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Omega-3 polyunsaturated fatty acids for major depressive disorder

, & , MD PhD
Pages 1519-1534 | Published online: 02 Oct 2013

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Jane Pei-Chen Chang, Hsueh-Chou Lai, Hui-Ting Yang, Wen-Pang Su, Cheng-Yuan Peng, Piotr Gałecki, Anna Walczewska, Carmine M. Pariante & Kuan-Pin Su. (2017) Polyunsaturated fatty acids levels and initial presentation of somatic symptoms induced by interferon-alpha therapy in patients with chronic hepatitis C viral infection. Nutritional Neuroscience 20:5, pages 291-296.
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Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand & Chi-Un Pae. (2015) Five potential therapeutic agents as antidepressants: a brief review and future directions. Expert Review of Neurotherapeutics 15:9, pages 1015-1029.
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Articles from other publishers (37)

Xinzhong Li, Jiahui Zhou, Min Wang, Chengmin Yang & Guibo Sun. (2023) Cardiovascular disease and depression: a narrative review. Frontiers in Cardiovascular Medicine 10.
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Łukasz Kołodziej, Piotr Lech Czarny, Sylwia Ziółkowska, Katarzyna Białek, Janusz Szemraj, Piotr Gałecki, Kuan-Pin Su & Tomasz Śliwiński. (2023) How fish consumption prevents the development of Major Depressive Disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF. Progress in Lipid Research 92, pages 101254.
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Hao Zhang, Xiaofang Liu, Bo Li, Yi Zhang, Hua Gao, Xianyong Zhao, Kailiang Leng & Zhenhua Song. (2023) Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice. Frontiers in Cell and Developmental Biology 11.
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Pan-Yen Lin, Chin Cheng, Senthil Kumaran Satyanarayanan, Lu-Ting Chiu, Yu-Chuan Chien, Chih-Pin Chuu, Tsuo-Hung Lan & Kuan-Pin Su. (2022) Omega-3 fatty acids and blood-based biomarkers in Alzheimer’s disease and mild cognitive impairment: A randomized placebo-controlled trial. Brain, Behavior, and Immunity 99, pages 289-298.
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Daniel Tzu-Li Chen, Jocelyn Chia-Yu Chen, Jane Pei-Chen Chang & Kuan-Pin Su. 2022. Advances in Dietary Lipids and Human Health. Advances in Dietary Lipids and Human Health 51 73 .
Peter Van Dael. (2021) Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: review of recent studies and recommendations. Nutrition Research and Practice 15:2, pages 137.
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Cheng-Hao Tu, Chun-Ming Chen, Chuan-Chih Yang, Piotr Gałecki & Kuan-Pin Su. (2020) Brain Responses to Emotional Stimuli after Eicosapentaenoic Acid and Docosahexaenoic Acid Treatments in Major Depressive Disorder: Toward Personalized Medicine with Anti-Inflammatory Nutraceuticals. Journal of Personalized Medicine 10:4, pages 283.
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Jiaqi Tong, Senthil Kumaran Satyanarayanan & Huanxing Su. (2020) Nutraceuticals and probiotics in the management of psychiatric and neurological disorders: A focus on microbiota-gut-brain-immune axis. Brain, Behavior, and Immunity 90, pages 403-419.
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Vicent Balanzá-Martínez, Flavio M. Shansis, Amparo Tatay-Manteiga & Pilar López-García. (2020) Diet and Neurocognition in Mood Disorders - An Overview of the Overlooked. Current Pharmaceutical Design 26:20, pages 2353-2362.
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Jelena Helene Cvejic, Antonio Luca Langellotti, Hubert Bonnefond, Vito Verardo & Olivier Bernard. 2020. Lipids and Edible Oils. Lipids and Edible Oils 175 211 .
