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Expert Opinion on Investigational Drugs Volume 9, 2000 - Issue 3
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Review

Soluble cytokine receptors: novel immunotherapeutic agents

Rafael Fernandez-Botran Departments of Pathology & Laboratory Medicine and Microbiology & Immunology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
Pages 497-514 | Published online: 24 Feb 2005

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Vadim Budagian, Elena Bulanova, Zane Orinska, Erwin Duitman, Katja Brandt, Andreas Ludwig, Dieter Hartmann, Greg Lemke, Paul Saftig & Silvia Bulfone-Paus. (2005) Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum. Molecular and Cellular Biology 25:21, pages 9324-9339.
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Katriina Vuolteenaho, Teemu Moilanen, Mari Hämäläinen & Eeva Moilanen. (2003) Regulation of nitric oxide production in osteoarthritic and rheumatoid cartilageRole of endogenous IL‐1 inhibitors. Scandinavian Journal of Rheumatology 32:1, pages 19-24.
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Rafael Fernandez-Botran, Xichun Sun & Fabian A Crespo. (2002) Soluble cytokine receptors in biological therapy. Expert Opinion on Biological Therapy 2:6, pages 585-605.
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Isaac Hurtado-Guerrero, Bruno Hernáez, María J. Pinto-Medel, Esther Calonge, José L. Rodriguez-Bada, Patricia Urbaneja, Ana Alonso, Natalia Mena-Vázquez, Pablo Aliaga, Shohreh Issazadeh-Navikas, José Pavia, Laura Leyva, José Alcamí, Antonio Alcamí, Óscar Fernández & Begoña Oliver-Martos. (2020) Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation. Journal of Clinical Medicine 9:4, pages 959.
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I. V. Smagina, S. A. Elchaninova, A. S. Palashchenko & L. P. Galaktionova. (2019) Pathological and protective effects of tumor necrosis factor-alpha in multiple sclerosis. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 119:10, pages 14.
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M. Suardíaz, D. Clemente, C. Marin-Bañasco, T. Orpez, I. Hurtado-Guerrero, J. Pavía, M.J. Pinto-Medel, F. De Castro, L. Leyva, O. Fernández & B. Oliver. (2016) Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis. Neuropharmacology 110, pages 480-492.
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Teresa Órpez-Zafra, Jose Pavía, Maria J Pinto-Medel, Isaac Hurtado-Guerrero, Jose L Rodriguez-Bada, Elisa Martín Montañez, Óscar Fernández, Laura Leyva & Begoña Oliver-Martos. (2015) Development and validation of an ELISA for quantification of soluble IFN-β receptor: assessment in multiple sclerosis. Bioanalysis 7:22, pages 2869-2880.
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彩虹 王. (2015) Efficient Expression of sTNFRII-gAD-Fc Fusion Protein in CHO Cell. Immunology Studies 03:01, pages 1-11.
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Qinzhen Cai, Ai Zhao, Yuting Yin, Lisha Ma, Zhenzhen Jiao, Huilin Zhi, Shouhua Lai, Sha Cheng, Hongmei Yang, Yinxiang Lu, Katherine A. Siminovitch & Jimin Gao. (2014) Efficient Production of sTNFRII-gAD Fusion Protein in Large Quantity by Use of the Modified CHO-S Cell Expression System. PLoS ONE 9:10, pages e111229.
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Zhi-han Li, Yang Zhang, Jian Wang & Zhan-jun Shi. (2012) Etanercept in the treatment of ankylosing spondylitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials, and the comparison of the Caucasian and Chinese population. European Journal of Orthopaedic Surgery & Traumatology 23:5, pages 497-506.
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Aris N. Economides & Neil Stahl. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 143 162 .
Zhonglin Liu, Leonie wyffels, Christy Barber, Li Wan, Hua Xu, Mizhou M. Hui, Lars R. Furenlid & James M. Woolfenden. (2012) Characterization of 99mTc-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways. Nuclear Medicine and Biology 39:7, pages 905-915.
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Virginia Sánchez-Quiles, Víctor Segura, Emilie Bigaud, Bin He, Bert W. O'Malley, Enrique Santamaría, Jesús Prieto & Fernando J. Corrales. (2012) Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury. Journal of Proteomics 75:18, pages 5783-5792.
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Zhi-Zhang Yang, Deanna M. Grote, Steven C. Ziesmer, Michelle K. Manske, Thomas E. Witzig, Anne J. Novak & Stephen M. Ansell. (2011) Soluble IL-2Rα facilitates IL-2–mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma. Blood 118:10, pages 2809-2820.
