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An update on bronchodilators in Phase I and II clinical trials

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Pages 1489-1501 | Published online: 23 Aug 2012

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Josuel Ora, Angelo Coppola, Mario Cazzola, Luigino Calzetta & Paola Rogliani. (2020) Long-Acting Muscarinic Antagonists Under Investigational to Treat Chronic Obstructive Pulmonary Disease. Journal of Experimental Pharmacology 12, pages 559-574.
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Mario Malerba, Alessandro Radaeli, Paolo Montuschi, Kesavan S. Babu & Jaymin B Morjaria. (2017) Investigational beta-2 adrenergic agonists for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Investigational Drugs 26:3, pages 319-329.
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Mark A. Mastrodicasa, Christopher A. Droege, Aaron M. Mulhall, Neil E. Ernst, Ralph J. Panos & Muhammad A. Zafar. (2017) Long acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs. Expert Opinion on Investigational Drugs 26:2, pages 161-174.
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Maria Gabriella Matera, Alessandro Sanduzzi & Mario Cazzola. (2016) Specific role of combination aclidinium: formoterol in the treatment of chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 73-79.
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Igor Z Barjaktarevic, Anthony F Arredondo & Christopher B Cooper. (2015) Positioning new pharmacotherapies for COPD. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 1427-1442.
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Chitra Lal & Charlie Strange. (2015) Aclidinium bromide plus formoterol for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 16:3, pages 427-434.
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Maria Gabriella Matera, Paola Rogliani, Barbara Rinaldi & Mario Cazzola. (2015) Umeclidinium bromide + vilanterol for the treatment of chronic obstructive pulmonary disease. Expert Review of Clinical Pharmacology 8:1, pages 35-41.
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Maria Gabriella Matera, Annalisa Capuano & Mario Cazzola. (2015) Fluticasone furoate and vilanterol inhalation powder for the treatment of chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 9:1, pages 5-12.
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Gaetano Caramori, Kian Fan Chung & Ian M Adcock. (2014) Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD. International Journal of Chronic Obstructive Pulmonary Disease 9, pages 249-256.
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Maria Gabriella Matera, Paola Rogliani & Mario Cazzola. (2014) Muscarinic receptor antagonists for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 15:7, pages 961-977.
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Javier de Miguel-Díez & Rodrigo Jiménez-García. (2014) Considerations for new dual-acting bronchodilator treatments for chronic obstructive pulmonary disease. Expert Opinion on Investigational Drugs 23:4, pages 453-456.
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Mario Cazzola, Andrea Segreti & Maria Gabriella Matera. (2013) New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol. Drug Design, Development and Therapy 7, pages 1201-1208.
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Mario Cazzola, Paola Rogliani, Lucia Novelli & Maria Gabriella Matera. (2013) Inhaled corticosteroids for chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 14:18, pages 2489-2499.
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Mario Cazzola, Clive P Page & Maria Gabriella Matera. (2013) Aclidinium bromide for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 14:9, pages 1205-1214.
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Mario Cazzola, Paola Rogliani & Maria Gabriella Matera. (2013) Aclidinium bromide/formoterol fumarate fixed-dose combination for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 14:6, pages 775-781.
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Sumel Ashique, Gabriele De Rubis, Ekta Sirohi, Neeraj Mishra, Mohd Rihan, Ashish Garg, Ruby-Jean Reyes, Bikash Manandhar, Shvetank Bhatt, Niraj Kumar Jha, Thakur Gurjeet Singh, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Keshav Raj Paudel, Philip M. Hansbro, Brian G. Oliver & Kamal Dua. (2022) Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases. Chemico-Biological Interactions 368, pages 110231.
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You Xu, Aneesh Thakur, Yibang Zhang & Camilla Foged. (2021) Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects. Pharmaceutics 13:2, pages 177.
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Ce Yi, Gang Xing, Siqi Wang, Xiaoran Li, Yichuang Liu, Jinyan Li, Bin Lin, Anthony Yiu-Ho Woo, Yuyang Zhang, Li Pan & Maosheng Cheng. (2020) Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent β2-adrenoceptor agonists. Bioorganic & Medicinal Chemistry 28:1, pages 115178.
