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Review

Toxicity of hepatotoxins: new insights into mechanisms and therapy

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Pages 585-607 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Cong Li, Li-Tao Yi, Di Geng, Yuan-Yuan Han & Lian-jin Weng. (2015) Hepatoprotective effect of ethanol extract from Berchemia lineate against CCl4-induced acute hepatotoxicity in mice. Pharmaceutical Biology 53:5, pages 767-772.
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M. Elias-Miró, M. B. Jiménez-Castro, J. Rodés & C. Peralta. (2013) Current knowledge on oxidative stress in hepatic ischemia/reperfusion. Free Radical Research 47:8, pages 555-568.
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Kirti Upadhyay, Nishant Kumar Gupta & Vinod Kumar Dixit. (2012) Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity. Drug Development and Industrial Pharmacy 38:9, pages 1152-1158.
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Sinan Ince, Hikmet Keles, Metin Erdogan, Omer Hazman & Ismail Kucukkurt. (2012) Protective effect of boric acid against carbon tetrachloride–induced hepatotoxicity in mice. Drug and Chemical Toxicology 35:3, pages 285-292.
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Articles from other publishers (43)

Jinling Yang, Xinqian Huo, Qinfang Jiang, Yun Liao, Caixing Zhang, Li Yu, Qiyan Wang, Tingting Niu, Cong Li, Na Pi, Yun Li, Heng Zhao, Ying Zhang, Ying Tan, Wenping Liao, Yong Li, Shengtao Fan & Qihan Li. (2023) Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques. Vaccine 41:17, pages 2837-2845.
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ASIYA KHATOON, SORABH KUMAR AGARWAL & SANA BUTOOL. (2022) PHARMACOLOGICAL EVALUATION OF CINNAMALDEHYDE AGAINST DMBA-INDUCED SKIN CANCER IN ALBINO MICE. Asian Journal of Pharmaceutical and Clinical Research, pages 56-59.
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Yu-Wen Hsu, Wen-Kang Chen & Chia-Fang Tsai. (2021) Senescence-Mediated Redox Imbalance in Liver and Kidney: Antioxidant Rejuvenating Potential of Green Tea Extract. International Journal of Environmental Research and Public Health 19:1, pages 260.
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Yu-Wen Hsu, Ya-Yu Chen & Chia-Fang Tsai. (2021) Protective Effects of Chlorogenic Acid against Carbon Tetrachloride-Induced Hepatotoxicity in Mice. Processes 10:1, pages 31.
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Giorgia Cerqueni, Annachiara Scalzone, Caterina Licini, Piergiorgio Gentile & Monica Mattioli-Belmonte. (2021) Insights into oxidative stress in bone tissue and novel challenges for biomaterials. Materials Science and Engineering: C 130, pages 112433.
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Lawrence E. Armstrong, Elaine C. Lee & Elizabeth M. Armstrong. (2018) Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke. Journal of Sports Medicine 2018, pages 1-33.
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Katsuhiro Isoda, Ryutaro Nagata, Tomoya Hasegawa, Yuichiro Taira, Ikuko Taira, Yoshimi Shimizu, Kazuo Isama, Tetsuji Nishimura & Isao Ishida. (2017) Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice. Nanoscale Research Letters 12:1.
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Pantea Gheibi, Kyung Jin Son, Gulnaz Stybayeva & Alexander Revzin. (2017) Harnessing endogenous signals from hepatocytes using a low volume multi-well plate. Integrative Biology 9:5, pages 427-435.
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Chinchu Joshy, P.A. Thahimon, R. Arun Kumar, Betty Carla & Christudas Sunil. (2016) Hepatoprotective, anti-inflammatory and antioxidant activities of Flacourtia montana J. Grah leaf extract in male Wistar rats. Bulletin of Faculty of Pharmacy, Cairo University 54:2, pages 209-217.
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Amranul Haque, Pantea Gheibi, Yandong Gao, Elena Foster, Kyung Jin Son, Jungmok You, Gulnaz Stybayeva, Dipali Patel & Alexander Revzin. (2016) Cell biology is different in small volumes: endogenous signals shape phenotype of primary hepatocytes cultured in microfluidic channels. Scientific Reports 6:1.
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Ji-Young Na, Kibbeum Song, Sokho Kim & Jungkee Kwon. (2015) Hepatoprotective effect of phosphatidylcholine against carbon tetrachloride liver damage in mice. Biochemical and Biophysical Research Communications 460:2, pages 308-313.
