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Review

Antifungals targeted to sphingolipid synthesis: focus on inositol phosphorylceramide synthase

Pages 1787-1796 | Published online: 24 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Caroline Mota Fernandes & Maurizio Del Poeta. (2020) Fungal sphingolipids: role in the regulation of virulence and potential as targets for future antifungal therapies. Expert Review of Anti-infective Therapy 18:11, pages 1083-1092.
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Russell E Lewis. (2002) Pharmacotherapy of Candida bloodstream infections: new treatment options, new era. Expert Opinion on Pharmacotherapy 3:8, pages 1039-1057.
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Nafsika H Georgopapadakou. (2002) Antifungals targeted to protein modification: focus on protein N-myristoyltransferase. Expert Opinion on Investigational Drugs 11:8, pages 1117-1125.
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Molly B Schmid. (2001) Microbial genomics – new targets, new drugs. Expert Opinion on Therapeutic Targets 5:4, pages 465-475.
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Articles from other publishers (38)

Enrico Garbe, Franziska Gerwien, Dominik Driesch, Tina Müller, Bettina Böttcher, Markus Gräler & Slavena Vylkova. (2022) Systematic Metabolic Profiling Identifies De Novo Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation . mSystems 7:6.
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Chunmiao Jiang, Jinxin Ge, Bin He & Bin Zeng. (2021) Glycosphingolipids in Filamentous Fungi: Biological Roles and Potential Applications in Cosmetics and Health Foods. Frontiers in Microbiology 12.
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John G. M. Mina, Rebecca L. Charlton, Edubiel Alpizar-Sosa, Douglas O. Escrivani, Christopher Brown, Amjed Alqaisi, Maria Paula G. Borsodi, Claudia P. Figueiredo, Emanuelle V. de Lima, Emily A. Dickie, Wenbin Wei, Robson Coutinho-Silva, Andy Merritt, Terry K. Smith, Michael P. Barrett, Bartira Rossi-Bergmann, Paul W. Denny & Patrick G. Steel. (2020) Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase . ACS Infectious Diseases 7:1, pages 47-63.
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Roya Vahedi-Shahandashti & Cornelia Lass-Flörl. (2020) Novel Antifungal Agents and Their Activity against Aspergillus Species. Journal of Fungi 6:4, pages 213.
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Caroline Mota Fernandes, Gustavo H. Goldman & Maurizio Del Poeta. (2018) Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi. mBio 9:3.
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Jennifer L. Norcliffe, John G. Mina, Emilio Alvarez, Juan Cantizani, Francisco de Dios-Anton, Gonzalo Colmenarejo, Silva Gonzalez-Del Valle, Maria Marco, José M. Fiandor, Julio J. Martin, Patrick G. Steel & Paul W. Denny. (2018) Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform. Scientific Reports 8:1.
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JOHN G. M. MINA & P. W. DENNY. (2017) Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis. Parasitology 145:2, pages 134-147.
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A. Q. I. ALQAISI, A. J. MBEKEANI, M. BASSAS LLORENS, A. P. ELHAMMER & P. W. DENNY. (2017) The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis . Parasitology 145:2, pages 148-155.
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Rodrigo Rollin-Pinheiro, Ashutosh Singh, Eliana Barreto-Bergter & Maurizio Del Poeta. (2016) Sphingolipids as targets for treatment of fungal infections. Future Medicinal Chemistry 8:12, pages 1469-1484.
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Anna Alcaide & Amadeu Llebaria. (2014) Aziridine Ring Opening for the Synthesis of Sphingolipid Analogues: Inhibitors of Sphingolipid-Metabolizing Enzymes. The Journal of Organic Chemistry 79:7, pages 2993-3029.
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Steven Pratt, Nilu K. Wansadhipathi-Kannangara, Catherine R. Bruce, John G. Mina, Hosam Shams-Eldin, Josefina Casas, Kentaro Hanada, Ralph T. Schwarz, Sabrina Sonda & Paul W. Denny. (2013) Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii. Molecular and Biochemical Parasitology 187:1, pages 43-51.
