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Expert Opinion on Investigational Drugs Volume 23, 2014 - Issue 11
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Reviews

Experimental trials in amyotrophic lateral sclerosis: a review of recently completed, ongoing and planned trials using existing and novel drugs

Namita A GoyalUniversity of California, Department of Neurology, Irvine, CA, USA;UC Irvine-MDA ALS and Neuromuscular Center, 200 S. Manchester Avenue, Suite 110, Orange, CA 92868, USA+1 714 456 2332; [email protected]
, MD &
Tahseen MozaffarUniversity of California, Department of Neurology, Irvine, CA, USA;UC Irvine-MDA ALS and Neuromuscular Center, 200 S. Manchester Avenue, Suite 110, Orange, CA 92868, USA+1 714 456 2332; [email protected]
, MD
Pages 1541-1551 | Published online: 26 Jun 2014

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Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D’Amico, Gabriele Ferlisi, Valeria Zullo, Floriana Denitto, Enrico Lauta, Crescenza Abbinante & Caterina V. Pesce. (2017) A basic technology-aided programme for leisure and communication of persons with advanced amyotrophic lateral sclerosis: performance and social rating. Disability and Rehabilitation: Assistive Technology 12:2, pages 145-152.
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Letizia Mazzini, Angelo Vescovi, Roberto Cantello, Maurizio Gelati & Alessandro Vercelli. (2016) Stem cells therapy for ALS. Expert Opinion on Biological Therapy 16:2, pages 187-199.
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Sungha Kim, Muhack Yang, Boncho Ku, Eunhye Cha, Wookcheol Seo, Ilhong Son, Hyungwon Kang, Dongwoung Kim, Bongkeun Song, Chang-Sop Yang & Sungchul Kim. (2023) Efficacy of mecasin for treatment of amyotrophic lateral sclerosis: A phase IIa multicenter randomized double-blinded placebo-controlled trial. Journal of Ethnopharmacology 315, pages 116670.
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José Afonso Corrêa da Silva & Nadja Schröder. (2023) The Role of Ca2+ Permeable AMPA Receptors in Neurodegeneration, Neurotoxicity, and Neuroinflammation. CNS & Neurological Disorders - Drug Targets 22:5, pages 624-633.
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Agnes Badu-Mensah, Xiufang Guo, Siddharth Nimbalkar, Yunqing Cai & James J. Hickman. (2022) ALS mutations in both human skeletal muscle and motoneurons differentially affects neuromuscular junction integrity and function. Biomaterials 289, pages 121752.
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Christina N. Fournier. (2022) Considerations for Amyotrophic Lateral Sclerosis (ALS) Clinical Trial Design. Neurotherapeutics 19:4, pages 1180-1192.
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Grazyna Debska-Vielhaber, Irina Miller, Viktoriya Peeva, Werner Zuschratter, Jaroslaw Walczak, Stefanie Schreiber, Susanne Petri, Judith Machts, Susanne Vogt, Joanna Szczepanowska, Frank N. Gellerich, Andreas Hermann, Stefan Vielhaber & Wolfram S. Kunz. (2021) Impairment of mitochondrial oxidative phosphorylation in skin fibroblasts of SALS and FALS patients is rescued by in vitro treatment with ROS scavengers. Experimental Neurology 339, pages 113620.
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B. A. Ashford, D. Boche, J. Cooper‐Knock, P. R. Heath, J. E. Simpson & J. R. Highley. (2020) Review: Microglia in motor neuron disease. Neuropathology and Applied Neurobiology 47:2, pages 179-197.
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Han-Jou Chen, Simon D Topp, Ho Sang Hui, Elsa Zacco, Malvika Katarya, Conor McLoughlin, Andrew King, Bradley N Smith, Claire Troakes, Annalisa Pastore & Christopher E Shaw. (2019) RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy. Brain 142:12, pages 3753-3770.
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Emma F. Smith, Pamela J. Shaw & Kurt J. De Vos. (2019) The role of mitochondria in amyotrophic lateral sclerosis. Neuroscience Letters 710, pages 132933.
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Na Gao, Yun-Peng Huang, Ting-Ting Chu, Qian-Qian Li, Bing Zhou, Yong-Xiang Chen, Yu-Fen Zhao & Yan-Mei Li. (2019) TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides. Bioorganic Chemistry 84, pages 254-259.
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Jeffrey M. Statland, Dan Moore, Yunxia Wang, Maureen Walsh, Tahseen Mozaffar, Lauren Elman, Sharon P. Nations, Hiroshi Mitsumoto, J. Americo Fernandes, David Saperstein, Ghazala Hayat, Laura Herbelin, Chafic Karam, Jonathan Katz, Heather M. Wilkins, Abdulbaki Agbas, Russell H. Swerdlow, Regina M. Santella, Mazen M. Dimachkie & Richard J. Barohn. (2019) Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial. Muscle & Nerve 59:2, pages 201-207.
