Advanced search
Publication Cover
Expert Opinion on Investigational Drugs Volume 4, 1995 - Issue 11
Submit an article Journal homepage
47
Views
53
CrossRef citations to date
0
Altmetric
Research Article

Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases

Jean-Claude Stoclet Laboratoire de Pharmacologie et de Physiopathologie Cellulaires, Université Louis Pasteur de Strasbourg, Faculté de Pharmacie, CNRS, URA 600, BP 24, F-67401, Illkirch, France
,
Thérèse Keravis Laboratoire de Pharmacologie et de Physiopathologie Cellulaires, Université Louis Pasteur de Strasbourg, Faculté de Pharmacie, CNRS, URA 600, BP 24, F-67401, Illkirch, France
,
Narcisse Komas Laboratoire de Pharmacologie et de Physiopathologie Cellulaires, Université Louis Pasteur de Strasbourg, Faculté de Pharmacie, CNRS, URA 600, BP 24, F-67401, Illkirch, France
&
Claire Lugnier Laboratoire de Pharmacologie et de Physiopathologie Cellulaires, Université Louis Pasteur de Strasbourg, Faculté de Pharmacie, CNRS, URA 600, BP 24, F-67401, Illkirch, France
Pages 1081-1100 | Published online: 03 Mar 2008

Citations (53)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Arooma Maryam, Rana Rehan Khalid, Abdul Rauf Siddiqi & Abdulilah Ece. (2021) E-pharmacophore based virtual screening for identification of dual specific PDE5A and PDE3A inhibitors as potential leads against cardiovascular diseases. Journal of Biomolecular Structure and Dynamics 39:7, pages 2302-2317.
Read now
Takao Saeki & Yasutaka Takase. (1996) Section Review Cardiovascular & Renal: Phosphodiesterase 5 inhibitors in development for cardiovascular therapy. Expert Opinion on Investigational Drugs 5:11, pages 1477-1486.
Read now

Articles from other publishers (51)

Claire Lugnier. (2022) The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches. International Journal of Molecular Sciences 23:18, pages 10616.
Crossref
Aniella Abi-Gerges, Liliana Castro, Jérôme Leroy, Valérie Domergue, Rodolphe Fischmeister & Grégoire Vandecasteele. (2021) Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy. Journal of Molecular and Cellular Cardiology 150, pages 109-121.
Crossref
Jes?s Hernandez-Cascales. (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ 5, pages e3113.
Crossref
Michael Gralinski, Liomar A. A. Neves & Olga Tiniakova. 2016. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 645 663 .
François Clauss, Anne Charloux, François Piquard, Stéphane Doutreleau, Samy Talha, Joffrey Zoll, Claire Lugnier & Bernard Geny. (2015) Angiotensin-converting enzyme inhibition prevents myocardial infarction-induced increase in renal cortical cGMP and cAMP phosphodiesterase activities. Fundamental & Clinical Pharmacology 29:4, pages 352-361.
Crossref
Michael Gralinski, Liomar A. A. Neves & Olga Tiniakova. 2014. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1 22 .
Carolina Otero, Juan P. Peñaloza, Paula I. Rodas, Ricardo Fernández-Ramires, Luis Velasquez & Juan E. Jung. (2014) Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases. Fundamental & Clinical Pharmacology 28:6, pages 593-607.
Crossref
Shailesh R. Agarwal, Pei-Chi Yang, Monica Rice, Cherie A. Singer, Viacheslav O. Nikolaev, Martin J. Lohse, Colleen E. Clancy & Robert D. Harvey. (2014) Role of Membrane Microdomains in Compartmentation of cAMP Signaling. PLoS ONE 9:4, pages e95835.
Crossref
Martyn J. Earle, Marco No?Alvise Perosa & Kenneth R. Seddon. (2014) Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids. RSC Adv. 4:3, pages 1204-1211.