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Simon A. Young, John G. Mina, Paul W. Denny & Terry K. Smith. (2012) Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets. Biochemistry Research International 2012, pages 1-12.
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John G. Mina, Jackie A. Mosely, Hayder Z. Ali, Paul W. Denny & Patrick G. Steel. (2011) Exploring Leishmania major Inositol Phosphorylceramide Synthase (LmjIPCS): Insights into the ceramide binding domain. Organic & Biomolecular Chemistry 9:6, pages 1823.
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Marcos S Toledo, Loriane Tagliari, Erika Suzuki, Claudinei M Silva, Anita H Straus & Helio K Takahashi. (2010) Effect of anti-glycosphingolipid monoclonal antibodies in pathogenic fungal growth and differentiation. Characterization of monoclonal antibody MEST-3 directed to Manp α1→3Manp α1→2IPC. BMC Microbiology 10:1.
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Anders Björkbom, Henna Ohvo-Rekilä, Pasi Kankaanpää, Thomas K.M. Nyholm, Bodil Westerlund & J. Peter Slotte. (2010) Characterization of membrane properties of inositol phosphorylceramide. Biochimica et Biophysica Acta (BBA) - Biomembranes 1798:3, pages 453-460.
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John G. Mina, Ssu-Ying Pan, Nilu K. Wansadhipathi, Catherine R. Bruce, Hosam Shams-Eldin, Ralph T. Schwarz, Patrick G. Steel & Paul W. Denny. (2009) The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target. Molecular and Biochemical Parasitology 168:1, pages 16-23.
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Helio K. Takahashi, Marcos S. Toledo, Erika Suzuki, Loriane Tagliari & Anita H. Straus. (2009) Current relevance of fungal and trypanosomatid glycolipids and sphingolipids: studies defining structures conspicuously absent in mammals. Anais da Academia Brasileira de Ciências 81:3, pages 477-488.
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Sherry A. Castle, Elizabeth A. Owuor, Stephanie H. Thompson, Michelle R. Garnsey, J. Stacey Klutts, Tamara L. Doering & Steven B. Levery. (2008) β1,2-Xylosyltransferase Cxt1p Is Solely Responsible for Xylose Incorporation into Cryptococcus neoformans Glycosphingolipids . Eukaryotic Cell 7:9, pages 1611-1615.
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Marcos S. Toledo, Steven B. Levery, Beau Bennion, Luciana L. Guimaraes, Sherry A. Castle, Rebecca Lindsey, Michelle Momany, Chaeho Park, Anita H. Straus & Helio K. Takahashi. (2007) Analysis of glycosylinositol phosphorylceramides expressed by the opportunistic mycopathogen Aspergillus fumigatus. Journal of Lipid Research 48:8, pages 1801-1824.
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Pedro Serrano, Josefina Casas, Amadeu Llebaria, Martine Zucco, Gilbert Emeric & Antonio Delgado. (2007) Parallel Synthesis and Yeast Growth Inhibition Screening of Succinamic Acid Libraries. Journal of Combinatorial Chemistry 9:4, pages 635-643.
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Antonio Delgado, Josefina Casas, Amadeu Llebaria, José Luis Abad & Gemma Fabriás. (2007) Chemical Tools to Investigate Sphingolipid Metabolism and Functions. ChemMedChem 2:5, pages 580-606.
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David Mormeneo, Josefina Casas, Amadeu Llebaria & Antonio Delgado. (2007) Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues. Organic & Biomolecular Chemistry 5:23, pages 3769.
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Paul W. Denny, Hosam Shams-Eldin, Helen. P. Price, Deborah F. Smith & Ralph T. Schwarz. (2006) The Protozoan Inositol Phosphorylceramide Synthase. Journal of Biological Chemistry 281:38, pages 28200-28209.
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Eliana Barreto-Bergter, Marcia R. Pinto & Marcio L. Rodrigues. 2006. 1025 1055 .
