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Drug Evaluation

Levobupivacaine: a new safer long acting local anaesthetic agent

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Pages 861-876 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Elena Pacella, Fernanda Pacella, Fabiana Troisi, Domenico Dell’Edera, Paolo Tuchetti, Tommaso Lenzi & Saul Collini. (2013) Efficacy and safety of 0.5% levobupivacaine versus 0.5% bupivacaine for peribulbar anesthesia. Clinical Ophthalmology 7, pages 927-932.
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Shu-Feng Zhou, Bo Wang, Li-Ping Yang & Jun-Ping Liu. (2010) Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metabolism Reviews 42:2, pages 268-354.
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Articles from other publishers (44)

Burak ERGÜDER, Özlem AKKEMİK KIPÇAK & Ramazan KÖYMEN. (2022) A Comparison of the Postoperative Pain Relief and Clinical Local Anesthetic Efficacy of Levobupivacaine and Articaine for Impacted Lower Third Molar RemovalGömülü Alt Üçüncü Molar Diş Çekiminde Levobupivakain ve Artikainin Postoperatif Ağrı Giderme ve Lokal Anestezik Etkinliğinin Karşılaştırılması. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 13:2, pages 253-262.
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Henning Hermanns, Elke M. E. Bos, Mark L. van Zuylen, Markus W. Hollmann & Markus F. Stevens. (2022) The Options for Neuraxial Drug Administration. CNS Drugs 36:8, pages 877-896.
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Abhishek R, Arun Aravind & Shankaranarayana P. (2021) A prospective randomized clinical study to compare the efficacy of 0.25% bupivacaine with clonidine and 0.25% levobupivacaine with clonidine in supraclavicular brachial plexus block for upper limb surgeries. Indian Journal of Clinical Anaesthesia 8:4, pages 543-550.
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Pasupathy Kiruparan, Charef RaslanYuet NG, David ArchampongDebasish Debnath. (2021) SHORT TERM OUTCOMES OF A COMPARATIVE ANALYSIS BETWEEN LOCAL ANESTHETIC WOUND INFILTRATION AND REGIONAL ANESTHESIA IN BREAST SURGERY: SHOULD WE OPT FOR A SELECTIVE APPROACH?. GLOBAL JOURNAL FOR RESEARCH ANALYSIS, pages 125-131.
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Veli F. Pehlivan, Murat Akçay, Özlem C. İkeda & Nermin Göğüş. (2021) Comparison Between the Effects of Bupivacaine and Levobupivacaine for Spinal Anesthesia on QT Dispersion. Cardiovascular & Hematological Disorders-Drug Targets 21:1, pages 66-72.
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Basak Pehlivan, Murat Akçay, Ahmet Atlas, Mehmet K Erol, Erdogan Duran, Mahmut A Karahan, Orhan Binici, Evren Büyükfırat & Nuray Altay. (2020) Comparison of General Anesthesia (Sevoflurane) and Spinal Anesthesia (Levobupivacaine) Methods on QT Dispersion in Inguinal Hernia Operations. Cureus.
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İlknur Suidiye YORULMAZ, Gökçe AKMAN KÖSE, Yavuz DEMİRARAN & Şengül CANGÜR. (2020) Farklı Anestezik Ajanların Rejyonel İntravenöz Anestezi Yapılan Hastalarda Elektrokardiyografik Değişiklikler Üzerine Etkisi. Online Türk Sağlık Bilimleri Dergisi, pages 8-11.
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Chantal A. A. Heppolette, Derek Brunnen, Sohail Bampoe & Peter M. Odor. (2020) Clinical Pharmacokinetics and Pharmacodynamics of Levobupivacaine. Clinical Pharmacokinetics 59:6, pages 715-745.
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Muralidar Vakkapatti, Thrivikram Shenoy & Sonal Bhat. (2019) Comparison of a Combination of Caudal Levobupivacaine with Fentanyl and Levobupivacaine Alone for Alleviating Postoperative Pain During Infraumbilical Procedures in Children Under 3 Years. The Open Pain Journal 12:1, pages 19-25.
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Gökhan Kılınç. (2019) Management of local anesthetic toxicity and importance of lipid infusion. Journal of Surgery and Medicine.
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Vincent Marolf, Helene Rohrbach, Géraldine Bolen, Anne-Sophie Van Wijnsberghe & Charlotte Sandersen. (2019) Sciatic nerve block in dogs: description and evaluation of a modified ultrasound-guided parasacral approach. Veterinary Anaesthesia and Analgesia 46:1, pages 106-115.
