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Expert Opinion on Investigational Drugs Volume 22, 2013 - Issue 5
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Original Research

Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors

Håkon ReikvamUniversity of Bergen, Department of Clinical Science, Division for Hematology, Bergen, Norway;Haukeland University Hospital, Division for Hematology, Department of Medicine, Bergen, N-5021, Norway+55 97 50 00; +55 97 29 50; [email protected];Haukeland University Hospital, Department of Immunology and Transfusion Medicine, Bergen, Norway
,
Ina NepstadUniversity of Bergen, Department of Clinical Science, Division for Hematology, Bergen, Norway
,
André SulenUniversity of Bergen, Department of Clinical Science, Division for Hematology, Bergen, Norway
,
Bjørn Tore GjertsenUniversity of Bergen, Department of Clinical Science, Division for Hematology, Bergen, Norway;Haukeland University Hospital, Division for Hematology, Department of Medicine, Bergen, N-5021, Norway+55 97 50 00; +55 97 29 50; [email protected]
,
Kimberley Joanne HatfieldUniversity of Bergen, Department of Clinical Science, Division for Hematology, Bergen, Norway
&
Øystein BruserudUniversity of Bergen, Department of Clinical Science, Division for Hematology, Bergen, Norway;Haukeland University Hospital, Division for Hematology, Department of Medicine, Bergen, N-5021, Norway+55 97 50 00; +55 97 29 50; [email protected]
Pages 551-563 | Published online: 16 Apr 2013

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Fortunato Morabito, Maria Teresa Voso, Stefan Hohaus, Massimo Gentile, Ernesto Vigna, Anna Grazia Recchia, Lorenzo Iovino, Edoardo Benedetti, Francesco Lo-Coco & Sara Galimberti. (2016) Panobinostat for the treatment of acute myelogenous leukemia. Expert Opinion on Investigational Drugs 25:9, pages 1117-1131.
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Håkon Reikvam, Tuyen Thi van Hoang & Øystein Bruserud. (2015) Emerging therapeutic targets in human acute myeloid leukemia (part 2) – bromodomain inhibition should be considered as a possible strategy for various patient subsets. Expert Review of Hematology 8:3, pages 315-327.
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Håkon Reikvam, Michelle Hauge, Annette K Brenner, Kimberley Joanne Hatfield & Øystein Bruserud. (2015) Emerging therapeutic targets for the treatment of human acute myeloid leukemia (part 1) – gene transcription, cell cycle regulation, metabolism and intercellular communication. Expert Review of Hematology 8:3, pages 299-313.
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Muneera Al-Hussaini & John F DiPersio. (2014) Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic. Expert Review of Hematology 7:4, pages 439-464.
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Håkon Reikvam, Annette K Brenner, Ina Nepstad, André Sulen & Øystein Bruserud. (2014) Heat shock protein 70 – the next chaperone to target in the treatment of human acute myelogenous leukemia?. Expert Opinion on Therapeutic Targets 18:8, pages 929-944.
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Alice C Fan, Jennifer J O'Rourke, Dave R Praharaj & Dean W Felsher. (2013) Real-time nanoscale proteomic analysis of the novel multi-kinase pathway inhibitor rigosertib to measure the response to treatment of cancer. Expert Opinion on Investigational Drugs 22:11, pages 1495-1509.
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Articles from other publishers (21)

