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Expert Opinion on Investigational Drugs Volume 9, 2000 - Issue 7
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Drug Evaluation

Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase

Hedy L Kindler Section of Hematology/Oncology, Biological Sciences Division, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637, USA. [email protected]
&
Richard L Schilsky Section of Hematology/Oncology, Biological Sciences Division, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637, USA. [email protected]
Pages 1635-1649 | Published online: 24 Feb 2005

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Himanshu Verma, Malkeet Singh Bahia, Shalki Choudhary, Pankaj Kumar Singh & Om Silakari. (2019) Drug metabolizing enzymes-associated chemo resistance and strategies to overcome it. Drug Metabolism Reviews 51:2, pages 196-223.
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Sara Tirendi, Barbara Marengo, Cinzia Domenicotti, Anna M. Bassi, Vanessa Almonti & Stefania Vernazza. (2023) Colorectal cancer and therapy response: a focus on the main mechanisms involved. Frontiers in Oncology 13.
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Himanshu Verma, Gera Narendra, Baddipadige Raju, Pankaj Kumar Singh & Om Silakari. (2022) Dihydropyrimidine Dehydrogenase-Mediated Resistance to 5-Fluorouracil: Mechanistic Investigation and Solution. ACS Pharmacology & Translational Science 5:11, pages 1017-1033.
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Gera Narendra, Shalki Choudhary, Baddipadige Raju, Himanshu Verma & Om Silakari. (2022) Role of Genetic Polymorphisms in Drug-Metabolizing Enzyme-Mediated Toxicity and Pharmacokinetic Resistance to Anti-Cancer Agents: A Review on the Pharmacogenomics Aspect. Clinical Pharmacokinetics 61:11, pages 1495-1517.
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Dariush C. Forouzesh, Brett A. Beaupre, Arseniy Butrin, Zdzislaw Wawrzak, Dali Liu & Graham R. Moran. (2021) The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil. Biochemistry 60:14, pages 1120-1132.
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Pilar García-Alfonso, Andrés Jesús Muñoz Martín, Laura Ortega Morán, Javier Soto Alsar, Gabriela Torres Pérez-Solero, Montserrat Blanco Codesido, Pilar Aitana Calvo Ferrandiz & Silvina Grasso Cicala. (2021) Oral drugs in the treatment of metastatic colorectal cancer. Therapeutic Advances in Medical Oncology 13, pages 175883592110090.
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G. Kaur, S. K. Gupta, P. Singh, V. Ali, V. Kumar & M. Verma. (2020) Drug-metabolizing enzymes: role in drug resistance in cancer. Clinical and Translational Oncology 22:10, pages 1667-1680.
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Alessio Biagioni, Fabio Staderini, Sara Peri, Giampaolo Versienti, Nicola Schiavone, Fabio Cianchi, Laura Papucci & Lucia Magnelli. (2020) 5-Fluorouracil Conversion Pathway Mutations in Gastric Cancer. Biology 9:9, pages 265.
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Sona Vodenkova, Tomas Buchler, Klara Cervena, Veronika Veskrnova, Pavel Vodicka & Veronika Vymetalkova. (2020) 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future. Pharmacology & Therapeutics 206, pages 107447.
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Jürgen Krauß & Franz Bracher. (2018) Pharmacokinetic Enhancers (Boosters)—Escort for Drugs against Degrading Enzymes and Beyond. Scientia Pharmaceutica 86:4, pages 43.
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Manuela Petaccia, Luisa Giansanti, Francesca Leonelli, Angela La Bella, Denise Gradella Villalva & Giovanna Mancini. (2017) Fluorescent lipid based sensor for the detection of thymidine phosphorylase as tumor biomarker. Sensors and Actuators B: Chemical 245, pages 213-220.
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Thomas Spector & Shousong Cao. (2010) A Possible Cause and Remedy for the Clinical Failure of 5-Fluorouracil Plus Eniluracil. Clinical Colorectal Cancer 9:1, pages 52-54.
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Miquel Nogué, Antonieta Salud, Eduard Batiste-Alentorn, Eugeni Saigí, Ferran Losa, Lluís Cirera, Miguel Méndez, Juan Manuel Campos, Antonio Galan, Pilar Escudero, Angels Arcusa, Hermini Manzano, Edelmira Vélez de Mendizábal, Joaquim Pérez de Olaguer, Montserrat Boleda, Immaculada Guasch & Pilar Vicente. (2005) Randomised study of tegafur and oral leucovorin versus intravenous 5-fluorouracil and leucovorin in patients with advanced colorectal cancer. European Journal of Cancer 41:15, pages 2241-2249.
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Jean-Emmanuel Kurtz, Emmanuel Andrès, Shanti Natarajan-Amé, Esther Noel & Patrick Dufour. (2003) Oral chemotherapy in colorectal cancer treatment: review of the literature. European Journal of Internal Medicine 14:1, pages 18-25.
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Hedy Lee Kindler & Keith L. Shulman. (2001) Metastatic colorectal cancer. Current Treatment Options in Oncology 2:6, pages 459-471.
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Axel Grothey & Hans-Joachim Schmoll. (2001) New chemotherapy approaches in colorectal cancer. Current Opinion in Oncology 13:4, pages 275-286.
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