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Expert Opinion on Investigational Drugs Volume 22, 2013 - Issue 5
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Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals

Christina N KontoghiorghePostgraduate Research Institute of Science, Technology, Environment and Medicine, 3, Ammochostou Street, Limassol, CY 3021, Cyprus [email protected]
,
Annita KolnagouPostgraduate Research Institute of Science, Technology, Environment and Medicine, 3, Ammochostou Street, Limassol, CY 3021, Cyprus [email protected]
&
George J KontoghiorghesPostgraduate Research Institute of Science, Technology, Environment and Medicine, 3, Ammochostou Street, Limassol, CY 3021, Cyprus [email protected]
Pages 591-618 | Published online: 16 Apr 2013

Citations (24)

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Read on this site (3)

George J Kontoghiorghes & Christina N Kontoghiorghe. (2019) Prospects for the introduction of targeted antioxidant drugs for the prevention and treatment of diseases related to free radical pathology. Expert Opinion on Investigational Drugs 28:7, pages 593-603.
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Christina N Kontoghiorghe & George J Kontoghiorghes. (2016) Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes. Drug Design, Development and Therapy 10, pages 465-481.
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Drorit G Merkel & Arnon Nagler. (2014) Toward resolving the unsettled role of iron chelation therapy in myelodysplastic syndromes. Expert Review of Anticancer Therapy 14:7, pages 817-829.
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Articles from other publishers (21)

George J. Kontoghiorghes. (2023) The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases. Pharmaceuticals 16:7, pages 1016.
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George J. Kontoghiorghes. (2023) Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. International Journal of Molecular Sciences 24:5, pages 4970.
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George J. Kontoghiorghes. (2022) New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer. International Journal of Molecular Sciences 23:22, pages 13990.
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Mufarreh Asmari, Muhammad Waqas, Adel Ehab Ibrahim, Sobia Ahsan Halim, Ajmal Khan, Ahmed Al-Harrasi, Hermann Wätzig & Sami El Deeb. (2022) Microscale Thermophoresis and Molecular Modelling to Explore the Chelating Drug Transportation in the Milk to Infant. Molecules 27:14, pages 4604.
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George J. Kontoghiorghes. (2022) Deferiprone: A Forty-Year-Old Multi-Targeting Drug with Possible Activity against COVID-19 and Diseases of Similar Symptomatology. International Journal of Molecular Sciences 23:12, pages 6735.
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George J. Kontoghiorghes. (2022) Questioning Established Theories and Treatment Methods Related to Iron and Other Metal Metabolic Changes, Affecting All Major Diseases and Billions of Patients. International Journal of Molecular Sciences 23:3, pages 1364.
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George Kontoghiorghes, Annita Kolnagou, Theodora Demetriou, Marina Neocleous & Christina Kontoghiorghe. (2021) New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications. International Journal of Molecular Sciences 22:11, pages 5546.
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Shalini S. Rao, Stuart. D. Portbury, Larissa Lago, Ashley I. Bush & Paul A. Adlard. (2020) The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy1. Journal of Alzheimer's Disease 77:2, pages 753-771.
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George J. Kontoghiorghes, Annita Kolnagou, Christina N. Kontoghiorghe, Loukia Mourouzidis, Viktor A. Timoshnikov & Nikolay E. Polyakov. (2020) Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications. Medicines 7:8, pages 45.
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George Kontoghiorghes & Christina Kontoghiorghe. (2020) Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases. Cells 9:6, pages 1456.
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Mufarreh Asmari, Ahmed M. Abdel-Megied, Lenka Michalcová, Zdeněk Glatz & Sami El Deeb. (2020) Analytical approaches for the determination of deferiprone and its iron (III) complex: Investigation of binding affinity based on liquid chromatography-mass spectrometry (LC-ESI/MS) and capillary electrophoresis-frontal analysis (CE/FA). Microchemical Journal 154, pages 104556.
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George J. Kontoghiorghes. (2020) Advances on Chelation and Chelator Metal Complexes in Medicine. International Journal of Molecular Sciences 21:7, pages 2499.
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Shalini S. Rao & Paul Anthony Adlard. (2018) Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration. Frontiers in Molecular Neuroscience 11.
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Mufarreh Asmari, Lenka Michalcová, Hassan A. Alhazmi, Zdeněk Glatz & Sami El Deeb. (2018) Investigation of deferiprone binding to different essential metal ions using microscale thermophoresis and electrospray ionization mass spectrometry. Microchemical Journal 137, pages 98-104.
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Etheresia Pretorius, Oore-Ofe Akeredolu, Prashilla Soma & Douglas B Kell. (2016) Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability. Experimental Biology and Medicine 242:4, pages 355-373.
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Christina N Kontoghiorghe & George J Kontoghiorghes. (2016) New developments and controversies in iron metabolism and iron chelation therapy. World Journal of Methodology 6:1, pages 1.
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Christina Kontoghiorghe, Annita Kolnagou & George Kontoghiorghes. (2015) Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology. Molecules 20:11, pages 20841-20872.
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Pamela Maher & George J. Kontoghiorghes. (2015) Characterization of the Neuroprotective Potential of Derivatives of the Iron Chelating Drug Deferiprone. Neurochemical Research 40:3, pages 609-620.
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V.A. Timoshnikov, T.V. Kobzeva, N.E. Polyakov & G.J. Kontoghiorghes. (2015) Inhibition of Fe2+- and Fe3+- induced hydroxyl radical production by the iron-chelating drug deferiprone. Free Radical Biology and Medicine 78, pages 118-122.
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Yee Kwan ChanHye Kyoung SungGary Sweeney. (2014) Regulation of Iron and Its Significance in Obesity and Complications. The Korean Journal of Obesity 23:4, pages 222.
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Annita Kolnagou. (2014) Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases. World Journal of Methodology 4:4, pages 197.
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