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New AMPA antagonists in epilepsy

, , , & , MD
Pages 1371-1389 | Published online: 13 Jul 2012

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Read on this site (8)

Marco Greco, Gaia Varriale, Giangennaro Coppola, Francesca Operto, Alberto Verrotti & Maria Laura Iezzi. (2018) Investigational small molecules in phase II clinical trials for the treatment of epilepsy. Expert Opinion on Investigational Drugs 27:12, pages 971-979.
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Carlo Di Bonaventura, Angelo Labate, Marta Maschio, Stefano Meletti & Emilio Russo. (2017) AMPA receptors and perampanel behind selected epilepsies: current evidence and future perspectives. Expert Opinion on Pharmacotherapy 18:16, pages 1751-1764.
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Caterina Palleria, Antonietta Coppola, Rita Citraro, Luigi Del Gaudio, Salvatore Striano, Giovambattista De Sarro & Emilio Russo. (2015) Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis. Expert Opinion on Pharmacotherapy 16:15, pages 2355-2371.
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Jerzy P Szaflarski, Yara Nazzal & Laura E Dreer. (2014) Post-traumatic epilepsy: current and emerging treatment options. Neuropsychiatric Disease and Treatment 10, pages 1469-1477.
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Valentina Franco, Alfonso Iudice, Elisabetta Grillo, Rita Citraro, Giovambattista De Sarro & Emilio Russo. (2014) Perspective on the use of perampanel and intravenous carbamazepine for generalized seizures. Expert Opinion on Pharmacotherapy 15:5, pages 637-644.
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Rita Citraro, Rossana Aiello, Valentina Franco, Giovambattista De Sarro & Emilio Russo. (2014) Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy. Expert Opinion on Therapeutic Targets 18:3, pages 319-334.
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Dolan Sondhi, Jonathan B Rosenberg, Benjamin G Van de Graaf, Stephen M Kaminsky & Ronald G Crystal. (2013) Advances in the treatment of neuronal ceroid lipofuscinosis. Expert Opinion on Orphan Drugs 1:12, pages 951-975.
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Marco Mula. (2013) Emerging drugs for focal epilepsy. Expert Opinion on Emerging Drugs 18:1, pages 87-95.
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Articles from other publishers (37)

Mohammad Qneibi, Mohammad Hawash, Nidal Jaradat & Sosana Bdir. (2022) Affecting AMPA Receptor Biophysical Gating Properties with Negative Allosteric Modulators. Molecular Neurobiology 59:9, pages 5264-5275.
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Fangli Cheng, Lijun Du, John J. Kim, Feng Zhu, Huiqin He & Ning Dai. (2022) NMDA and AMPA receptor physiology and role in visceral hypersensitivity: a review. European Journal of Gastroenterology & Hepatology 34:5, pages 471-477.
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Gniewomir Latacz, Kinga Sałat, Anna Furgała-Wojas, Adrian Martyniak, Agnieszka Olejarz-Maciej, Ewelina Honkisz-Orzechowska & Ewa Szymańska. (2022) Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies. Molecules 27:3, pages 875.
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Carmen De Caro, Claudia Cristiano, Carmen Avagliano, Mariarosaria Cuozzo, Giovanna La Rana, Gabriella Aviello, Giovambattista De Sarro, Antonio Calignano, Emilio Russo & Roberto Russo. (2021) Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System. Frontiers in Pharmacology 11.
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Takashi Hayashi. (2020) Post‐translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions. British Journal of Pharmacology 178:4, pages 784-797.
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Tatiana N. Zamay, Galina S. Zamay, Natalia A. Shnayder, Diana V. Dmitrenko, Sergey S. Zamay, Victoria Yushchenko, Olga S. Kolovskaya, Vanessa Susevski, Maxim V. Berezovski & Anna S. Kichkailo. (2020) Nucleic Acid Aptamers for Molecular Therapy of Epilepsy and Blood-Brain Barrier Damages. Molecular Therapy - Nucleic Acids 19, pages 157-167.
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Rong Li, Miaoqing He, Bing Wu, Peng Zhang, Qinbin Zhang & Yangmei Chen. (2020) SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model. Brazilian Journal of Medical and Biological Research 53:4.
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Pakhuri Mehta, Shubham Srivastava, Manish Sharma & Ruchi Malik. (2019) Discovery of novel chemotypes for competitive AMPA receptor antagonists as potential antiepileptic agents through structure-based virtual screening of natural products library. Structural Chemistry 30:4, pages 1159-1172.
