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Expert Opinion on Investigational Drugs Volume 21, 2012 - Issue 10
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Drug Evaluations

Olaparib, PARP1 inhibitor in ovarian cancer

Claudia Marchetti“Sapienza” University of Rome, Department of Gynecologic-Obstetrical and Urologic Sciences, Viale del Policlinico, 155 - 00161, Rome, Italy+39 3384652744; +0649972564; [email protected]
, MD PhD,
Ludovica Imperiale“Sapienza” University of Rome, Department of Gynecologic-Obstetrical and Urologic Sciences, Viale del Policlinico, 155 - 00161, Rome, Italy+39 3384652744; +0649972564; [email protected]
, MD,
Maria Luisa Gasparri“Sapienza” University of Rome, Department of Gynecologic-Obstetrical and Urologic Sciences, Viale del Policlinico, 155 - 00161, Rome, Italy+39 3384652744; +0649972564; [email protected]
, MD,
Innocenza Palaia “Sapienza” University of Rome, Department of Gynecologic-Obstetrical and Urologic Sciences, Viale del Policlinico, 155 - 00161, Rome, Italy
, MD, PhD,
Sandro PignataNational Cancer Institute of Naples, Department of Urology and Gynecology, Via Mariano Semmola, Naples, Italy
, MD,
Terenzio Boni “Sapienza” University of Rome, Department of Gynecologic-Obstetrical and Urologic Sciences, Viale del Policlinico, 155 - 00161, Rome, Italy
, MD,
Filippo Bellati “Sapienza” University of Rome, Department of Gynecologic-Obstetrical and Urologic Sciences, Viale del Policlinico, 155 - 00161, Rome, Italy
, MD, PhD &
Pierluigi Benedetti PaniciFull Professor, “Sapienza” University of Rome, Department of Gynecologic-Obstetrical and Urologic Sciences, Viale del Policlinico, 155 - 00161, Rome, Italy
, MD show all
Pages 1575-1584 | Published online: 13 Jul 2012

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Xin-Yue Zhou, Jin-Yao Li, Jing-Tong Tan, Yi-Li HuangLi, Xiao-Cui Nie & Pu Xia. (2023) Clinical significance of the CD98hc-CD147 complex in ovarian cancer: a bioinformatics analysis. Journal of Obstetrics and Gynaecology 43:1.
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Francesca De Felice, Vincenzo Tombolini, Francesco Marampon, Angela Musella & Claudia Marchetti. (2017) Defective DNA repair mechanisms in prostate cancer: impact of olaparib. Drug Design, Development and Therapy 11, pages 547-552.
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Helen HW Chen, Wen-Chung Chen, Zhang-Dong Liang, Wen-Bin Tsai, Yan Long, Isamu Aiba, Siqing Fu, Russell Broaddus, Jinsong Liu, Lynn G Feun, Niramol Savaraj & Macus Tien Kuo. (2015) Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy. Expert Opinion on Therapeutic Targets 19:10, pages 1307-1317.
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Claudia Marchetti, Jonathan A Ledermann & Pierluigi Benedetti Panici. (2015) An overview of early investigational therapies for chemoresistant ovarian cancer. Expert Opinion on Investigational Drugs 24:9, pages 1163-1183.
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Peter Norman. (2015) Orphan drug approvals of 2014: Europe and the United States. Expert Opinion on Orphan Drugs 3:4, pages 445-455.
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Stephanie Lheureux & Amit M Oza. (2014) Olaparib for the treatment of ovarian cancer. Expert Opinion on Orphan Drugs 2:5, pages 497-508.
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Articles from other publishers (21)

