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Expert Opinion on Investigational Drugs Volume 24, 2015 - Issue 2
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Review

Early investigational drugs for hearing loss

Debashree MukherjeaSouthern Illinois University School of Medicine, Department of Surgery, P.O. Box 19629, Springfield, IL 62794-9629, [email protected];Southern Illinois University School of Medicine, Department of Pharmacology and Neuroscience, Springfield, IL, USA
, PhD (Research Assistant Professor) ,
Sumana GhoshSouthern Illinois University School of Medicine, Department of Pharmacology and Neuroscience, Springfield, IL, USA
, MS,
Puspanjali BhattaSouthern Illinois University School of Medicine, Department of Pharmacology and Neuroscience, Springfield, IL, USA
, BS,
Sandeep ShethSouthern Illinois University School of Medicine, Department of Pharmacology and Neuroscience, Springfield, IL, USA
, PhD,
Srinivasan TupalSouthern Illinois University School of Medicine, Department of Pharmacology and Neuroscience, Springfield, IL, USA
, PhD,
Vikrant BorseSouthern Illinois University School of Medicine, Department of Pharmacology and Neuroscience, Springfield, IL, USA
, BS,
Thomas BrozoskiSouthern Illinois University School of Medicine, Department of Surgery, Springfield, IL, USA
, PhD (Professor) ,
Kelly E SheehanSouthern Illinois University School of Medicine, Department of Surgery, Springfield, IL, USA
, MS,
Leonard P RybakSouthern Illinois University School of Medicine, Department of Surgery, Springfield, IL, USA;Professor,Southern Illinois University School of Medicine, Department of Pharmacology, P.O. Box 19649 Springfield, IL 62794-9649, USA
, MD PhD &
Vickram RamkumarSouthern Illinois University School of Medicine, Department of Pharmacology and Neuroscience, PO Box 19629, Springfield, IL, USA
, PhD (Professor) show all
Pages 201-217 | Published online: 22 Sep 2014

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Colleen G. Le Prell. (2023) Preclinical prospects of investigational agents for hearing loss treatment. Expert Opinion on Investigational Drugs 32:8, pages 685-692.
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Articles from other publishers (18)

Phillip M. Uribe, Alexandria M. Hudson, Gavin Lockard, Meiyan Jiang, Joseph Harding, Peter S. Steyger & Allison B. Coffin. (2023) Hepatocyte growth factor mimetic confers protection from aminoglycoside-induced hair cell death in vitro. Hearing Research 434, pages 108786.
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Tamar M. Gordis, Sunny R. Shah, Celine Ward & Habib G. Rizk. (2023) Disease-Modifying Antirheumatic Drugs in the Treatment of Autoimmune Inner Ear Disease: A Systematic Review and Meta-Analysis of Auditory and Vestibular Outcomes. Otology & Neurotology 44:1, pages 2-9.
Crossref
Gia Gill & Brian W. Blakley. (2022) Does N‐acetylcysteine Improve Established Hearing Loss in Guinea Pigs?. OTO Open 6:2.
Crossref
Douglas M. Bennion, Ryan Horne, Adreann Peel, Parker Reineke, Allan Henslee, Christopher Kaufmann, C. Allan Guymon & Marlan R. Hansen. (2021) Zwitterionic Photografted Coatings of Cochlear Implant Biomaterials Reduce Friction and Insertion Forces. Otology & Neurotology 42:10, pages 1476-1483.
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Zhiwei Zheng, Shan Zeng, Chang Liu, Wen Li, Liping Zhao, Chengfu Cai, Guohui Nie & Yingzi He. (2021) The DNA methylation inhibitor RG108 protects against noise-induced hearing loss. Cell Biology and Toxicology 37:5, pages 751-771.
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Peng Wu, Xianmin Wu, Chunhong Zhang, Xiaoyun Chen, Yideng Huang & He Li. (2021) Hair Cell Protection from Ototoxic Drugs. Neural Plasticity 2021, pages 1-9.
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Ryan J. Longenecker, Rende Gu, Jennifer Homan & Jonathan Kil. (2020) A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus. Frontiers in Neuroscience 14.
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Michael Eisenhut. (2019) Evidence Supporting the Hypothesis That Inflammation-Induced Vasospasm Is Involved in the Pathogenesis of Acquired Sensorineural Hearing Loss. International Journal of Otolaryngology 2019, pages 1-15.
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Rick P. C. Cousins. (2019) Medicines discovery for auditory disorders: Challenges for industry. The Journal of the Acoustical Society of America 146:5, pages 3652-3667.
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Yan Yu, Bing Hu, Jianxin Bao, Jessica Mulvany, Eric Bielefeld, Ryan T. Harrison, Sarah A. Neton, Partha Thirumala, Yingying Chen, Debin Lei, Ziyu Qiu, Qingyin Zheng, Jihao Ren, Maria Cristina Perez-Flores, Ebenezer N. Yamoah & Pezhman Salehi. (2018) Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma. Journal of the Association for Research in Otolaryngology 19:6, pages 653-668.
Crossref
Jing Wang & Jean-Luc Puel. (2018) Toward Cochlear Therapies. Physiological Reviews 98:4, pages 2477-2522.
Crossref
Minjin Jeong, Molly O’Reilly, Nerissa K. Kirkwood, Jumana Al-Aama, Majlinda Lako, Corné J. Kros & Lyle Armstrong. (2018) Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells. Cell Death & Disease 9:9.
Crossref
Burhan Balta, Ramazan Gundogdu, Murat Erdogan, Murat Alisik, Aslihan Kiraz, Ibrahim Ozcan & Ozcan Erel. (2018) Decreased disulphide/thiol ratio in patients with autosomal recessive non-syndromic hearing loss. International Journal of Pediatric Otorhinolaryngology 112, pages 188-192.
Crossref
Claus-Peter Richter, Hunter Young, Sonja V. Richter, Virginia Smith-Bronstein, Stuart R. Stock, Xianghui Xiao, Carmen Soriano & Donna S. Whitlon. (2018) Fluvastatin protects cochleae from damage by high-level noise. Scientific Reports 8:1.
Crossref
Samson Jamesdaniel. 2018. Inflammatory Mechanisms in Mediating Hearing Loss. Inflammatory Mechanisms in Mediating Hearing Loss 15 30 .
Arwa Kurabi, Elizabeth M. Keithley, Gary D. Housley, Allen F. Ryan & Ann C.-Y. Wong. (2017) Cellular mechanisms of noise-induced hearing loss. Hearing Research 349, pages 129-137.
Crossref
Anna M. H. Korver, Richard J. H. Smith, Guy Van Camp, Mark R. Schleiss, Maria A. K. Bitner-Glindzicz, Lawrence R. Lustig, Shin-ichi Usami & An N. Boudewyns. (2017) Congenital hearing loss. Nature Reviews Disease Primers 3:1.
Crossref
Xiaodong Tan, Nan Xia & Claus-Peter Richter. 2016. Translational Research in Audiology, Neurotology, and the Hearing Sciences. Translational Research in Audiology, Neurotology, and the Hearing Sciences 219 239 .

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