157
Views
47
CrossRef citations to date
0
Altmetric
Review

CCR3 blockade as a new therapy for asthma

&
Pages 43-52 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Xin-Feng Zhang, Xiao-Li Zhang, Ya-Jing Wang, Yuan Fang, Meng-Li Li, Xing-Yu Liu, Hua-You Luo & Yan Tian. (2023) The regulatory network of the chemokine CCL5 in colorectal cancer. Annals of Medicine 55:1.
Read now
Maria G Belvisi, David J Hele & Mark A Birrell. (2004) New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease. Expert Opinion on Therapeutic Targets 8:4, pages 265-285.
Read now
Chun Kwok Wong, Wai Ki Ip & Christopher Wai Kei Lam. (2004) Biochemical Assessment of Intracellular Signal Transduction Pathways in Eosinophils: Implications for Pharmacotherapy. Critical Reviews in Clinical Laboratory Sciences 41:1, pages 79-113.
Read now
Peter Norman. (2003) Emerging approaches to the treatment of asthma: highlights from the patents of 2001 and 2002. Expert Opinion on Therapeutic Patents 13:7, pages 949-956.
Read now
David J Hele & Maria G Belvisi. (2003) Novel therapies for the treatment of inflammatory airway disease. Expert Opinion on Investigational Drugs 12:1, pages 5-18.
Read now
. (2002) Cinnamide chemokine CCR3 antagonists. Expert Opinion on Therapeutic Patents 12:11, pages 1741-1745.
Read now
Helena Linardou & Samuel Murray. (2002) Non-cancer therapeutic antibodies. Expert Opinion on Therapeutic Patents 12:3, pages 401-417.
Read now
Chun Kwok Wong, Jiping Zhang, Wai Ki Ip & Christopher Wai Kei Lam. (2002) INTRACELLULAR SIGNAL TRANSDUCTION IN EOSINOPHILS AND ITS CLINICAL SIGNIFICANCE. Immunopharmacology and Immunotoxicology 24:2, pages 165-186.
Read now
. (2000) Chemokine CCR3 antagonists. Expert Opinion on Therapeutic Patents 10:9, pages 1455-1459.
Read now

Articles from other publishers (38)

Katarzyna Pawlik & Joanna Mika. (2023) Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain. Molecules 28:15, pages 5766.
Crossref
Rui Liang, Yaqin Yuan, Yakun Bai, Xinnan Liu, Jieqiong Chen, Dandan Jiang, Dehua Meng, Guangjie Chen, Bin Li, Luxian Zhou & Wenzhi Guo. (2022) Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation. International Immunopharmacology 110, pages 108953.
Crossref
Donya Nazarinia, Mahin Behzadifard, Javad Gholampour, Roqaye Karimi & Mohammadali Gholampour. (2022) Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complications. Acta Neurologica Belgica 122:4, pages 865-869.
Crossref
Katarzyna Pawlik, Agata Ciechanowska, Katarzyna Ciapała, Ewelina Rojewska, Wioletta Makuch & Joanna Mika. (2021) Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain. Frontiers in Immunology 12.
Crossref
Sharon Grisaru-Tal, Michal Itan, Amy D. Klion & Ariel Munitz. (2020) A new dawn for eosinophils in the tumour microenvironment. Nature Reviews Cancer 20:10, pages 594-607.
Crossref
Evelyn Saba, Young-sil Lee, Won-Kyung Yang, Yuan Yee Lee, MinKi Kim, Su-Min Woo, KilSoo Kim, Young-Sam Kwon, Tae-Hwan Kim, Dongmi Kwak, Yang-Chun Park, Han Jae Shin, Chang Kyun Han, Jae-Wook Oh, Young Cheol Lee, Hyung-Sik Kang, Man Hee Rhee & Seung-Hyung Kim. (2020) Effects of a herbal formulation, KGC3P, and its individual component, nepetin, on coal fly dust-induced airway inflammation. Scientific Reports 10:1.
Crossref
Perri Rozenberg, Hadar Reichman, Itay Moshkovits & Ariel Munitz. (2018) CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions. Journal of Leukocyte Biology 104:1, pages 21-29.
Crossref
Raphael S. Peres, Gustavo B. Menezes, Mauro M. Teixeira & Fernando Q. Cunha. (2016) Pharmacological opportunities to control inflammatory diseases through inhibition of the leukocyte recruitment. Pharmacological Research 112, pages 37-48.
Crossref
Xin Chang, Jirong Shen, Haiwei Yang, Yanan Xu, Wei Gao, Junling Wang, Huiyun Zhang & Shaoheng He. (2016) Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes. Cytokine 77, pages 211-219.
