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Expert Opinion on Investigational Drugs Volume 23, 2014 - Issue 7
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Targeting IL-6 for the treatment of rheumatoid arthritis: Phase II investigational drugs

Luca SemeranoInserm UMR 1125, 74, rue Marcel Cachin 93017 Bobigny, France;Sorbonne Paris Cité – Université Paris 13, 74, rue Marcel Cachin 93017 Bobigny, France;Assistance Publique – Hôpitaux de Paris (AP-HP) Groupe Hospitalier Avicenne – Jean Verdier – René Muret, Service de Rhumatologie, 125 rue de Stalingrad 93017 Bobigny, [email protected]
,
Allan ThiolatInserm UMR 1125, 74, rue Marcel Cachin 93017 Bobigny, France;Sorbonne Paris Cité – Université Paris 13, 74, rue Marcel Cachin 93017 Bobigny, France
,
Emeline MinichielloInserm UMR 1125, 74, rue Marcel Cachin 93017 Bobigny, France;Sorbonne Paris Cité – Université Paris 13, 74, rue Marcel Cachin 93017 Bobigny, France;Assistance Publique – Hôpitaux de Paris (AP-HP) Groupe Hospitalier Avicenne – Jean Verdier – René Muret, Service de Rhumatologie, 125 rue de Stalingrad 93017 Bobigny, [email protected]
,
Gaëlle ClavelInserm UMR 1125, 74, rue Marcel Cachin 93017 Bobigny, France;Sorbonne Paris Cité – Université Paris 13, 74, rue Marcel Cachin 93017 Bobigny, France;Service de Médecine Interne, Fondation Ophtalmologique A de Rothschild, 75019 Paris, France
,
Natacha BessisInserm UMR 1125, 74, rue Marcel Cachin 93017 Bobigny, France;Sorbonne Paris Cité – Université Paris 13, 74, rue Marcel Cachin 93017 Bobigny, France
&
Marie-Christophe BoissierInserm UMR 1125, 74, rue Marcel Cachin 93017 Bobigny, France;Sorbonne Paris Cité – Université Paris 13, 74, rue Marcel Cachin 93017 Bobigny, France;Assistance Publique – Hôpitaux de Paris (AP-HP) Groupe Hospitalier Avicenne – Jean Verdier – René Muret, Service de Rhumatologie, 125 rue de Stalingrad 93017 Bobigny, [email protected]
Pages 979-999 | Published online: 26 Apr 2014

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Silvia Rosina, Gabriella Giancane & Nicolino Ruperto. (2022) Emerging therapies for juvenile arthritis: agents in early clinical trials. Expert Opinion on Investigational Drugs 31:10, pages 1109-1124.
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Francesca Bartoli, Sangmee Bae, Laura Cometi, Marco Matucci Cerinic & Daniel E Furst. (2018) Sirukumab for the treatment of rheumatoid arthritis: update on sirukumab, 2018. Expert Review of Clinical Immunology 14:7, pages 539-547.
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Fatemeh Safari, Safar Farajnia, Maryam Arya, Habib Zarredar & Ava Nasrolahi. (2018) CRISPR and personalized Treg therapy: new insights into the treatment of rheumatoid arthritis. Immunopharmacology and Immunotoxicology 40:3, pages 201-211.
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Luca Semerano, Patrice Decker, Gaëlle Clavel & Marie-Christophe Boissier. (2016) Developments with investigational Janus kinase inhibitors for rheumatoid arthritis. Expert Opinion on Investigational Drugs 25:12, pages 1355-1359.
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Minping Zhang, Chunyan Shi, Chun Xia, Jin Yang, Xingyang Niu, Guohong Zhuang & Ping Yin. (2015) Anti-DR5 mAb inhibits proliferation of human fibroblast-like synovial cells and reduces their cytokine secretion in vitro. OncoTargets and Therapy 8, pages 2745-2755.
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Soken-Nakazawa J Song & Kazuyuki Yoshizaki. (2015) Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy. Expert Opinion on Drug Metabolism & Toxicology 11:2, pages 307-316.