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You-Liang Hsieh, Yen-Hung Yeh, Ya-Ting Lee & Chih-Yang Huang. (2015) Protective effects of Cholestin on ethanol induced oxidative stress in rats. Journal of the Science of Food and Agriculture 95:4, pages 799-808.
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Rizwana Tabassum, Kumar Vaibhav, Pallavi Shrivastava, Andleeb Khan, Mohd. Ejaz Ahmed, Mohammad Ashafaq, M. Badruzzaman Khan, Farah Islam, Mohammed M. Safhi & Fakhrul Islam. (2015) Perillyl alcohol improves functional and histological outcomes against ischemia–reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-κB in middle cerebral artery occlusion rats. European Journal of Pharmacology 747, pages 190-199.
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Ulrike A. Köhler, Svitlana Kurinna, Dominik Schwitter, Andrea Marti, Matthias Schäfer, Claus Hellerbrand, Tobias Speicher & Sabine Werner. (2014) Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis. Hepatology 60:2, pages 670-678.
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Túlio Rezende, José Corrêa, Beatriz Aarestrup, Fernando Aarestrup, Orlando de Sousa & Ademar da Silva Filho. (2014) Protective Effects of Baccharis dracunculifolia Leaves Extract against Carbon Tetrachloride- and Acetaminophen-Induced Hepatotoxicity in Experimental Animals. Molecules 19:7, pages 9257-9272.
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Xing Lin, Shijun Zhang, Renbin Huang, Shimei Tan, Shuang Liang, Xiaoyan Wu, Lang Zhuo & Quanfang Huang. (2014) Protective effect of tormentic acid from Potentilla chinensis against lipopolysaccharide/d-galactosamine induced fulminant hepatic failure in mice. International Immunopharmacology 19:2, pages 365-372.
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Yen-Hung Yeh, You-Liang Hsieh & Ya-Ting Lee. (2013) Effects of Yam Peel Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Journal of Agricultural and Food Chemistry 61:30, pages 7387-7396.
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Shuangchan Wu, Yuan Yue, Hui Tian, Zhike Li, Xiaofei Li, Wei He & Hong Ding. (2013) Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway. Journal of Ethnopharmacology 148:2, pages 570-578.
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Jae-Young Je, Jae-Young Cha, Young-Sook Cho, Hee-Young Ahn, Jae Hong Lee, Young-Su Cho & Chang-Bum Ahn. (2013) Hepatoprotective effect of peptic hydrolysate from salmon pectoral fin protein byproducts on ethanol-induced oxidative stress in Sprague–Dawley rats. Food Research International 51:2, pages 648-653.
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Yen-Hung Yeh, You-Liang Hsieh, Ya-Ting Lee & Chao-Chin Hu. (2012) Protective effects of Geloina eros extract against carbon tetrachloride-induced hepatotoxicity in rats. Food Research International 48:2, pages 551-558.
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Mingu KANG, Changgeun KANG, Hyunkyoung LEE, Euikyung KIM, Jongshu KIM, Ohseok KWON, Hyoki LEE, Hyunjun KANG, Chunghui KIM & Heeseung JANG. (2012) Effects of fermented aloe vera mixed diet on larval growth of Protaetia brevitarsis seulensis (Kolbe) (coleopteran:Cetoniidae) and protective effects of its extract against CCl4-induced hepatotoxicity in Sprague-Dawley rats. Entomological Research 42:2, pages 111-121.
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QuanFang Huang, ShiJun Zhang, Li Zheng, Min He, RenBin Huang & Xing Lin. (2012) Hepatoprotective effects of total saponins isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats. Food and Chemical Toxicology 50:3-4, pages 713-718.
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Yen-Hung Yeh, You-Liang Hsieh, Ya-Ting Lee & Cheng-Hong Hsieh. (2011) Protective effects of cholestin against carbon tetrachloride-induced hepatotoxicity in rats. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 6:6, pages e264-e271.
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Leo Lap Yan Wong, Sheung Tat Fan, Kwan Man, Wai-Hung Sit, Ping Ping Jiang, Irene Wing-Yan Jor, Carol Yee-Ki Lee, Wai Lim Ling, Kin Tung Tam & Jennifer Man-Fan Wan. (2010) Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Human & Experimental Toxicology 30:9, pages 1369-1381.
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DingGuo Zhang, MinYue Jiang & DengShun Miao. (2011) Transplanted Human Amniotic Membrane-Derived Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Cirrhosis in Mouse. PLoS ONE 6:2, pages e16789.
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Yu-Wen Hsu, Chia-Fang Tsai, Wen-Chen Chuang, Wen-Kang Chen, Yung-Chyuan Ho & Fung-Jou Lu. (2010) Protective effects of silica hydride against carbon tetrachloride-induced hepatotoxicity in mice. Food and Chemical Toxicology 48:6, pages 1644-1653.