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Sanjeev Kumar, Tanmay Tiwari, Navab Singh, Sweta Singh, Subhash Dahiya & Vipin Dhama. (2018) Comparative Study of Isobaric Levobupivacaine and Hyperbaric Bupivacaine for Lower Segment Caesarean Section Under Spinal Anaesthesia in Northen India. Annals of Anesthesiology and Critical Care 3:1.
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Ying Chen, Jian Zhang, Zhe Chen, Quanguang Wang, Bing Li, Rujing Lai, Xuzhong Xu, Zhifang Cao & Lizhen Yu. (2018) Lipid Emulsion Pretreatment Decreased the Maximum Total and Free Plasma Concentration of Levobupivacaine for Femoral and Sciatic Nerve Block in Below-Knee Fracture Surgery. Regional Anesthesia and Pain Medicine, pages 1.
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Nattapol Tammachote, Supakit Kanitnate, Sudsayam Manuwong & Phonthakorn Panichkul. (2017) Periarticular multimodal drug injection is better than single anesthetic drug in controlling pain after total knee arthroplasty. European Journal of Orthopaedic Surgery & Traumatology 28:4, pages 667-675.
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Raffael Vorberg, Nils Trapp, Daniel Zimmerli, Björn Wagner, Holger Fischer, Nicole A. Kratochwil, Manfred Kansy, Erick M. Carreira & Klaus Müller. (2016) Effect of Partially Fluorinated N -Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties . ChemMedChem 11:19, pages 2216-2239.
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Juhong Ran, Yanping Wang, Fangkun Li, Wei Zhang & Minyu Ma. (2015) Pharmacodynamics and Pharmacokinetics of Levobupivacaine Used for Epidural Anesthesia in Patients with Liver Dysfunction. Cell Biochemistry and Biophysics 73:3, pages 717-721.
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Rui Fang, Zhenfeng Liu, Asila Alijiang, Heng Jia, Yingjie Deng, Yucheng Song & Qingcai Meng. (2015) Efficacy of Intra-articular Local Anesthetics in Total Knee Arthroplasty. Orthopedics 38:7.
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R DeRossi, PHA Jardim, LC Hermeto & RC Pagliosa. (2015) Comparison of analgesic and systemic effects of bupivacaine, methadone, or bupivacaine/methadone administered epidurally in conscious sheep. Australian Veterinary Journal 93:5, pages 164-169.
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Hasan Ozkaya, Tuba Berra Sarıtaş, Zulfıkar Kadır Sarıtaş, Musa Korkmaz, Alper Sevımlı, İdris Mehmetoglu & Şeref Otelcıoglu. (2014) Investigation of effects of levobupivacaine injection to rabbit knee joint on histopathologic changes of joint cartilage tissue and changes of serum biochemical parameters. Fundamental & Clinical Pharmacology 28:6, pages 627-632.
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Demet Gulec, Bilge Karsli, Fatma Ertugrul, Zekiye Bigat & Nurten Kayacan. (2014) Intrathecal bupivacaine or levobupivacaine: Which should be used for elderly patients?. Journal of International Medical Research 42:2, pages 376-385.
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Nick Holford, Young-A Heo & Brian Anderson. (2013) A Pharmacokinetic Standard for Babies and Adults. Journal of Pharmaceutical Sciences 102:9, pages 2941-2952.
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Carmen Valenzuela, Cristina Moreno, Alicia de la Cruz, Álvaro Macías, Ángela Prieto & Teresa González. (2012) Stereoselective Interactions between Local Anesthetics and Ion Channels. Chirality 24:11, pages 944-950.
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Vesna Novak-Jankovic, Zoka Milan, Iztok Potocnik, Tomaz Stupnik, Stela Maric, Tatjana Stopar-Pintaric & Boriana Kremzar. (2012) A Prospective, Randomized, Double-Blinded Comparison Between Multimodal Thoracic Paravertebral Bupivacaine and Levobupivacaine Analgesia in Patients Undergoing Lung Surgery. Journal of Cardiothoracic and Vascular Anesthesia 26:5, pages 863-867.
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Jiin-Tarng Liou, Chih-Chieh Mao, Fu-Chao Liu, Huan-Tang Lin, Li-Man Hung, Chang-Hui Liao & Yuan-Ji Day. (2012) Levobupivacaine differentially suppresses platelet aggregation by modulating calcium release in a dose-dependent manner. Acta Anaesthesiologica Taiwanica 50:3, pages 112-121.
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Rafael DeRossi, Amadeu B. Silva-Neto, Cassio T.D. Pompermeyer, Fabrício O. Frazílio, Paulo H.A. Jardim & Andrea C.L. de Barros. (2012) The efficacy and safety of levobupivacaine administered by lumbosacral epidural route in conscious sheep. Research in Veterinary Science 92:2, pages 278-282.
