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NMDA antagonists under investigation for the treatment of major depressive disorder

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Matthew D. Cooper, Joshua D. Rosenblat, Danielle S. Cha, Yena Lee, Ron Kakar & Roger S. McIntyre. (2017) Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review. The World Journal of Biological Psychiatry 18:6, pages 410-423.
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Ricardo P. Garay, Carlos A. Zarate$suffix/text()$suffix/text(), Thomas Charpeaud, Leslie Citrome, Christoph U. Correll, Ahcène Hameg & Pierre-Michel Llorca. (2017) Investigational drugs in recent clinical trials for treatment-resistant depression. Expert Review of Neurotherapeutics 17:6, pages 593-609.
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Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand & Chi-Un Pae. (2015) Five potential therapeutic agents as antidepressants: a brief review and future directions. Expert Review of Neurotherapeutics 15:9, pages 1015-1029.
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Sheng-Min Wang, Changsu Han & Chi-Un Pae. (2015) Criticisms of drugs in early development for the treatment of depression: what can be improved?. Expert Opinion on Investigational Drugs 24:4, pages 445-453.
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Ezio Bettini, Stephen M. Stahl, Sara De Martin, Andrea Mattarei, Jacopo Sgrignani, Corrado Carignani, Selena Nola, Patrizia Locatelli, Marco Pappagallo, Charles E. Inturrisi, Francesco Bifari, Andrea Cavalli, Andrea Alimonti, Luca Pani, Maurizio Fava, Sergio Traversa, Franco Folli & Paolo L. Manfredi. (2022) Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors. Pharmaceuticals 15:8, pages 997.
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Sourav Ghosh, Arvind Kumar, Neetu Sachan & Phool Chandra. (2022) Evaluation of the Antidepressant-like Effect of Total Sterols Fraction and Stigmasterol Isolated from Leaves of Aegle marmelos and Possible Mechanism( s) of Action Involved . Current Drug Discovery Technologies 19:2.
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Maurizio FavaStephen StahlLuca PaniSara De MartinMarco PappagalloClotilde GuidettiAndrea AlimontiEzio BettiniRichard M. ManganoThomas WesselMarc de SomerJudy CaronOttavio V. VitoloGina R. DiGuglielmoAdam GilbertHiren MehtaMorgan KearneyAndrea MattareiMarco GentilucciFranco FolliSergio TraversaCharles E. InturrisiPaolo L. Manfredi. (2022) REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial. American Journal of Psychiatry 179:2, pages 122-131.
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Ryan T. McCallum & Melissa L. Perreault. (2021) Glycogen Synthase Kinase-3: A Focal Point for Advancing Pathogenic Inflammation in Depression. Cells 10:9, pages 2270.
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Bo Zhang, Hong-sheng Chang, Kai-li Hu, Xue Yu, Li-na Li & Xiang-qing Xu. (2019) Combination of Geniposide and Eleutheroside B Exerts Antidepressant-like Effect on Lipopolysaccharide-Induced Depression Mice Model. Chinese Journal of Integrative Medicine 27:7, pages 534-541.
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Sara De Martin, Daniela Gabbia, Franco Folli, Francesco Bifari, Paolo Fiorina, Nicola Ferri, Stephen Stahl, Charles E. Inturrisi, Marco Pappagallo, Sergio Traversa & Paolo L. Manfredi. (2021) REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study. Frontiers in Pharmacology 12.
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Dongyeong Yoon, Min-Tae Jeon, Kim Dong Woon & Sang Ryong Kim. (2020) Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. NeuroReport 31:13, pages 971-978.
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I. A. Novakov, D. S. Sheikin, M. B. Navrotskii, A. S. Mkrtchyan, L. L. Brunilina & K. V. Balakin. (2020) Dexoxadrol and its bioisosteres: structure, synthesis, and pharmacological activity. Russian Chemical Bulletin 69:9, pages 1625-1671.
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Li Zi-Rong, Han Yuan-Shan, Wu Meng-Yao, Liu Jian, Jin Shi, Zhang Xi & Wang Yu-Hong. (2020) Compound Chai Jin Jie Yu Tablets, Acts as An Antidepressant by Promoting Synaptic Function in the Hippocampal Neurons. Digital Chinese Medicine 3:2, pages 80-95.
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Yamin Yao, Peijun Ju, Hongmei Liu, Xiaohui Wu, Zhiang Niu, Yuncheng Zhu, Chen Zhang & Yiru Fang. (2020) Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats. Psychopharmacology 237:5, pages 1421-1433.
