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Review

The therapeutic potential of targeting the cell cycle

Pages 865-887 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Jianzhong Chen, Laixue Pang, Wei Wang, Lifei Wang, John Z. H. Zhang & Tong Zhu. (2020) Decoding molecular mechanism of inhibitor bindings to CDK2 using molecular dynamics simulations and binding free energy calculations. Journal of Biomolecular Structure and Dynamics 38:4, pages 985-996.
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Kazutomo Kawaguchi, Muhammad Saleh Arwansyah, Tatsuki Kataoka & Hidemi Nagao. (2019) Theoretical study of conformational transition of CDK4 by association of cyclin D3. Molecular Physics 117:17, pages 2355-2361.
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Michael R Jirousek & Peter G Goekjian. (2001) Protein kinase C inhibitors as novel anticancer drugs. Expert Opinion on Investigational Drugs 10:12, pages 2117-2140.
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John C Kath. (2000) Patent focus: inhibitors of tumour cell growth. Expert Opinion on Therapeutic Patents 10:6, pages 803-818.
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Articles from other publishers (37)

Vijay kumar Bhardwaj, Pralay Das & Rituraj Purohit. (2022) Identification and comparison of plant-derived scaffolds as selective CDK5 inhibitors against standard molecules: Insights from umbrella sampling simulations. Journal of Molecular Liquids 348, pages 118015.
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Fan Yun, Chunhui Cheng, Sadeeq Ullah & Qipeng Yuan. (2020) Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer. European Journal of Medicinal Chemistry 198, pages 112322.
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Mengzhu Zheng, Lixia Chen & Li Hua. 2019. In Silico Drug Design. In Silico Drug Design 527 548 .
Sandra-Annika Quast, Katja Steinhorst, Michael Plötz & Jürgen Eberle. (2015) Sensitization of Melanoma Cells for Death Ligand TRAIL Is Based on Cell Cycle Arrest, ROS Production, and Activation of Proapoptotic Bcl-2 Proteins. Journal of Investigative Dermatology 135:11, pages 2794-2804.
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Lili Xi, Shuyan Li, Xiaojun Yao, Yuhui Wei, Jiazhong Li, Huanxiang Liu & Xin'an Wu. (2014) In Silico Study Combining Docking and QSAR Methods on a Series of Matrix Metalloproteinase 13 Inhibitors . Archiv der Pharmazie 347:11, pages 825-833.
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Huiying Luo, He Su, Xiaopeng Wang, Lijuan Wang & Juan Li. (2012) N-Succinyl-chitosan nanoparticles induced mitochondria-dependent apoptosis in K562. Molecular and Cellular Probes 26:4, pages 164-169.
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Bing Zhang, Caroline Corbel, Françoise Guéritte, Cyril Couturier, Stéphane Bach & Vincent B. C. Tan. (2011) An in silico approach for the discovery of CDK5/p25 interaction inhibitors. Biotechnology Journal 6:7, pages 871-881.
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Bing Zhang, Zhou Cheng Su, Tong Earn Tay & Vincent B. C. Tan. (2009) Mechanism of CDK5 activation revealed by steered molecular dynamics simulations and energy calculations. Journal of Molecular Modeling 16:6, pages 1159-1168.
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Vinod R. Hegde, Scott Borges, Mahesh Patel, Pradip R. Das, Bonnie Wu, Vincent P. Gullo & Tze-Ming Chan. (2010) New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. Bioorganic & Medicinal Chemistry Letters 20:4, pages 1344-1346.
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Vincent B. C. Tan, Bing Zhang, Kian Meng Lim & Tong Earn Tay. (2009) Explaining the inhibition of cyclin-dependent kinase 5 by peptides derived from p25 with molecular dynamics simulations and MM-PBSA. Journal of Molecular Modeling 16:1, pages 1-8.
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Kim Jun-Hee, Han Kwon Ki, Ji-Youn Jung, Hye-Suk Han, Jung Hyun Shim, SeJun Oh, Kyeong-Hee Choi, Eun-Sun Choi, Ji-Ae Shin, Dae-Ho Leem, Yunjo Soh, Nam-Pyo Cho & Sung-Dae Cho. (2009) Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G2/M Cell Cycle Arrest. Journal of Clinical Biochemistry and Nutrition 46:1, pages 60-67.
