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New pharmacological avenues for the treatment of l-DOPA-induced dyskinesias in Parkinson's disease: targeting glutamate and adenosine receptors

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Pages 153-168 | Published online: 11 Jan 2012

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Silvia Cerri, Francesca Siani & Fabio Blandini. (2017) Investigational drugs in Phase I and Phase II for Levodopa-induced dyskinesias. Expert Opinion on Investigational Drugs 26:7, pages 777-791.
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Fabio Blandini & Marie-Therese Armentero. (2014) Dopamine receptor agonists for Parkinson's disease. Expert Opinion on Investigational Drugs 23:3, pages 387-410.
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Panagiotis Bargiotas & Spyridon Konitsiotis. (2013) Levodopa-induced dyskinesias in Parkinson’s disease: emerging treatments. Neuropsychiatric Disease and Treatment 9, pages 1605-1617.
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Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy & Awanish Mishra. (2022) Molecular Mechanisms and Therapeutic Strategies for Levodopa-Induced Dyskinesia in Parkinson’s Disease: A Perspective Through Preclinical and Clinical Evidence. Frontiers in Pharmacology 13.
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Efthalia Angelopoulou, Yam Nath Paudel, Thomas Julian, Mohd Farooq Shaikh & Christina Piperi. (2020) Pivotal Role of Fyn Kinase in Parkinson’s Disease and Levodopa-Induced Dyskinesia: a Novel Therapeutic Target?. Molecular Neurobiology 58:4, pages 1372-1391.
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Aijuan Yan, Lu Song, Yu Zhang, Xijin Wang & Zhenguo Liu. (2021) Systemic Inflammation Increases the Susceptibility to Levodopa-Induced Dyskinesia in 6-OHDA Lesioned Rats by Targeting the NR2B-Medicated PKC/MEK/ERK Pathway. Frontiers in Aging Neuroscience 12.
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Mercè Pallàs, Santiago Vázquez, Coral Sanfeliu, Carles Galdeano & Christian Griñán-Ferré. (2020) Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy. Biomolecules 10:5, pages 703.
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Maria Laura Ester Bianchi, Giulio Riboldazzi, Marco Mauri & Maurizio Versino. (2018) Efficacy of safinamide on non-motor symptoms in a cohort of patients affected by idiopathic Parkinson’s disease. Neurological Sciences 40:2, pages 275-279.
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Tonghui Su, Yi Lu, Yang Geng, Wei Lu & Yelin Chen. (2019) How could N-Methyl-D-Aspartate Receptor Antagonists Lead to Excitation Instead of Inhibition?. Brain Science Advances 4:2, pages 73-98.
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Delphine Charvin, Therese Di Paolo, Erwan Bezard, Laurent Gregoire, Akihiro Takano, Guillaume Duvey, Elsa Pioli, Christer Halldin, Rossella Medori & François Conquet. (2018) An mGlu4-Positive Allosteric Modulator Alleviates Parkinsonism in Primates. Movement Disorders 33:10, pages 1619-1631.
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Delphine Charvin. (2018) mGlu4 allosteric modulation for treating Parkinson's disease. Neuropharmacology 135, pages 308-315.
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Yixian Huang, Haiyang Shu, Li Li, Tili Zhen, Junyan Zhao, Xianju Zhou & Weifeng Luo. (2018) L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats. ASN Neuro 10, pages 175909141881102.
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Wen-Wen Wang, Man-Man Zhang, Xing-Ru Zhang, Zeng-Rui Zhang, Jie Chen, Liang Feng & Cheng-Long Xie. (2017) A Meta-Analysis of Adenosine A2A Receptor Antagonists on Levodopa-Induced Dyskinesia In Vivo. Frontiers in Neurology 8.
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Juan-Juan Du & Sheng-Di Chen. (2017) Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease. Chinese Medical Journal 130:15, pages 1856-1866.
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Nicolas Morin & Thérèse Di Paolo. 2017. mGLU Receptors. mGLU Receptors 183 205 .
Qiang Wang & Wangming Zhang. (2016) Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia. Frontiers in Neural Circuits 10.
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Luca Loprete, Chiara Leuratti, Carlo Cattaneo, Mita M. Thapar, Colm Farrell & Marco Sardina. (2016) Population pharmacokinetic and pharmacodynamic analyses of safinamide in subjects with Parkinson's disease. Pharmacology Research & Perspectives 4:5.
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Rajib Paul & Anupom Borah. (2016) L-DOPA-induced hyperhomocysteinemia in Parkinson's disease: Elephant in the room. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:9, pages 1989-1997.
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Tanuja Bordia, Xiomara A. Perez, Jaime E. Heiss, Danhui Zhang & Maryka Quik. (2016) Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias. Neurobiology of Disease 91, pages 47-58.
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Vincent A. Jourdain, Nicolas Morin, Laurent Grégoire, Marc Morissette & Thérèse Di Paolo. (2015) Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy. Journal of Neurosurgery 123:6, pages 1383-1393.
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Danhui Zhang, Matthew McGregor, Tanuja Bordia, Xiomara A. Perez, J. Michael McIntosh, Michael W. Decker & Maryka Quik. (2015) α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Movement Disorders 30:14, pages 1901-1911.
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Danhui Zhang, Matthew McGregor, Michael W. Decker & Maryka Quik. (2014) The α 7 Nicotinic Receptor Agonist ABT-107 Decreases l-Dopa–Induced Dyskinesias in Parkinsonian Monkeys . Journal of Pharmacology and Experimental Therapeutics 351:1, pages 25-32.
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Nicolas Morin & Thérèse Di Paolo. (2014) Pharmacological Treatments Inhibiting Levodopa-Induced Dyskinesias in MPTP-Lesioned Monkeys: Brain Glutamate Biochemical Correlates. Frontiers in Neurology 5.
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Nicolas Morin, Vincent A. Jourdain, Marc Morissette, Laurent Grégoire & Thérèse Di Paolo. (2014) Long-term treatment with l-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys. Neuropharmacology 79, pages 688-706.
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