Advanced search
Publication Cover
Expert Opinion on Investigational Drugs Volume 24, 2015 - Issue 6
Submit an article Journal homepage
461
Views
18
CrossRef citations to date
0
Altmetric
Drug Evaluation

Cebranopadol: a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors

Kinga SałatJagiellonian University, Chair of Pharmacodynamics, Faculty of Pharmacy, Medyczna 9 St., 30-688 Kraków, Poland
,
Anna JakubowskaJagiellonian University, Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Medyczna 9 St., 30-688 Kraków, [email protected]
&
Katarzyna KuligJagiellonian University, Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Medyczna 9 St., 30-688 Kraków, [email protected]
Pages 837-844 | Published online: 12 Apr 2015

Citations (18)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Qiu Qiu, Joshua CJ Chew & Michael G Irwin. (2022) Opioid MOP receptor agonists in late-stage development for the treatment of postoperative pain. Expert Opinion on Pharmacotherapy 23:16, pages 1831-1843.
Read now
Kinga Sałat, Adrian Podkowa, Natalia Malikowska & Jędrzej Trajer. (2017) Effect of pregabalin on fear-based conditioned avoidance learning and spatial learning in a mouse model of scopolamine-induced amnesia. Toxicology Mechanisms and Methods 27:3, pages 181-190.
Read now

Articles from other publishers (16)

Mehar Sanam, Sajda Ashraf, Maria Saeed, Asaad Khalid, Ashraf N. Abdalla, Urooj Qureshi & Zaheer Ul‐Haq. (2023) Cebranopadol: An Assessment for Its Biased Activation Potential at the Mu Opioid Receptor by DFT, Molecular Docking and Molecular Dynamic Simulation Studies. ChemistrySelect 8:37.
Crossref
Flaminia Coluzzi, Laura Rullo, Maria Sole Scerpa, Loredana Maria Losapio, Monica Rocco, Domenico Billeci, Sanzio Candeletti & Patrizia Romualdi. (2022) Current and Future Therapeutic Options in Pain Management: Multi-mechanistic Opioids Involving Both MOR and NOP Receptor Activation. CNS Drugs 36:6, pages 617-632.
Crossref
Daniel Wachtendorf, Marc Schmidtmann & Jens Christoffers. (2020) Improved and Flexible Synthetic Access to the Spiroindole Backbone of Cebranopadol. Organic Letters 22:16, pages 6420-6423.
Crossref
Kinga Sałat. (2020) Chemotherapy-induced peripheral neuropathy—part 2: focus on the prevention of oxaliplatin-induced neurotoxicity. Pharmacological Reports 72:3, pages 508-527.
Crossref
Chiara Ruzza, Victor A. Holanda, Elaine C. Gavioli, Claudio Trapella & Girolamo Calo. (2019) NOP agonist action of cebranopadol counteracts its liability to promote physical dependence. Peptides 112, pages 101-105.
Crossref
Karin Göhler, Marta Sokolowska, Kerri A. Schoedel, Robert Nemeth, Elke Kleideiter, Isabella Szeto & Marie-Henriette Eerdekens. (2019) Assessment of the Abuse Potential of Cebranopadol in Nondependent Recreational Opioid Users. Journal of Clinical Psychopharmacology 39:1, pages 46-56.
Crossref
Thomas M. Tzschentke, Klaus Linz, Thomas Koch & Thomas Christoph. 2019. The Nociceptin/Orphanin FQ Peptide Receptor. The Nociceptin/Orphanin FQ Peptide Receptor 367 398 .
Rafael Maldonado, Josep Eladi Baños & David Cabañero. (2018) Usefulness of knockout mice to clarify the role of the opioid system in chronic pain. British Journal of Pharmacology 175:14, pages 2791-2808.
Crossref
Kinga Sałat, Anna Furgała & Robert Sałat. (2017) Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain. Inflammopharmacology 26:2, pages 361-374.
Crossref
Mohammad Zafar Imam, Andy Kuo, Sussan Ghassabian & Maree T. Smith. (2018) Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology 131, pages 238-255.
Crossref
Klaus LinzWolfgang SchröderStefanie FroschThomas Christoph. (2017) Opioid-type Respiratory Depressant Side Effects of Cebranopadol in Rats Are Limited by Its Nociceptin/Orphanin FQ Peptide Receptor Agonist Activity. Anesthesiology 126:4, pages 708-715.
Crossref
R. B. Raffa, G. Burdge, J. Gambrah, H. E. Kinecki, F. Lin, B. Lu, J. T. Nguyen, V. Phan, A. Ruan, M. A. Sesay & T. N. Watkins. (2017) Cebranopadol: novel dual opioid/NOP receptor agonist analgesic. Journal of Clinical Pharmacy and Therapeutics 42:1, pages 8-17.
Crossref
Richard J. Bodnar. (2017) Endogenous Opiates and Behavior: 2015. Peptides 88, pages 126-188.
Crossref
Zi-Long Wang, Jia-Xin Pan, Jing-Jing Song, Hong-Hai Tang, Hong-Ping Yu, Xu-Hui Li, Ning Li, Ting Zhang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang & Rui Wang. (2016) Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities. Journal of Medicinal Chemistry 59:22, pages 10198-10208.
Crossref
Nurulain T. Zaveri. (2016) Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility. Journal of Medicinal Chemistry 59:15, pages 7011-7028.
Crossref
Norikazu Kiguchi, Huiping Ding & Mei-Chuan Ko. 2016. Pharmacological Mechanisms and the Modulation of Pain. Pharmacological Mechanisms and the Modulation of Pain 217 243 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.