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Original Article

Leading Article: Oncologic, Endocrine & Metabolic: New antimetabolites in preclinical and clinical development

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Pages 637-679 | Published online: 03 Mar 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Godefridus J Peters & Richard J Honeywell. (2015) Drug transport and metabolism of novel anticancer drugs. Expert Opinion on Drug Metabolism & Toxicology 11:5, pages 661-663.
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IreneV. Bijnsdorp, RetoA. Schwendener, Herbert Schott, Iduna Fichtner, Kees Smid, Sarah Schott, AdrieC. Laan & GodefridusJ. Peters. (2007) In Vivo and in Vitro Activity And Mechanism Of Action of the Multidrug Cytarabine-L-Glycerylyl-Fluorodeoxyuridine. Nucleosides, Nucleotides & Nucleic Acids 26:10-12, pages 1619-1624.
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R. Honeywell, C.J. van Groeningen, A.C. Laan, E. Strocchi, R. Ruiter, G. Giaccone & G.J. Peters. (2006) Analysis of Deoxycytidine Accumulation in Gemcitabine Treated Patients. Nucleosides, Nucleotides & Nucleic Acids 25:9-11, pages 1225-1232.
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I. Hubeek, G. J. Peters, A. J. F. Broekhuizen, I. Talianidis, A. Y. N. Schouten van Meeteren, E. R. van Wering, B. Gibson, U. Creutzig & G. J. L. Kaspers. (2004) Immunocytochemical Detection of Deoxycytidine Kinase in Pediatric Malignancies in Relation to In Vitro Cytarabine Sensitivity. Nucleosides, Nucleotides & Nucleic Acids 23:8-9, pages 1351-1356.
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Selvaraj Kunjiappan, Panneerselvam Theivendran, Suraj Baskararaj, Bathrinath Sankaranarayanan, Ponnusamy Palanisamy, Govindaraj Saravanan, Sankarganesh Arunachalam, Murugesan Sankaranarayanan, Jawahar Natarajan, Balasubramanian Somasundaram & Ashish Wadhwani. (2019) Modeling a pH-sensitive Zein-co-acrylic acid hybrid hydrogels loaded 5-fluorouracil and rutin for enhanced anticancer efficacy by oral delivery. 3 Biotech 9:5.
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R. Martino, V. Gilard & M. Malet-Martino. 2008. NMR Spectroscopy in Pharmaceutical Analysis. NMR Spectroscopy in Pharmaceutical Analysis 369 406 .
J. Sigmond, J.A.E. Kamphuis, A.C. Laan, E.K. Hoebe, A.M. Bergman & G.J. Peters. (2007) The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent. Biochemical Pharmacology 73:10, pages 1548-1557.
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Myriam Malet-Martino, Véronique Gilard, Franck Desmoulin & Robert Martino. (2006) Fluorine nuclear magnetic resonance spectroscopy of human biofluids in the field of metabolic studies of anticancer and antifungal fluoropyrimidine drugs. Clinica Chimica Acta 366:1-2, pages 61-73.
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Stephen G. Divers, Sharon A. Spencer, Delicia Carey, Elizabeth M. Busby, Mark D. Hyatt & Francisco Robert. (2005) Phase I/IIa Study of Cisplatin and Gemcitabine As Induction Chemotherapy Followed by Concurrent Chemoradiotherapy With Gemcitabine and Paclitaxel for Locally Advanced Non–Small-Cell Lung Cancer. Journal of Clinical Oncology 23:27, pages 6664-6673.
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Robert Martino, Véronique Gilard, Franck Desmoulin & Myriam Malet-Martino. (2005) Fluorine-19 or phosphorus-31 NMR spectroscopy: A suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs. Journal of Pharmaceutical and Biomedical Analysis 38:5, pages 871-891.
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Jean-François Rosier, Monique Bruniaux, Bernard Husson, Michelle Octave-Prignot, Marc Beauduin & Vincent Grégoire. (2004) Role of 2′-2′ difluorodeoxycytidine (gemcitabine)-induced cell cycle dysregulation in radio-enhancement of human head and neck squamous cell carcinomas. Radiotherapy and Oncology 70:1, pages 55-61.
