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Antigen-specific tolerization approaches in multiple sclerosis

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Catalina Coclitu, Cris S. Constantinescu & Radu Tanasescu. (2016) The future of multiple sclerosis treatments. Expert Review of Neurotherapeutics 16:12, pages 1341-1356.
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Victor Ivanovich Seledtsov, Galina V. Seledtsova & Alexei A. von Delwig. (2023) Immune-based, multifaceted inactivation of pathogenic T lymphocytes in treating autoimmune diseases. Exploration of Immunology, pages 506-512.
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Sefina Arif, Clara Domingo-Vila, Emily Pollock, Eleni Christakou, Evangelia Williams & Timothy I. M. Tree. (2023) Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials. Frontiers in Immunology 14.
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Sundararajan Jayaraman & Arathi Jayaraman. (2022) Impact of histone modifier-induced protection against autoimmune encephalomyelitis on multiple sclerosis treatment. Frontiers in Neurology 13.
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Alexandre Ferreira Lima, Isabel R. Amado & Liliana R. Pires. (2020) Poly(d,l-lactide-co-glycolide) (PLGA) Nanoparticles Loaded with Proteolipid Protein (PLP)—Exploring a New Administration Route. Polymers 12:12, pages 3063.
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Liliana R Pires, Isabel R Amado & João Gaspar. (2020) Dissolving microneedles for the delivery of peptides – Towards tolerance-inducing vaccines. International Journal of Pharmaceutics 586, pages 119590.
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Qiang Miao, Xiao-Xue Zhang, Qing-Xian Han, Si-Si Ren, Ruo-Xuan Sui, Jing-Wen Yu, Jing Wang, Qing Wang, Jie-Zhong Yu, Liang Cao, Wei Xiao, Bao-Guo Xiao & Cun-Gen Ma. (2020) The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice. Metabolic Brain Disease 35:5, pages 793-807.
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Olga Kammona & Costas Kiparissides. (2020) Recent Advances in Antigen-Specific Immunotherapies for the Treatment of Multiple Sclerosis. Brain Sciences 10:6, pages 333.
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Barbara Willekens, Silvia Presas-Rodríguez, MJ Mansilla, Judith Derdelinckx, Wai-Ping Lee, Griet Nijs, Maxime De Laere, Inez Wens, Patrick Cras, Paul Parizel, Wim Van Hecke, Annemie Ribbens, Thibo Billiet, Geert Adams, Marie-Madeleine Couttenye, Juan Navarro-Barriuso, Aina Teniente-Serra, Bibiana Quirant-Sánchez, Ascensión Lopez-Diaz de Cerio, Susana Inogés, Felipe Prosper, Anke Kip, Herman Verheij, Catharina C Gross, Heinz Wiendl, Marieke (SM) Van Ham, Anja Ten Brinke, Ana Maria Barriocanal, Anna Massuet-Vilamajó, Niel Hens, Zwi Berneman, Eva Martínez-Cáceres, Nathalie Cools & Cristina Ramo-Tello. (2019) Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration. BMJ Open 9:9, pages e030309.
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Tobias Zrzavy, Herwig Kollaritsch, Paulus S. Rommer, Nina Boxberger, Micha Loebermann, Isabella Wimmer, Alexander Winkelmann & Uwe K. Zettl. (2019) Vaccination in Multiple Sclerosis: Friend or Foe?. Frontiers in Immunology 10.
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Mattias Bronge, Sabrina Ruhrmann, Claudia Carvalho-Queiroz, Ola B. Nilsson, Andreas Kaiser, Erik Holmgren, Caterina Macrini, Stephan Winklmeier, Edgar Meinl, Lou Brundin, Mohsen Khademi, Tomas Olsson, Guro Gafvelin & Hans Grönlund. (2019) Myelin oligodendrocyte glycoprotein revisited—sensitive detection of MOG-specific T-cells in multiple sclerosis. Journal of Autoimmunity 102, pages 38-49.
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Cody D. Moorman, Alan D. CurtisIIII, Alexander G. Bastian, Sarah E. Elliott & Mark D. Mannie. (2019) A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition. Frontiers in Immunology 9.