Crossref
Bijay Parajuli, Hiroshi Horiuchi, Tetsuya Mizuno, Hideyuki Takeuchi & Akio Suzumura. (2015) CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia. Glia 63:12, pages 2274-2284.
Crossref
Ting Wen & Marc E. Rothenberg. 2015. Mucosal Immunology. Mucosal Immunology 883 914 .
Yoshimitsu KuwabaraAkira KatayamaTsutomu Igarashi, Ryoko TomiyamaHua PiaoReika KanekoTakashi AbeKatsuya MineShigeo AkiraHideo OrimoToshiyuki Takeshita. (2012) Rapid and Transient Upregulation of CCL 11 (Eotaxin‐1) in Mouse Ovary During Terminal Stages of Follicular Development . American Journal of Reproductive Immunology 67:5, pages 358-368.
Crossref
Vaibhav Jain, Ashish Pandey, Shikhar Gupta & C. Gopi Mohan. (2009) Ligand-based molecular design of 4-benzylpiperidinealkylureas and amides as CCR3 antagonists. Journal of Molecular Modeling 16:4, pages 669-676.
Crossref
Charles W. DeBrosse & Marc E. Rothenberg. 2010. Pediatric Allergy: Principles and Practice. Pediatric Allergy: Principles and Practice 52 67 .
Vera Levina, Brian M. Nolen, Adele M. Marrangoni, Peng Cheng, Jeffrey R. Marks, Miroslaw J. Szczepanski, Marta E. Szajnik, Elieser Gorelik & Anna E. Lokshin. (2009) Role of Eotaxin-1 Signaling in Ovarian Cancer. Clinical Cancer Research 15:8, pages 2647-2656.
Crossref
C. Bachert, N. Van Bruaene, E. Toskala, N. Zhang, H. Olze, G. Scadding, C. M. Van Drunen, J. Mullol, L. Cardell, P. Gevaert, T. Van Zele, S. Claeys, C. Halldén, K. Kostamo, U. Foerster, M. Kowalski, K. Bieniek, A. Olszewska-Ziaber, E. Nizankowska-Mogilnicka, A. Szczeklik, M. Swierczynska, M. Arcimowicz, V. Lund, W. Fokkens, T. Zuberbier, C. Akdis, G. Canonica, P. Van Cauwenberge, P. Burney & J. Bousquet. (2009) Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA 2 LEN study . Allergy 64:4, pages 520-533.
Crossref
Joseph B. SantellaIIIIII, Daniel S. Gardner, Wenqing Yao, Chongsheng Shi, Prabhakar Reddy, Andrew J. Tebben, George V. DeLucca, Dean A. Wacker, Paul S. Watson, Patricia K. Welch, Eric A. Wadman, Paul Davies, Kimberly A. Solomon, Dani M. Graden, Swamy Yeleswaram, Sandhya Mandlekar, Ilona Kariv, Carl P. Decicco, Soo S. Ko, Percy H. Carter & John V. Duncia. (2008) From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: The discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis. Bioorganic & Medicinal Chemistry Letters 18:2, pages 576-585.
Crossref
Helene F. Rosenberg, Simon Phipps & Paul S. Foster. (2007) Eosinophil trafficking in allergy and asthma. Journal of Allergy and Clinical Immunology 119:6, pages 1303-1310.
Crossref
Dennis M. Lindell & Nicholas W. Lukacs. 2007. The Chemokine Receptors. The Chemokine Receptors 235 257 .
Marylène FortinNicolay FerrariMarie-Ève HigginsSerge SéguinMustapha AllamZoulfia AllakhverdiCarmen Piaget-RodriguezLuc PaquetPaolo M. Renzi. (2006) Effects of Antisense Oligodeoxynucleotides Targeting CCR3 on the Airway Response to Antigen in Rats. Oligonucleotides 16:3, pages 203-212.
Crossref
Angelo Vedani, Max Dobler, Horst Dollinger, Kai-Malte Hasselbach, Franz Birke & Markus A. Lill. (2005) Novel Ligands for the Chemokine Receptor-3 (CCR3):  A Receptor-Modeling Study Based on 5D-QSAR. Journal of Medicinal Chemistry 48:5, pages 1515-1527.
Crossref
Marc E. Rothenberg. 2005. Mucosal Immunology. Mucosal Immunology 717 735 .
C Kruschinski, T Skripuletz, S Bedoui, T Tschernig, R Pabst, C Nassenstein, A Braun & S Von Hörsten. (2005) CD26 (dipeptidyl-peptidase IV)-dependent recruitment of T cells in a rat asthma model. Clinical and Experimental Immunology 139:1, pages 17-24.