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G. J. Peters, P. Noordhuis, A. B. P. Van Kuilenburg, J. H. Schornagel, H. Gall, S. L. Turner, M. S. Swart, D. Voorn, A. H. Van Gennip, J. Wanders, U. Holwerda, K. Smid, G. Giaccone, P. Fumoleau & C. J. Van Groeningen. (2003) Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors. Cancer Chemotherapy and Pharmacology 52:1, pages 1-12.
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Jean-François Rosier, Lucienne Michaux, Geneviève Ameye, Björn Cedervall, Jeanne-Marie Libouton, Michèle Octave-Prignot, Christine Verellen-Dumoulin, Pierre Scalliet & Vincent Grégoire. (2003) The radioenhancement of two human head and neck squamous cell carcinomas by 2′-2′ difluorodeoxycytidine (gemcitabine; dFdC) is mediated by an increase in radiation-induced residual chromosome aberrations but not residual DNA DSBs. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 527:1-2, pages 15-26.
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Richard I. Christopherson, Stephen D. Lyons & Paul K. Wilson. (2002) Inhibitors of de Novo Nucleotide Biosynthesis as Drugs. Accounts of Chemical Research 35:11, pages 961-971.
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H Oettle, D Arnold, M Kern, N Hoepffner, U Settmacher, P Neuhaus & H Riess. (2002) Phase I study of gemcitabine in combination with cisplatin, 5-fluorouracil and folinic acid in patients with advanced esophageal cancer. Anti-Cancer Drugs 13:8, pages 833-838.
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M. Malet-Martino & R. Martino. (2002) Clinical Studies of Three Oral Prodrugs of 5-Fluorouracil (Capecitabine, UFT, S-1): A Review. The Oncologist 7:4, pages 288-323.
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Vincent Grégoire, Jean-François Rosier, Marc De Bast, Monique Bruniaux, Blanche De Coster, Michelle Octave-Prignot & Pierre Scalliet. (2002) Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro. Radiotherapy and Oncology 63:3, pages 329-338.
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Barton A. Kamen & Peter Cole. 2002. Encyclopedia of Cancer. Encyclopedia of Cancer 235 241 .
Jennifer Sigmond, Harold H. J. Backus, Dorine Wouters, Gerrit Jansen & Godefridus J. Peters. 2002. Chemistry and Biology of Pteridines and Folates. Chemistry and Biology of Pteridines and Folates 473 477 .
Harold H.J. Backus, Dirube Wouters, Clasina L. Van Der Wilt, Catherina M. Kuiper, Cees J. Van Groeningen, Herbert, M. Pinedo & Godefridus J. Peters. 2002. Purine and Pyrimidine Metabolism in Man X. Purine and Pyrimidine Metabolism in Man X 303 306 .
H.H.J. Backus, D.F. Dukers, C.J. van Groeningen, W. Vos, E. Bloemena, D. Wouters, J.M.G.H. van Riel, K. Smid, G. Giaccone, H.M. Pinedo & G.J. Peters. (2001) 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. Annals of Oncology 12:2, pages 209-216.
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Stephen J. Clarke, Philip J. Beale & Laurent P. Rivory. (2000) Clinical and Preclinical Pharmacokinetics of Raltitrexed. Clinical Pharmacokinetics 39:6, pages 429-443.
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A.M. Bergman, G. Giaccone, C.J.A. van Moorsel, R. Mauritz, P. Noordhuis, H.M. Pinedo & G.J. Peters. (2000) Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs. European Journal of Cancer 36:15, pages 1974-1983.
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H.H.J. Backus, H.M. Pinedo, D. Wouters, J.M. Padrón, N. Molders, C.L. van der Wilt, C.J. van Groeningen, G. Jansen & G.J. Peters. (2000) Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates. International Journal of Cancer 87:6, pages 771-778.