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Cihangir Bicer, Teoman Eskıtascıoglu, Recep Aksu, Ayse Ulgey, Karamehmet Yildiz & Halit Madenoglu. (2011) Comparison of Preincisional Infiltrated Levobupivacaine and Ropivacaine for Acute Postoperative Pain Relief After Septorhinoplasty. Current Therapeutic Research 72:1, pages 13-22.
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Mark Sanford & Gillian M. Keating. (2010) Levobupivacaine. Drugs 70:6, pages 761-791.
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Derek Dillane & Brendan T. Finucane. (2010) Local anesthetic systemic toxicityLa toxicité systémique des anesthésiques locaux. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 57:4, pages 368-380.
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Livia Ferrari, Valerio Crestan, Giancarlo Sabattini, Federica Vinco, Stefano Fontana & Alessandro Gozzi. (2010) Brain penetration of local anaesthetics in the rat: Implications for experimental neuroscience. Journal of Neuroscience Methods 186:2, pages 143-149.
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David J. Birnbach & Ingrid M. Browne. 2010. Miller's Anesthesia. Miller's Anesthesia 2203 2240 .
G. De Cosmo, E. Congedo, C. Lai, M. Sgreccia, A. Amato, G. Beccia & P. Aceto. (2008) Ropivacaine vs. levobupivacaine combined with sufentanil for epidural analgesia after lung surgery. European Journal of Anaesthesiology 25:12, pages 1020-1025.
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Paul Coulthard, Richard Oliver, Kousar Ali Khan Afridi, Debbie Jackson-Leech, Linda Adamson & Helen Worthington. (2008) The efficacy of local anaesthetic for pain after iliac bone harvesting: A randomised controlled trial. International Journal of Surgery 6:1, pages 57-63.
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C. L. Burlacu, H. P. Frizelle, D. C. Moriarty & D. J. Buggy. (2006) Fentanyl and clonidine as adjunctive analgesics with levobupivacaine in paravertebral analgesia for breast surgery. Anaesthesia 61:10, pages 932-937.
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. 2006. Obstetric Anesthesia Handbook. Obstetric Anesthesia Handbook 14 26 .
Raffaella Parpaglioni, Maria Grazia Frigo, Anna Lemma, Massimo Sebastiani, Giulia Barbati & Danilo Celleno. (2005) Minimum Local Analgesic Dose. Anesthesiology 103:6, pages 1233-1237.
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M. J. G. Simon, B. T. Veering, R. Stienstra, J. W. van Kleef, S. G. P. Williams, G. M. McGuire & A. G. L. Burm. (2004) The systemic absorption and disposition of levobupivacaine 0.5% after epidural administration in surgical patients: a stable-isotope study. European Journal of Anaesthesiology 21:6, pages 460-470.
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S. Gallego-Sandin, J. Novalbos, M. A. Santos-Ampuero, M. A. Galvez-Mugica, A. G. Garcia & F. Abad-Santos. (2004) The comparative hemodynamic effects of intravenous IQB-9302 and bupivacaine in anesthetized rats. Acta Anaesthesiologica Scandinavica 48:5, pages 607-612.
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R. Taylor, R. Eyres, G.A. Chalkiadis & S. Austin. (2003) Efficacy and safety of caudal injection of levobupivacaine, 0.25%, in children under 2 years of age undergoing inguinal hernia repair, circumcision or orchidopexy. Pediatric Anesthesia 13:2, pages 114-121.
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Israel Agranat, Hava Caner & John Caldwell. (2002) Putting chirality to work: the strategy of chiral switches. Nature Reviews Drug Discovery 1:10, pages 753-768.
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I. A. Gomez De Segura, I. Vazquez, J. Benito, A. Galiano & E. De Miguel. (2002) Electrophysiologic cardiac effects of the new local anesthetic IQB‐9302 and of bupivacaine in the anesthetised dog. Acta Anaesthesiologica Scandinavica 46:6, pages 666-673.
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Robert W. Gristwood. (2002) Cardiac and CNS Toxicity of Levobupivacaine. Drug Safety 25:3, pages 153-163.
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Christian Glaser, Peter Marhofer, Gabriela Zimpfer, Marie T. Heinz, Christian Sitzwohl, Stephan Kapral & Ingrid Schindler. (2002) Levobupivacaine Versus Racemic Bupivacaine for Spinal Anesthesia. Anesthesia & Analgesia 94:1, pages 194-198.
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Christian Glaser, Peter Marhofer, Gabriela Zimpfer, Marie T. Heinz, Christian Sitzwohl, Stephan Kapral & Ingrid Schindler. (2002) Levobupivacaine Versus Racemic Bupivacaine for Spinal Anesthesia. Anesthesia & Analgesia 94:1, pages 194-198.
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