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Arshia Shahini & Ali Shahini. (2022) Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome. Journal of Cell Communication and Signaling.
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Wei He, Neha Kapate, C. Wyatt ShieldsIVIV & Samir Mitragotri. (2020) Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases. Advanced Drug Delivery Reviews 165-166, pages 15-40.
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Wen-Tao Ma, Fei Gao, Kui Gu & De-Kun Chen. (2019) The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review. Frontiers in Immunology 10.
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Kevin D. Pile, Garry G. Graham, Stephen M. Mahler & Richard O. Day. 2019. Nijkamp and Parnham's Principles of Immunopharmacology. Nijkamp and Parnham's Principles of Immunopharmacology 709 750 .
Tsutomu Takeuchi, Josef S Smolen, Ernest H Choy, Daniel Aletaha, Iain McInnes & Simon A Jones. (2018) Considering new lessons about the use of IL-6 inhibitors in arthritis. Considerations in Medicine 2:1, pages 7-11.
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Jiajie Tu, Wenming Hong, Pengying Zhang, Xinming Wang, Heinrich Körner & Wei Wei. (2018) Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?. Frontiers in Immunology 9.
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Bettina Sehnert, Harald Burkhardt, Stephanie Finzel, Stefan Dübel & Reinhard E. Voll. (2018) The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways. Clinical Immunology 186, pages 14-20.
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Darong Kim, Hee Yeon Won, Eun Sook Hwang, Young-Kook Kim & Hea-Young Park Choo. (2017) Synthesis of benzoxazole derivatives as interleukin-6 antagonists. Bioorganic & Medicinal Chemistry 25:12, pages 3127-3134.
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Swamy Venuturupalli. (2017) Immune Mechanisms and Novel Targets in Rheumatoid Arthritis. Immunology and Allergy Clinics of North America 37:2, pages 301-313.
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Xiongyan Wu, Pan Tao, Quan Zhou, Jie Li, Zhenjia Yu, Xiaofeng Wang, Jiaanfang Li, Chen Li, Min Yan, Zhenggang Zhu, Bingya Liu & Liping Su. (2017) IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway. Oncotarget 8:13, pages 20741-20750.
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Peng Wang, Jin-Hui Tao & Hai-Feng Pan. (2016) Probiotic bacteria: a viable adjuvant therapy for relieving symptoms of rheumatoid arthritis. Inflammopharmacology 24:5, pages 189-196.
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Irina A. Udalova, Alberto Mantovani & Marc Feldmann. (2016) Macrophage heterogeneity in the context of rheumatoid arthritis. Nature Reviews Rheumatology 12:8, pages 472-485.
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J. R. Kalden. (2016) BiologikaBiologics. Zeitschrift für Rheumatologie 75:6, pages 604-610.
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Liyan Dou, Baiquan Yu, Kaiyu Han, Mochao Xiao, Yaxin Liu & Fuzhen Lv. (2016) Association of IL-6 polymorphisms with chronic obstructive pulmonary disease risk: meta-analysis of genetic association, gene expression and expression quantitative trait locus analysis . Personalized Medicine 13:4, pages 395-403.
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Nayely Leyva-López, Erick Gutierrez-Grijalva, Dulce Ambriz-Perez & J. Heredia. (2016) Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. International Journal of Molecular Sciences 17:6, pages 921.
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Joachim. R. Kalden. (2016) Emerging Therapies for Rheumatoid Arthritis. Rheumatology and Therapy 3:1, pages 31-42.
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Luca Semerano, Emeline Minichiello, Natacha Bessis & Marie-Christophe Boissier. (2016) Novel Immunotherapeutic Avenues for Rheumatoid Arthritis. Trends in Molecular Medicine 22:3, pages 214-229.
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Frauke Henjes, Lucı́a Lourido, Cristina Ruiz-Romero, Juan Fernández-Tajes, Jochen M. Schwenk, María Gonzalez-Gonzalez, Francisco J. Blanco, Peter Nilsson & Manuel Fuentes. (2014) Analysis of Autoantibody Profiles in Osteoarthritis Using Comprehensive Protein Array Concepts. Journal of Proteome Research 13:11, pages 5218-5229.
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