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Expert Opinion on Investigational Drugs Volume 8, 1999 - Issue 12
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Review

Aldose reductase inhibitors: therapeutic implications for diabetic complications

Peter J Oates Department of Metabolic Diseases, Pfizer Inc., Central Research Division, Groton, CT 06340, USA. [email protected]
&
Banavara L Mylari Department of Metabolic Diseases, Pfizer Inc., Central Research Division, Groton, CT 06340, USA. [email protected]
Pages 2095-2119 | Published online: 23 Feb 2005

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N V Reddy, Huizhen Li, Tianyu Hou, M S Bethu, Zhiqing Ren & Zhijun Zhang. (2021) Phytosynthesis of Silver Nanoparticles Using Perilla frutescens Leaf Extract: Characterization and Evaluation of Antibacterial, Antioxidant, and Anticancer Activities. International Journal of Nanomedicine 16, pages 15-29.
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Luca Quattrini & Concettina La Motta. (2019) Aldose reductase inhibitors: 2013-present. Expert Opinion on Therapeutic Patents 29:3, pages 199-213.
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Peter F. Kador, Tomofumi Hamada, Richard A. Reinhardt & Karen Blessing. (2010) Effect of an Aldose Reductase Inhibitor on Alveolar Bone Loss Associated with Periodontitis in Diabetic Rats. Postgraduate Medicine 122:3, pages 138-144.
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Ravichandran Ramasamy, Shi Fang Yan & Ann Marie Schmidt. (2010) Polyol pathway and RAGE: a central metabolic and signaling axis in diabetic complications. Expert Review of Endocrinology & Metabolism 5:1, pages 65-75.
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Monica Cortinovis, Dario Cattaneo, Norberto Perico & Giuseppe Remuzzi. (2008) Investigational drugs for diabetic nephropathy. Expert Opinion on Investigational Drugs 17:10, pages 1487-1500.
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Sara Klemin, Richard Y. Calvo, Stephanie Bond, Heather Dingess, Balakrishnan Rajkumar, Rachel Perez, Lucy Chow & Ganesaratnam K. Balendiran. (2006) WY 14,643 inhibits human aldose reductase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 21:5, pages 569-573.
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Simona Bruno, Dario Cattaneo, Norberto Perico & Giuseppe Remuzzi. (2005) Emerging drugs for diabetic nephropathy. Expert Opinion on Emerging Drugs 10:4, pages 747-771.
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Anders AF Sima. (2003) C-peptide and diabetic neuropathy. Expert Opinion on Investigational Drugs 12:9, pages 1471-1488.
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Renu A Kowluru & Alexander Kennedy. (2001) Therapeutic potential of anti-oxidants and diabetic retinopathy. Expert Opinion on Investigational Drugs 10:9, pages 1665-1676.
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Saurabh Kumar Gupta & Pushpendra Kumar Tripathi. (2023) CADD Studies in the Discovery of Potential ARI (Aldose Reductase Inhibitors) Agents for the Treatment of Diabetic Complications. Current Diabetes Reviews 19:9.
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Anthony C Oganov, Ian Seddon, Mike Zein, Ghasem Yazdanpanah, Hossein Fonoudi & Sayena Jabbehdari. (2023) Composition of the gut microbiome, role of diet, lifestyle, and antioxidant therapies in diabetes mellitus and diabetic retinopathy. European Journal of Ophthalmology, pages 112067212311744.
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Tianyu Hou, Vasudeva Reddy Netala, Hongjiao Zhang, Yun Xing, Huizhen Li & Zhijun Zhang. (2022) Perilla frutescens: A Rich Source of Pharmacological Active Compounds. Molecules 27:11, pages 3578.
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Anita Mehar BishtTariq MasoodDr.Dr., Tarannum ShakeelDr.Dr., Vikas TiwariRadhika PushkarNiharika Thapliyal. (2022) “CORRELATION BETWEEN OXIDATIVE STRESS MARKERS AND DIABETIC CATARACT”. INDIAN JOURNAL OF APPLIED RESEARCH, pages 46-48.
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Zunaira Alvi, Muhammad Akhtar, Nisar U. Rahman, Khaled M. Hosny, Amal M. Sindi, Barkat A. Khan, Imran Nazir & Hadia Sadaquat. (2021) Utilization of Gelling Polymer to Formulate Nanoparticles Loaded with Epalrestat-Cyclodextrin Inclusion Complex: Formulation, Characterization, In-Silico Modelling and In-Vivo Toxicity Evaluation. Polymers 13:24, pages 4350.
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Sravya Jannapureddy, Mira Sharma, Gautham Yepuri, Ann Marie Schmidt & Ravichandran Ramasamy. (2021) Aldose Reductase: An Emerging Target for Development of Interventions for Diabetic Cardiovascular Complications. Frontiers in Endocrinology 12.
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Ajmer Singh Grewal, Komal Thapa, Neha Kanojia, Neelam Sharma & Sukhbir Singh. (2020) Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review. Current Drug Metabolism 21:14, pages 1091-1116.
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Huan Chen, Xin Zhang, Xiaonan Zhang, Zhenya Fan, Wenchao Liu, Yanqi Lei, Changjin Zhu & Bing Ma. (2020) Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. Bioorganic & Medicinal Chemistry 28:20, pages 115699.
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Sandhya Pillai Nair & N C Shah. (2020) Association of oxidative stress with the bone turnover in pre and post menopausal diabetic women. International Journal of Clinical Biochemistry and Research 7:2, pages 181-184.
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Xin Hao, Xiangyu Qin, Xin Zhang, Bing Ma, Gang Qi, Taiming Yu, Zhongfei Han & Changjin Zhu. (2019) Identification of quinoxalin-2(1 H )-one derivatives as a novel class of multifunctional aldose reductase inhibitors . Future Medicinal Chemistry 11:23, pages 2989-3004.
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R. Thiagarajan, M. K. N. Sai Varsha, V. Srinivasan, R. Ravichandran & K. Saraboji. (2019) Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity. Scientific Reports 9:1.
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Zhaoxi Sun, Xiaohui Wang, Qianqian Zhao & Tong Zhu. (2019) Understanding Aldose Reductase-Inhibitors interactions with free energy simulation. Journal of Molecular Graphics and Modelling 91, pages 10-21.
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Suman Samaddar & Raju Koneri. (2019) Polyphenols of marine red macroalga Symphyocladia latiuscula ameliorate diabetic peripheral neuropathy in experimental animals. Heliyon 5:5, pages e01781.
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