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Investigational drugs for visceral leishmaniasis

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Read on this site (6)

Jaya Chakravarty & Shyam Sundar. (2019) Current and emerging medications for the treatment of leishmaniasis. Expert Opinion on Pharmacotherapy 20:10, pages 1251-1265.
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Carolina Bruno de Sousa, João Henrique G. Lago, Jorge Macridachis, Marta Oliveira, Luis Brito, Catarina Vizetto-Duarte, Cláudia Florindo, Sarah Hendrickx, Louis Maes, Thiago Morais, Miriam Uemi, Luís Neto, Lídia Dionísio, Sofia Cortes, Luísa Barreira, Luísa Custódio, Fernando Alberício, Lenea Campino & João Varela. (2019) Report of in vitro antileishmanial properties of Iberian macroalgae. Natural Product Research 33:12, pages 1778-1782.
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Shyam Sundar, Jaya Chakravarty & Lalit P Meena. (2019) Leishmaniasis: treatment, drug resistance and emerging therapies. Expert Opinion on Orphan Drugs 7:1, pages 1-10.
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Natascia Bruni, Barbara Stella, Leonardo Giraudo, Carlo Della Pepa, Daniela Gastaldi & Franco Dosio. (2017) Nanostructured delivery systems with improved leishmanicidal activity: a critical review. International Journal of Nanomedicine 12, pages 5289-5311.
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Rajan Kumar Pandey, Bajarang Vasant Kumbhar, Shubham Srivastava, Ruchi Malik, Shyam Sundar, Ambarish Kunwar & Vijay Kumar Prajapati. (2017) Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics 35:1, pages 141-158.
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Rajan Kumar Pandey, Drista Sharma, Tarun Kumar Bhatt, Shyam Sundar & Vijay Kumar Prajapati. (2015) Developing imidazole analogues as potential inhibitor for Leishmania donovani trypanothione reductase: virtual screening, molecular docking, dynamics and ADMET approach. Journal of Biomolecular Structure and Dynamics 33:12, pages 2541-2553.
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Articles from other publishers (35)

Boobalan Gopu, Parampreet Kour, Ramajayan Pandian & Kuljit Singh. (2023) Insights into the drug screening approaches in leishmaniasis. International Immunopharmacology 114, pages 109591.
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André L.S. Santos, Ana Karina C. Lima, Simone S.C. Oliveira, Rosiane F. dos Santos, Michael Devereux, Malachy McCann, Marta H. Branquinha & Patrícia M.L. Dutra. (2022) Decoding the anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its silver- and copper-based complexes: In vitro and in vivo approaches. European Journal of Medicinal Chemistry Reports 6, pages 100093.
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Henry Nettey, Isaac Joe Erskine, Afia Antwi Mensah, Nana Kwame Ofori Gyamera, Charles Kwadwo Obuobi, Doris Kumadoh, Isaac Julius Asiedu-Gyekye & Grace Lovia Allotey-Babington. (2022) Oral amodiaquine microparticles repurposed for the treatment of visceral leishmaniasis. Scientific African 17, pages e01285.
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Laura Dirkx, Sarah Hendrickx, Margot Merlot, Dimitri Bulté, Marick Starick, Jessy Elst, André Bafica, Didier G. Ebo, Louis Maes, Johan Van Weyenbergh & Guy Caljon. (2022) Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis. Communications Biology 5:1.
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Gilbert O. Silveira, Helena S. Coelho, Murilo S. Amaral & Sergio Verjovski-Almeida. (2021) Long non-coding RNAs as possible therapeutic targets in protozoa, and in Schistosoma and other helminths. Parasitology Research 121:4, pages 1091-1115.
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Manoj Kumar Singh, Arpita Das, Rudra P Saha, Joydeep Paul & Debkumar Nandi. (2022) Leishmaniasis: Plants as a source of antileishmanial agents. Journal of Experimental Biology and Agricultural Sciences 10:1, pages 227-247.
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Pedro Alves Bezerra Morais, Carla Santana Francisco, Heberth de Paula, Rayssa Ribeiro, Mariana Alves Eloy, Clara Lirian Javarini, Álvaro Cunha Neto & Valdemar Lacerda Júnior. (2021) Semisynthetic Triazoles as an Approach in the Discovery of Novel Lead Compounds. Current Organic Chemistry 25:10, pages 1097-1179.
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Aline N. Silva da Gama & Maria N.C. Soeiro. (2021) Quinoline-based Compounds as Key Candidates to Tackle Drug Discovery Programs of Microbicidal Agents. Current Pharmaceutical Design 27:15, pages 1757-1762.
