Advanced search
Publication Cover
Expert Opinion on Investigational Drugs Volume 3, 1994 - Issue 2
Submit an article Journal homepage
14
Views
27
CrossRef citations to date
0
Altmetric
Research

New quinolones in development

Thomas D Gootz Central Research Division, Pfizer Inc., Eastern Point Road, Groton, Connecticut, 06340, USA
&
Paul R McGuirk Central Research Division, Pfizer Inc., Eastern Point Road, Groton, Connecticut, 06340, USA
Pages 93-114 | Published online: 03 Mar 2008

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Daniel TW Chu. (1996) Section Review Anti-infectives: The future role of quinolones. Expert Opinion on Therapeutic Patents 6:8, pages 711-737.
Read now

Articles from other publishers (26)

Imran Ali, Khaled Sekkoum, Nasser Belboukhari, Mohamed N Rebizi, Mohammed El Amin Zaid, Kareem Yusuf, Asma A Alothman, Bayan A AlJumah & Mohamed Ouladsmane. (2021) Determination of enantio‐separation, absolute configuration and chiral recognition mechanism of ofloxacin and flumequine by HPLC and modeling studies . Journal of Chemical Technology & Biotechnology 96:10, pages 2901-2908.
Crossref
Zeid A. ALOthman, Ahmad Yacine Badjah, Khalid M. Alsheetan, Mohd. Suhail & Imran Ali. (2021) Enantiomeric resolution of quinolones on crown ether CSP: Thermodynamics, chiral discrimination mechanism and application in biological samples. Journal of Chromatography B 1166, pages 122550.
Crossref
Zeid A. ALOthman, Abdullah G. ALanazi, Mohd. Suhail & Imran Ali. (2020) HPLC enantio-separation and chiral recognition mechanism of quinolones on vancomycin CSP. Journal of Chromatography B 1157, pages 122335.
Crossref
Imran Ali, Mohd. Suhail & Leonid Asnin. (2017) Chiral separation of quinolones by liquid chromatography and capillary electrophoresis. Journal of Separation Science 40:14, pages 2863-2882.
Crossref
Ryo Mitsugi, Kyohei Sumida, Yoshiko Fujie, Robert H. Tukey, Tomoo Itoh & Ryoichi Fujiwara. (2016) Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 39:10, pages 1604-1610.
Crossref
Ryoichi Fujiwara, Kyohei Sumida, Yuki Kutsuno, Masaya Sakamoto & Tomoo Itoh. (2015) UDP-glucuronosyltransferase (UGT) 1A1 mainly contributes to the glucuronidation of trovafloxacin. Drug Metabolism and Pharmacokinetics 30:1, pages 82-88.
Crossref
Lester A. Mitscher. (2005) Bacterial Topoisomerase Inhibitors:  Quinolone and Pyridone Antibacterial Agents. Chemical Reviews 105:2, pages 559-592.
Crossref
Michael A. Pfaller & Ronald N. Jones. (2002) Gatifloxacin Phase IV surveillance trial (TeqCES Study) utilizing 5000 primary care physician practices: report of pathogens isolated and susceptibility patterns in community-acquired respiratory tract infections. Diagnostic Microbiology and Infectious Disease 44:1, pages 77-84.
Crossref
Abdullah A Alghasham & Milap C Nahata. (2016) Clinical Use of Fluoroquinolones in Children. Annals of Pharmacotherapy 34:3, pages 347-359.
Crossref
Letizia Brandi, Maurizio Falconi & Sandro Ripa. (2000) Plasmid curing effect of trovafloxacin. FEMS Microbiology Letters 184:2, pages 297-302.
Crossref
J Hamzah, T Skinner-Adams & T.M.E Davis. (2000) In vitro antimalarial activity of trovafloxacin, a fourth-generation fluoroquinolone. Acta Tropica 74:1, pages 39-42.
Crossref
Katherine E. Brighty & Thomas D. Gootz. 2000. The Quinolones. The Quinolones 33 97 .
Franz-Josef Schmitz, Ad C Fluit, Sylvain Brisse, Jan Verhoef, Karl Köhrer & Dana Milatovic. (1999) Molecular epidemiology of quinolone resistance and comparative in vitro activities of new quinolones against European Staphylococcus aureus isolates . FEMS Immunology & Medical Microbiology 26:3-4, pages 281-287.
Crossref
Ronald N Jones, Mondell L Beach, Michael A Pfaller & Gary V Doern. (1998) Antimicrobial activity of gatifloxacin tested against 1676 strains of ciprofloxacin-resistant Gram-positive cocci isolated from patient infections in North and South America. Diagnostic Microbiology and Infectious Disease 32:3, pages 247-252.
Crossref
David C Hooper. (1998) Clinical applications of quinolones. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1400:1-3, pages 45-61.
Crossref
Eugene W.M Ng, Nasrollah Samiy, Kathryn L Ruoff, Felecia V Cousins, David C Hooper, Sylviane von Gunten, Donald J D’Amico & Ann Sullivan Baker. (1998) Treatment of experimental Staphylococcus epidermidis endophthalmitis with oral trovafloxacin. American Journal of Ophthalmology 126:2, pages 278-287.
Crossref
C. Thornsberry. 1998. Quinolone Antibacterials. Quinolone Antibacterials 167 178 .
Y S Kim, Q Liu, L L Chow & M G Täuber. (1997) Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae.. Antimicrobial Agents and Chemotherapy 41:5, pages 1186-1189.
Crossref
T D GootzR ZaniewskiS HaskellB SchmiederJ TankovicD GirardP CourvalinR J Polzer. (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrobial Agents and Chemotherapy 40:12, pages 2691-2697.
Crossref
B. Pod?nyi, G. Kereszt?ri, L. Vasv?ri-Debreczy, I. Hermecz & G. T?th. (1996) An NMR Study of Halogenated 1,4-Dihydro-1-ethyl-4-oxoquinoline-3-carboxylates. Magnetic Resonance in Chemistry 34:11, pages 972-978.
Crossref
Sándor Bátori, Géza Tímári, István Koczka & István Hermecz. (1996) Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro-quinolone-3-carboxylic acids. Bioorganic & Medicinal Chemistry Letters 6:13, pages 1507-1510.
Crossref
Burton H. Jaynes, John P. Dirlam & Scott J. Hecker. 1996. 121 130 .
M. A. Shapiro, J. A. Dever, E. T. Joannides, J. C. Sesnie & S. R. Vanderroest. (1995) In vivo therapeutic efficacies of PD 138312 and PD 140248, two novel fluoronaphthyridines with outstanding gram-positive potency. Antimicrobial Agents and Chemotherapy 39:10, pages 2183-2186.
Crossref
R NauT SchmidtK KayeJ L FroulaM G Täuber. (1995) Quinolone antibiotics in therapy of experimental pneumococcal meningitis in rabbits. Antimicrobial Agents and Chemotherapy 39:3, pages 593-597.
Crossref
John P. Dirlam, Burton H. Jaynes & Martin R. Jefson. 1995. 101 110 .
Thomas D. Gootz, Katherine E. Brighty, Marge R. Anderson, Brenda J. Schmieder, Suzanne L. Haskell, Joyce A. Sutcliffe, Michael J. Castaldi & Paul R. McGuirk. (1994) In vitro activity of CP-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl) naphthyridone antimicrobial. Diagnostic Microbiology and Infectious Disease 19:4, pages 235-243.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.