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Expert Opinion on Investigational Drugs Volume 21, 2012 - Issue 10
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The role of heat shock protein 90 in modulating ischemia–reperfusion injury in the kidney

Stephen O'NeillMRC Centre for Inflammation Research, Tissue Injury and Repair Group, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK;University of Edinburgh, MRC Centre for Inflammation Research, Tissue Injury and Repair Group, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK+0044 7849592113; +0044 1312426520; [email protected]
, MB BCh BAO MSc (dist) MRCSEd,
James A RossMRC Centre for Inflammation Research, Tissue Injury and Repair Group, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK;Professor of Liver Cell Biology, University of Edinburgh, MRC Centre for Regenerative Medicine, Tissue Injury and Repair Group, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
, PhD,
Stephen J WigmoreProfessor of Transplantation Surgery and Honorary Consultant Surgeon, MRC Centre for Regenerative Medicine, Tissue Injury and Repair Group, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
, BSc MBBS MD FRCSEd FRCS &
Ewen M HarrisonMRC Centre for Inflammation Research, Tissue Injury and Repair Group, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK;Lecturer in General Surgery, University of Edinburgh, MRC Centre for Inflammation Research, Tissue Injury and Repair Group, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
, MB ChB PhD FRCS (Gen Surg)
Pages 1535-1548 | Published online: 09 Aug 2012

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Stephen O’Neill, Kevin Gallagher, Jeremy Hughes, Stephen J Wigmore, James A Ross & Ewen M Harrison. (2015) Challenges in early clinical drug development for ischemia-reperfusion injury in kidney transplantation. Expert Opinion on Drug Discovery 10:7, pages 753-762.
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Articles from other publishers (27)