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Leandro Val Sayson, Chrislean Jun Botanas, Raly James Perez Custodio, Arvie Abiero, Mikyung Kim, Hyun Jun Lee, Hee Jin Kim, Sung Yeun Yoo, Kun Won Lee, Hye Won Ryu, Srijan Acharya, Kyeong-Man Kim, Yong Sup Lee & Jae Hoon Cheong. (2019) The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors. Psychopharmacology 236:7, pages 2201-2210.
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Peter J. Steenbergen. (2018) Response of zebrafish larvae to mild electrical stimuli: A 96-well setup for behavioural screening. Journal of Neuroscience Methods 301, pages 52-61.
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Tobias Kvist Stripp, Martin Balslev Jorgensen & Niels Vidiendal Olsen. (2017) Anaesthesia for electroconvulsive therapy – new tricks for old drugs: a systematic review. Acta Neuropsychiatrica 30:2, pages 61-69.
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Xingbo Bian, Xiaofeng Liu, Jinping Liu, Yan Zhao, Haijun Li, Enbo Cai, Pingya Li & Yugang Gao. (2018) Study on antidepressant activity of chiisanoside in mice. International Immunopharmacology 57, pages 33-42.
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Katarzyna Stachowicz. (2018) The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders. Acta Neurobiologiae Experimentalis 78:3, pages 210-219.
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Hristo Varbanov & Alexander Dityatev. (2017) Regulation of extrasynaptic signaling by polysialylated NCAM: Impact for synaptic plasticity and cognitive functions. Molecular and Cellular Neuroscience 81, pages 12-21.
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Weijia Ge, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Yugang Gao, Shuangli Liu, He Yang & Lianxue Zhang. (2017) Study on antidepressant activity of sesquiterpenoids from ginseng root. Journal of Functional Foods 33, pages 261-267.
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Mingzhu Lin, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Yugang Gao, Shuangli Liu, He Yang, Lianxue Zhang, Guosheng Tang & Ruiqing Wang. (2017) Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems. Molecules 22:4, pages 565.
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Jason Wallach, Heather Kang, Tristan Colestock, Hamilton Morris, Zuner A. Bortolotto, Graham L. Collingridge, David Lodge, Adam L. Halberstadt, Simon D. Brandt & Adeboye Adejare. (2016) Pharmacological Investigations of the Dissociative ‘Legal Highs’ Diphenidine, Methoxphenidine and Analogues. PLOS ONE 11:6, pages e0157021.
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Fangxi Zhang, Jing Shao, Jingwei Tian, Yan Zhong, Liang Ye, Xiangjing Meng, Qiaofeng Liu & Hongbo Wang. (2016) Antidepressant-like Effects of LPM580153, A Novel Potent Triple Reuptake Inhibitor. Scientific Reports 6:1.
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Tingxu Yan, Mengjie Xu, Bo Wu, Zhengzheng Liao, Zhi Liu, Xu Zhao, Kaishun Bi & Ying Jia. (2016) The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice. Food & Function 7:6, pages 2811-2819.
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Colin Davidson & Fabrizio Schifano. (2016) The potential utility of some legal highs in CNS disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 64, pages 267-274.
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Danuta Jantas. 2016. Herbal Medicine in Depression. Herbal Medicine in Depression 75 117 .
Bernadeta Szewczyk, Bart?omiej Pochwat, Anna Rafa?o, Agnieszka Palucha-Poniewiera, Helena Domin & Gabriel Nowak. (2015) Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc. Neuropharmacology 99, pages 517-526.
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Urszula Doboszewska, Bernadeta Szewczyk, Magdalena Sowa-Kućma, Katarzyna Młyniec, Anna Rafało, Beata Ostachowicz, Marek Lankosz & Gabriel Nowak. (2015) Antidepressant activity of fluoxetine in the zinc deficiency model in rats involves the NMDA receptor complex. Behavioural Brain Research 287, pages 323-330.
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Małgorzata Wolak, Agata Siwek, Bernadeta Szewczyk, Ewa Poleszak, Beata Bystrowska, Andrzej Moniczewski, Anita Rutkowska, Katarzyna Młyniec & Gabriel Nowak. (2015) Evaluation of the role of NMDA receptor function in antidepressant-like activity. A new study with citalopram and fluoxetine in the forced swim test in mice. Pharmacological Reports 67:3, pages 490-493.
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E R Workman, P C G Haddick, K Bush, G A Dilly, F Niere, B V Zemelman & K F Raab-Graham. (2015) Rapid antidepressants stimulate the decoupling of GABAB receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η. Molecular Psychiatry 20:3, pages 298-310.
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