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Vijay Kumar, Tara Kashav & Md. Imtaiyaz Hassan. 2019. Pathology, Prevention and Therapeutics of Neurodegenerative Disease. Pathology, Prevention and Therapeutics of Neurodegenerative Disease 207 224 .
Sungha Kim, Jae Kyoun Kim, Mi Ju Son, Dongwoung Kim, Bongkeun Song, Ilhong Son, Hyung Won Kang, Jongdeok Lee & Sungchul Kim. (2018) Mecasin treatment in patients with amyotrophic lateral sclerosis: study protocol for a randomized controlled trial. Trials 19:1.
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Alex G. Karanevich, Luke J. Weisbrod, Omar Jawdat, Richard J. Barohn, Byron J. Gajewski, Jianghua He & Jeffrey M. Statland. (2018) Using automated electronic medical record data extraction to model ALS survival and progression. BMC Neurology 18:1.
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Sebastiano Giuseppe Crisafulli, Simona Brajkovic, Maria Sara Cipolat Mis, Valeria Parente & Stefania Corti. (2017) Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis. Molecular Neurobiology 55:4, pages 2789-2813.
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Tara Kashav & Vijay Kumar. 2018. Systems Biology. Systems Biology 59 75 .
Bor Luen Tang. (2017) The use of mesenchymal stem cells (MSCs) for amyotrophic lateral sclerosis (ALS) therapy – a perspective on cell biological mechanisms. Reviews in the Neurosciences 28:7, pages 725-738.
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Jia Liu & Fei Wang. (2017) Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications. Frontiers in Immunology 8.
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S Fadilah Abdul Wahid, Zhe Kang Law, Nor Azimah Ismail, Raymond Azman Ali & Nai Ming Lai. (2016) Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews.
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Sarah Morgan & Richard W. Orrell. (2016) Pathogenesis of amyotrophic lateral sclerosis. British Medical Bulletin 119:1, pages 87-98.
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Megumi Akamatsu, Takenari Yamashita, Naoki Hirose, Sayaka Teramoto & Shin Kwak. (2016) The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice. Scientific Reports 6:1.
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Han-Jou Chen, Jacqueline C. Mitchell, Sergey Novoselov, Jack Miller, Agnes L. Nishimura, Emma L. Scotter, Caroline A. Vance, Michael E. Cheetham & Christopher E. Shaw. (2016) The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis. Brain 139:5, pages 1417-1432.
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Reyk Hillert, Anne Gieseler, Andreas Krusche, Daniel Humme, Hans-Joachim Röwert-Huber, Wolfram Sterry, Peter Walden & Walter Schubert. (2016) Large molecular systems landscape uncovers T cell trapping in human skin cancer. Scientific Reports 6:1.
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Chiara Parisi, Giulia Napoli, Pablo Pelegrin & Cinzia Volont?. (2016) M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b. Mediators of Inflammation 2016, pages 1-9.
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Yongsoon Park, Jinhee Park, Yeonsun Kim, Heejoon Baek & Seung Hyun Kim. (2015) Association between nutritional status and disease severity using the amyotrophic lateral sclerosis (ALS) functional rating scale in ALS patients. Nutrition 31:11-12, pages 1362-1367.
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Walter Schubert. (2015) Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis. Cytometry Part A 87:8, pages 696-703.
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Giulio E. Lancioni, Isabella L. Simone, Maria F. De Caro, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Gabriele Ferlisi, Valeria Zullo, Simona Schirone, Floriana Denitto & Nadia Zonno. (2015) Assisting persons with advanced amyotrophic lateral sclerosis in their leisure engagement and communication needs with a basic technology-aided program. NeuroRehabilitation 36:3, pages 355-365.
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Kristopher G. Hooten, David R. Beers, Weihua Zhao & Stanley H. Appel. (2015) Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:2, pages 364-375.
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Nam-Hee KimMin Oh Lee. (2015) Update of Therapeutic Clinical Trials for Amyotrophic Lateral Sclerosis. Korean Journal of Clinical Neurophysiology 17:1, pages 1.
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Gretchen M. Thomsen, Genevieve Gowing, Jessica Latter, Maximus Chen, Jean-Philippe Vit, Kevin Staggenborg, Pablo Avalos, Mor Alkaslasi, Laura Ferraiuolo, Shibi Likhite, Brian K. Kaspar & Clive N. Svendsen. (2014) Delayed Disease Onset and Extended Survival in the SOD1 G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex . The Journal of Neuroscience 34:47, pages 15587-15600.
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