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Review

Importance of antifungal drug-resistance: clinical significance and need for novel therapy

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Pages 175-198 | Published online: 23 Feb 2005

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Nafsika H Georgopapadakou. (2002) Antifungals targeted to protein modification: focus on protein N-myristoyltransferase. Expert Opinion on Investigational Drugs 11:8, pages 1117-1125.
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Nafsika H Georgopapadakou. (2001) Update on antifungals targeted to the cell wall: focus on β-1,3-glucan synthase inhibitors. Expert Opinion on Investigational Drugs 10:2, pages 269-280.
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Shweta Nim, Lucia Gonzalez Lobato, Alexis Moreno, Vincent Chaptal, Manpreet Kaur Rawal, Pierre Falson & Rajendra Prasad. (2016) Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1. Biochimica et Biophysica Acta (BBA) - Biomembranes 1858:11, pages 2858-2870.
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Christopher J. Stenland, Lev G. Lis, Frederick J. Schendel, Nicholas J. Hahn, Mary A. Smart, Amy L. Miller, Marc G. von Keitz & Vadim J. Gurvich. (2013) A Practical and Scalable Manufacturing Process for an Antifungal Agent, Nikkomycin Z. Organic Process Research & Development 17:2, pages 265-272.
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Hojjatollah Shokri. (2011) Evaluation of inhibitory effects of citric and tartaric acids and their combination on the growth of Trichophyton mentagrophytes, Aspergillus fumigatus, Candida albicans, and Malassezia furfur. Comparative Clinical Pathology 20:5, pages 543-545.
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P.M. Sivakumar, S. Prabhu Seenivasan, Vanaja Kumar & Mukesh Doble. (2010) Novel 1,3,5-triphenyl-2-pyrazolines as anti-infective agents. Bioorganic & Medicinal Chemistry Letters 20:10, pages 3169-3172.
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Ponnurengam Malliappan Sivakumar, Thangavelu Muthu Kumar & Mukesh Doble. (2009) Antifungal Activity, Mechanism and QSAR Studies on Chalcones. Chemical Biology & Drug Design 74:1, pages 68-79.
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Bansi Lal, Vitthal Genbhau Gund, Nandu Baban Bhise & Ashok Kumar Gangopadhyay. (2004) Mannich reaction: an approach for the synthesis of water soluble mulundocandin analogues. Bioorganic & Medicinal Chemistry 12:7, pages 1751-1768.
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Xiang Y. Yu, John Finn, Jason M. Hill, Zhong G. Wang, Dennis Keith, Jared Silverman & N. Oliver. (2004) A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl- t RNA synthetases. Bioorganic & Medicinal Chemistry Letters 14:5, pages 1339-1342.
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Bansi Lal, Vitthal Genbhau Gund, Ashok Kumar Gangopadhyay, S.R. Nadkarni, Vidula Dikshit, D.K. Chatterjee & R. Shirvaikar. (2003) Semisynthetic modifications of hemiaminal function at ornithine unit of mulundocandin, towards chemical stability and antifungal activity. Bioorganic & Medicinal Chemistry 11:23, pages 5189-5198.
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Vidmantas Petraitis, Ruta Petraitiene, Andreas H. Groll, Kristin Roussillon, Melissa Hemmings, Caron A. Lyman, Tin Sein, John Bacher, Ihor Bekersky & Thomas J. Walsh. (2002) Comparative Antifungal Activities and Plasma Pharmacokinetics of Micafungin (FK463) against Disseminated Candidiasis and Invasive Pulmonary Aspergillosis in Persistently Neutropenic Rabbits. Antimicrobial Agents and Chemotherapy 46:6, pages 1857-1869.
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Xiang Y. Yu, Jason M. Hill, Guixue Yu, Yifeng Yang, Arthur F. Kluge, Dennis Keith, John Finn, Paul Gallant, Jared Silverman & Audrey Lim. (2001) A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase. Bioorganic & Medicinal Chemistry Letters 11:4, pages 541-544.
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Patrick Marichal, Jos Gorrens, Leen Laurijssens, Karen Vermuyten, Carl Van Hove, Ludo Le Jeune, Peter VerhasseltDominique Sanglard, Marcel Borgers, Frans C. S. Ramaekers, Frank Odds & Hugo Vanden Bossche. (1999) Accumulation of 3-Ketosteroids Induced by Itraconazole in Azole-Resistant Clinical Candida albicans Isolates. Antimicrobial Agents and Chemotherapy 43:11, pages 2663-2670.
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Patrick Marichal, Luc Koymans, Staf Willemsens, Danny Bellens, Peter Verhasselt, Walter Luyten, Marcel Borgers, Frans C. S. Ramaekers, Frank C. Odds & Hugo Vanden Bossche. (1999) Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 145:10, pages 2701-2713.
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Ruta Petraitiene, Vidmantas Petraitis, Andreas H. Groll, Myrna Candelario, Tin Sein, Aaron Bell, Caron A. Lyman, Carl L. McMillian, John Bacher & Thomas J. Walsh. (1999) Antifungal Activity of LY303366, a Novel Echinocandin B, in Experimental Disseminated Candidiasis in Rabbits. Antimicrobial Agents and Chemotherapy 43:9, pages 2148-2155.
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