Crossref
Maria P. Giovannoni, Alessia Graziano, Rosanna Matucci, Marta Nesi, Nicoletta Cesari, Claudia Vergelli, Claudio Biancalani, Letizia Crocetti, Agostino Cilibrizzi & Vittorio Dal Piaz. (2011) Synthesis and evaluation as PDE4 inhibitors of pyrimidine-2,4-dione derivatives. Drug Development Research 72:3, pages 274-288.
Crossref
Sen Xiao, Xiao-Xin Shi, Feng Ni, Jing Xing, Jing-Jing Yan & Shi-Ling Liu. (2010) An Efficient and General Method for the Stereodivergent Syntheses of Tadalafil-Like Tetracyclic Compounds. European Journal of Organic Chemistry 2010:9, pages 1711-1716.
Crossref
Rima Tahseldar-Roumieh, Th?r?se Keravis, Suha Maarouf, H?l?ne Justiniano, Ramzi Sabra & Claire Lugnier. (2009) PDEs1-5 activity and expression in tissues of cirrhotic rats reveal a role for aortic PDE3 in NO desensitization. International Journal of Experimental Pathology 90:6, pages 605-614.
Crossref
Aniella Abi-GergesWito RichterFlorence LefebvrePhilippe MateoAudrey VarinChristophe HeymesJane-Lise SamuelClaire LugnierMarco ContiRodolphe FischmeisterGrégoire Vandecasteele. (2009) Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals. Circulation Research 105:8, pages 784-792.
Crossref
Roberta L. Gonçalves, Claire Lugnier, Thérèse Keravis, Miguel J. Lopes, Fernando A. Fantini, Martine Schmitt, Steyner F. Cortes & Virginia S. Lemos. (2009) The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue. European Journal of Pharmacology 620:1-3, pages 78-83.
Crossref
Sen Xiao, Xiao-Xin Shi, Jing Xing, Jing-Jing Yan, Shi-Ling Liu & Wei-Dong Lu. (2009) Synthesis of tadalafil (Cialis) from l-tryptophan. Tetrahedron: Asymmetry 20:18, pages 2090-2096.
Crossref
Radu V. Iancu, Stephen W. Jones & Robert D. Harvey. (2007) Compartmentation of cAMP Signaling in Cardiac Myocytes: A Computational Study. Biophysical Journal 92:9, pages 3317-3331.
Crossref
Hans Gerhard Vogel. 2008. Drug Discovery and Evaluation. Drug Discovery and Evaluation 47 391 .
Dmitri Pissarnitski. (2006) Phosphodiesterase 5 (PDE 5) inhibitors for the treatment of male erectile disorder: Attaining selectivity versus PDE6. Medicinal Research Reviews 26:3, pages 369-395.
Crossref
Francesca RochaisAniella Abi-GergesKathleen HornerFlorence LefebvreDermot M.F. CooperMarco ContiRodolphe FischmeisterGrégoire Vandecasteele. (2006) A Specific Pattern of Phosphodiesterases Controls the cAMP Signals Generated by Different G s -Coupled Receptors in Adult Rat Ventricular Myocytes . Circulation Research 98:8, pages 1081-1088.
Crossref
Claire Lugnier. (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacology & Therapeutics 109:3, pages 366-398.
Crossref
Ezequiel Álvarez, Manuel Campos-Toimil, Hélène Justiniano-Basaran, Claire Lugnier & Francisco Orallo. (2006) Study of the mechanisms involved in the vasorelaxation induced by (−)-epigallocatechin-3-gallate in rat aorta. British Journal of Pharmacology 147:3, pages 269-280.
Crossref
Danish SaleheenShabbar BukhariShajjia Razi HaiderAisha NazirShaheen KhanumSaad ShafqatM. Kashif AnisPhilippe Frossard. (2005) Association of Phosphodiesterase 4D Gene With Ischemic Stroke in a Pakistani Population . Stroke 36:10, pages 2275-2277.
Crossref
Yang Xiang, Fabio Naro, Maria Zoudilova, S.-L. Catherine Jin, Marco Conti & Brian Kobilka. (2005) Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes . Proceedings of the National Academy of Sciences 102:3, pages 909-914.
