Sahab Uddin, Sini T. Inasu, Hoon Kim, Akash Marathakam, Mazhuvancherry Kesavan Unnikrishnan & Simone Carradori. (2019) Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases. Archiv der Pharmazie 352:11.
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Daniela Catarzi, Flavia Varano, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Diego Dal Ben, Rosaria Volpini & Vittoria Colotta. (2019) Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists. Pharmaceuticals 12:4, pages 159.
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Hira Choudhury, Dinesh K. Chellappan, Pallav Sengupta, Manisha Pandey & Bapi Gorain. (2019) Adenosine Receptors in Modulation of Central Nervous System Disorders. Current Pharmaceutical Design 25:26, pages 2808-2827.
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Nadezda Nedeljkovic. (2019) Complex regulation of ecto-5′-nucleotidase/CD73 and A2AR-mediated adenosine signaling at neurovascular unit: A link between acute and chronic neuroinflammation. Pharmacological Research 144, pages 99-115.
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Caifeng Meng, Qingjie Han, Xin Wang, Xiaochen Liu, Xueyan Fan, Ruina Liu, Qiao Wang & Chunying Wang. (2019) Determination and Quantitative Comparison of Nucleosides in two Cordyceps by HPLC–ESI–MS-MS. Journal of Chromatographic Science 57:5, pages 426-433.
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Amirhossein Bahreyni, Amir Avan, Mohammad Shabani, Mikhail Ryzhikov, Hamid Fiuji, Saman Soleimanpour, Majid Khazaei & Seyed Mahdi Hassanian. (2018) Therapeutic potential of A2 adenosine receptor pharmacological regulators in the treatment of cardiovascular diseases, recent progress, and prospective. Journal of Cellular Physiology 234:2, pages 1295-1299.
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F. Veronesi, M. Fini, M. Sartori, A. Parrilli, L. Martini & M. Tschon. (2018) Pulsed electromagnetic fields and platelet rich plasma alone and combined for the treatment of wear-mediated periprosthetic osteolysis: An in vivo study. Acta Biomaterialia 77, pages 106-115.
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Siao-Wei Jiang, Yi-Wen Lin & Ching-Liang Hsieh. (2018) Electroacupuncture at Hua Tuo Jia Ji Acupoints Reduced Neuropathic Pain and Increased GABA A Receptors in Rat Spinal Cord . Evidence-Based Complementary and Alternative Medicine 2018, pages 1-10.
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Pier Andrea Borea, Stefania Gessi, Stefania Merighi, Fabrizio Vincenzi & Katia Varani. (2018) Pharmacology of Adenosine Receptors: The State of the Art. Physiological Reviews 98:3, pages 1591-1625.
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Kenneth A. Jacobson, Stefania Merighi, Katia Varani, Pier Andrea Borea, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Romeo Romagnoli, Pier Giovanni Baraldi, Antonella Ciancetta, Dilip K. Tosh, Zhan-Guo Gao & Stefania Gessi. (2018) A 3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy . Medicinal Research Reviews 38:4, pages 1031-1072.
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Matilde Tschon, Francesca Veronesi, Deyanira Contartese, Maria Sartori, Lucia Martini, Fabrizio Vincenzi, Annalisa Ravani, Katia Varani & Milena Fini. (2018) Effects of pulsed electromagnetic fields and platelet rich plasma in preventing osteoclastogenesis in an in vitro model of osteolysis. Journal of Cellular Physiology 233:3, pages 2645-2656.
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Amirhossein Bahreyni, Majid Khazaei, Majid Rajabian, Mikhail Ryzhikov, Amir Avan & Seyed M. Hassanian. (2018) Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives. Journal of Pharmacy and Pharmacology 70:2, pages 191-196.
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Inmaculada Ballesteros-Yáñez, Carlos A. Castillo, Stefania Merighi & Stefania Gessi. (2018) The Role of Adenosine Receptors in Psychostimulant Addiction. Frontiers in Pharmacology 8.
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Jaden Lee & Özlem Yilmaz. (2018) Unfolding Role of a Danger Molecule Adenosine Signaling in Modulation of Microbial Infection and Host Cell Response. International Journal of Molecular Sciences 19:1, pages 199.
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Pierre Camateros, Cynthia Kanagaratham, Lukáš Najdekr, Dušan Holub, Jana Vrbkova, Lucie Coté, Jocelyn Fournier, Jim Gourdon, David Creery, Ron Olivenstein, Frantisek Kopriva, Tomáš Adam, David Friedecký, Petr Džubák, Marian Hajdúch & Danuta Radzioch. (2018) Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris suum –induced Allergic Asthma in Nonhuman Primates . American Journal of Respiratory Cell and Molecular Biology 58:1, pages 55-65.