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G.J. Peters, C.L. van der Wilt, C.J.A. van Moorsel, J.R. Kroep, A.M. Bergman & S.P. Ackland. (2000) Basis for effective combination cancer chemotherapy with antimetabolites. Pharmacology & Therapeutics 87:2-3, pages 227-253.
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Baukelien Van Triest, Barbara M. Loftus, Herbert M. Pinedo, Harold H.J. Backus, Pascale Schoenmakers, Frank Telleman, Thea Tadema, G. Wynne Aherne, Cornelius J. Van Groeningen, Frans A.N. Zoetmulder, Babs G. Taal, Patrick G. Johnston & Godefridus J. Peters. (2016) Thymidylate Synthase Expression in Patients with Colorectal Carcinoma Using a Polyclonal Thymidylate Synthase Antibody in Comparison to the TS 106 Monoclonal Antibody. Journal of Histochemistry & Cytochemistry 48:6, pages 755-760.
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J.R. Kroep, G.J. Peters, C.J.A. van Moorsel, A. Çatik, J.B. Vermorken, H.M. Pinedo & C.J. van Groeningen. (1999) Gemcitabine–cisplatin: A schedule finding study. Annals of Oncology 10:12, pages 1503-1510.
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A. Hughes & H. Calvert. (1999) An update on thymidylate synthase inhibitors. Annals of Oncology 10:10, pages 1137-1139.
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Stephen P. Ackland & Godefridus J. Peters. (1999) Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs. Drug Resistance Updates 2:4, pages 205-214.
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Judith R. KroepGiuseppe GiacconeDaphne A. VoornEgbert F. SmitJos H. BeijnenHilde RosingCatharina J.A. van MoorselCornelis J. van GroeningenPieter E. PostmusHerbert M. PinedoGodefridus J. Peters. (1999) Gemcitabine and Paclitaxel: Pharmacokinetic and Pharmacodynamic Interactions in Patients With Non–Small-Cell Lung Cancer. Journal of Clinical Oncology 17:7, pages 2190-2190.
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J.R. Kroep, H.M. Pinedo, C.J. van Groeningen & G.J. Peters. (1999) Experimental drugs and drug combinations in pancreatic cancer. Annals of Oncology 10, pages S234-S238.
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G. J. Peters & C. H. Köhne. 1999. Antifolate Drugs in Cancer Therapy. Antifolate Drugs in Cancer Therapy 101 145 .
Stephen P. Ackland & Rosemary Kimbell. 1999. Antifolate Drugs in Cancer Therapy. Antifolate Drugs in Cancer Therapy 365 382 .
G. Jansen. 1999. Antifolate Drugs in Cancer Therapy. Antifolate Drugs in Cancer Therapy 293 321 .
Gerrit Jansen, Robert Mauritz, Stavit Drori, Hannah Sprecher, Ietje Kathmann, Marlene Bunni, David G. Priest, Paul Noordhuis, Jan H. Schornagel, Herbert M. Pinedo, Godefridus J. Peters & Yehuda G. Assaraf. (1998) A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance. Journal of Biological Chemistry 273:46, pages 30189-30198.
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Gerrit Jansen & Rob Pieters. (1998) The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates. Drug Resistance Updates 1:3, pages 211-218.
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Balu N. Balasubramanian, John F. Kadow, Robert A. Kramer & Dolatrai M. Vyas. 1998. 151 162 .
G. J. Peters, C. J. van Groeningen & H. M. Pinedo. 1998. Purine and Pyrimidine Metabolism in Man IX. Purine and Pyrimidine Metabolism in Man IX 633 636 .
Herbert M Pinedo & Giuseppe Giaccone. (1997) Chemotherapy. The Lancet 349, pages S7-S9.
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Gerrit Jansen, Robert M. Mauritz, Yehuda G. Assaraf, Hannah Sprecher, Stavit Drori, Ietje Kathmann, G.Robbin Westerhof, David G. Priest, Marlene Bunni, Herbert M. Pinedo, Jan H. Schornagel & Godefridus J. Peters. (1997) Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells. Advances in Enzyme Regulation 37, pages 59-76.
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