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N. M. Malik, P. Jin, Y. Raatz, P. F. Sumariwalla, S. Kiriakidis, M. Shepard, M. Feldmann & E. M. Paleolog. (2010) Regulation of the Angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis. Rheumatology 49:10, pages 1828-1839.
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T. Mark Doherty, Robert S. Wallis & Alimuddin Zumla. (2009) Biomarkers of Disease Activity, Cure, and Relapse in Tuberculosis. Clinics in Chest Medicine 30:4, pages 783-796.
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Mark Doherty, Robert S Wallis & Alimuddin Zumla. (2009) Biomarkers for tuberculosis disease status and diagnosis. Current Opinion in Pulmonary Medicine 15:3, pages 181-187.
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Tadhg P. BegleyKeren Miller & Ronit Satchi-Fainaro. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology.
Elena Bulanova, Vadim Budagian, Erwin Duitman, Zane Orinska, Hans Krause, Rene Rückert, Norbert Reiling & Silvia Bulfone-Paus. (2007) Soluble Interleukin (IL)-15Rα Is Generated by Alternative Splicing or Proteolytic Cleavage and Forms Functional Complexes with IL-15. Journal of Biological Chemistry 282:18, pages 13167-13179.
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Enrico Heffler, Mike Berry & Ian D Pavord. (2007) Tumor Necrosis Factor-α. BioDrugs 21:6, pages 345-349.
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Rainer Haag & Felix Kratz. (2006) Polymer Therapeutics: Concepts and Applications. Angewandte Chemie International Edition 45:8, pages 1198-1215.
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René Rückert, Katja Brandt, Armin Braun, Heinz-Gerd Hoymann, Udo Herz, Vadim Budagian, Horst Dürkop, Harald Renz & Silvia Bulfone-Paus. (2005) Blocking IL-15 Prevents the Induction of Allergen-Specific T Cells and Allergic Inflammation In Vivo. The Journal of Immunology 174:9, pages 5507-5515.
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Lena BrånénLars HovgaardMihaela NitulescuEva BengtssonJan NilssonStefan Jovinge. (2004) Inhibition of Tumor Necrosis Factor-α Reduces Atherosclerosis in Apolipoprotein E Knockout Mice. Arteriosclerosis, Thrombosis, and Vascular Biology 24:11, pages 2137-2142.
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Vadim Budagian, Elena Bulanova, Zane Orinska, Andreas Ludwig, Stefan Rose-John, Paul Saftig, Ernest C. Borden & Silvia Bulfone-Paus. (2004) Natural Soluble Interleukin-15Rα Is Generated by Cleavage That Involves the Tumor Necrosis Factor-α-converting Enzyme (TACE/ADAM17). Journal of Biological Chemistry 279:39, pages 40368-40375.
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B Weiss, K Wolk, B H Grünberg, H-D Volk, W Sterry, K Asadullah & R Sabat. (2004) Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. Genes & Immunity 5:5, pages 330-336.
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Don Foster, Julia Parrish-Novak, Brian Fox & Wenfeng Xu. (2004) Cytokine–receptor pairing: accelerating discovery of cytokine function. Nature Reviews Drug Discovery 3:2, pages 160-170.
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Milan Petelin, Koji Naruishi, Nobuyuki Shiomi, Junji Mineshiba, Hideo Arai, Fusanori Nishimura, Shogo Takashiba & Yoji Murayama. (2004) Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice. Experimental and Molecular Pathology 76:1, pages 76-81.
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T. Cartmell, C. Ball, A. F. Bristow, D. Mitchell & S. Poole. (2003) Endogenous Interleukin‐10 is Required for the Defervescence of Fever Evoked by Local Lipopolysaccharide‐Induced and Staphylococcus Aureus ‐Induced Inflammation in Rats . The Journal of Physiology 549:2, pages 653-664.
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Yu-an Yang, Oksana Dukhanina, Binwu Tang, Mizuko Mamura, John J. Letterio, Jennifer MacGregor, Sejal C. Patel, Shahram Khozin, Zi-yao Liu, Jeffrey Green, Miriam R. Anver, Glenn Merlino & Lalage M. Wakefield. (2002) Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. Journal of Clinical Investigation 109:12, pages 1607-1615.
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David J MacEwan. (2009) TNF ligands and receptors – a matter of life and death. British Journal of Pharmacology 135:4, pages 855-875.
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