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Stefania Merighi, Stefania Gessi & Pier Andrea Borea. 2018. The Adenosine Receptors. The Adenosine Receptors 33 57 .
Katia Varani, Fabrizio Vincenzi, Matteo Cadossi, Stefania Setti, Pier Andrea Borea & Ruggero Cadossi. 2018. The Adenosine Receptors. The Adenosine Receptors 557 580 .
Stefania Gessi, Stefania Merighi & Katia Varani. 2018. The Adenosine Receptors. The Adenosine Receptors 1 11 .
Yanan Sun & Wenxiang Li. (2017) Activity-guided isolation and structural identification of immunomodulating substances from Pleurotus eryngii byproducts. International Immunopharmacology 51, pages 82-90.
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Pier Andrea Borea, Stefania Gessi, Stefania Merighi, Fabrizio Vincenzi & Katia Varani. (2017) Pathological overproduction: the bad side of adenosine. British Journal of Pharmacology 174:13, pages 1945-1960.
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Annalisa Ravani, Fabrizio Vincenzi, Alessandra Bortoluzzi, Melissa Padovan, Silvia Pasquini, Stefania Gessi, Stefania Merighi, Pier Borea, Marcello Govoni & Katia Varani. (2017) Role and Function of A2A and A3 Adenosine Receptors in Patients with Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis. International Journal of Molecular Sciences 18:4, pages 697.
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Katia Varani, Fabrizio Vincenzi, Annalisa Ravani, Silvia Pasquini, Stefania Merighi, Stefania Gessi, Stefania Setti, Matteo Cadossi, Pier Andrea Borea & Ruggero Cadossi. (2017) Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields. Mediators of Inflammation 2017, pages 1-11.
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Katia Varani, Fabrizio Vincenzi, Stefania Merighi, Stefania Gessi & Pier Andrea Borea. 2017. Protein Reviews. Protein Reviews 193 232 .
Alessandra Bortoluzzi, Fabrizio Vincenzi, Marcello Govoni, Melissa Padovan, Annalisa Ravani, Pier Andrea Borea & Katia Varani. (2016) A2A adenosine receptor upregulation correlates with disease activity in patients with systemic lupus erythematosus. Arthritis Research & Therapy 18:1.
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J. Sawynok. (2016) Adenosine receptor targets for pain. Neuroscience 338, pages 1-18.
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Pier Andrea Borea, Stefania Gessi, Stefania Merighi & Katia Varani. (2016) Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?. Trends in Pharmacological Sciences 37:6, pages 419-434.
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Pei Li, Xiang-Yu Kong, Ganhua Xie, Kai Xiao, Zhen Zhang, Liping Wen & Lei Jiang. (2016) Adenosine-Activated Nanochannels Inspired by G-Protein-Coupled Receptors. Small 12:14, pages 1854-1858.
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Stefania Merighi, Pier Andrea Borea & Stefania Gessi. (2015) Adenosine receptors and diabetes: Focus on the A2B adenosine receptor subtype. Pharmacological Research 99, pages 229-236.
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Hyun Keun Chee, Jin-San Yang, Je-Gun Joung, Byoung-Tak Zhang & S. June Oh. (2015) Characteristic molecular vibrations of adenosine receptor ligands. FEBS Letters 589:4, pages 548-552.
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Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Pier Giovanni Baraldi, Mojgan Aghazadeh Tabrizi, Stefania Merighi & Stefania Gessi. (2015) The A 3 Adenosine Receptor: History and Perspectives . Pharmacological Reviews 67:1, pages 74-102.
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Romeo Romagnoli, Pier Giovanni Baraldi, Adriaan P. IJzerman, Arnault Massink, Olga Cruz-Lopez, Luisa Carlota Lopez-Cara, Giulia Saponaro, Delia Preti, Mojgan Aghazadeh Tabrizi, Stefania Baraldi, Allan R. Moorman, Fabrizio Vincenzi, Pier Andrea Borea & Katia Varani. (2014) Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A 1 Adenosine Receptor Based on 2-Amino-3-(4′-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene . Journal of Medicinal Chemistry 57:18, pages 7673-7686.
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Stefania Gessi, Stefania Merighi & Pier Andrea Borea. (2014) Targeting adenosine receptors to prevent inflammatory skin diseases. Experimental Dermatology 23:8, pages 553-554.