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Ruo Jia, Li-Jun Yang & Sheng-Yong Yang. (2008) Binding energy contributions of the conserved bridging water molecules in CDK2-inhibitor complexes: A combined QM/MM study. Chemical Physics Letters 460:1-3, pages 300-305.
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Li Aixiao, Barbault Florent, Maurel François, Delamar Michel & Wang Baoshan. (2008) Interaction mode and selectivity of the 2PU inhibitor with the CDK4 and CDK2 cyclin-dependant kinases: A molecular dynamics study. Journal of Molecular Structure: THEOCHEM 849:1-3, pages 62-75.
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B. Zhang, V. B. C. Tan, K. M. Lim & T. E. Tay. (2007) Significance of Water Molecules in the Inhibition of Cylin-Dependent Kinase 2 and 5 Complexes. Journal of Chemical Information and Modeling 47:5, pages 1877-1885.
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Kamran SalimPaul C. GuestHeather A. SkynnerJames G. BilslandTimothy P. BonnertGeorge McAllisterIgnacio Munoz-Sanjuan. (2007) Identification of Proteomic Changes during Differentiation of Adult Mouse Subventricular Zone Progenitor Cells. Stem Cells and Development 16:1, pages 143-166.
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Kamran Salim, Paul C. Guest, Heather A. Skynner, James G. Bilsland, Timothy P. Bonnert, George McAllister & Ignacio Munoz-Sanjuan. (2007) Identification of Proteomic Changes During Differentiation of Adult Mouse Subventricular Zone Progenitor Cells. Stem Cells and Development 0:0, pages 071004031550001.
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Jiazhong Li, Huanxiang Liu, Xiaojun Yao, Mancang Liu, Zhide Hu & Botao Fan. (2007) Structure–activity relationship study of oxindole-based inhibitors of cyclin-dependent kinases based on least-squares support vector machines. Analytica Chimica Acta 581:2, pages 333-342.
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Hideyuki Sato, Lisa M. Shewchuk & Jun Tang. (2006) Prediction of Multiple Binding Modes of the CDK2 Inhibitors, Anilinopyrazoles, Using the Automated Docking Programs GOLD, FlexX, and LigandFit:  An Evaluation of Performance. Journal of Chemical Information and Modeling 46:6, pages 2552-2562.
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Bing Zhang, Vincent B. C. Tan, Kian Meng Lim & Tong Earn Tay. (2006) Molecular dynamics simulations on the inhibition of Cyclin-Dependent Kinases 2 and 5 in the presence of activators. Journal of Computer-Aided Molecular Design 20:6, pages 395-404.
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Manjinder Kaur, Rana P. Singh, Mallikarjuna Gu, Rajesh Agarwal & Chapla Agarwal. (2006) Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells . Clinical Cancer Research 12:20, pages 6194-6202.
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Myoung Ju Moon, Sang Kook Lee, Jong-Won Lee, Woo Keun Song, Si Wouk Kim, Jae Il Kim, Chunghee Cho, Soo Jeong Choi & Yong-Chul Kim. (2006) Synthesis and structure–activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities. Bioorganic & Medicinal Chemistry 14:1, pages 237-246.
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Harish Dureja & Anil Kumar Madan. (2005) Topochemical models for prediction of cyclin-dependent kinase 2 inhibitory activity of indole-2-ones. Journal of Molecular Modeling 11:6, pages 525-531.
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Yongjun Jiang, Jianwei Zou & Chunshan Gui. (2005) Study of a ligand complexed with Cdk2/Cdk4 by computer simulation. Journal of Molecular Modeling 11:6, pages 509-515.
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Carlos Jaramillo, J. Eugenio de Diego, Chafiq Hamdouchi, Elizabeth Collins, Heather Keyser, Concha Sánchez-Martı́nez, Miriam del Prado, Bryan Norman, Harold B. Brooks, Scott A. Watkins, Charles D. Spencer, Jack Alan Dempsey, Bryan D. Anderson, Robert M. Campbell, Tellie Leggett, Bharvin Patel, Richard M. Schultz, Juan Espinosa, Michal Vieth, Faming Zhang & David E. Timm. (2004) Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation. Bioorganic & Medicinal Chemistry Letters 14:24, pages 6095-6099.
