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Phase II drugs that are currently in development for the treatment of cachexia

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Alessio Molfino, Maria Ida Amabile, Antonella Giorgi, Massimo Monti, Vito D’Andrea & Maurizio Muscaritoli. (2019) Investigational drugs for the treatment of cancer cachexia: a focus on phase I and phase II clinical trials. Expert Opinion on Investigational Drugs 28:8, pages 733-740.
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Articles from other publishers (34)

Jung Yoon Jang, Donghwan Kim & Nam Deuk Kim. (2023) Pathogenesis, Intervention, and Current Status of Drug Development for Sarcopenia: A Review. Biomedicines 11:6, pages 1635.
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Ruoxin Fang, Ling Yan & Zhengkai Liao. (2023) Abnormal lipid metabolism in cancer-associated cachexia and potential therapy strategy. Frontiers in Oncology 13.
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Dandan Chen, Yaoyu Liu, Junqi Chen, Hua Lin, Huijuan Guo, Yifan Wu, Yuan Xu, Yuan Zhou, Wei Zhou, Ruirui Lu, Jiuyao Zhou & Junbiao Wu. (2021) JAK/STAT pathway promotes the progression of diabetic kidney disease via autophagy in podocytes. European Journal of Pharmacology 902, pages 174121.
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Yonghua Li, Huan Jin, Yibing Chen, Ting Huang, Yanjun Mi & Zhengzhi Zou. (2021) Cancer cachexia: molecular mechanism and pharmacological management. Biochemical Journal 478:9, pages 1663-1688.
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Ana Pereira, Joaquim Costa Pereira & Sandra F. Martins. (2021) Clinical Impact of Sarcopenia on Gastrointestinal Tumors. Gastrointestinal Disorders 3:1, pages 51-60.
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Simonetta Ausoni, Sara Calamelli, Salvatore Saccà & Giuseppe Azzarello. (2020) How progressive cancer endangers the heart: an intriguing and underestimated problem. Cancer and Metastasis Reviews 39:2, pages 535-552.
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Ilaria Trestini, Anastasios Gkountakos, Luisa Carbognin, Alice Avancini, Massimo Lanza, Alessio Molfino, Simonetta Friso, Vincenzo Corbo, Giampaolo Tortora, Aldo Scarpa, Michele Milella, Emilio Bria & Sara Pilotto. (2019) Muscle derangement and alteration of the nutritional machinery in NSCLC. Critical Reviews in Oncology/Hematology 141, pages 43-53.
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Thomas K. Sin, James Z. Zhu, Guohua Zhang & Yi-Ping Li. (2019) p300 Mediates Muscle Wasting in Lewis Lung Carcinoma. Cancer Research 79:7, pages 1331-1342.
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Leon Naar, Despoina-Amalia Spanomichou & Panteleimon Vassiliu. (2019) Comment on “Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma”. Clinical Nutrition 38:2, pages 962-963.
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Susan C. Kandarian, Rachel L. Nosacka, Andrea E. Delitto, Andrew R. Judge, Sarah M. Judge, John D. Ganey, Jesse D. Moreira & Robert W. Jackman. (2018) Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice. Journal of Cachexia, Sarcopenia and Muscle 9:6, pages 1109-1120.
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Jeroen L.A. van Vugt, Robert R.J. Coebergh van den Braak, Henk J.W. Schippers, Kevin M. Veen, Stef Levolger, Ron W.F. de Bruin, Marcel Koek, Wiro J. Niessen, Jan N.M. IJzermans & François E.J.A. Willemsen. (2018) Contrast-enhancement influences skeletal muscle density, but not skeletal muscle mass, measurements on computed tomography. Clinical Nutrition 37:5, pages 1707-1714.
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S. Levolger, M.G. van Vledder, W.J. Alberda, C. Verhoef, R.W.F. de Bruin, J.N.M. IJzermans & J.W. Burger. (2018) Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma. Clinical Nutrition 37:5, pages 1728-1735.
