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Therapeutical approaches under investigation for treatment of Chagas disease

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Ana Lia Mazzeti, Patricia Capelari-Oliveira, Maria Terezinha Bahia & Vanessa Carla Furtado Mosqueira. (2021) Review on Experimental Treatment Strategies Against Trypanosoma cruzi. Journal of Experimental Pharmacology 13, pages 409-432.
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Cristina Alonso-Vega, Irene Losada-Galván, María-Jesus Pinazo, Javier Sancho Mas, Joaquim Gascón Brustenga & Julio Alonso-Padilla. (2019) The senseless orphanage of Chagas disease. Expert Opinion on Orphan Drugs 7:12, pages 535-545.
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Ihatanderson Alves-Silva, Ricardo N. Marreto, Guilherme M. Gelfuso, Lívia C. L. Sá-Barreto, Eliana M. Lima & Marcílio S. S. Cunha-Filho. (2017) Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique. Drug Development and Industrial Pharmacy 43:5, pages 762-769.
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Dayanne da Rocha de Menezes, Claudia Magalhães Calvet, Giseli Capaci Rodrigues, Mirian Claudia de Souza Pereira, Igor Rodrigues Almeida, Alcino Palermo de Aguiar, Claudiu T. Supuran & Alane Beatriz Vermelho. (2016) Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 964-973.
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Articles from other publishers (48)

Raiza Brandão Peres, Marcos Meuser Batista, Ana Luíza Rangel Bérenger, Flávia da Cunha Camillo, Maria Raquel Figueiredo & Maria de Nazaré Correia Soeiro. (2023) Antiparasitic Activity of Plumbago auriculata Extracts and Its Naphthoquinone Plumbagin against Trypanosoma cruzi. Pharmaceutics 15:5, pages 1535.
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Bruno Lisboa Timm, Aline Nefertiti Silva da Gama, Marcos Meuser Batista, Denise da Gama Jaén Batista, David W. Boykin, Harry P. De Koning & Maria de Nazaré Correia Soeiro. (2023) Arylimidamides Have Potential for Chemoprophylaxis against Blood-Transmitted Chagas Disease. Pathogens 12:5, pages 701.
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Ana Lia Mazzeti, Karolina R. Gonçalves, Patrícia Ferreira Boasquívis, Jamile Barbosa, Bruno G. Pereira, Maria de Nazaré Correia Soeiro, Vanessa Carla Furtado Mosqueira & Maria Terezinha Bahia. (2023) Poly-ε-Caprolactone Implants for Benznidazole Prolonged Release: An Alternative to Chagas Disease Oral Treatment. Pharmaceutics 15:4, pages 1126.
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Ludmila F. de A. Fiuza, Denise G. J. Batista, Roberson D. Girão, Fabian Hulpia, Paula Finamore-Araújo, Mustafa M. Aldfer, Ehab Kotb Elmahallawy, Harry P. De Koning, Otacílio Moreira, Serge Van Calenbergh & Maria de Nazaré C. Soeiro. (2022) Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches. Molecules 27:22, pages 8087.
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Cristina Fonseca-Berzal, Alexandra Ibáñez-Escribano, Sonia de Castro, José A. Escario, Alicia Gómez-Barrio & Vicente J. Arán. (2022) 5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents. Acta Tropica 234, pages 106607.
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Raoni Pais Siqueira, Matheus Marques Milagre, Maria Alice de Oliveira, Renata Tupinambá Branquinho, Fernanda Karoline Vieira Torchelsen, Marta de Lana, Marina Guimarães Carvalho Machado, Margareth Spangler Andrade, Maria Terezinha Bahia & Vanessa Carla Furtado Mosqueira. (2022) In vitro interaction of polyethylene glycol-block-poly(D,L-lactide) nanocapsule devices with host cardiomyoblasts and Trypanosoma cruzi-infective forms. Parasitology Research 121:10, pages 2861-2874.
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Eleonora Lima Alves Cunha, Fernanda Karoline Vieira da Silva Torchelsen, Kátia da Silva Fonseca, Lucas Resende Dutra Sousa, Paula Melo Abreu Vieira, Cláudia Martins Carneiro, Kelerson Mauro de Castro Pinto, Rosália Morais Torres & Marta de Lana. (2022) Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs. Experimental Parasitology 238, pages 108266.
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Lenci K. Vázquez-Jiménez, Antonio Moreno-Herrera, Alfredo Juárez-Saldivar, Alonzo González-González, Eyra Ortiz-Pérez, Alma D. Paz-González, Isidro Palos, Esther Ramírez-Moreno & Gildardo Rivera. (2022) Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents. Current Medicinal Chemistry 29:14, pages 2504-2529.