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Fabrizio Vincenzi, Martina Targa, Romeo Romagnoli, Stefania Merighi, Stefania Gessi, Pier Giovanni Baraldi, Pier Andrea Borea & Katia Varani. (2014) TRR469, a potent A1 adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice. Neuropharmacology 81, pages 6-14.
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Ana Guzman-Aranguez, Xavier Gasull, Yolanda Diebold & Jesús Pintor. (2014) Purinergic Receptors in Ocular Inflammation. Mediators of Inflammation 2014, pages 1-11.
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J. Zhao, J. Xie, L.Y. Wang & S.P. Li. (2014) Advanced development in chemical analysis of Cordyceps. Journal of Pharmaceutical and Biomedical Analysis 87, pages 271-289.
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Milena FiniStefania PaganiGianluca GiavaresiMonica De MatteiAlessia OngaroKatia VaraniFabrizio VincenziLeo MassariMatteo Cadossi. (2013) Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation?. Tissue Engineering Part B: Reviews 19:4, pages 353-367.
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Fabrizio Vincenzi, Carmen Corciulo, Martina Targa, Stefania Merighi, Stefania Gessi, Ilaria Casetta, Mauro Gentile, Enrico Granieri, Pier Andrea Borea & Katia Varani. (2013) Multiple sclerosis lymphocytes upregulate A 2A adenosine receptors that are antiinflammatory when stimulated . European Journal of Immunology 43:8, pages 2206-2216.
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Kenneth A. Jacobson. (2013) Structure-Based Approaches to Ligands for G-Protein-Coupled Adenosine and P2Y Receptors, from Small Molecules to Nanoconjugates. Journal of Medicinal Chemistry 56:10, pages 3749-3767.
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Nagavedi Siddaramappa Umapathy, Elzbieta Kaczmarek, Nooreen Fatteh, Nana Burns, Rudolf Lucas, Kurt R. Stenmark, Alexander D. Verin & Evgenia V. Gerasimovskaya. (2013) Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling. PLoS ONE 8:4, pages e59733.
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Jiang-Fan Chen, Holger K. Eltzschig & Bertil B. Fredholm. (2013) Adenosine receptors as drug targets — what are the challenges?. Nature Reviews Drug Discovery 12:4, pages 265-286.
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Edwin K. Jackson, Dongmei Cheng, Travis C. Jackson, Jonathan D. Verrier & Delbert G. Gillespie. (2013) Extracellular guanosine regulates extracellular adenosine levels. American Journal of Physiology-Cell Physiology 304:5, pages C406-C421.
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Maria Letizia Trincavelli. (2013) Unveiling the binding mode of adenosine deaminase inhibitors to the active site of the enzyme: implication for rational drug design. Purinergic Signalling 9:1, pages 1-3.
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Melissa Padovan, Fabrizio Vincenzi, Marcello Govoni, Alessandra Bortoluzzi, Pier Andrea Borea & Katia Varani. (2013) Adenosine and adenosine receptors in rheumatoid arthritis. International Journal of Clinical Rheumatology 8:1, pages 13-25.
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Fabrizio Vincenzi, Melissa Padovan, Martina Targa, Carmen Corciulo, Sarah Giacuzzo, Stefania Merighi, Stefania Gessi, Marcello Govoni, Pier Andrea Borea & Katia Varani. (2013) A2A Adenosine Receptors Are Differentially Modulated by Pharmacological Treatments in Rheumatoid Arthritis Patients and Their Stimulation Ameliorates Adjuvant-Induced Arthritis in Rats. PLoS ONE 8:1, pages e54195.
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Kenneth A. Jacobson, Stefano Costanzi & Francesca Deflorian. 2013. G Protein Coupled Receptors - Structure. G Protein Coupled Receptors - Structure 199 217 .
Pier Giovanni Baraldi, Delia Preti, Pier Andrea Borea & Katia Varani. (2012) Medicinal Chemistry of A 3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications . Journal of Medicinal Chemistry 55:12, pages 5676-5703.
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Eszter Kozma, T. Santhosh Kumar, Stephanie Federico, Khai Phan, Ramachandran Balasubramanian, Zhan-Guo Gao, Silvia Paoletta, Stefano Moro, Giampiero Spalluto & Kenneth A. Jacobson. (2012) Novel fluorescent antagonist as a molecular probe in A3 adenosine receptor binding assays using flow cytometry. Biochemical Pharmacology 83:11, pages 1552-1561.
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