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Expert Opinion on Investigational Drugs Volume 21, 2012 - Issue 7
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Drug Evaluations

Lonafarnib for cancer and progeria

Nan Soon WongNational Cancer Centre Singapore, Department of Medical Oncology, Singapore
, MBBS MRCP FAMS &
Michael A MorseDuke University Medical Centre, Department of Medical Oncology, Durham, NC, USA
, MD FACP
Pages 1043-1055 | Published online: 24 May 2012

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Jing Gu, Zheng Sui, Chunshu Fang & Qunyou Tan. (2017) Stereochemical considerations in pharmacokinetic processes of representative antineoplastic agents. Drug Metabolism Reviews 49:4, pages 438-450.
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Ibrahim Halil Bahcecioglu & Abdurrahman Sahin. (2017) Treatment of Delta Hepatitis: Today and in the Future - A review. Infectious Diseases 49:4, pages 241-250.
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Mark W Kieran, Leslie B Gordon & Monica E Kleinman. (2014) The role of the farnesyltransferase inhibitor lonafarnib in the treatment of Progeria. Expert Opinion on Orphan Drugs 2:1, pages 95-105.
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Articles from other publishers (16)

Yap Jiajun & Hu Jiancheng. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 39 .
Ying Zhou, Jia-Jie Yang, Yuan Cheng, Ge-Xuan Feng, Rong-Hui Yang, Yuan Yuan, Li-Yong Wang, Miao Wang & Lu Kong. (2022) Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation. Cells 11:24, pages 3988.
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Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. LansburyJrJr, Joseph R. Mazzulli & Robert Vassar. (2022) Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice. Molecular Neurodegeneration 17:1.
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Elena Vehns, Rouven Arnold & Karima Djabali. (2022) Impact of MnTBAP and Baricitinib Treatment on Hutchinson–Gilford Progeria Fibroblasts. Pharmaceuticals 15:8, pages 945.
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Shi-Ming Tu & Louis L. Pisters. (2022) Stem-Cell Theory of Cancer: Implications for Antiaging and Anticancer Strategies. Cancers 14:5, pages 1338.
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Shuo Yuan, Yong-Qiang Luo, Jia-Hui Zuo, Hui Liu, Fang Li & Bin Yu. (2021) New drug approvals for 2020: Synthesis and clinical applications. European Journal of Medicinal Chemistry 215, pages 113284.
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Zijing Ruan, Chao Liu, Yuting Guo, Zhenqing He, Xinhe Huang, Xu Jia & Tai Yang. (2020) SARS‐CoV‐2 and SARS‐CoV: Virtual screening of potential inhibitors targeting RNA‐dependent RNA polymerase activity (NSP12). Journal of Medical Virology 93:1, pages 389-400.
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Gina Wall, Emily Chen, Mitchell V. Hull & Jose L. Lopez-Ribot. (2020) Screening the CALIBR ReFRAME Library in Search for Inhibitors of Candida auris Biofilm Formation. Frontiers in Cellular and Infection Microbiology 10.
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Jialiang Wang, Huan Wei, Yanlin Huang, Dongmei Chen, Guofen Zeng, Yifan Lian & Yuehua Huang. (2019) The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells. Aging 11:15, pages 5769-5785.
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Ben L Da, Theo Heller & Christopher Koh. (2019) Hepatitis D infection: from initial discovery to current investigational therapies. Gastroenterology Report 7:4, pages 231-245.
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Christopher Koh, Ben L. Da & Jeffrey S. Glenn. (2019) HBV/HDV Coinfection. Clinics in Liver Disease 23:3, pages 557-572.
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Jianjun Qiao, Yi Sun, Lujuan Gao, Chengyan He & Wenqian Zheng. (2018) Lonafarnib synergizes with azoles against Aspergillus spp. and Exophiala spp.. Medical Mycology 56:4, pages 452-457.
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Jialiang Wang, Yifan Lian, Yurong Gu, Hongbo Wang, Lin Gu, Yanlin Huang, Liang Zhou & Yuehua Huang. (2017) Synergistic effect of farnesyl transferase inhibitor lonafarnib combined with chemotherapeutic agents against the growth of hepatocellular carcinoma cells. Oncotarget 8:62, pages 105047-105060.
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Jingyuan Wang, Xue Yao & Jin Huang. (2017) New tricks for human farnesyltransferase inhibitor: cancer and beyond. MedChemComm 8:5, pages 841-854.
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Devinderjit K. Moudgil, Nathan Westcott, Jakub K. Famulski, Kinjal Patel, Dawn Macdonald, Howard Hang & Gordon K.T. Chan. (2015) A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores. Journal of Cell Biology 208:7, pages 881-896.
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Yuanxiang Wang, Christine E. Kaiser, Brendan Frett & Hong-yu Li. (2013) Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators. Journal of Medicinal Chemistry 56:13, pages 5219-5230.
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