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Expert Opinion on Investigational Drugs Volume 7, 1998 - Issue 11
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Drug Evaluation

Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure

Kenneth Dickstein Cardiology Division, Central Hospital in Rogaland, Stavanger, Norway.
,
Pieter Timmermans Tularic Inc., South San Francisco, CA, USA & Merck Research Laboratories, Merck & Co., Inc., West Point, PA, USA.
&
Robert Segal Merck Research Laboratories, Merck & Co., Inc., West Point, PA, USA.
Pages 1897-1914 | Published online: 23 Feb 2005

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Chiara Delli Gatti, Elena Osto, Alexei Kouroedov, Masato Eto, Sidney Shaw, Massimo Volpe, Thomas F. Lüscher & Francesco Cosentino. (2008) Pulsatile Stretch Induces Release of Angiotensin II and Oxidative Stress in Human Endothelial Cells: Effects of ACE Inhibition and AT1 Receptor Antagonism. Clinical and Experimental Hypertension 30:7, pages 616-627.
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Articles from other publishers (22)

Yuanqiang Li, Boyu Li, Wei-Dong Chen & Yan-Dong Wang. (2023) Role of G-protein coupled receptors in cardiovascular diseases. Frontiers in Cardiovascular Medicine 10.
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Marta Kantauskaite, Anna Hucke, Beatrice Snieder & Giuliano Ciarimboli. (2022) Exacerbation of Cisplatin Cellular Toxicity by Regulation of the Human Organic Cation Transporter 2 through Angiotensin II. International Journal of Molecular Sciences 23:24, pages 15866.
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Maurizio D'Auria, Rocco Racioppi & Licia Viggiani. (2022) Regioselectivity of [3+2] Cycloadditions of Heteroaryl Azides and Ethyl‐Vinyl Ether. ChemistrySelect 7:17.
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Safendra Siregar, Rulianov Rulianov, Rangga Adhazi Ksatriapraja & Dicky Stefanus. (2023) The role of angiotensin receptor blocker (losartan) on decreasing fibrotic process of corpora cavernosa in priapism model of wistar rats. F1000Research 11, pages 831.
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Safendra Siregar, Rulianov Rulianov, Rangga Adhazi Ksatriapraja & Dicky Stefanus. (2022) The role of angiotensin receptor blocker (losartan) on decreasing fibrotic process of corpora cavernosa in priapism model of wistar rats. F1000Research 11, pages 831.
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Israel Ramirez-Sanchez, Christina Mansour, Viridiana Navarrete-Yañez, Marcos Ayala-Hernandez, Gustavo Guevara, Carmen Castillo, Maria Loredo, Moises Bustamante, Guillermo Ceballos & Francisco J. Villarreal. (2018) (−)-Epicatechin induced reversal of endothelial cell aging and improved vascular function: underlying mechanisms. Food & Function 9:9, pages 4802-4813.
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Glen Stephen Patten & Mahinda Yapa Abeywardena. (2017) Effects of Antihypertensive Agents on Intestinal Contractility in the Spontaneously Hypertensive Rat: Angiotensin Receptor System Downregulation by Losartan. Journal of Pharmacology and Experimental Therapeutics 360:2, pages 260-266.
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Anselmo Gomes Moura, Washington Pires, Laura Hora Rios Leite, Daise Nunes Queiroz da Cunha, Tiago Peçanha, Jorge Roberto Peurrot de Lima, Antônio José Natali & Thales Nicolau Prímola-Gomes. (2016) Power spectrum analysis of cardiovascular variability during passive heating in conscious rats. Journal of Thermal Biology 62, pages 20-29.
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Maryam Hachem, Mario Tiberi, Basma Ismail, Chad R. Hunter, Natasha Arksey, Tayebeh Hadizad, Rob S. Beanlands, Robert A. deKemp & Jean N. DaSilva. (2016) Characterization of 18 F-FPyKYNE-Losartan for Imaging AT 1 Receptors . Journal of Nuclear Medicine 57:10, pages 1612-1617.
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Jacek Kujawski, Kornelia Czaja, Tomasz Ratajczak, Elżbieta Jodłowska & Marcin Chmielewski. (2015) Investigations on Synperiplanar and Antiperiplanar Isomers of Losartan: Theoretical and Experimental NMR Studies. Molecules 20:7, pages 11875-11890.
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Nageswar Rao Challa, Balaji Mamidisetty, Mahesh Reddy Ghanta & Pratap Reddy Padi. (2014) Synthesis and pharmacological evaluation of 5-[2′-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine derivatives as platelet aggregation inhibitors. Journal of Saudi Chemical Society 18:5, pages 513-519.
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Adriana Farias Silva, Erick Leite Bastos, Marcelo Der Torossian Torres, André Luis Costa-da-Silva, Rafaella Sayuri Ioshino, Margareth Lara Capurro, Flávio Lopes Alves, Antonio Miranda, Renata de Freitas Fischer Vieira & Vani Xavier OliveiraJr.Jr.. (2014) Antiplasmodial activity study of angiotensin II via Ala scan analogs. Journal of Peptide Science 20:8, pages 640-648.
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Maria Zervou, Zoe Cournia, Constantinos Potamitis, George Patargias, Serdar Durdagi, Simona Golic Grdadolnik & Thomas Mavromoustakos. (2014) Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:3, pages 1031-1046.
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S. Madan Kumar, B. C. Manjunath, G. S. Lingaraju, M. M. M. Abdoh, M. P. Sadashiva & N. K. Lokanath. (2013) A Hirshfeld Surface Analysis and Crystal Structure of 2’-[1-(2-Fluoro-Phenyl)-1H-tetrazol-5-Yl]-4-Methoxy-Biphenyl-2-Carbaldehyde. Crystal Structure Theory and Applications 02:03, pages 124-131.
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Xinying Zhang, Xuefei Jia, Liangliang Fang, Nan Liu, Jianji Wang & Xuesen Fan. (2011) Tandem Reactions of 1,2-Allenic Ketones Leading to Substituted Benzenes and α,β-Unsaturated Nitriles. Organic Letters 13:19, pages 5024-5027.
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Stefan Bräse, Carmen Gil, Kerstin Knepper & Viktor Zimmermann. (2005) Organic Azides: An Exploding Diversity of a Unique Class of Compounds. Angewandte Chemie International Edition 44:33, pages 5188-5240.
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Stefan Bräse, Carmen Gil, Kerstin Knepper & Viktor Zimmermann. (2005) Organische Azide – explodierende Vielfalt bei einer einzigartigen Substanzklasse. Angewandte Chemie 117:33, pages 5320-5374.
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Olga Kivrakidou, Stefan Bräse, Frank Hülshorst & Nils Griebenow. (2004) Solid-Phase Synthesis of 5-Biphenyl-2-yl-1 H- tetrazoles . Organic Letters 6:7, pages 1143-1146.
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Thomas Unger & Bernward A. SchölkensW. Schulz. 2004. Angiotensin Vol. II. Angiotensin Vol. II 545 592 .
Marion Gurrath. (2001) Der humane AT1-Rezeptor: Wettlauf um ein neues Target. Pharmazie in unserer Zeit 30:4, pages 288-295.
Crossref
Levon M. Khachigian, Yoh Takuwa & Tucker Collins. 2000. Control of Gene Expression by Catecholamines and the Renin-Angiotensin System. Control of Gene Expression by Catecholamines and the Renin-Angiotensin System 183 186 .
P. Dominiak & A. Dendorfer. 1999. Angiotensin II AT1-Rezeptorantagonisten. Angiotensin II AT1-Rezeptorantagonisten 39 75 .

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