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Marcella Paula Mansano Sarto, Hevillyn Fernanda Lucas da Silva, Nilma de Souza Fernandes, Ana Paula de Abreu, Gerson Zanusso Junior & Max Jean de Ornelas Toledo. (2021) Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II. BMC Complementary Medicine and Therapies 21:1.
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Raiza B. Peres, Ludmila F. de A. Fiuza, Patrícia B. da Silva, Marcos M. Batista, Flávia da C. Camillo, André M. Marques, Lavínia de C. Brito, Maria R. Figueiredo & Maria de N. C. Soeiro. (2021) In Vitro Phenotypic Activity and In Silico Analysis of Natural Products from Brazilian Biodiversity on Trypanosoma cruzi. Molecules 26:18, pages 5676.
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Pollyanna Álvaro Spósito, Ana Lia Mazzeti, Kelly Christyne Miranda Pereira de Castro, Priscila Fagundes Mendes, Julio A. Urbina, Maria Terezinha Bahia & Vanessa Carla Furtado Mosqueira. (2021) Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease. Experimental Parasitology 228, pages 108142.
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Carolina Machado Macedo, Francis Monique de Souza Saraiva, Jéssica Isis Oliveira Paula, Suelen de Brito Nascimento, Débora de Souza dos Santos Costa, Paulo Roberto Ribeiro Costa, Ayres Guimarães Dias, Marcia Cristina Paes & Natália Pereira Nogueira. (2021) The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi. Frontiers in Microbiology 12.
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Brindha J, Balamurali M. M & Kaushik Chanda. (2021) An Overview on the Therapeutics of Neglected Infectious Diseases—Leishmaniasis and Chagas Diseases. Frontiers in Chemistry 9.
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Vanessa Carla Furtado Mosqueira, Ana Lia Mazzeti & Maria Terezinha Bahia. 2021. Applications of Nanobiotechnology for Neglected Tropical Diseases. Applications of Nanobiotechnology for Neglected Tropical Diseases 169 189 .
Andréa A.S. Mendonça, Elda Gonçalves-Santos, Thaiany G. Souza-Silva, Kelly J. González-Lozano, Ivo S. Caldas, Reggiani V. Gonçalves, Lívia F. Diniz & Rômulo D. Novaes. (2020) Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice. International Immunopharmacology 85, pages 106611.
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Yara Almeida Machado, Maria Terezinha Bahia, Ivo Santana Caldas, Ana Lia Mazzeti, Rômulo Dias Novaes, Breno Raimundo Vilas Boas, Lorena Júnia de Souza Santos, Olindo Assis Martins-Filho, Marcos José Marques & Lívia de Figueiredo Diniz. (2020) Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection. Antimicrobial Agents and Chemotherapy 64:8.
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Paul Zaki, Elisa LBC Domingues, Farhad M Amjad, Maiara B Narde, Karolina R Gonçalves, Mirelle L Viana, Heberth de Paula, Wanderson G de Lima, Huan Huang, Maria T Bahia, Philipp E Sherer, Fabiane M dos Santos, Louis M Weiss & Herbert B Tanowitz. (2020) The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection. Parasitology Research 119:6, pages 1829-1843.
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Minerva Arce-Fonseca, Ana C. Carbajal-Hernández, Mónica Lozano-Camacho, Silvia del C. Carrillo-Sánchez, Francisco-Javier Roldán, Alberto Aranda-Fraustro, José Luis Rosales-Encina & Olivia Rodríguez-Morales. (2020) DNA Vaccine Treatment in Dogs Experimentally Infected with Trypanosoma cruzi . Journal of Immunology Research 2020, pages 1-18.
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Renata Tupinambá Branquinho, Carlos Geraldo Campos de Mello, Maykon Tavares Oliveira, Levi Eduardo Soares Reis, Paula Mello de Abreu Vieira, Dênia Antunes Saúde-Guimarães, Vanessa Carla Furtado Mosqueira & Marta de Lana. (2020) Lychnopholide in Poly( d , l -Lactide)- Block -Polyethylene Glycol Nanocapsules Cures Infection with a Drug-Resistant Trypanosoma cruzi Strain at Acute and Chronic Phases . Antimicrobial Agents and Chemotherapy 64:4.
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Luísa Perin, Kátia da Silva Fonseca, Thaís Vieira de Carvalho, Lívia Mendes Carvalho, João Vitor Madeira, Luciana da Fonseca Medeiros, Israel Molina, Rodrigo Correa-Oliveira, Cláudia Martins Carneiro & Paula Melo de Abreu Vieira. (2020) Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon. Experimental Parasitology 210, pages 107834.
