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Expert Opinion on Investigational Drugs Volume 23, 2014 - Issue 9
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AMP-activated protein kinase activators in diabetic ulcers: from animal studies to Phase II drugs under investigation

Jiun-Tsai LinEnergenesis Biomedical Co., Ltd., New Taipei City, Taiwan
, PhD,
Han-Min ChenFu-Jen Catholic University, Graduate Institute of Applied Science and Engineering, New Taipei City, Taiwan;Fu-Jen Catholic University, Department and Institute of Life Science, No. 510 Zhongzheng Road, Xinzhuang Dist, New Taipei City 24205, ROC, Taiwan+886 2 2905 2468; + 886 2 2905 2193; [email protected]
, PhD,
Chih-Hsien ChiuNational Taiwan University, Department of Animal Science and Technology, Taipei, Taiwan
, PhD &
Yao-Jen LiangFu-Jen Catholic University, Graduate Institute of Applied Science and Engineering, New Taipei City, Taiwan;Fu-Jen Catholic University, Department and Institute of Life Science, No. 510 Zhongzheng Road, Xinzhuang Dist, New Taipei City 24205, ROC, Taiwan+886 2 2905 2468; + 886 2 2905 2193; [email protected];Fu-Jen Catholic University, Biomedical and photonic interdisciplinary research center, New Taipei City, Taiwan
, PhD
Pages 1253-1265 | Published online: 26 May 2014

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Hui-Chun Ku & Yao-Jen Liang. (2018) Incretin-based therapy for diabetic ulcers: from bench to bedside. Expert Opinion on Investigational Drugs 27:12, pages 989-996.
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Articles from other publishers (15)

Xiaohong Wang, Hadrian Schepler, Meik Neufurth, Shunfeng Wang, Heinz C. Schröder & Werner E. G. Müller. 2022. Inorganic Polyphosphates. Inorganic Polyphosphates 51 82 .
Huiya Huang, Linlin Wang, Fanyu Qian, Xiong Chen, Haiping Zhu, Mei Yang, Chunxiang Zhang, Maoping Chu, Xiaorong Wang & Xiaozhong Huang. (2021) Liraglutide via Activation of AMP-Activated Protein Kinase-Hypoxia Inducible Factor-1α-Heme Oxygenase-1 Signaling Promotes Wound Healing by Preventing Endothelial Dysfunction in Diabetic Mice. Frontiers in Physiology 12.
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Keshen Qu, HuiJung Cha, Yi Ru, Huafa Que & Meng Xing. (2021) Buxuhuayu decoction accelerates angiogenesis by activating the PI3K-Akt-eNOS signalling pathway in a streptozotocin-induced diabetic ulcer rat model. Journal of Ethnopharmacology 273, pages 113824.
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Guang‐Huar Young, Jiun‐Tsai Lin, Yi‐Fang Cheng, Chia‐Fang Ho, Qian‐Yu Kuok, Ru‐Chun Hsu, Wan‐Rou Liao, Chin‐Chen Chen & Han‐Min Chen. (2021) Modulation of adenine phosphoribosyltransferase‐mediated salvage pathway to accelerate diabetic wound healing. The FASEB Journal 35:3.
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Muhammet Emin Cam, Busra Ertas, Hussain Alenezi, Ayse Nur Hazar-Yavuz, Sumeyye Cesur, Gul Sinemcan Ozcan, Ceyda Ekentok, Ece Guler, Christina Katsakouli, Zehra Demirbas, Dilek Akakin, Mehmet Sayip Eroglu, Levent Kabasakal, Oguzhan Gunduz & Mohan Edirisinghe. (2021) Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study. Materials Science and Engineering: C 119, pages 111586.
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Simona Federica Spampinato, Grazia Ilaria Caruso, Rocco De Pasquale, Maria Angela Sortino & Sara Merlo. (2020) The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs. Pharmaceuticals 13:4, pages 60.
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Hemalatha Nanjaiah & Baskaran Vallikannan. (2019) Enhanced phosphorylation of AMPK by lutein and oxidised lutein that lead to mitochondrial biogenesis in hyperglycemic HepG2 cells. Journal of Cellular Biochemistry 120:9, pages 15255-15267.
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Ewa Klara Stuermer, M. Besser, N. Terberger, V. Koester, H. S. Bachmann & A. L. Severing. (2018) Side effects of frequently used oral antidiabetics on wound healing in vitro. Naunyn-Schmiedeberg's Archives of Pharmacology 392:3, pages 371-380.
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Xue Han, Yulong Tao, Yaping Deng, Jiawen Yu, Yuannan Sun & Guojun Jiang. (2017) Metformin accelerates wound healing in type 2 diabetic db/db mice. Molecular Medicine Reports 16:6, pages 8691-8698.
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Shu-Juan Wang, Wen-Yi Lu & Kai-Yan Liu. (2017) Adiponectin receptor agonist AdipoRon suppresses adipogenesis in C3H10T1/2 cells through the adenosine monophosphate-activated protein kinase signaling pathway. Molecular Medicine Reports 16:5, pages 7163-7169.
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Jia-Wen Yu, Ya-Ping Deng, Xue Han, Guo-Fei Ren, Jian Cai & Guo-Jun Jiang. (2016) Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice. Cardiovascular Diabetology 15:1.
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Ajay Kumar, Shailendra Giri & Ashok Kumar. (2016) 5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis. Cellular Microbiology 18:12, pages 1815-1830.
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Ping Wu, Yu Yan, Lin-lin Ma, Bi-yu Hou, Yang-yang He, Li Zhang, Zi-ran Niu, Jun-ke Song, Xiao-cong Pang, Xiu-ying Yang & Guan-hua Du. (2016) Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury. Journal of Biological Chemistry 291:42, pages 22288-22301.
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Narciso Couto, Jennifer Wood & Jill Barber. (2016) The role of glutathione reductase and related enzymes on cellular redox homoeostasis network. Free Radical Biology and Medicine 95, pages 27-42.
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Chian-Jiun Liou, Xuan-Yu Lai, Ya-Ling Chen, Chia-Ling Wang, Ciao-Han Wei & Wen-Chung Huang. (2015) Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-10.
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