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Expert Opinion on Investigational Drugs Volume 23, 2014 - Issue 7
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The challenge of targeted therapies for gastric cancer patients: the beginning of a long journey

Giuseppe AprileUniversity and General Hospital, Department of Medical Oncology, Piazzale S Maria della Misericordia 1, 33100, Udine, Italy+39 432 559308; +39 432 559305; [email protected]
, MD,
Riccardo GiampieriAzienda Ospedali Riuniti-Università Politecnica delle Marche, Department of Medical Oncology, Ancona, Italy
,
Marta BonottoUniversity and General Hospital, Department of Medical Oncology, Piazzale S Maria della Misericordia 1, 33100, Udine, Italy+39 432 559308; +39 432 559305; [email protected]
,
Alessandro BittoniAzienda Ospedali Riuniti-Università Politecnica delle Marche, Department of Medical Oncology, Ancona, Italy
,
Elena OngaroUniversity and General Hospital, Department of Medical Oncology, Piazzale S Maria della Misericordia 1, 33100, Udine, Italy+39 432 559308; +39 432 559305; [email protected]
,
Giovanni Gerardo CardellinoUniversity and General Hospital, Department of Medical Oncology, Piazzale S Maria della Misericordia 1, 33100, Udine, Italy+39 432 559308; +39 432 559305; [email protected]
,
Francesco GrazianoAzienda Ospedali Riuniti Marche Nord, Department of Onco-Hematology, Pesaro, Italy
,
Francesco GiulianiNational Cancer Institute ‘G. Paolo II’, Department of Medical Oncology, Bari, Italy
,
Gianpiero FasolaUniversity and General Hospital, Department of Medical Oncology, Piazzale S Maria della Misericordia 1, 33100, Udine, Italy+39 432 559308; +39 432 559305; [email protected]
,
Stefano CascinuAzienda Ospedali Riuniti-Università Politecnica delle Marche, Department of Medical Oncology, Ancona, Italy
&
Mario ScartozziAzienda Ospedali Riuniti-Università Politecnica delle Marche, Department of Medical Oncology, Ancona, Italy
 show all
Pages 925-942 | Published online: 07 May 2014

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Jieer Ying, Qi Xu, Bixia Liu, Gu Zhang, Lei Chen & Hongming Pan. (2015) The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis. OncoTargets and Therapy 8, pages 2427-2433.
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Giuseppe Aprile, Francesco Leone, Riccardo Giampieri, Mariaelena Casagrande, Donatella Marino, Luca Faloppi, Stefano Cascinu, Gianpiero Fasola & Mario Scartozzi. (2015) Tracking the 2015 Gastrointestinal Cancers Symposium: bridging cancer biology to clinical gastrointestinal oncology. OncoTargets and Therapy 8, pages 1149-1156.
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Articles from other publishers (26)