Rheaclare Fraser-Spears. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 135 140 .
Xue-qi Liu, Ming-ming Liu, Ling Jiang, Li Gao, Yao Zhang, Yue-bo Huang, Xian Wang, Wei Zhu, Han-xu Zeng, Xiao-ming Meng & Yong-gui Wu. (2022) A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis. International Immunopharmacology 108, pages 108849.
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Chuang Li & Ying Maggie Chen. (2021) Endoplasmic Reticulum-Associated Biomarkers for Molecular Phenotyping of Rare Kidney Disease. International Journal of Molecular Sciences 22:4, pages 2161.
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Chenhao Tong, Jiandong Li, Weiguo Lin, Wenda Cen, Weiguang Zhang, Zhiyang Zhu, Baochun Lu & Jianhua Yu. (2021) Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression. Experimental and Therapeutic Medicine 21:3.
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Shant Der Sarkissian, Henry Aceros, Pierre‐Marc Williams, Catherine Scalabrini, Mélanie Borie & Nicolas Noiseux. (2020) Heat shock protein 90 inhibition and multi‐target approach to maximize cardioprotection in ischaemic injury. British Journal of Pharmacology 177:15, pages 3378-3388.
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Natalia Chebotareva, Anatoliy Vinogradov, Alla Gindis, Ekaterina Tao & Sergey Moiseev. (2020) Heat shock protein 90 and NFkB levels in serum and urine in patients with chronic glomerulonephritis. Cell Stress and Chaperones 25:3, pages 495-501.
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Marwa S. Zaghloul & Rehab S. Abdelrahman. (2019) Nilotinib ameliorates folic acid-induced acute kidney injury through modulation of TWEAK and HSP-70 pathways. Toxicology 427, pages 152303.
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Samantha Milanesi, Silvano Garibaldi, Michela Saio, Giorgio Ghigliotti, Daniela Picciotto, Pietro Ameri, Giacomo Garibotto, Chiara Barisione & Daniela Verzola. (2019) Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway. Oxidative Medicine and Cellular Longevity 2019, pages 1-11.
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Maria Lucia Angelotti, Elena Lazzeri & Paola Romagnani. 2019. Critical Care Nephrology. Critical Care Nephrology 173 178.e2 .
Zhen Wang, Li-min Guo, Yong Wang, Hong-kang Zhou, Shu-chao Wang, Dan Chen, Ju-fang Huang & Kun Xiong. (2018) Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression. Journal of Cellular Physiology 233:6, pages 4864-4884.
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Shobhana Nayak Rao. 2018. HSP70 in Human Diseases and Disorders. HSP70 in Human Diseases and Disorders 261 271 .
Natalia Chebotareva, Irina Bobkova & Evgeniy Shilov. (2017) Heat shock proteins and kidney disease: perspectives of HSP therapy. Cell Stress and Chaperones 22:3, pages 319-343.
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Shobhana Nayak Rao. (2016) The role of heat shock proteins in kidney disease. Journal of Translational Internal Medicine 4:3, pages 114-117.
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Thiago J. Borges, Benjamin J. Lang, Rafael L. Lopes & Cristina Bonorino. (2016) Modulation of Alloimmunity by Heat Shock Proteins. Frontiers in Immunology 7.
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Michaela-Diana Fitrolaki, Helen Dimitriou, Maria Venihaki, Marianna Katrinaki, Stavroula Ilia & George Briassoulis. (2016) Increased extracellular heat shock protein 90α in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children. Medicine 95:35, pages e4651.
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Francesco Segreto, Giovanni Francesco Marangi, Pierluigi Gigliofiorito, Francesca Briganti & Paolo Persichetti. (2016) HSP90 and TLR4 Interplay in Keloids. Plastic and Reconstructive Surgery 137:2, pages 480e-481e.
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Luciana Mazzei, Neil G. Docherty & Walter Manucha. (2015) Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy. Cell Stress and Chaperones 20:6, pages 893-906.
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M.H. Levine, Z. Wang, T.R. Bhatti, Y. Wang, D.D. Aufhauser, S. McNeal, Y. Liu, S. Cheraghlou, R. Han, L. Wang & W.W. Hancock. (2015) Class-Specific Histone/Protein Deacetylase Inhibition Protects Against Renal Ischemia Reperfusion Injury and Fibrosis Formation. American Journal of Transplantation 15:4, pages 965-973.
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Fang-Jiang Li, Tao Hsu, Hui-Xian Li, Jin-Zheng Shi, Mei-Ling Du, Xiao-Yuan Wang & Wen-Ting Zhang. (2014) Protective effect and mechanism of lithium chloride pretreatment on myocardial ischemia-reperfusion injury in rats. Asian Pacific Journal of Tropical Medicine 7:9, pages 744-748.
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YE CAI, HUI XU, JIA YAN, LEI ZHANG & YI LU. (2014) Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury (Review). Molecular Medicine Reports 9:5, pages 1542-1550.
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Tamás Kaucsár, Csaba Bodor, Mária Godó, Csaba Szalay, Csaba Révész, Zalán Németh, Miklós Mózes, Gábor Szénási, László Rosivall, Csaba Sőti & Péter Hamar. (2014) LPS-Induced Delayed Preconditioning Is Mediated by Hsp90 and Involves the Heat Shock Response in Mouse Kidney. PLoS ONE 9:3, pages e92004.
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Sunyi Ye, Chenxi Zhang, Jie Zhou, Jun Cheng, Zhen Lv, Lin Zhou, Haiyang Xie, Jian Wu & Shusen Zheng. (2014) Human heat shock protein 27 exacerbates ischemia reperfusion injury in rats by reducing the number of T regulatory cells. Molecular Medicine Reports.
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Daniel N. Mori, Daniel Kreisel, James N. Fullerton, Derek W. Gilroy & Daniel R. Goldstein. (2014) Inflammatory triggers of acute rejection of organ allografts. Immunological Reviews 258:1, pages 132-144.
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J. Barrera-Chimal, R. Perez-Villalva, J. A. Ortega, N. Uribe, G. Gamba, C. Cortes-Gonzalez & N. A. Bobadilla. (2013) Intra-renal transfection of heat shock protein 90 alpha or beta (Hsp90  or Hsp90 ) protects against ischemia/reperfusion injury. Nephrology Dialysis Transplantation 29:2, pages 301-312.
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K. Shankar & H.M. Mehendale. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 830 831 .
. (2013) Current World Literature. Current Opinion in Organ Transplantation 18:2, pages 241-250.
Crossref
Xueqi Liu, Mingming Liu, Ling Jiang, Li Gao, Yuebo Huang, Yao Zhang, Xian Wang, Wei Zhu, Hanxu Zeng, Xiaoming Meng & Yonggui Wu. (2022) A Novel Small Molecule Hsp90 Inhibitor, C-316-1, Attenuates Acute Kidney Injury by Suppressing Ripk1-Mediated Necroptosis. SSRN Electronic Journal.
Crossref

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