Xiu Chen, Qinglian Wen, Liqiu Kou, Xiaolu Xie, Jun Li & Yaling Li. (2023) Incidence and risk of hypertension associated with PARP inhibitors in cancer patients: a systematic review and meta-analysis. BMC Cancer 23:1.
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Po-Han Lin, Yun-Wen Tien, Wen-Fang Cheng, Ying-Cheng Chiang, Chien-Huei Wu, Karen Yang & Chiun-Sheng Huang. (2023) Diverse genetic spectrum among patients who met the criteria of hereditary breast, ovarian and pancreatic cancer syndrome. Journal of Gynecologic Oncology 34.
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Wang & Mbalaviele. (2019) Role of APD-Ribosylation in Bone Health and Disease. Cells 8:10, pages 1201.
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Yen Ting Shen, James C. Evans, Gaetano Zafarana, Christine Allen & Micheline Piquette-Miller. (2018) BRCA Status Does Not Predict Synergism of a Carboplatin and Olaparib Combination in High-Grade Serous Ovarian Cancer Cell Lines. Molecular Pharmaceutics 15:7, pages 2742-2753.
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Qianghua Xia, Sumei Lu, Julian Ostrovsky, Shana E McCormack, Marni J Falk & Struan F. A Grant. (2018) PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells. Aging and disease 9:1, pages 17.
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Juanjuan Wang, Chenggang Zhu, Dan Song, Ruiqi Xia, Wenbo Yu, Yongjun Dang, Yiyan Fei, Long Yu & Jiaxue Wu. (2017) Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity. Cell Death Discovery 3:1.
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Maria Luisa Gasparri, Assunta Casorelli, Erlisa Bardhi, Aris Raad Besharat, Delia Savone, Ilary Ruscito, Ammad Ahmad Farooqi, Andrea Papadia, Michael David Mueller, Elisabetta Ferretti & Pierluigi Benedetti Panici. (2017) Beyond circulating microRNA biomarkers: Urinary microRNAs in ovarian and breast cancer. Tumor Biology 39:5, pages 101042831769552.
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Ilary Ruscito, Maria Luisa Gasparri, Claudia Marchetti, Caterina De Medici, Carlotta Bracchi, Innocenza Palaia, Sara Imboden, Michael D. Mueller, Andrea Papadia, Ludovico Muzii & Pierluigi Benedetti Panici. (2016) Cediranib in ovarian cancer: state of the art and future perspectives. Tumor Biology 37:3, pages 2833-2839.
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Maria Luisa Gasparri, Delia Savone, Raad Aris Besharat, Ammad Ahmad Farooqi, Filippo Bellati, Ilary Ruscito, Pierluigi Benedetti Panici & Andrea Papadia. (2015) Circulating tumor cells as trigger to hematogenous spreads and potential biomarkers to predict the prognosis in ovarian cancer. Tumor Biology 37:1, pages 71-75.
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Ruth Plummer, Helen Swaisland, Karin Leunen, Carla M. L. van Herpen, Guy Jerusalem, Jacques De Grève, Martijn P. Lolkema, Patricia Soetekouw, Morten Mau-Sørensen, Dorte Nielsen, James Spicer, Anitra Fielding, Karen So, Wendy Bannister & L. Rhoda Molife. (2015) Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. Cancer Chemotherapy and Pharmacology 76:4, pages 723-729.
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Jing Huang, Lei Wang, Zhongyi Cong, Zohreh Amoozgar, Evgeny Kiner, Deyin Xing, Sandra Orsulic, Ursula Matulonis & Michael S. Goldberg. (2015) The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1 −/− murine model of ovarian cancer. Biochemical and Biophysical Research Communications 463:4, pages 551-556.
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Maria Luisa Gasparri, Rukset Attar, Innocenza Palaia, Giorgia Perniola, Claudia Marchetti, Violante Di Donato, Ammad Ahmad Farooqi, Andrea Papadia & Pierluigi Benedetti Panici. (2015) Tumor Infiltrating Lymphocytes in Ovarian Cancer. Asian Pacific Journal of Cancer Prevention 16:9, pages 3635-3638.
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Jun Dong, Tian Zhang & Bixiu Wen. (2015) Impact of Olaparib for Maintenance Monotherapy on Survival in Breast and Ovarian Cancer: A Systematic Review and Pooled Analysis of Published Trials. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 04:04, pages 338-347.
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Tarek M.A. Abdel-Fatah, Arvind Arora, Paul Moseley, Clare Coveney, Christina Perry, Kerstie Johnson, Christopher Kent, Graham Ball, Stephen Chan & Srinivasan Madhusudan. (2014) ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers. BBA Clinical 2, pages 10-17.
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Dan Canaani. (2014) Application of the concept synthetic lethality toward anticancer therapy: A promise fulfilled?. Cancer Letters 352:1, pages 59-65.
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Guelaguetza Vazquez-Ortiz, Cristine Chisholm, Xiaoling Xu, Tyler J Lahusen, Cuiling Li, Srilatha Sakamuru, Ruili Huang, Craig J Thomas, Menghang Xia & Chuxia Deng. (2014) Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells. Breast Cancer Research 16:3.
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Jaeyoung Lim, Kun Yang, Barbie Taylor-Harding, W. Ruprecht Wiedemeyer & Ronald J. Buckanovich. (2014) VEGFR3 Inhibition Chemosensitizes Ovarian Cancer Stemlike Cells through Down-Regulation of BRCA1 and BRCA2. Neoplasia 16:4, pages 343-353.e2.
Crossref
Paulette Mhawech-Fauceglia, Dan Wang, Grace Kim, Maryam Sharifian, Xiwie Chen, Qian Liu, Yvonne G. Lin, Song Liu & Tanja Pejovic. (2014) Expression of DNA repair proteins in endometrial cancer predicts disease outcome. Gynecologic Oncology 132:3, pages 593-598.
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Arpita Desai. (2014) Epithelial ovarian cancer: An overview. World Journal of Translational Medicine 3:1, pages 1.
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Ying Chen, Lei Zhang & Quan Hao. (2013) Olaparib: a promising PARP inhibitor in ovarian cancer therapy. Archives of Gynecology and Obstetrics 288:2, pages 367-374.
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He Huang, Yang Cao, Wei Wei, Wei Liu, Shao-Yong Lu, Yu-Bao Chen, Yan Wang, Hua Yan & Ying-Li Wu. (2013) Targeting Poly (ADP-Ribose) Polymerase Partially Contributes to Bufalin-Induced Cell Death in Multiple Myeloma Cells. PLoS ONE 8:6, pages e66130.
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