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Diana Caridha, Richard J. Sciotti, Jason Sousa, Brian Vesely, Tesfaye Teshome, Gustave Bonkoungou, Chau Vuong, Susan Leed, Mozna Khraiwesh, Erica Penn, Mara Kreishman-Deitrick, Patricia Lee, Brandon Pybus, John S. Lazo & Elizabeth R. Sharlow. (2021) Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures Leishmania major -Induced Cutaneous Lesions in Murine Models . ACS Infectious Diseases 7:2, pages 506-517.
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Lipika Ray, R. Karthik, Vikas Srivastava, Sheelendra Pratap Singh, A. B. Pant, Neena Goyal & Kailash C. Gupta. (2020) Efficient antileishmanial activity of amphotericin B and piperine entrapped in enteric coated guar gum nanoparticles. Drug Delivery and Translational Research 11:1, pages 118-130.
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Camila S. Freitas, João A. Oliveira-da-Silva, Daniela P. Lage, Rafaella R. Costa, Débora V. C. Mendonça, Vívian T. Martins, Thiago A. R. Reis, Luciana M. R. Antinarelli, Amanda S. Machado, Grasiele S. V. Tavares, Fernanda F. Ramos, Vinicio T. S. Coelho, Rory C. F. Brito, Fernanda Ludolf, Miguel A. Chávez-Fumagalli, Bruno M. Roatt, Gabriela S. Ramos, Jennifer Munkert, Flaviano M. Ottoni, Priscilla R. V. Campana, Maria V. Humbert, Elaine S. Coimbra, Fernão C. Braga, Rodrigo M. Pádua & Eduardo A. F. Coelho. (2020) Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis. Parasitology Research 120:1, pages 321-335.
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Neena Goyal, Manveer Patel & Sanjay Batra. 2021. Drug Discovery and Drug Development. Drug Discovery and Drug Development 123 158 .
Debarati Mukherjee, Md Yousuf, Somaditya Dey, Sondipon Chakraborty, Ankur Chaudhuri, Vinay Kumar, Biswajyoti Sarkar, Supriya Nath, Aabid Hussain, Aritri Dutta, Tanushree Mishra, Biswajit Gopal Roy, Sushma Singh, Sibani Chakraborty, Susanta Adhikari & Chiranjib Pal. (2020) Targeting the Trypanothione Reductase of Tissue-Residing Leishmania in Hosts’ Reticuloendothelial System: A Flexible Water-Soluble Ferrocenylquinoline-Based Preclinical Drug Candidate . Journal of Medicinal Chemistry 63:24, pages 15621-15638.
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Camila Marques Queiroz, Gevanio Bezerra de Oliveira Filho, José Wanderlan Pontes Espíndola, Amanda Vasconcelos do Nascimento, Amanda Silva dos Santos Aliança, Virginia Maria Barros de Lorena, Ana Paula Sampaio Feitosa, Paula Roberta da Silva, Luiz Carlos Alves, Ana Cristina Lima Leite & Fábio André Brayner. (2020) Thiosemicarbazone and thiazole: in vitro evaluation of leishmanicidal and ultrastructural activity on Leishmania infantum. Medicinal Chemistry Research 29:11, pages 2050-2065.
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Ona Illa, José-Antonio Olivares, Nerea Gaztelumendi, Laura Martínez-Castro, Jimena Ospina, María-Ángeles Abengozar, Giuseppe Sciortino, Jean-Didier Maréchal, Carme Nogués, Míriam Royo, Luis Rivas & Rosa M. Ortuño. (2020) Chiral Cyclobutane-Containing Cell-Penetrating Peptides as Selective Vectors for Anti-Leishmania Drug Delivery Systems. International Journal of Molecular Sciences 21:20, pages 7502.
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Rubem Figueiredo Sadok Menna-Barreto. (2019) Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill. Cell Death & Disease 10:2.
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Vladimir V. Kouznetsov, Carlos M. Meléndez Gómez, José Luis Valencia Peña & Leonor Y. Vargas-Méndez. 2019. Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases. Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases 87 164 .
Erika G. Pinto & Andre G. Tempone. (2018) Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach. Journal of Venomous Animals and Toxins including Tropical Diseases 24:1.
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Yih Ching Ong, Lukasz Kedzierski & Philip C Andrews. (2018) Do bismuth complexes hold promise as antileishmanial drugs?. Future Medicinal Chemistry 10:14, pages 1721-1733.
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SHYAM SUNDAR & ANUP SINGH. (2017) Chemotherapeutics of visceral leishmaniasis: present and future developments. Parasitology 145:4, pages 481-489.
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Róbson Ricardo Teixeira, Poliana Aparecida Rodrigues Gazolla, Adalberto Manoel da Silva, Maria Paula Gonçalves Borsodi, Bartira Rossi Bergmann, Rafaela Salgado Ferreira, Boniek Gontijo Vaz, Géssica Adriana Vasconcelos & Wallace Pacienza Lima. (2018) Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities. European Journal of Medicinal Chemistry 146, pages 274-286.