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Matheus Marques Milagre, Renata Tupinambá Branquinho, Maira Fonseca Gonçalves, GMP de Assis, Maykon Tavares de Oliveira, LES Reis, Dênia Antunes Saúde-Guimarães & Marta de Lana. (2019) Activity of the sesquiterpene lactone goyazensolide against Trypanosoma cruzi in vitro and in vivo . Parasitology 147:1, pages 108-119.
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Marcos André Vannier-Santos, Giselle V. Brunoro, Maria de Nazaré C. Soeiro, Solange L. DeCastro & Rubem F.S. Menna-Barreto. 2019. Biology of Trypanosoma cruzi . Biology of Trypanosoma cruzi .
Elena Aguilera, Guzmán Alvarez, Hugo Cerecetto & Mercedes González. (2019) Polypharmacology in the Treatment of Chagas Disease. Current Medicinal Chemistry 26:23, pages 4476-4489.
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Linda Campos-Fernández, Carolina Barrientos-Salcedo, Edtson E. Herrera Valencia, Rocío Ortiz-Muñiz & Catalina Soriano-Correa. (2019) Substituent effects on the stability, physicochemical properties and chemical reactivity of nitroimidazole derivatives with potential antiparasitic effect: a computational study. New Journal of Chemistry 43:28, pages 11125-11134.
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Francisca Hildemagna Guedes-da-Silva, Denise da Gama Jaén Batista, Cristiane França Da Silva, Beatriz Philot Pavão, Marcos Meuser Batista, Otacílio Cruz Moreira, Letícia Rocha Quintino Souza, Constança Britto, Girish RachakondaFernando VillaltaGalina I. Lepesheva & Maria de Nazaré Correia Soeiro. (2019) Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi . ACS Infectious Diseases 5:3, pages 365-371.
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Rudy Parrado, Juan Carlos Ramirez, Anabelle de la Barra, Cristina Alonso-Vega, Natalia Juiz, Lourdes Ortiz, Daniel Illanes, Faustino Torrico, Joaquim Gascon, Fabiana Alves, Laurence Flevaud, Lineth Garcia, Alejandro G. Schijman & Isabela Ribeiro. (2019) Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease. Antimicrobial Agents and Chemotherapy 63:2.
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Carolina Barrientos-Salcedo, Bertha Espinoza & Catalina Soriano-Correa. (2018) Computational study of substituent effects on the physicochemical properties and chemical reactivity of selected antiparasitic 5-nitrofurans. Journal of Molecular Structure 1173, pages 92-99.
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Elizabeth Ruiz-Lancheros, Asieh Rasoolizadeh, Eric Chatelain, Facundo Garcia-Bournissen, Samanta Moroni, Guillermo Moscatelli, Jaime Altcheh & Momar Ndao. (2018) Validation of Apolipoprotein A-1 and Fibronectin Fragments as Markers of Parasitological Cure for Congenital Chagas Disease in Children Treated With Benznidazole. Open Forum Infectious Diseases 5:11.
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Cristina Fonseca-Berzal, Vicente J. Arán, José A. Escario & Alicia Gómez-Barrio. (2018) Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi. Parasitology Research 117:11, pages 3367-3380.
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Andréa Aparecida Santos Mendonça, Camila Morais Coelho, Marcia Paranho Veloso, Ivo Santana Caldas, Reggiani Vilela Gonçalves, Antônio Lucio Teixeira, Aline Silva de Miranda & Rômulo Dias Novaes. (2018) Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach . Oxidative Medicine and Cellular Longevity 2018, pages 1-20.
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Javier Varela, Hugo Cerecetto & Mercedes González. 2018. Chagas Disease - Basic Investigations and Challenges. Chagas Disease - Basic Investigations and Challenges.
Lívia de Figueiredo Diniz, Ana Lia Mazzeti, Ivo Santana Caldas, Isabela Ribeiro & Maria Terezinha Bahia. (2018) Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice. Antimicrobial Agents and Chemotherapy 62:6.
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Elena Aguilera, Javier Varela, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa Vera de Bilbao, Hugo Cerecetto, Guzmán Alvarez & Mercedes González. (2018) Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment. Memórias do Instituto Oswaldo Cruz 113:3, pages 153-160.
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Ana Lia Mazzeti, Lívia de F. Diniz, Karolina R. Gonçalves, Alvaro F.S. Nascimento, Pollyanna A.F. Spósito, Vanessa C.F. Mosqueira, George L.L. Machado-Coelho, Isabela Ribeiro & Maria T. Bahia. (2018) Time and dose-dependence evaluation of nitroheterocyclic drugs for improving efficacy following Trypanosoma cruzi infection: A pre-clinical study. Biochemical Pharmacology 148, pages 213-221.