Crossref
Francesca Rochais, Grégoire Vandecasteele, Florence Lefebvre, Claire Lugnier, Hazel Lum, Jean-Luc Mazet, Dermot M.F. Cooper & Rodolphe Fischmeister. (2004) Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes. Journal of Biological Chemistry 279:50, pages 52095-52105.
Crossref
Francisco Orallo, Ezequiel �lvarez, H�l�ne Basaran & Claire Lugnier. (2004) Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin. Naunyn-Schmiedeberg's Archives of Pharmacology 370:6, pages 452-463.
Crossref
Olivier Pauvert, Sébastien Bonnet, Eric Rousseau, Roger Marthan & Jean-Pierre Savineau. (2004) Sildenafil alters calcium signaling and vascular tone in pulmonary arteries from chronically hypoxic rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 287:3, pages L577-L583.
Crossref
Steffen Birk, Lars Edvinsson, Jes Olesen & Christina Kruuse. (2004) Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries. European Journal of Pharmacology 489:1-2, pages 93-100.
Crossref
J. Jurevicius, V A. Skeberdis & R. Fischmeister. (2003) Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following  2-adrenergic stimulation of ICa,L in frog ventricular myocytes. The Journal of Physiology 551:1, pages 239-252.
Crossref
Jonas Jurevicius, V. Arvydas Skeberdis & Rodolphe Fischmeister. (2003) Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes. The Journal of Physiology 551:1, pages 239-252.
Crossref
Marie Georget, Philippe Mateo, Grégoire Vandecasteele, Larissa Lipskaia, Nicole Defer, Jacques Hanoune, Jacqueline Hoerter, Claire Lugnier & Rodolphe Fischmeister. (2003) Cyclic AMP compartmentation due to increased cAMP‐phosphodiesterase activity in transgenic mice with a cardiac‐directed expression of the human adenylyl cyclase type 8 (AC8). The FASEB Journal 17:11, pages 1380-1391.
Crossref
O Pauvert, C Lugnier, T Keravis, R Marthan, E Rousseau & J P Savineau. (2003) Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery. British Journal of Pharmacology 139:3, pages 513-522.
Crossref
Laure Favot, Thérèse Keravis, Vincent Holl, Alain Bec & Claire Lugnier. (2017) VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors. Thrombosis and Haemostasis 90:08, pages 334-343.
Crossref
Christina Kruuse, Lars Lykke Thomsen, Torsten Bjørn Jacobsen & Jes Olesen. (2016) The Phosphodiesterase 5 Inhibitor Sildenafil Has No Effect on Cerebral Blood Flow or Blood Velocity, but Nevertheless Induces Headache in Healthy Subjects. Journal of Cerebral Blood Flow & Metabolism 22:9, pages 1124-1131.
Crossref
O. Pauvert, D. Salvail, E. Rousseau, C. Lugnier, R. Marthan & J.P. Savineau. (2002) Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery. Biochemical Pharmacology 63:9, pages 1763-1772.
Crossref
P. Schmidt, K. P. Jünemann, H. Derouet, W. H. Jost, S. Ückert, A. Küthe, C. G. Stief, G. Popken, U. Wetterauer, H. M. Behre, U. Hartmann, W. F. Thon & A. Thon. 2002. Zeitgemäße Therapie der erektilen Dysfunktion. Zeitgemäße Therapie der erektilen Dysfunktion 13 101 .
Fabrice Morin, Claire Lugnier, Jacques Kameni & Pierre Voisin. (2001) Expression and role of phosphodiesterase 6 in the chicken pineal gland. Journal of Neurochemistry 78:1, pages 88-99.
Crossref
Grégoire Vandecasteele, Ignacio Verde, Catherine Rücker‐Martin, Patrick Donzeau‐Gouge & Rodolphe Fischmeister. (2001) Cyclic GMP regulation of the L‐type Ca 2+ channel current in human atrial myocytes . The Journal of Physiology 533:2, pages 329-340.
Crossref
Christina Kruuse, Sergei D Rybalkin, Tejvir S Khurana, Inger Jansen-Olesen, Jes Olesen & Lars Edvinsson. (2001) The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation. European Journal of Pharmacology 420:1, pages 55-65.