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Chen Zhang, Sandra Bourgeade Delmas, Álvaro Fernández Álvarez, Alexis Valentin, Catherine Hemmert & Heinz Gornitzka. (2018) Synthesis, characterization, and antileishmanial activity of neutral N-heterocyclic carbenes gold(I) complexes. European Journal of Medicinal Chemistry 143, pages 1635-1643.
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Vanessa Yardley & Markella Koniordou. 2017. Drug Discovery for Leishmaniasis. Drug Discovery for Leishmaniasis 55 76 .
Andrew M. Thompson, Patrick D. O’Connor, Andrew J. Marshall, Vanessa Yardley, Louis Maes, Suman Gupta, Delphine Launay, Stephanie Braillard, Eric Chatelain, Scott G. Franzblau, Baojie Wan, Yuehong Wang, Zhenkun Ma, Christopher B. Cooper & William A. Denny. (2017) 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1- b ][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis . Journal of Medicinal Chemistry 60:10, pages 4212-4233.
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Aya Hefnawy, Maya Berg, Jean-Claude Dujardin & Géraldine De Muylder. (2017) Exploiting Knowledge on Leishmania Drug Resistance to Support the Quest for New Drugs. Trends in Parasitology 33:3, pages 162-174.
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Swati Pund & Amita Joshi. 2017. Nano- and Microscale Drug Delivery Systems. Nano- and Microscale Drug Delivery Systems 439 480 .
M. E. Della Pepa, F. Martora, E. Finamore, M. Vitiello, M. Galdiero & G. Franci. 2017. Nanotechnology Applied To Pharmaceutical Technology. Nanotechnology Applied To Pharmaceutical Technology 307 333 .
Amyra Amat Sain, Azimah Amanah, Zuriati Zahari, Roshan Jahn Mohd Salim, Sharif Mahsufi Mansor & Mohd Ilham Adenan. (2016) (+)-Spectaline, a Piperidine Alkaloid from <i>Senna spectabilis</i> DC. Effective in Reducing the <i>In Vitro</i> Infection of <i>Leishmania major</i>. International Journal of Pharmacology, Phytochemistry and Ethnomedicine 3, pages 1-8.
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Shyam Sundar & Anup Singh. (2016) Recent developments and future prospects in the treatment of visceral leishmaniasis. Therapeutic Advances in Infectious Disease 3:3-4, pages 98-109.
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Helene Djakpa, Aditya Kulkarni, Scheneque Barrows‐Murphy, Greg Miller, Weihong Zhou, Hyejin Cho, Béla Török & Kimberly Stieglitz. (2016) Identifying New Drug Targets for Potent Phospholipase D Inhibitors: Combining Sequence Alignment, Molecular Docking, and Enzyme Activity/Binding Assays. Chemical Biology & Drug Design 87:5, pages 714-729.
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Pankaj K. Singh, Prachi Sah, Jaya Gopal Meher, Sumit Joshi, Vivek K. Pawar, Kavit Raval, Yuvraj Singh, Komal Sharma, Animesh Kumar, Anuradha Dube & Manish K. Chourasia. (2016) Macrophage-targeted chitosan anchored PLGA nanoparticles bearing doxorubicin and amphotericin B against visceral leishmaniasis. RSC Advances 6:75, pages 71705-71718.
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Wagner Pereira, Raphael de Souza Vasconcellos, Christiane Mariotini-Moura, Rodrigo Saar Gomes, Rafaela Firmino, Adalberto da Silva, Abelardo Silva Júnior, Gustavo Bressan, Márcia Almeida, Luís Crocco Afonso, Róbson Teixeira & Juliana Lopes Rangel Fietto. (2015) The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi. Molecules 20:12, pages 22435-22444.
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Nathanial K. Copeland & Naomi E. Aronson. (2015) Leishmaniasis. Current Opinion in Infectious Diseases 28:5, pages 426-437.
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Xiaohua Zhu, Kurt S. Van Horn, Megan M. Barber, Sihyung Yang, Michael Zhuo Wang, Roman Manetsch & Karl A. Werbovetz. (2015) SAR refinement of antileishmanial N2,N4-disubstituted quinazoline-2,4-diamines. Bioorganic & Medicinal Chemistry 23:16, pages 5182-5189.
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Lucie Paloque, Catherine Hemmert, Alexis Valentin & Heinz Gornitzka. (2015) Synthesis, characterization, and antileishmanial activities of gold(I) complexes involving quinoline functionalized N-heterocyclic carbenes. European Journal of Medicinal Chemistry 94, pages 22-29.
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