Frank C. Odds. (2005) Genomics, molecular targets and the discovery of antifungal drugs. Revista Iberoamericana de Micología 22:4, pages 229-237.
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Maria Helena Villas-Boas, Robin Wait, Rosana B. Silva, Marcio L. Rodrigues & Eliana Barreto-Bergter. (2005) Ceramide glycosylation and fatty acid hydroxylation influence serological reactivity in Trypanosoma cruzi glycosphingolipids . FEMS Microbiology Letters 244:1, pages 47-52.
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Paul W. Denny & Deborah F. Smith. (2004) Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa. Molecular Microbiology 53:3, pages 725-733.
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Leonardo Nimrichter, Eliana Barreto-Bergter, Ricardo R. Mendonça-Filho, Lucimar F. Kneipp, Mariana T. Mazzi, Patrícia Salve, Sandra E. Farias, Robin Wait, Celuta S. Alviano & Marcio L. Rodrigues. (2004) A monoclonal antibody to glucosylceramide inhibits the growth of Fonsecaea pedrosoi and enhances the antifungal action of mouse macrophages. Microbes and Infection 6:7, pages 657-665.
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K. Niimi, D. R. K. Harding, R. Parshot, A. King, D. J. Lun, A. Decottignies, M. Niimi, S. Lin, R. D. Cannon, A. Goffeau & B. C. Monk. (2004) Chemosensitization of Fluconazole Resistance in Saccharomyces cerevisiae and Pathogenic Fungi by a d -Octapeptide Derivative . Antimicrobial Agents and Chemotherapy 48:4, pages 1256-1271.
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Paul W. Denny, David Goulding, Michael A. J. Ferguson & Deborah F. Smith. (2004) Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity. Molecular Microbiology 52:2, pages 313-327.
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Eliana Barreto-Bergter, Marcia R. Pinto & Marcio L. Rodrigues. (2004) Structure and biological functions of fungal cerebrosides. Anais da Academia Brasileira de Ciências 76:1, pages 67-84.
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Beau Bennion, Chaeho Park, Matthew Fuller, Rebecca Lindsey, Michelle Momany, Richard Jennemann & Steven B. Levery. (2003) Glycosphingolipids of the model fungus Aspergillus nidulans. Journal of Lipid Research 44:11, pages 2073-2088.
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Marek M. Nagiec, Casey L. Young, Phillip G. Zaworski & Scott D. Kobayashi. (2003) Yeast sphingolipid bypass mutants as indicators of antifungal agents selectively targeting sphingolipid synthesis. Biochemical and Biophysical Research Communications 307:2, pages 369-374.
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Arifa Husain & Bruce Ganem. (2002) syn -Selective additions to Garner aldehyde: synthesis of a potent glucosylceramide synthase inhibitor. Tetrahedron Letters 43:47, pages 8621-8623.
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Steven B Levery, Michelle Momany, Rebecca Lindsey, Marcos S Toledo, James A Shayman, Matthew Fuller, Kelly Brooks, Ron Lou Doong, Anita H Straus & Helio K Takahashi. (2002) Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth . FEBS Letters 525:1-3, pages 59-64.
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Rosanna Pena-Muralla, Patricia Ayoubi, Marcia Graminha, Nilce M. Martinez-Rossi, Antonio Rossi & Rolf A. Prade. 2002. Pathogen Genomics. Pathogen Genomics 215 230 .
Steven B. Levery, Marcos S. Toledo, Anita H. Straus & Helio K. Takahashi. (2001) Comparative analysis of glycosylinositol phosphorylceramides from fungi by electrospray tandem mass spectrometry with low-energy collision-induced dissociation of Li+ adduct ions. Rapid Communications in Mass Spectrometry 15:23, pages 2240-2258.
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Marcos S. Toledo, Steven B. Levery, Anita H. Straus & Helio K. Takahashi. (2001) Sphingolipids of the mycopathogen Sporothrix schenckii : identification of a glycosylinositol phosphorylceramide with novel core GlcNH 2 α1→2Ins motif . FEBS Letters 493:1, pages 50-56.
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