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Sundararajan Jayaraman & Bellur S. Prabhakar. 2019. Neuroimmune Diseases. Neuroimmune Diseases 143 166 .
Arathi Jayaraman, Advait Soni, Bellur S. Prabhakar, Mark Holterman & Sundararajan Jayaraman. (2017) The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord. Neurobiology of Disease 108, pages 1-12.
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Joshua M. Gammon, Arjun R. Adapa & Christopher M. Jewell. (2017) Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors. Journal of Biomedical Materials Research Part A 105:11, pages 2977-2985.
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Lucie Barateau, Roland Liblau, Christelle Peyron & Yves Dauvilliers. (2017) Narcolepsy Type 1 as an Autoimmune Disorder: Evidence, and Implications for Pharmacological Treatment. CNS Drugs 31:10, pages 821-834.
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Krystina L. Hess, Eunkeu Oh, Lisa H. Tostanoski, James I. Andorko, Kimihiro Susumu, Jeffrey R. Deschamps, Igor L. Medintz & Christopher M. Jewell. (2017) Engineering Immunological Tolerance Using Quantum Dots to Tune the Density of Self‐Antigen Display. Advanced Functional Materials 27:22, pages 1700290.
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Medhat A. Al-Ghobashy, Aliaa N. ElMeshad, Rania M. Abdelsalam, Mohammed M. Nooh, Muhammad Al-Shorbagy & Götz Laible. (2017) Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model. Scientific Reports 7:1.
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Krystina L. Hess, James I. Andorko, Lisa H. Tostanoski & Christopher M. Jewell. (2017) Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity. Biomaterials 118, pages 51-62.
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Lisa H. Tostanoski, Yu-Chieh Chiu, James I. Andorko, Ming Guo, Xiangbin Zeng, Peipei Zhang, Walter RoyalIIIIII & Christopher M. Jewell. (2016) Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance. ACS Nano 10:10, pages 9334-9345.
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Lisa H. Tostanoski, Yu-Chieh Chiu, Joshua M. Gammon, Thomas Simon, James I. Andorko, Jonathan S. Bromberg & Christopher M. Jewell. (2016) Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific. Cell Reports 16:11, pages 2940-2952.
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Dilip K. Challa, Wentao Mi, Su-Tang Lo, Raimund J. Ober & E. Sally Ward. (2016) Antigen dynamics govern the induction of CD4 + T cell tolerance during autoimmunity. Journal of Autoimmunity 72, pages 84-94.
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Andreas Lossius, Jorunn N. Johansen, Frode Vartdal & Trygve Holmøy. (2016) High‐throughput sequencing of immune repertoires in multiple sclerosis. Annals of Clinical and Translational Neurology 3:4, pages 295-306.
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Reinhard Hohlfeld, Klaus Dornmair, Edgar Meinl & Hartmut Wekerle. (2016) The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets. The Lancet Neurology 15:2, pages 198-209.
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Adriana Sofron, Danilo Ritz, Dario Neri & Tim Fugmann. (2016) High-resolution analysis of the murine MHC class II immunopeptidome. European Journal of Immunology 46:2, pages 319-328.
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Stefan Bittner & Heinz Wiendl. (2015) Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications. Neurotherapeutics 13:1, pages 4-19.
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Laurine Legroux & Nathalie Arbour. (2015) Multiple Sclerosis and T Lymphocytes: An Entangled Story. Journal of Neuroimmune Pharmacology 10:4, pages 528-546.
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Megan KL MacLeod & Stephen M Anderton. (2015) Antigen-based immunotherapy (AIT) for autoimmune and allergic disease. Current Opinion in Pharmacology 23, pages 11-16.
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Joshua M. Gammon, Lisa H. Tostanoski, Arjun R. Adapa, Yu-Chieh Chiu & Christopher M. Jewell. (2015) Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity. Journal of Controlled Release 210, pages 169-178.
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James I. Andorko, Krystina L. Hess & Christopher M. Jewell. (2014) Harnessing Biomaterials to Engineer the Lymph Node Microenvironment for Immunity or Tolerance. The AAPS Journal 17:2, pages 323-338.
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