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Review

Recent advances in the development of telomerase inhibitors for the treatment of cancer

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Pages 1981-2008 | Published online: 23 Feb 2005

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Martine Demeunynck. (2004) Antitumour acridines. Expert Opinion on Therapeutic Patents 14:1, pages 55-70.
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Vishal P. Zambre, Prashant R. Murumkar, Rajani Giridhar & Mange Ram Yadav. (2009) Structural Investigations of Acridine Derivatives by CoMFA and CoMSIA Reveal Novel Insight into Their Structures toward DNA G-Quadruplex Mediated Telomerase Inhibition and Offer a Highly Predictive 3D-Model for Substituted Acridines. Journal of Chemical Information and Modeling 49:5, pages 1298-1311.
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Evripidis Gavathiotis, Robert A. Heald, Malcolm F.G. Stevens & Mark S. Searle. (2003) Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat. Journal of Molecular Biology 334:1, pages 25-36.
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Tetsuzo Tauchi, Kazuo Shin-ya, Goro Sashida, Masahiko Sumi, Akihiro Nakajima, Takashi Shimamoto, Junko H Ohyashiki & Kazuma Ohyashiki. (2003) Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene 22:34, pages 5338-5347.
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J. Fajkus, M. Šimíčková & J. Maláska. (2002) Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 357:1420, pages 545-562.
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J. F. Riou, L. Guittat, P. Mailliet, A. Laoui, E. Renou, O. Petitgenet, F. Mégnin-Chanet, C. Hélène & J. L. Mergny. (2002) Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proceedings of the National Academy of Sciences 99:5, pages 2672-2677.
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Janusz Błasiak, Magdalena Kadłubek, Joanna Kowalik, Hanna Romanowicz‐Makowska & Tomasz Pertyński. (2001) Inhibition of telomerase activity in endometrial cancer cells by selenium‐cisplatin conjugate despite suppression of its DNA‐damaging activity by sodium ascorbate. Teratogenesis, Carcinogenesis, and Mutagenesis 22:1, pages 73-82.
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Evripidis Gavathiotis, Robert A. Heald, Malcolm F. G. Stevens & Mark S. Searle. (2001) Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4. Angewandte Chemie International Edition 40:24, pages 4749-4751.
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Evripidis Gavathiotis, Robert A. Heald, Malcolm F. G. Stevens & Mark S. Searle. (2001) Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4. Angewandte Chemie 113:24, pages 4885-4887.
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Jinsong Ren, Xiaogang Qu, Nanibhushan Dattagupta & Jonathan B. Chaires. (2001) Molecular Recognition of a RNA:DNA Hybrid Structure. Journal of the American Chemical Society 123:27, pages 6742-6743.
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Jean-Louis MergnyLaurent LacroixMarie-Paule Teulade-FichouCandide HounsouLionel GuittatMagali HoarauPaola B. ArimondoJean-Pierre VigneronJean-Marie LehnJean-François RiouThérèse GarestierClaude Hélène. (2001) Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay. Proceedings of the National Academy of Sciences 98:6, pages 3062-3067.
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Jean-Louis Mergny & Jean-Claude Maurizot. (2001) Fluorescence Resonance Energy Transfer as a Probe for G-Quartet Formation by a Telomeric Repeat. ChemBioChem 2:2, pages 124-132.
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Ihtshamul Haq, Babur Z Chowdhry & Terence C Jenkins. 2001. Drug-Nucleic Acid Interactions. Drug-Nucleic Acid Interactions 109 149 .
Xiaogang Qu, John O. Trent, Izabela Fokt, Waldemar Priebe & Jonathan B. Chaires. (2000) Allosteric, chiral-selective drug binding to DNA. Proceedings of the National Academy of Sciences 97:22, pages 12032-12037.
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M. Folini, C. De Marco, L. Orlandi, M.G. Daidone & N. Zaffaroni. (2000) Attenuation of telomerase activity does not increase sensitivity of human melanoma cells to anticancer agents. European Journal of Cancer 36:16, pages 2137-2145.
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Lloyd R Kelland. (2000) Telomerase inhibitors: targeting the vulnerable end of cancer?. Anti-Cancer Drugs 11:7, pages 503-513.
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Ihtshamul Haq & John Ladbury. (2000) Drug-DNA recognition: energetics and implications for design. Journal of Molecular Recognition 13:4, pages 188-197.
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