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Hiroshi InamiJun-ichi ShishikuraTomoyuki YasunagaMasaaki HiranoTakenori KimuraHiroshi YamashitaKazushige OhnoShuichi Sakamoto. (2019) Synthesis and Pharmacological Evaluation of 3-[(4-Oxo-4<i>H</i>-pyrido[3,2-<i>e</i>][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile Derivatives as Orally Active AMPA Receptor Antagonists. Chemical and Pharmaceutical Bulletin 67:7, pages 699-706.
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Emilio Russo & Rita Citraro. (2018) Pharmacology of epileptogenesis and related comorbidities in the WAG/Rij rat model of genetic absence epilepsy. Journal of Neuroscience Methods 310, pages 54-62.
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Masayuki Itoh, Mariko Yamashita, Masaki Kaneko, Hiroyuki Okuno, Manabu Abe, Maya Yamazaki, Rie Natsume, Daisuke Yamada, Toshie Kaizuka, Reiko Suwa, Kenji Sakimura, Masayuki Sekiguchi, Keiji Wada, Mikio Hoshino, Masayoshi Mishina & Takashi Hayashi. (2018) Deficiency of AMPAR–Palmitoylation Aggravates Seizure Susceptibility. The Journal of Neuroscience 38:47, pages 10220-10235.
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Antonio Leo, Giada Giovannini, Emilio Russo & Stefano Meletti. (2018) The role of AMPA receptors and their antagonists in status epilepticus. Epilepsia 59:6, pages 1098-1108.
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Jinghui Zhang, Nana Qiao, Xiufang Ding & Jiwen Wang. (2018) Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy. NeuroReport 29:5, pages 432-439.
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Ewa Szymańska, Paulina Chałupnik, Tommy N. Johansen, Birgitte Nielsen, Ana Maria Cuñado Moral, Darryl S. Pickering, Anna Więckowska & Katarzyna Kieć-Kononowicz. (2017) Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands. Chemical Biology & Drug Design 90:6, pages 1271-1281.
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Michael P. Maher, Jose A. Matta, Shenyan Gu, Mark Seierstad & David S. Bredt. (2017) Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins. Neuron 96:5, pages 989-1001.
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Johannes Wiest, Marco Saedtler, Anja Balk, Benjamin Merget, Toni Widmer, Heike Bruhn, Marc Raccuglia, Elbast Walid, Franck Picard, Helga Stopper, Wolfgang Dekant, Tessa Lühmann, Christoph Sotriffer, Bruno Galli, Ulrike Holzgrabe & Lorenz Meinel. (2017) Mapping the pharmaceutical design space by amorphous ionic liquid strategies. Journal of Controlled Release 268, pages 314-322.
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Ewa Szymańska, Birgitte Nielsen, Tommy N. Johansen, Ana Maria Cuñado Moral, Darryl S. Pickering, Katarzyna Szczepańska, Anna Mickowska & Katarzyna Kieć-Kononowicz. (2017) Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors. European Journal of Medicinal Chemistry 138, pages 874-883.
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Milad Espahbodinia, Roberta Ettari, Wei Wen, Andrew Wu, Yu-Chuan Shen, Li Niu, Silvana Grasso & Maria Zappalà. (2017) Development of novel N -3-bromoisoxazolin-5-yl substituted 2,3-benzodiazepines as noncompetitive AMPAR antagonists. Bioorganic & Medicinal Chemistry 25:14, pages 3631-3637.
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Jun Ren, Xiuqing Ding & John J. Greer. (2017) Mechanistic Studies of Capsaicin-Induced Apnea in Rodents. American Journal of Respiratory Cell and Molecular Biology 56:2, pages 252-260.
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Rita Citraro, Antonio Leo, Valentina Franco, Roberto Marchiselli, Emilio Perucca, Giovambattista De Sarro & Emilio Russo. (2017) Perampanel effects in the WAG/Rij rat model of epileptogenesis, absence epilepsy, and comorbid depressive-like behavior. Epilepsia 58:2, pages 231-238.
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Tristan Reuillon, Simon E. Ward & Paul Beswick. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 447 480 .
Rita Citraro, Michele Navarra, Antonio Leo, Eugenio Donato Di Paola, Ermenegildo Santangelo, Pellegrino Lippiello, Rossana Aiello, Emilio Russo & Giovambattista De Sarro. (2016) The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes. Molecules 21:9, pages 1261.
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Richard Macrez, Peter K Stys, Denis Vivien, Stuart A Lipton & Fabian Docagne. (2016) Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. The Lancet Neurology 15:10, pages 1089-1102.