Nayla Mouawad, Guido Capasso, Edoardo Ruggeri, Leonardo Martinello, Filippo Severin, Andrea Visentin, Monica Facco, Livio Trentin & Federica Frezzato. (2023) Is It Still Possible to Think about HSP70 as a Therapeutic Target in Onco-Hematological Diseases?. Biomolecules 13:4, pages 604.
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Kejia Zhao, Guanyu Zhou, Yu Liu, Jian Zhang, Yaohui Chen, Lunxu Liu & Gao Zhang. (2023) HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances. Biomolecules 13:4, pages 601.
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Rangrang Fan, Caili Chen, Junshan Hu, Min Mu, Di Chuan, Zhouyun Chen, Gang Guo & Jianguo Xu. (2023) Multifunctional gold nanorods in low-temperature photothermal interactions for combined tumor starvation and RNA interference therapy. Acta Biomaterialia 159, pages 324-337.
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Bianca Nitzsche, Michael Höpfner & Bernhard Biersack. (2023) Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents. International Journal of Molecular Sciences 24:4, pages 4083.
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Marte Karen Brattås, Anette Lodvir Hemsing, Kristin Paulsen Rye, Kimberley Joanne Hatfield & Håkon Reikvam. (2022) Heterogeneity of Patient-Derived Acute Myeloid Leukemia Cells Subjected to SYK In Vitro Inhibition. International Journal of Molecular Sciences 23:23, pages 14706.
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Chen Hu, Jing Yang, Ziping Qi, Hong Wu, Beilei Wang, Fengming Zou, Husheng Mei, Jing Liu, Wenchao Wang & Qingsong Liu. (2022) Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities. MedComm 3:3.
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Jing Yang & Ellen L. Weisberg. (2021) HSP70 and FLT3-ITD: Targeting chaperone system to overcome drug resistance. Blood Science 3:4, pages 151-153.
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Xuqiao Hu, Hongyan Li, Tiffany Ka-Yan Ip, Yam Fung Cheung, Mohamad Koohi-Moghadam, Haibo Wang, Xinming Yang, Daniel N. Tritton, Yuchuan Wang, Yi Wang, Runming Wang, Kwan-Ming Ng, Hua Naranmandura, Eric Wai-Choi Tse & Hongzhe Sun. (2021) Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin. Chemical Science 12:32, pages 10893-10900.
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Reyhaneh Moradi‐Marjaneh, Maryam Paseban & Mahdi Moradi Marjaneh. (2019) Hsp70 inhibitors: Implications for the treatment of colorectal cancer. IUBMB Life 71:12, pages 1834-1845.
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Vijay P. Kale, Sangita Phadtare, Shantu G. Amin & Manoj K. Pandey. 2019. Heat Shock Proteins in Signaling Pathways. Heat Shock Proteins in Signaling Pathways 233 251 .
Sook-Kyoung Heo, Eui-Kyu Noh, Jeong Yi Kim, Yoo Kyung Jeong, Jae-Cheol Jo, Yunsuk Choi, SuJin Koh, Jin Ho Baek, Young Joo Min & Hawk Kim. (2017) Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death. Scientific Reports 7:1.
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Rachel Piddock, Kristian Bowles & Stuart Rushworth. (2017) The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma. Cancers 9:12, pages 29.
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Yixiang Chen, Sandra Germano, Chris Clements, Jesvin Samuel, Ghalia Shelmani, Sandrine Jayne, Martin J. S. Dyer & Salvador Macip. (2016) Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia. British Journal of Haematology 175:4, pages 641-651.
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Ayisha Shabbir, Elena Bianchetti, Renato Cargonja, Antonela Petrovic, Miranda Mladinic, Kristina Pilipović & Andrea Nistri. (2015) Role of HSP70 in motoneuron survival after excitotoxic stress in a rat spinal cord injury model in vitro . European Journal of Neuroscience 42:12, pages 3054-3065.
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M. Lazenby, R. Hills, A.K. Burnett & J. Zabkiewicz. (2015) The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine. Leukemia Research 39:6, pages 617-624.
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Daniela Schilling, Annett Kühnel, Sarah Konrad, Fabian Tetzlaff, Christine Bayer, Julia Yaglom & Gabriele Multhoff. (2015) Sensitizing tumor cells to radiation by targeting the heat shock response. Cancer Letters 360:2, pages 294-301.
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Y. Wang & S. R. McAlpine. (2015) Combining an Hsp70 inhibitor with either an N- or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes. Organic & Biomolecular Chemistry 13:12, pages 3691-3698.
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Y. Wang & S. R. McAlpine. (2015) Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70. Organic & Biomolecular Chemistry 13:7, pages 2108-2116.
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Laura K. Buckton, Yao Wang, Jeanette R. McConnell & Shelli R. McAlpine. 2016. Heat Shock Protein Inhibitors. Heat Shock Protein Inhibitors 55 80 .
Alexandra Manos-Turvey, Jeffrey L. Brodsky & Peter Wipf. 2016. Heat Shock Protein Inhibitors. Heat Shock Protein Inhibitors 81 129 .
Bu-Kyung Kim, Bo-Ram Kim, Hyun-Joo Lee, Seoung-Ae Lee, Byoung-Jun Kim, Hong Kim, Yu-Sub Won, Won-Jun Shon, Na-Rae Lee, Kyung-Soo Inn & Bum-Joon Kim. (2014) Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-1α-VEGF signaling axis. Biomaterials 35:9, pages 2924-2933.
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