Crossref
J. Elsner, S. E. Escher & U. Forssmann. (2004) Chemokine receptor antagonists: a novel therapeutic approach in allergic diseases. Allergy 59:12, pages 1243-1258.
Crossref
Markus A. Lill, Angelo Vedani & Max Dobler. (2004) Raptor:  Combining Dual-Shell Representation, Induced-Fit Simulation, and Hydrophobicity Scoring in Receptor Modeling:  Application toward the Simulation of Structurally Diverse Ligand Sets. Journal of Medicinal Chemistry 47:25, pages 6174-6186.
Crossref
Ulf Forssmann, Inka Hartung, Ralf Bälder, Barbara Fuchs, Sylvia E. Escher, Nikolaj Spodsberg, Yasmin Dulkys, Michael Walden, Aleksandra Heitland, Armin Braun, Wolf-Georg Forssmann & Jörn Elsner. (2004) n -Nonanoyl-CC Chemokine Ligand 14, a Potent CC Chemokine Ligand 14 Analogue That Prevents the Recruitment of Eosinophils in Allergic Airway Inflammation . The Journal of Immunology 173:5, pages 3456-3466.
Crossref
Santa Jeremy Ono, Takao Nakamura, Dai Miyazaki, Masaharu Ohbayashi, Maria Dawson & Masako Toda. (2003) Chemokines: Roles in leukocyte development, trafficking, and effector function. Journal of Allergy and Clinical Immunology 111:6, pages 1185-1199.
Crossref
Maggie J. Leckie. (2012) Anti-Interleukin-5 Monoclonal Antibodies. American Journal of Respiratory Medicine 2:3, pages 245-259.
Crossref
Lanny J. Rosenwasser, Nives Zimmermann, Gurjit Khurana Hershey, Paul S. Foster & Marc E. Rothenberg. (2003) Chemokines in asthma: Cooperative interaction between chemokines and IL-13. Journal of Allergy and Clinical Immunology 111:2, pages 227-242.
Crossref
Li Li, Anuk M Das, Theodore J Torphy & Don E Griswold. (2002) What's in the Pipeline? Prospects for Monoclonal Antibodies (mAbs) as Therapies for Lung Diseases. Pulmonary Pharmacology & Therapeutics 15:5, pages 409-416.
Crossref
A.P. Badewa, C.E. Hudson & A.S. Heiman. (2016) Regulatory Effects of Eotaxin, Eotaxin-2, and Eotaxin-3 on Eosinophil Degranulation and Superoxide Anion Generation 1 . Experimental Biology and Medicine 227:8, pages 645-651.
Crossref
Stephen L Underwood, El-Bdaoui Haddad, Mark A Birrell, Kerryn McCluskie, Michaela Pecoraro, Dominika Dabrowski, Stephen E Webber, Martyn L Foster & Maria G Belvisi. (2002) Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation. British Journal of Pharmacology 137:2, pages 263-275.
Crossref
Nives Zimmermann & Marc Rothenberg. 2002. Biotherapeutic Approaches to Asthma. Biotherapeutic Approaches to Asthma 167 209 .
Jane M. Schuh, Kate Blease, Steven L. Kunkel & Cory M. Hogaboam. (2002) Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus . American Journal of Physiology-Lung Cellular and Molecular Physiology 283:1, pages L198-L204.
Crossref
Stéphanie Sénéchal, Olivier Fahy, Thibaut Gentina, Han Vorng, Monique Capron, Andrew F Walls, Alan R McEuen, Mark G Buckley, Qutayba Hamid, Benoît Wallaert, André Bernard Tonnel & Anne Tsicopoulos. (2002) CCR3-Blocking Antibody Inhibits Allergen-Induced Eosinophil Recruitment in Human Skin Xenografts from Allergic Patients. Laboratory Investigation 82:7, pages 929-939.
Crossref
Alan Wise, Katy Gearing & Stephen Rees. (2002) Target validation of G-protein coupled receptors. Drug Discovery Today 7:4, pages 235-246.
Crossref
Dashyant Dhanak, Lisa T. Christmann, Michael G. Darcy, Anthony J. Jurewicz, Richard M. Keenan, Judithann Lee, Henry M. Sarau, Katherine L. Widdowson & John R. White. (2001) Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1. Bioorganic & Medicinal Chemistry Letters 11:11, pages 1441-1444.
Crossref
Claude P Bertrand. (2000) Asthma: where beyond steroids?. Current Opinion in Chemical Biology 4:4, pages 407-411.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.