志民 江. (2023) New Advances in Molecular Typing of Gastric Cancer. Advances in Clinical Medicine 13:02, pages 2392-2396.
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Mengqi Zhang, Beifang Li, Haiyan Liao, Zuhua Chen, Wenwen Huang, Jing Yang, Sai Ge, Zhongwu Li, Lin Shen, Cheng Zhang & Jing Gao. (2022) Targeting HER3 or MEK overcomes acquired Trastuzumab resistance in HER2-positive gastric cancer-derived xenograft. Cell Death Discovery 8:1.
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Linyang Fan, Weizhi Wang, Zihua Wang & Minzhi Zhao. (2021) Gold nanoparticles enhance antibody effect through direct cancer cell cytotoxicity by differential regulation of phagocytosis. Nature Communications 12:1.
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Maria Grazia Refolo, Claudio Lotesoriere, Caterina Messa, Maria Gabriella Caruso & Rosalba D'Alessandro. (2020) Integrated immune gene expression signature and molecular classification in gastric cancer: New insights. Journal of Leukocyte Biology 108:2, pages 633-646.
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Ze-Yuan Yu, Xiang-Yan Jiang, Rong-Rong ZhaoJun-Jie Qin, Chang-Jiang Luo, Yan-Xian Ren, Wen Ren, Zhi-Jian Ma & Zuo-Yi Jiao. (2020) Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways. Chinese Medical Journal 133:8, pages 919-928.
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Lara Alessandrini, Melissa Manchi, Fabrizio Italia, Tiziana Perin & Vincenzo Canzonieri. 2019. Gastric Cancer In The Precision Medicine Era. Gastric Cancer In The Precision Medicine Era 155 172 .
Daniela Cornelia Lazăr, Mihaela Flavia Avram, Ioan Romoșan, Mărioara Cornianu, Sorina Tăban & Adrian Goldiș. (2018) Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer. World Journal of Gastroenterology 24:32, pages 3583-3616.
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Stavros Gkolfinopoulos, Demetris Papamichael, Konstantinos Papadimitriou, Panos Papanastasopoulos, Vassilios Vassiliou & Panteleimon Kountourakis. (2018) Advances in molecular, genetic and immune signatures of gastric cancer: Are we ready to apply them in our patients’ decision making?. World Journal of Gastrointestinal Oncology 10:7, pages 172-183.
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Lara Alessandrini, Melissa Manchi, Valli De Re, Riccardo Dolcetti & Vincenzo Canzonieri. (2018) Proposed Molecular and miRNA Classification of Gastric Cancer. International Journal of Molecular Sciences 19:6, pages 1683.
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Ting-Ting Zhao, Hao Xu, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Song-Cheng Yin, Xing-Yu Liu & Zhi-Feng Miao. (2018) The efficacy and safety of targeted therapy with or without chemotherapy in advanced gastric cancer treatment: a network meta-analysis of well-designed randomized controlled trials. Gastric Cancer 21:3, pages 361-371.
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Ru Huang, Wenchao Gu, Bin Sun & Lei Gao. (2018) Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on bioinformatics analysis. Molecular Medicine Reports.
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Valentina Fanotto, Stefano Cordio, Giulia Pasquini, Caterina Fontanella, Lorenza Rimassa, Francesco Leone, Gerardo Rosati, Daniele Santini, Riccardo Giampieri, Samantha Di Donato, Gianluca Tomasello, Nicola Silvestris, Filippo Pietrantonio, Francesca Battaglin, Antonio Avallone, Mario Scartozzi, Eufemia Stefania Lutrino, Davide Melisi, Lorenzo Antonuzzo, Antonio Pellegrino, Valter Torri & Giuseppe Aprile. (2016) Prognostic factors in 868 advanced gastric cancer patients treated with second-line chemotherapy in the real world. Gastric Cancer 20:5, pages 825-833.
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Silvio Ken Garattini, Debora Basile, Monica Cattaneo, Valentina Fanotto, Elena Ongaro, Marta Bonotto, Francesca V Negri, Rosa Berenato, Paola Ermacora, Giovanni Gerardo Cardellino, Mariella Giovannoni, Nicoletta Pella, Mario Scartozzi, Lorenzo Antonuzzo, Nicola Silvestris, Gianpiero Fasola & Giuseppe Aprile. (2017) Molecular classifications of gastric cancers: Novel insights and possible future applications. World Journal of Gastrointestinal Oncology 9:5, pages 194.
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Geny Piro, Carmine Carbone, Ivana Cataldo, Federica Di Nicolantonio, Simone Giacopuzzi, Giuseppe Aprile, Francesca Simionato, Federico Boschi, Marco Zanotto, Maria Mihaela Mina, Raffaela Santoro, Valeria Merz, Andrea Sbarbati, Giovanni de Manzoni, Aldo Scarpa, Giampaolo Tortora & Davide Melisi. (2016) An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients. Clinical Cancer Research 22:24, pages 6164-6175.
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Jing Liu, Changqie Pan, Lihong Guo, Mengwan Wu, Jing Guo, Sheng Peng, Qianying Wu & Qiang Zuo. (2016) A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway. Journal of Hematology & Oncology 9:1.
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Fang Zhou, Ercheng Chen, Dong You, Yipeng Song, Zhenni Sun & Lu Yue. (2016) Both high expression of nucleophosmin/B23 and CRM1 predicts poorer prognosis in human gastric cancer. APMIS 124:12, pages 1046-1053.
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Valentina Fanotto, Elena Ongaro, Karim Rihawi, Antonio Avallone, Nicola Silvestris, Lorenzo Fornaro, Enrico Vasile, Lorenzo Antonuzzo, Francesco Leone, Gerardo Rosati, Francesco Giuliani, Roberto Bordonaro, Mario Scartozzi, Giovanna De Maglio, Francesca V. Negri, Gianpiero Fasola & Giuseppe Aprile. (2016) HER-2 inhibition in gastric and colorectal cancers: tangible achievements, novel acquisitions and future perspectives. Oncotarget 7:42, pages 69060-69074.
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Bo Chen, Qi-Cong Luo, Jian-Bo Chen, Li-E Lin, Ming-Xu Luo, Hong-Yue Ren, Pei-Qiong Chen & Lian-Guo Shi. (2016) Efficient isolation and proteomic analysis of cell plasma membrane proteins in gastric cancer reveal a novel differentiation and progression related cell surface marker, R-cadherin. Tumor Biology 37:9, pages 11775-11787.
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Jan Bornschein, Jessica Nielitz, Ignat Drozdov, Michael Selgrad, Thomas Wex, Doerthe Jechorek, Alexander Link, Michael Vieth & Peter Malfertheiner. (2016) Expression of aurora kinase A correlates with the Wnt‐modulator RACGAP 1 in gastric cancer . Cancer Medicine 5:3, pages 516-526.
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W Ruoming, Y Zhen, Z Tengteng & H Jisheng. (2015) RETRACTED ARTICLE: Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2. Cancer Gene Therapy 22:12, pages 564-572.
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Giuseppe Aprile, Nicola Silvestris, Lorenzo Antonuzzo & Mario Scartozzi. (2015) Metastatic gastric cancer in the last two decades: goals achieved and future promises. Future Oncology 11:19, pages 2633-2636.
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Georgios D Lianos, Christina D Bali, Christos Katsios & Dimitrios H Roukos. (2015) From traditional to whole-genome sequencing biomarkers for gastric cancer. Biomarkers in Medicine 9:6, pages 559-562.
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Xiao Xiao He, Li Ding, Yuan Lin, Man Shu, Jian Ming Wen & Ling Xue. (2015) Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival. Journal of Clinical Pathology 68:5, pages 374-380.
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X Han, Y Chen, N Yao, H Liu & Z Wang. (2015) MicroRNA let-7b suppresses human gastric cancer malignancy by targeting ING1. Cancer Gene Therapy 22:3, pages 122-129.
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Georgios D. Lianos, Alberto Mangano, Stefano Rausei, Aikaterini Lianou, Zoi Anastasiadi, Gianlorenzo Dionigi & Dimitrios H. Roukos. 2015. Gastric Cancer. Gastric Cancer 317 330 .
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