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Raj N. Misra, Hai-yun Xiao, David K. Williams, Kyoung S. Kim, Songfeng Lu, Kristen A. Keller, Janet G. Mulheron, Roberta Batorsky, John S. Tokarski, John S. Sack, S.David Kimball, Francis Y. Lee & Kevin R. Webster. (2004) Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorganic & Medicinal Chemistry Letters 14:11, pages 2973-2977.
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Chafiq Hamdouchi, Heather Keyser, Elizabeth Collins, Carlos Jaramillo, Jose Eugenio De Diego, Charles D. Spencer, Jack Alan Dempsey, Bryan D. Anderson, Tillie Leggett, Nancy B. Stamm, Richard M. Schultz, Scott A. Watkins, Kim Cocke, Stephanie Lemke, Teresa F. Burke, Richard P. Beckmann, Jeffrey T. Dixon, Thomas M. Gurganus, Nancy B. Rankl, Keith A. Houck, Faming Zhang, Michal Vieth, Juan Espinosa, David E. Timm, Robert M. Campbell, Bharvin K. R. Patel & Harold B. Brooks. (2004) The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2- a ]pyridines . Molecular Cancer Therapeutics 3:1, pages 1-9.
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Jun Tang, Lisa M. Shewchuk, Hideyuki Sato, Masaichi Hasegawa, Yoshiaki Washio & Naohiko Nishigaki. (2003) Anilinopyrazole as selective CDK2 inhibitors. Bioorganic & Medicinal Chemistry Letters 13:18, pages 2985-2988.
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Raj N. Misra, Hai-yun Xiao, David B. Rawlins, Weifang Shan, Kristen A. Kellar, Janet G. Mulheron, John S. Sack, John S. Tokarski, S.David Kimball & Kevin R. Webster. (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorganic & Medicinal Chemistry Letters 13:14, pages 2405-2408.
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Xiaoyuan Li, Ping Huang, Jingrong Jean Cui, Jennifer Zhang & Cho Tang. (2003) Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-Dependent kinase 2 inhibitors. Bioorganic & Medicinal Chemistry Letters 13:11, pages 1939-1942.
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Raj N. Misra, David B. Rawlins, Hai-yun Xiao, Weifang Shan, Isia Bursuker, Kristin A. Kellar, Janet G. Mulheron, John S. Sack, John S. Tokarski, S.David Kimball & Kevin R. Webster. (2003) 1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases. Bioorganic & Medicinal Chemistry Letters 13:6, pages 1133-1136.
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H. Neal Bramson, John Corona, Stephen T. Davis, Scott H. Dickerson, Mark Edelstein, Stephen V. Frye, Robert T. Gampe, Phil A. Harris, Anne Hassell, William D. Holmes, Robert N. Hunter, Karen E. Lackey, Brett Lovejoy, Michael J. Luzzio, Val Montana, Warren J. Rocque, David Rusnak, Lisa Shewchuk, James M. Veal, Duncan H. Walker & Lee F. Kuyper. (2001) Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2):  Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis. Journal of Medicinal Chemistry 44:25, pages 4339-4358.
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S.David Kimball & Kevin R. Webster. 2001. 139 148 .
Kyoung Soon Kim, John S. Sack, John S. Tokarski, Ligang Qian, Sam T. Chao, Leslie Leith, Yolanda F. Kelly, Raj N. Misra, John T. Hunt, S. David Kimball, William G. Humphreys, Barris S. Wautlet, Janet G. Mulheron & Kevin R. Webster. (2000) Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors:  Synthesis and Biological Effects. Journal of Medicinal Chemistry 43:22, pages 4126-4134.
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Chung-Kyu Ryu, Hye-Young Kang, Sang Kook Lee, Kyung Ae Nam, Chang Yong Hong, Won-Gil Ko & Byung-Hoon Lee. (2000) 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorganic & Medicinal Chemistry Letters 10:5, pages 461-464.
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Chung-Kyu Ryu, Hye-Young Kang, Yu-Jin Yi & Chong-Ock Lee. (2000) Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines. Archives of Pharmacal Research 23:1, pages 42-45.
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Thais M. Sielecki, John F. Boylan, Pamela A. Benfield & George L. Trainor. (2000) Cyclin-Dependent Kinase Inhibitors:  Useful Targets in Cell Cycle Regulation. Journal of Medicinal Chemistry 43:1, pages 1-18.
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