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Discontinued Drug Perspective

Discontinued drugs in 2012 – 2013: hepatitis C virus infection

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Emanuela Zappulo, Riccardo Scotto, Antonio Riccardo Buonomo, Alberto Enrico Maraolo, Biagio Pinchera & Ivan Gentile. (2020) Efficacy and safety of a fixed dose combination tablet of asunaprevir + beclabuvir + daclatasvir for the treatment of Hepatitis C. Expert Opinion on Pharmacotherapy 21:3, pages 261-273.
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Guglielmo Borgia, Alberto Enrico Maraolo, Salvatore Nappa, Ivan Gentile & Antonio Riccardo Buonomo. (2018) NS5B polymerase inhibitors in phase II clinical trials for HCV infection. Expert Opinion on Investigational Drugs 27:3, pages 243-250.
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Yan A. Ivanenkov, Vladimir A. Aladinskiy, Nikolay A. Bushkov, Andrey A. Ayginin, Alexander G. Majouga & Alexandre V. Ivachtchenko. (2017) Small-molecule inhibitors of hepatitis C virus (HCV) non-structural protein 5A (NS5A): a patent review (2010-2015). Expert Opinion on Therapeutic Patents 27:4, pages 401-414.
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Ivan Gentile, Alberto E. Maraolo, Massimo Niola, Vincenzo Graziano, Guglielmo Borgia & Mariano Paternoster. (2016) Limiting the access to direct-acting antivirals against HCV: an ethical dilemma. Expert Review of Gastroenterology & Hepatology 10:11, pages 1227-1234.
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Ivan Gentile, Riccardo Scotto, Emanuela Zappulo, Antonio Riccardo Buonomo, Biagio Pinchera & Guglielmo Borgia. (2016) Investigational direct-acting antivirals in hepatitis C treatment: the latest drugs in clinical development. Expert Opinion on Investigational Drugs 25:5, pages 557-572.
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Ivan Gentile, Emanuela Zappulo, Antonio Riccardo Buonomo, Riccardo Scotto & Guglielmo Borgia. (2015) Asunaprevir for hepatitis C: a safety evaluation. Expert Opinion on Drug Safety 14:10, pages 1631-1646.
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Ivan Gentile, Emanuela Zappulo, Antonio Riccardo Buonomo, Alberto Enrico Maraolo & Guglielmo Borgia. (2015) Beclabuvir for the treatment of hepatitis C. Expert Opinion on Investigational Drugs 24:8, pages 1111-1121.
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Zhen-Xi Niu, Peng Nie, Piet Herdewijn & Ya-Tao Wang. (2023) Synthetic approaches and application of clinically approved small-molecule drugs to treat hepatitis. European Journal of Medicinal Chemistry 262, pages 115919.
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Serhiy M. Desenko, Mykola Yu. Gorobets, Victoria V. Lipson, Yana I. Sakhno & Valentyn A. Chebanov. (2023) Dihydroazolopyrimidines: Past, Present and Perspectives in Synthesis, Green Chemistry and Drug Discovery. The Chemical Record.
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Tommaso Felicetti, Maria Chiara Pismataro, Violetta Cecchetti, Oriana Tabarrini & Serena Massari. (2022) Triazolopyrimidine Nuclei: Privileged Scaffolds for Developing Antiviral Agents with a Proper Pharmacokinetic Profile. Current Medicinal Chemistry 29:8, pages 1379-1407.
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Helga Rübsamen‐Schaeff & Helmut BuschmannMichael J. Sofia. 2022. New Drug Development for Known and Emerging Viruses. New Drug Development for Known and Emerging Viruses 13 57 .
Bing Gao, Dongdong Zhao, Lingmu Li, Zhigang Cheng & Ye Guo. (2021) Antiviral Peptides with in vivo Activity: Development and Modes of Action . ChemPlusChem 86:12, pages 1547-1558.
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Rahul Kumar, Sahil Mishra, Shreya & Sushil K. Maurya. (2021) Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses. RSC Medicinal Chemistry 12:3, pages 306-320.
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Francesca Picarazzi, Ilaria Vicenti, Francesco Saladini, Maurizio Zazzi & Mattia Mori. (2020) Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge. Molecules 25:23, pages 5695.
