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Glutamate-based anxiolytic ligands in clinical trials

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Pages 1007-1022 | Published online: 30 May 2013

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James W Murrough, Sahab Yaqubi, Sehrish Sayed & Dennis S Charney. (2015) Emerging drugs for the treatment of anxiety. Expert Opinion on Emerging Drugs 20:3, pages 393-406.
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Jeffrey M. Witkin, Arnold Lippa, Jodi L. Smith, Xiaoming Jin, Xingjie Ping, Andrew Biggerstaff, Bronwyn M. Kivell, Daniel E. Knutson, Dishary Sharmin, Kamal P. Pandey, Md Yeunus Mian, James M. Cook & Rok Cerne. (2022) The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders. Pharmacology Biochemistry and Behavior 213, pages 173321.
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Florence Charnay-Pouget, Matthieu Le Liepvre, Hendrik Eijsberg, Régis Guillot, Jean Ollivier, Francesco Secci, Angelo Frongia & David J. Aitken. (2021) A short synthesis of both enantiomers of 2-aminobicyclo[3.2.0]heptane-2,7-dicarboxylic acid. Tetrahedron Letters 68, pages 152912.
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Bin Li, Lei-Lei Chang & Kang Xi. (2021) Neurotensin 1 receptor in the prelimbic cortex regulates anxiety-like behavior in rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry 104, pages 110011.
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Joselma Maria da Silva, Ricardo Abadie-guedes, Andréia Albuquerque Cunha Lopes-de-Morais, Kelly Rayanne Gondim-Silva & Rubem Carlos Araújo Guedes. (2019) Long lasting behavioral and electrophysiological action of early administration of guanosine: Analysis in the adult rat brain. Brain Research Bulletin 150, pages 266-271.
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Xia Chen, Joop van Gerven, Adam Cohen & Gabriel Jacobs. (2018) Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety. Acta Pharmacologica Sinica 40:5, pages 571-582.
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Zohreh Zare, Mohsen Tehrani, Noorollah Rezaei, Babak Dana Ghalebarzand & Moslem Mohammadi. (2019) Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system. Neurotoxicology and Teratology 71, pages 32-40.
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Kathy Sengmany & Karen J. Gregory. 2018. Biochemical Approaches for Glutamatergic Neurotransmission. Biochemical Approaches for Glutamatergic Neurotransmission 227 261 .
Julia Fedotova, Peter Kubatka, Dietrich Büsselberg, Alexander G. Shleikin, Martin Caprnda, Jozef Dragasek, Luis Rodrigo, Miroslav Pohanka, Iveta Gasparova, Vladimir Nosal, Radka Opatrilova, Tawar Qaradakhi, Anthony Zulli & Peter Kruzliak. (2017) Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts. Biomedicine & Pharmacotherapy 95, pages 437-446.
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Roberto Farina Almeida, Daniel Diniz Comasseto, Denise Barbosa Ramos, Gisele Hansel, Eduardo R. Zimmer, Samanta Oliveira Loureiro, Marcelo Ganzella & Diogo Onofre Souza. (2016) Guanosine Anxiolytic-Like Effect Involves Adenosinergic and Glutamatergic Neurotransmitter Systems. Molecular Neurobiology 54:1, pages 423-436.
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Francesco Ferraguti. 2017. mGLU Receptors. mGLU Receptors 241 277 .
K Sengmany & K J Gregory. (2016) Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias. British Journal of Pharmacology 173:20, pages 3001-3017.
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H. Javelot. (2016) Psychopharmacologie de l’anxiété et de la dépression : aspects historiques, traitements actuels et perspectives. Annales Pharmaceutiques Françaises 74:2, pages 93-118.
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Tri H. V. Huynh, Mette N. Erichsen, Amélie S. Tora, Cyril Goudet, Emmanuelle Sagot, Zeinab Assaf, Christian Thomsen, Robb Brodbeck, Tine B. Stensbøl, Walden E. Bjørn-Yoshimoto, Birgitte Nielsen, Jean-Philippe Pin, Thierry Gefflaut & Lennart Bunch. (2016) New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. Journal of Medicinal Chemistry 59:3, pages 914-924.
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Alice M. S. Durieux, Cathy Fernandes, Declan Murphy, Marie Anais Labouesse, Sandra Giovanoli, Urs Meyer, Qi Li, Po-Wah So & Grainne McAlonan. (2015) Targeting Glia with N-Acetylcysteine Modulates Brain Glutamate and Behaviors Relevant to Neurodevelopmental Disorders in C57BL/6J Mice. Frontiers in Behavioral Neuroscience 9.
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