Matthew C. Valdez, Danielle Freeborn, Joseph M. Valdez, Andrew F.M. Johnstone, Samantha J. Snow, Alan H. Tennant, Urmila P. Kodavanti & Prasada Rao S. Kodavanti. (2019) Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets. International Journal of Molecular Sciences 20:24, pages 6303.
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Jane Pei-Chen Chang, Kuan-Pin Su, Valeria Mondelli, Senthil Kumaran Satyanarayanan, Hui-Ting Yang, Yi-Ju Chiang, Hui-Ting Chen & Carmine M. Pariante. (2019) High-dose eicosapentaenoic acid (EPA) improves attention and vigilance in children and adolescents with attention deficit hyperactivity disorder (ADHD) and low endogenous EPA levels. Translational Psychiatry 9:1.
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Ta-Wei Guu, David Mischoulon, Jerome Sarris, Joseph Hibbeln, Robert K. McNamara, Kei Hamazaki, Marlene P. Freeman, Michael Maes, Yutaka J. Matsuoka, R.H. Belmaker, Felice Jacka, Carmine Pariante, Michael Berk, Wolfgang Marx & Kuan-Pin Su. (2019) International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder. Psychotherapy and Psychosomatics 88:5, pages 263-273.
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Hui-Ting Yang, Ruey-Yun Wang, Shih-Yi Huang, Chieh-Liang Huang & Kuan-Pin Su. (2018) Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy. Prostaglandins, Leukotrienes and Essential Fatty Acids 136, pages 117-121.
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Senthil Kumaran Satyanarayanan, Yin-Hwa Shih, Yu-Chuan Chien, Shih-Yi Huang, Piotr Gałecki, Siegfried Kasper, Jane Pei-Chen Chang & Kuan-Pin Su. (2018) Anti-Oxidative Effects of Melatonin Receptor Agonist and Omega-3 Polyunsaturated Fatty Acids in Neuronal SH-SY5Y Cells: Deciphering Synergic Effects on Anti-Depressant Mechanisms. Molecular Neurobiology 55:9, pages 7271-7284.
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Ruili Dang, Xueyuan Zhou, Mimi Tang, Pengfei Xu, Xiaoxue Gong, Yuanyuan Liu, Hongxiao Jiao & Pei Jiang. (2017) Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide. European Journal of Nutrition 57:3, pages 893-906.
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Cheng-Ho Chang, Ping-Tao Tseng, Nai-Yu Chen, Pei-Chin Lin, Pao-Yen Lin, Jane Pei- Chen Chang, Feng-Yu Kuo, Jenshinn Lin, Ming-Chang Wu & Kuan-Pin Su. (2018) Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids 129, pages 1-12.
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Kuan-Pin Su, Hui-Ting Yang, Jane Pei-Chen Chang, Yin-Hua Shih, Ta-Wei Guu, Satyanarayanan Senthil Kumaran, Piotr Gałecki, Anna Walczewska & Carmine M. Pariante. (2018) Eicosapentaenoic and docosahexaenoic acids have different effects on peripheral phospholipase A2 gene expressions in acute depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry 80, pages 227-233.
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Jane Pei-Chen Chang, Chih-Ying Lin, Pan-Yen Lin, Yin-Hua Shih, Tsan-Hung Chiu, Ming Ho, Hui-Ting Yang, Shih-Yi Huang, Piotr Gałecki & Kuan-Pin Su. (2018) Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy. Progress in Neuro-Psychopharmacology and Biological Psychiatry 80, pages 273-278.
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Kuan-Pin Su, Li-Wei Chou, Mao-Feng Sun & Jaung-Geng Lin. 2018. Experimental Acupuncturology. Experimental Acupuncturology 43 66 .
Cora Schefft, Laura L. Kilarski, Tom Bschor & Stephan Köhler. (2017) Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis. European Neuropsychopharmacology 27:11, pages 1090-1109.