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Jeroen L.A. van Vugt, Robert R.J. Coebergh van den Braak, Zarina S. Lalmahomed, Wietske W. Vrijland, Jan W.T. Dekker, David D.E. Zimmerman, Wouter J. Vles, Peter-Paul L.O. Coene & Jan N.M. IJzermans. (2018) Impact of low skeletal muscle mass and density on short and long-term outcome after resection of stage I-III colorectal cancer. European Journal of Surgical Oncology 44:9, pages 1354-1360.
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Sarthak Gupta, Robinder J.S. Dhillon & Sarfaraz Hasni. (2018) Sarcopenia. Rheumatic Disease Clinics of North America 44:3, pages 393-404.
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Jeroen L. A. van Vugt, Stefan Buettner, Louise J. M. Alferink, Niek Bossche, Ron W. F. de Bruin, Sarwa Darwish Murad, Wojciech G. Polak, Herold J. Metselaar & Jan N. M. IJzermans. (2018) Low skeletal muscle mass is associated with increased hospital costs in patients with cirrhosis listed for liver transplantation-a retrospective study. Transplant International 31:2, pages 165-174.
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Jeroen L. A. van Vugt, Stefan Buettner, Stef Levolger, Robert R. J. Coebergh van den Braak, Mustafa Suker, Marcia P. Gaspersz, Ron W. F. de Bruin, Cornelis Verhoef, Casper H. C. van Eijck, Niek Bossche, Bas Groot Koerkamp & Jan N. M. IJzermans. (2017) Low skeletal muscle mass is associated with increased hospital expenditure in patients undergoing cancer surgery of the alimentary tract. PLOS ONE 12:10, pages e0186547.
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Guohua Zhang, Zhelong Liu, Hui Ding, Yong Zhou, Hoang Anh Doan, Ka Wai Thomas Sin, Zhiren J. Zhu, Rene Flores, Yefei Wen, Xing Gong, Qingyun Liu & Yi-Ping Li. (2017) Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nature Communications 8:1.
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Janneke van Grinsven, Jeroen L. A. van Vugt, Arvind Gharbharan, Thomas L. Bollen, Marc G. Besselink, Hjalmar C. van Santvoort, Casper H. J. van Eijck & Djamila Boerma. (2017) The Association of Computed Tomography-Assessed Body Composition with Mortality in Patients with Necrotizing Pancreatitis. Journal of Gastrointestinal Surgery 21:6, pages 1000-1008.
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Guohua Zhang, Zhelong Liu, Hui Ding, Hongyu Miao, Jose M. Garcia & Yi-Ping Li. (2017) Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways. Scientific Reports 7:1.
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Zaira Aversa, Paola Costelli & Maurizio Muscaritoli. (2017) Cancer-induced muscle wasting: latest findings in prevention and treatment. Therapeutic Advances in Medical Oncology 9:5, pages 369-382.
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Janina A Vaitkus & Francesco S Celi. (2016) The role of adipose tissue in cancer-associated cachexia. Experimental Biology and Medicine 242:5, pages 473-481.
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Robinder J.S. Dhillon & Sarfaraz Hasni. (2017) Pathogenesis and Management of Sarcopenia. Clinics in Geriatric Medicine 33:1, pages 17-26.
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J.L.A. van Vugt, S. Levolger, R.W.F. de Bruin, J. van Rosmalen, H.J. Metselaar & J.N.M. IJzermans. (2016) Systematic Review and Meta-Analysis of the Impact of Computed Tomography–Assessed Skeletal Muscle Mass on Outcome in Patients Awaiting or Undergoing Liver Transplantation. American Journal of Transplantation 16:8, pages 2277-2292.
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Mario Thevis, Tiia Kuuranne, Katja Walpurgis, Hans Geyer & Wilhelm Schänzer. (2016) Annual banned-substance review: analytical approaches in human sports drug testing. Drug Testing and Analysis 8:1, pages 7-29.
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