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Brigitte Vollmar & Michael D. Menger. (2009) The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair. Physiological Reviews 89:4, pages 1269-1339.
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Yu-Wen Hsu, Chia-Fang Tsai, Wen-Kang Chen & Fung-Jou Lu. (2009) Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food and Chemical Toxicology 47:9, pages 2281-2288.
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Cecilia Haro, Sandra Lazarte, Hortensia Zelaya, Susana Alvarez & Graciela Agüero. (2009) Yogurt: Effect on Leukocytes and Blood Coagulation in an Acute Liver Injury Model. Journal of Medicinal Food 12:4, pages 796-802.
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Chia-Fang Tsai, Yu-Wen Hsu, Wen-Kang Chen, Wen-Huei Chang, Cheng-Chieh Yen, Yung-Chyuan Ho & Fung-Jou Lu. (2009) Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food and Chemical Toxicology 47:8, pages 2031-2036.
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Cecilia HaroHortensia ZelayaSandra LazarteSusana AlvarezGraciela Agüero. (2009) Lactobacillus casei : influence on the innate immune response and haemostatic alterations in a liver-injury model . Canadian Journal of Microbiology 55:6, pages 648-656.
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Jian Wu, James G. Hecker & Nipavan Chiamvimonvat. (2009) Antioxidant enzyme gene transfer for ischemic diseases. Advanced Drug Delivery Reviews 61:4, pages 351-363.
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R. Urtasun, L. Conde de la Rosa & N. Nieto. (2008) Oxidative and Nitrosative Stress and Fibrogenic Response. Clinics in Liver Disease 12:4, pages 769-790.
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Yu-Wen Hsu, Chia-Fang Tsai, Wen-Huei Chang, Yung-Chyuan Ho, Wen-Kang Chen & Fung-Jou Lu. (2008) Protective effects of Dunaliella salina – A carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Food and Chemical Toxicology 46:10, pages 3311-3317.
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Ben-Jian Zhang, Dan Xu, Yu Guo, Jie Ping, Liao-bin Chen & Hui Wang. (2008) PROTECTION BY AND ANTI-OXIDANT MECHANISM OF BERBERINE AGAINST RAT LIVER FIBROSIS INDUCED BY MULTIPLE HEPATOTOXIC FACTORS. Clinical and Experimental Pharmacology and Physiology 35:3, pages 303-309.
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H. Kirimlioglu, A. Ecevit, S. Yilmaz, V. Kirimlioglu & A. Bay Karabulut. (2008) Effect of Resveratrol and Melatonin on Oxidative Stress Enzymes, Regeneration, and Hepatocyte Ultrastructure in Rats Subjected to 70% Partial Hepatectomy. Transplantation Proceedings 40:1, pages 285-289.
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Zhaoyang YeHoussam S. Hajj HousseinRam I. Mahato. (2007) Bioconjugation of Oligonucleotides for Treating Liver Fibrosis. Oligonucleotides 17:4, pages 349-404.
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Harold M. SwartzNadeem KhanValery V. Khramtsov. (2007) Use of Electron Paramagnetic Resonance Spectroscopy to Evaluate the Redox State In Vivo . Antioxidants & Redox Signaling 9:10, pages 1757-1772.
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Guido Kroemer, Lorenzo Galluzzi & Catherine Brenner. (2007) Mitochondrial Membrane Permeabilization in Cell Death. Physiological Reviews 87:1, pages 99-163.
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Karl Kashofer, Elena K. Siapati & Dominique Bonnet. (2006) In Vivo Formation of Unstable Heterokaryons after Liver Damage and Hematopoietic Stem Cell/Progenitor Transplantation. Stem Cells 24:4, pages 1104-1112.
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Fragiska Sigala, Stamatis Theocharis, Konstantinos Sigalas, Sophia Markantonis-Kyroudis, Efstathios Papalabros, Aggeliki Triantafyllou, Georgia Kostopanagiotou & Ioanna Andreadou. (2006) Therapeutic value of melatonin in an experimental model of liver injury and regeneration. Journal of Pineal Research 40:3, pages 270-279.
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Colette C Prosser. (2006) Molecular therapy for hepatic injury and fibrosis: Where are we. World Journal of Gastroenterology 12:4, pages 509.
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Jian Wu, Li Liu, Roy D. Yen, Andreea Catana, Michael H. Nantz & Mark A. Zern. (2004) Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice. Hepatology 40:1, pages 195-204.
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