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Pao-Yen Lin, Cheng-Ho Chang, Mary Foong-Fong Chong, Helen Chen & Kuan-Pin Su. (2017) Polyunsaturated Fatty Acids in Perinatal Depression: A Systematic Review and Meta-analysis. Biological Psychiatry 82:8, pages 560-569.
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T. J. P. Pinto, A. A. F. Vilela, D. R. Farias, J. Lepsch, G. M. Cunha, J. S. Vaz, P. Factor-Litvak & G. Kac. (2016) Serum n -3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy . Epidemiology and Psychiatric Sciences 26:2, pages 157-168.
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Maria Cristina Poscablo-Stein & Adriana P. Hermida. 2017. Bipolar Disorder in Older Age Patients. Bipolar Disorder in Older Age Patients 191 212 .
Jane Pei-Chen Chang, Li Jingling, Ya-Ting Huang, Yu-Ji Lu & Kuan-Pin Su. (2016) Delay Aversion, Temporal Processing, and N-3 Fatty Acids Intake in Children With Attention-Deficit/Hyperactivity Disorder (ADHD). Clinical Psychological Science 4:6, pages 1094-1103.
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Zahra Sepehrmanesh, Abdollah Omidi & Narges Gholampoor. (2016) Acid Folic Supplementation in Major Depressive Disorder Treatment: A Double-Blind Randomized Clinical Trial. Iranian Red Crescent Medical Journal 19:2.
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Satyanarayanan Senthil Kumaran, Yin-Hua Shih & Kuan-Pin Su. (2016) Detecting the modest signals of omega-3 fatty acids' antidepressant effects by homogenizing depressed patient groups. Lipid Technology 28:5-6, pages 86-87.
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Walter Swardfager, Joshua D. Rosenblat, Meriem Benlamri & Roger S. McIntyre. (2016) Mapping inflammation onto mood: Inflammatory mediators of anhedonia. Neuroscience & Biobehavioral Reviews 64, pages 148-166.
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Kristian Søborg Husted & Elena V. Bouzinova. (2016) The importance of n-6/n-3 fatty acids ratio in the major depressive disorder. Medicina 52:3, pages 139-147.
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Joshua D. Rosenblat, Ron Kakar & Roger S. McIntyre. 2016. Cardiovascular Diseases and Depression. Cardiovascular Diseases and Depression 211 233 .
Kuan-Pin Su. (2015) Nutrition, psychoneuroimmunology and depression: the therapeutic implications of omega-3 fatty acids in interferon-α-induced depression. BioMedicine 5:4.
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Ab Latif Wani, Sajad Ahmad Bhat & Anjum Ara. (2015) Omega-3 fatty acids and the treatment of depression: a review of scientific evidence. Integrative Medicine Research 4:3, pages 132-141.
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Kuan-Pin Su, Yutaka Matsuoka & Chi-Un Pae. (2015) Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders. Clinical Psychopharmacology and Neuroscience 13:2, pages 129-137.
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Changsu Han, Sheng-Min Wang, Kyung-Phil Kwak, Wang-Yeon Won, HwaYoung Lee, Chia Ming Chang, Tze Chun Tang & Chi-Un Pae. (2015) Aripiprazole augmentation versus antidepressant switching for patients with major depressive disorder: A 6-week, randomized, rater-blinded,prospective study. Journal of Psychiatric Research 66-67, pages 84-94.
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Alan C Logan & Felice N Jacka. (2014) Nutritional psychiatry research: an emerging discipline and its intersection with global urbanization, environmental challenges and the evolutionary mismatch. Journal of Physiological Anthropology 33:1.
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Joshua D. Rosenblat, Danielle S. Cha, Rodrigo B. Mansur & Roger S. McIntyre. (2014) Inflamed moods: A review of the interactions between inflammation and mood disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 53, pages 23-34.
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Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A. Patkar, Prakash S. Masand & Chi-Un Pae. (2014) A review of current evidence for acetyl-l-carnitine in the treatment of depression. Journal of Psychiatric Research 53, pages 30-37.
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