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Ratna Karuna, Fumiaki Yokokawa, Keshi Wang, Jin Zhang, Haoying Xu, Gang Wang, Mei Ding, Wai Ling Chan, Nahdiyah Abdul Ghafar, Andrea Leonardi, Cheah Chen Seh, Peck Gee Seah, Wei Liu, Rao P. S. Srinivasa, Siew Pheng Lim, Suresh B. Lakshminarayana, Ellie Growcott, Sreehari Babu, Martijn Fenaux, Weidong Zhong, Feng Gu, Pei-Yong Shi, Francesca Blasco & Yen-Liang Chen. (2020) A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′- C -Methylguanosine for the Treatment of Dengue Virus Infection . Antimicrobial Agents and Chemotherapy 64:12.
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Robert M. Cox, Julien Sourimant, Mart Toots, Jeong-Joong Yoon, Satoshi Ikegame, Mugunthan Govindarajan, Ruth E. Watkinson, Patricia Thibault, Negar Makhsous, Michelle J. Lin, Jose R. Marengo, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, Alexander L. Greninger, Benhur Lee & Richard K. Plemper. (2020) Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase. Nature Microbiology 5:10, pages 1232-1246.
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Hyejin Lee, Dnyandev B. Jarhad, Jinha Yu, Choongho Lee & Lak Shin Jeong. (2019) Asymmetric Synthesis of 2′- C -Methyl-4′-selenonucleosides as Anti-Hepatitis C Virus Agents . The Journal of Organic Chemistry 84:22, pages 14414-14426.
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Takashi Nishiyama, Tominari Kobayashi, Suljid Jirintai, Shigeo Nagashima, Putu Prathiwi Primadharsini, Tsutomu Nishizawa & Hiroaki Okamoto. (2019) Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro. Antiviral Research 170, pages 104570.
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Mary K. Yates & Katherine L. Seley-Radtke. (2019) The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold. Antiviral Research 162, pages 5-21.
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Vaishali M. Patil, Krishnan Balasubramanian & Neeraj Masand. 2019. Viral Polymerases. Viral Polymerases 387 428 .
William J. Watkins. 2019. HCV: The Journey from Discovery to a Cure. HCV: The Journey from Discovery to a Cure 171 191 .
Magdalena Slusarczyk, Michaela Serpi & Fabrizio Pertusati. (2018) Phosphoramidates and phosphonamidates (ProTides) with antiviral activity. Antiviral Chemistry and Chemotherapy 26, pages 204020661877524.
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Williams E. Miranda, Van A. Ngo, Laura L. Perissinotti & Sergei Yu. Noskov. (2017) Computational membrane biophysics: From ion channel interactions with drugs to cellular function. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1865:11, pages 1643-1653.
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Zhinan Jin, April Kinkade, Ishani Behera, Shuvam Chaudhuri, Kathryn Tucker, Natalia Dyatkina, Vivek K. Rajwanshi, Guangyi Wang, Andreas Jekle, David B. Smith, Leo Beigelman, Julian A. Symons & Jerome Deval. (2017) Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs. Antiviral Research 143, pages 151-161.
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Eldar Abdurakhmanov, Sara Øie Solbak & U. Danielson. (2017) Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase. Viruses 9:6, pages 151.
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Guangdi Li & Erik De Clercq. (2017) Current therapy for chronic hepatitis C: The role of direct-acting antivirals. Antiviral Research 142, pages 83-122.
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Mira A. M. Behnam, Christoph Nitsche, Veaceslav Boldescu & Christian D. Klein. (2016) The Medicinal Chemistry of Dengue Virus. Journal of Medicinal Chemistry 59:12, pages 5622-5649.
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Youcef Mehellou. (2016) The ProTides Boom. ChemMedChem 11:11, pages 1114-1116.
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Tatsunori Sato, Kunisuke Izawa, José Luis Aceña, Hong Liu & Vadim A. Soloshonok. (2016) Tailor-Made α-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA). European Journal of Organic Chemistry 2016:16, pages 2757-2774.
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Aki Kawashima, Shuangjie Shu, Ryosuke Takeda, Akie Kawamura, Tatsunori Sato, Hiroki Moriwaki, Jiang Wang, Kunisuke Izawa, Jos? Luis Ace?a, Vadim A. Soloshonok & Hong Liu. (2015) Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base. Amino Acids 48:4, pages 973-986.
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Ivan Gentile & Guglielmo Borgia. (2015) A pill a day keeps HCV away. The Lancet Infectious Diseases 15:6, pages 616-617.
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