Crossref
ANDREA K?THE, ANDREA WIEDENROTH, HANS-J?RGEN M?GERT, STEFAN ?CKERT, WOLF G. FORSSMANN, CHRISTIAN G. STIEF & UDO JONAS. (2001) EXPRESSION OF DIFFERENT PHOSPHODIESTERASE GENES IN HUMAN CAVERNOUS SMOOTH MUSCLE. The Journal of Urology 165:1, pages 280-283.
Crossref
Miles D Houslay. 2001. 249 315 .
Claire Lugnier. 2001. Diabetes and Cardiovascular Disease. Diabetes and Cardiovascular Disease 253 261 .
Piotr Musialek, Lauren Rigg, Derek A. Terrar, David J. Paterson & Barbara Casadei. (2000) Role of cGMP-inhibited Phosphodiesterase and Sarcoplasmic Calcium in Mediating the Increase in Basal Heart Rate with Nitric Oxide Donors. Journal of Molecular and Cellular Cardiology 32:10, pages 1831-1840.
Crossref
Hammed A. Olanrewaju & S.Jamal Mustafa. (2000) Adenosine A2A and A2B receptors mediated nitric oxide production in coronary artery endothelial cells. General Pharmacology: The Vascular System 35:3, pages 171-177.
Crossref
Claire Lugnier, Th?r?se Keravis, Alain Le Bec, Olivier Pauvert, Sonia Proteau & Eric Rousseau. (1999) Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei. Biochimica et Biophysica Acta (BBA) - General Subjects 1472:3, pages 431-446.
Crossref
Mylène Côté, Marcel Daniel Payet, Eric Rousseau, Gilles Guillon & Nicole Gallo-Payet. (1999) Comparative Involvement of Cyclic Nucleotide Phosphodiesterases and Adenylyl Cyclase on Adrenocorticotropin-Induced Increase of Cyclic Adenosine Monophosphate in Rat and Human Glomerulosa Cells*. Endocrinology 140:8, pages 3594-3601.
Crossref
Ignacio Verde, Grégoire Vandecasteele, Frank Lezoualc'h & Rodolphe Fischmeister. (1999) Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L-type Ca 2+ current in rat ventricular myocytes . British Journal of Pharmacology 127:1, pages 65-74.
Crossref
Andrea K?the, Heike Eckel, Christian G. Stief, Stefan ?ckert, Wolf G. Forssmann, Udo Jonas & Hans J. M?gert. (1999) Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum. Chemico-Biological Interactions 119-120, pages 593-598.
Crossref
Fukuichi Ohsawa, Miki Yamauchi, Hiroshi Nagaso, Shoichi Murakami, Jun Baba & Aiko Sawa. (1998) Inhibitory Effects of Rolipram on Partially Purified Phosphodiesterase 4 From Rat Brains. Japanese Journal of Pharmacology 77:2, pages 147-154.
Crossref
Nobuyuki Yamashita, Miki Yamauchi, Jun Baba & Aiko Sawa. (1997) Phosphodiesterase type 4 that regulates cAMP level in cortical neurons shows high sensitivity to rolipram. European Journal of Pharmacology 337:1, pages 95-102.
Crossref
Pierre-Fran?ois M?ry, Najah Abi-Gerges, Gr?goire Vandecasteele, Jonas Jurevicius, Thomas Eschenhagen & Rodolphe Fischmeister. (1997) Muscarinic regulation of the L-type calcium current in isolated cardiac myocytes. Life Sciences 60:13-14, pages 1113-1120.
Crossref
Yamashita Nobuyuki, Miyashiro Mio, Baba Jun & Sawa Aiko. (1997) Rolipram, a Selective Inhibitor of Phosphodiesterase Type 4, Pronouncedly Enhanced the Forskolin-Induced Promotion of Dopamine Biosynthesis in Primary Cultured Rat Mesencephalic Neurons. Japanese Journal of Pharmacology 75:1, pages 91-95.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.