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Editorial Article. (2016) Therapeutic strategy to prevent acute exacerbations of chronic obstructive pulmonary disease: clinical guidelines of American College of Chest Physicians and Canadian Thoracic Society Guideline (Part 2). PULMONOLOGIYA 26:3, pages 267-291.
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Maria Gabriella Matera & Mario Cazzola. 2017. Pharmacology and Therapeutics of Asthma and COPD. Pharmacology and Therapeutics of Asthma and COPD 41 62 .
Mario Cazzola & Maria Gabriella Matera. 2017. Pharmacology and Therapeutics of Asthma and COPD. Pharmacology and Therapeutics of Asthma and COPD 117 129 .
E.D. Bateman, P.M. O'Byrne, R. Buhl & K.F. Rabe. (2015) Roflumilast for asthma: Weighing the evidence. Pulmonary Pharmacology & Therapeutics 35, pages S1-S3.
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Gerard J. Criner, Jean Bourbeau, Rebecca L. Diekemper, Daniel R. Ouellette, Donna Goodridge, Paul Hernandez, Kristen Curren, Meyer S. Balter, Mohit Bhutani, Pat G. Camp, Bartolome R. Celli, Gail Dechman, Mark T. Dransfield, Stanley B. Fiel, Marilyn G. Foreman, Nicola A. Hanania, Belinda K. Ireland, Nathaniel Marchetti, Darcy D. Marciniuk, Richard A. Mularski, Joseph Ornelas, Jeremy D. Road & Michael K. Stickland. (2015) Prevention of Acute Exacerbations of COPD. Chest 147:4, pages 894-942.
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K. Suresh Babu & Jaymin B. Morjaria. (2015) Clinicopharmacological profile of the fixed-dose combination of aclidinium bromide and formoterol fumarate in the management of chronic obstructive pulmonary disease. Therapeutic Advances in Respiratory Disease 9:2, pages 56-68.
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Binita Kane, Stephen J Fowler & Rob Niven. (2014) Refractory asthma – beyond step 5, the role of new and emerging adjuvant therapies. Chronic Respiratory Disease 12:1, pages 69-77.
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Clive Page & Mario Cazzola. (2014) Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease. European Respiratory Journal 44:2, pages 475-482.
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Michael Salmon, Stacey L. Tannheimer, Terry T. Gentzler, Zhi‐Hua Cui, Eric A. Sorensen, Kimberly C. Hartsough, Musong Kim, Lafe J. Purvis, Edward G. Barrett, Jacob D. McDonald, Karin Rudolph, Melanie Doyle‐Eisele, Philip J. Kuehl, Christopher M. Royer, William R. Baker, Gary B. Phillips & Clifford D. Wright. (2014) The in vivo efficacy and side effect pharmacology of GS ‐5759, a novel bifunctional phosphodiesterase 4 inhibitor and long‐acting β 2 ‐adrenoceptor agonist in preclinical animal species . Pharmacology Research & Perspectives 2:4.
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Philippa R Dale, Hana Cernecka, Martina Schmidt, Mark R Dowling, Steven J Charlton, Michael P Pieper & Martin C Michel. (2014) The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease. Current Opinion in Pharmacology 16, pages 31-42.
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Mario Cazzola & Maria Gabriella Matera. (2014) Bronchodilators. Clinics in Chest Medicine 35:1, pages 191-201.
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Panayiotis A. Procopiou, Victoria J. Barrett, Keith Biggadike, Peter R. Butchers, Andrew Craven, Alison J. Ford, Stephen B. Guntrip, Duncan S. Holmes, Sara C. Hughes, Anne E. Jones, Brian E. Looker, Peter J. Mutch, Mark Ruston, Deborah Needham & Claire E. Smith. (2013) Discovery of a Rapidly Metabolized, Long-Acting β 2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing . Journal of Medicinal Chemistry 57:1, pages 159-170.
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Mario Cazzola, Clive P. Page, Paola Rogliani & M. Gabriella Matera. (2013) β 2 -Agonist Therapy in Lung Disease . American Journal of Respiratory and Critical Care Medicine 187:7, pages 690-696.
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Donald P Tashkin & Gary T Ferguson. (2013) Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respiratory Research 14:1, pages 49.
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