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Claudia Magalhaes Calvet, Jun Yong Choi, Diane Thomas, Brian Suzuki, Ken Hirata, Sharon Lostracco-Johnson, Liliane Batista de Mesquita, Alanderson Nogueira, Marcelo Meuser-Batista, Tatiana Araujo Silva, Jair Lage Siqueira-Neto, William R. Roush, Mirian Claudia de Souza Pereira, James H. McKerrow & Larissa M. Podust. (2017) 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLOS Neglected Tropical Diseases 11:12, pages e0006132.
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Renata Tupinambá Branquinho, Gwenaelle Pound-Lana, Matheus Marques Milagre, Dênia Antunes Saúde-Guimarães, José Mário Carneiro Vilela, Margareth Spangler Andrade, Marta de Lana & Vanessa Carla Furtado Mosqueira. (2017) Increased Body Exposure to New Anti-Trypanosomal Through Nanoencapsulation. Scientific Reports 7:1.
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Nat?lia Fernanda Couto, Dina Pedersane, Luisa Rezende, Patr?cia P. Dias, Tayanne L. Corbani, L?via C. Bentini, Anny C. S. Oliveira, Ludmila F. Kelles, Thiago Castro-Gomes & Luciana O. Andrade. (2017) LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion. PLOS Neglected Tropical Diseases 11:6, pages e0005657.
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Ivani Pauli, Leonardo G Ferreira, Mariana L de Souza, Glaucius Oliva, Rafaela S Ferreira, Marco A Dessoy, Brian W Slafer, Luiz C Dias & Adriano D Andricopulo. (2017) Molecular modeling and structure–activity relationships for a series of benzimidazole derivatives as cruzain inhibitors. Future Medicinal Chemistry 9:7, pages 641-657.
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Maria V. Papadopoulou, William D. Bloomer, Howard S. Rosenzweig, Ana Lia Mazzeti, Karolina Ribeiro Gonçalves, Priscila Fagundes Mendes & Maria Terezinha Bahia. (2017) Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment In Vivo Assay . Antimicrobial Agents and Chemotherapy 61:5.
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Andrew Reddy, Leandro Stefano Sangenito, Arthur de Azevedo Guedes, Marta Helena Branquinha, Kevin Kavanagh, John McGinley, André Luis Souza dos Santos & Trinidad Velasco-Torrijos. (2017) Glycosylated metal chelators as anti-parasitic agents with tunable selectivity. Dalton Transactions 46:16, pages 5297-5307.
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Matías Hernández, Susana Wicz & Ricardo S. Corral. (2016) Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection. Phytomedicine 23:12, pages 1392-1400.
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Leonardo G. Ferreira & Adriano D. Andricopulo. (2016) Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective. Drug Discovery Today 21:10, pages 1699-1710.
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Carlos Geraldo Campos de Mello, Renata Tupinambá Branquinho, Maykon Tavares Oliveira, Matheus Marques Milagre, Dênia Antunes Saúde-Guimarães, Vanessa Carla Furtado Mosqueira & Marta de Lana. (2016) Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease. Antimicrobial Agents and Chemotherapy 60:9, pages 5215-5222.
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CRISTINA FONSECA-BERZAL, CRISTIANE FRANÇA DA SILVA, RUBEM F. S. MENNA-BARRETO, MARCOS MEUSER BATISTA, JOSÉ A. ESCARIO, VICENTE J. ARÁN, ALICIA GÓMEZ-BARRIO & MARIA DE NAZARÉ C. SOEIRO. (2016) Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes . Parasitology 143:11, pages 1469-1478.
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Daniela De Vita, Francesca Moraca, Claudio Zamperini, Fabiana Pandolfi, Roberto Di Santo, An Matheeussen, Louis Maes, Silvano Tortorella & Luigi Scipione. (2016) In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51. European Journal of Medicinal Chemistry 113, pages 28-33.
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Linda J. Herrera, Stephen Brand, Andres Santos, Lilian L. Nohara, Justin Harrison, Neil R. Norcross, Stephen Thompson, Victoria Smith, Carolina Lema, Armando Varela-Ramirez, Ian H. Gilbert, Igor C. Almeida & Rosa A. Maldonado. (2016) Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi. PLOS Neglected Tropical Diseases 10:4, pages e0004540.
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Ludmila A.G. Pinho, Lívia C.L. Sá-Barreto, Carlos M.C. Infante & Marcílio S.S. Cunha-Filho. (2016) Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 159, pages 48-52.
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Tassiane Assíria Fontes Martins, Lívia de Figueiredo Diniz, Ana Lia Mazzeti, Álvaro Fernando da Silva do Nascimento, Sérgio Caldas, Ivo Santana Caldas, Isabel Mayer de Andrade, Isabela Ribeiro & Maria Terezinha Bahia. (2015) Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease. PLOS ONE 10:6, pages e0128707.
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