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Preeti Dohare, Muhammad T. Zia, Ehsan Ahmed, Asad Ahmed, Vivek Yadala, Alexandra L. Schober, Juan Alberto Ortega, Robert Kayton, Zoltan Ungvari, Alexander A. Mongin & Praveen Ballabh. (2016) AMPA-Kainate Receptor Inhibition Promotes Neurologic Recovery in Premature Rabbits with Intraventricular Hemorrhage. The Journal of Neuroscience 36:11, pages 3363-3377.
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Pishan Chang, Katrin Augustin, Kim Boddum, Sophie Williams, Min Sun, John A. Terschak, J?rg D. Hardege, Philip E. Chen, Matthew C. Walker & Robin S. B. Williams. (2016) Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain 139:2, pages 431-443.
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Gaetano Zaccara & Dieter Schmidt. (2016) Do traditional anti-seizure drugs have a future? A review of potential anti-seizure drugs in clinical development. Pharmacological Research 104, pages 38-48.
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Asit Ghosh, Ashok Kumar Pandey & Prabal Banerjee. (2015) Lewis Acid Catalyzed Annulation of Donor–Acceptor Cyclopropane and N -Tosylaziridinedicarboxylate: One-Step Synthesis of Functionalized 2 H -Furo[2,3- c ]pyrroles . The Journal of Organic Chemistry 80:14, pages 7235-7242.
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Anja Balk, Toni Widmer, Johannes Wiest, Heike Bruhn, Jens-Christoph Rybak, Philipp Matthes, Klaus Müller-Buschbaum, Anastasios Sakalis, Tessa Lühmann, Jörg Berghausen, Ulrike Holzgrabe, Bruno Galli & Lorenz Meinel. (2014) Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges. Pharmaceutical Research 32:6, pages 2154-2167.
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Hiroshi Inami, Jun-ichi Shishikura, Tomoyuki Yasunaga, Kazushige Ohno, Hiroshi Yamashita, Kota Kato & Shuichi Sakamoto. (2015) Synthesis, structure–activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists. Bioorganic & Medicinal Chemistry 23:8, pages 1788-1799.
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Alvaro Takeo Omori, Camila de Souza de Oliveira, Kleber Tellini Andrade & Marina Gonçalves Capeletto. (2015) Sassafras oil, carrot bits and microwaves: green lessons learned from the formal total synthesis of (−)-talampanel. RSC Advances 5:125, pages 103563-103565.
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Vincenzo Belcastro & Alberto Verrotti. 2015. Epilepsy Towards the Next Decade. Epilepsy Towards the Next Decade 183 199 .
R. Zwart, E. Sher, X. Ping, X. Jin, J. R. SimsJr.Jr., A. S. Chappell, S. D. Gleason, P. J. Hahn, K. Gardinier, D. L. Gernert, J. Hobbs, J. L. Smith, S. N. Valli & J. M. Witkin. (2014) Perampanel, an Antagonist of α -Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors, for the Treatment of Epilepsy: Studies in Human Epileptic Brain and Nonepileptic Brain and in Rodent Models . Journal of Pharmacology and Experimental Therapeutics 351:1, pages 124-133.
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Donald C. Rojas. (2014) The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment. Journal of Neural Transmission 121:8, pages 891-905.
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Yi Luo, Peng-Fei Wu, Jun Zhou, Wen Xiao, Jin-Gang He, Xin-Lei Guan, Jie-Ting Zhang, Zhuang-Li Hu, Fang Wang & Jian-Guo Chen. (2014) Aggravation of Seizure-like Events by Hydrogen Sulfide: Involvement of Multiple Targets that Control Neuronal Excitability. CNS Neuroscience & Therapeutics 20:5, pages 411-419.
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Francis J. Golder, Matthew M. Hewitt & James F. McLeod. (2013) Respiratory stimulant drugs in the post-operative setting. Respiratory Physiology & Neurobiology 189:2, pages 395-402.
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Antonio Siniscalchi, Luca Gallelli, Emilio Russo & Giovambattista De Sarro. (2013) A review on antiepileptic drugs-dependent fatigue: Pathophysiological mechanisms and incidence. European Journal of Pharmacology 718:1-3, pages 10-16.
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V. Franco, F. Crema, A. Iudice, G. Zaccara & E. Grillo. (2013) Novel treatment options for epilepsy: Focus on perampanel. Pharmacological Research 70:1, pages 35-40.
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