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Examining the roles of cannabinoids in pain and other therapeutic indications: a review

, BSc Pharm, , BSc, , MD, , PhD, , MD & , PhD
Pages 17-31 | Published online: 10 Dec 2009

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Gordon D Ko, Sara L Bober, Sean Mindra & Jason M Moreau. (2016) Medical cannabis – the Canadian perspective. Journal of Pain Research 9, pages 735-744.
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Mellar P Davis. (2014) Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert Opinion on Investigational Drugs 23:8, pages 1123-1140.
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Afshin Zarghi & Zahra Hajimahdi. (2013) Substituted oxadiazoles: a patent review (2010 – 2012). Expert Opinion on Therapeutic Patents 23:9, pages 1209-1232.
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Belinda J Cridge & Rhonda J Rosengren. (2013) Critical appraisal of the potential use of cannabinoids in cancer management. Cancer Management and Research 5, pages 301-313.
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Doris Riether. (2012) Selective cannabinoid receptor 2 modulators: a patent review 2009 – present. Expert Opinion on Therapeutic Patents 22:5, pages 495-510.
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Avinash K Bhandary, Gary P Chimes & Gerard A Malanga. (2010) Investigational pharmacology for low back pain. Journal of Pain Research 3, pages 169-181.
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Articles from other publishers (41)

Kangtai Xu, Yifei Wu, Zhuangzhuang Tian, Yuanfan Xu, Chaoran Wu & Zilong Wang. (2023) Microglial Cannabinoid CB2 Receptors in Pain Modulation. International Journal of Molecular Sciences 24:3, pages 2348.
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Sultan Mayar, Mina Memarpoor-Yazdi, Ahmad Makky, Romina Eslami Sarokhalil & Nazzareno D'Avanzo. (2022) Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids. Frontiers in Molecular Neuroscience 15.
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María Soledad Belingeri & Laura Romina Caltana. 2021. Discovery and Development of Anti-Breast Cancer Agents from Natural Products. Discovery and Development of Anti-Breast Cancer Agents from Natural Products 103 122 .
Kathleen S Romanowski, Joshua Carson, Kate Pape, Eileen Bernal, Sam Sharar, Shelley Wiechman, Damien Carter, Yuk Ming Liu, Stephanie Nitzschke, Paul Bhalla, Jeffrey Litt, Rene Przkora, Bruce Friedman, Stephanie Popiak, James Jeng, Colleen M Ryan & Victor Joe. (2020) American Burn Association Guidelines on the Management of Acute Pain in the Adult Burn Patient: A Review of the Literature, a Compilation of Expert Opinion, and Next Steps. Journal of Burn Care & Research 41:6, pages 1129-1151.
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Ece Unal, Brigitte Anderson, Andrew Helber & John H. Marks. (2020) Cannabinoids. Journal of Clinical Gastroenterology 54:9, pages 769-788.
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Mensah* Kwesi Boadu & Adu-Gyamfi Paa Kofi Tawiah. (2019) To legalize cannabis in Ghana or not to legalize? Reviewing the pharmacological evidence. Archives of Pharmacy and Pharmaceutical Sciences 3:1, pages 082-088.
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Raquel Guerrero-Alba, Paulino Barragán-Iglesias, Abimael González-Hernández, Eduardo E. Valdez-Moráles, Vinicio Granados-Soto, Miguel Condés-Lara, Martín G. Rodríguez & Bruno A. Marichal-Cancino. (2019) Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55. Frontiers in Pharmacology 9.
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W. Häuser, F. Petzke & M.A. Fitzcharles. (2018) Efficacy, tolerability and safety of cannabis-based medicines for chronic pain management - An overview of systematic reviews. European Journal of Pain 22:3, pages 455-470.
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Winfried Häuser, Mary-Ann Fitzcharles, Lukas Radbruch & Frank Petzke. (2017) Cannabinoids in Pain Management and Palliative Medicine. Deutsches Ärzteblatt international.
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Sydney Tateo. (2017) State of the evidence. Journal of the American Association of Nurse Practitioners 29:2, pages 94-103.
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Ernest Small. 2016. Cannabis. Cannabis 229 252 .
Keith A. Sharkey & John W. Wiley. (2016) The Role of the Endocannabinoid System in the Brain–Gut Axis. Gastroenterology 151:2, pages 252-266.
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Scott E. Hadland, John R. Knight & Sion K. Harris. (2015) Medical Marijuana. Journal of Developmental & Behavioral Pediatrics 36:2, pages 115-123.
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Barliz Waissengrin, Damien Urban, Yasmin Leshem, Meital Garty & Ido Wolf. (2015) Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience. Journal of Pain and Symptom Management 49:2, pages 223-230.
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Dana Turcotte, Malcolm Doupe, Mahmoud Torabi, Andrew Gomori, Karen Ethans, Farid Esfahani, Katie Galloway & Mike Namaka. (2015) Nabilone as an Adjunctive to Gabapentin for Multiple Sclerosis-Induced Neuropathic Pain: A Randomized Controlled Trial. Pain Medicine 16:1, pages 149-159.
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Helene Retrouvey & Shahriar Shahrokhi. (2015) Pain and the Thermally Injured Patient—A Review of Current Therapies. Journal of Burn Care & Research 36:2, pages 315-323.
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KEVIN P. HILL. (2014) Medical Marijuana. Journal of Psychiatric Practice 20:5, pages 389-391.
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Andrew J. Saxon & Kendall W. Browne. (2014) Marijuana not ready for prime time as an analgesic. General Hospital Psychiatry 36:1, pages 4-6.
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S.J. Ward & R.F. Tuma. 2014. Encyclopedia of the Neurological Sciences. Encyclopedia of the Neurological Sciences 42 47 .
Amy L. Patton, Kathryn A. Seely, Krishna C. Chimalakonda, Johnny P. Tran, Matthew Trass, Art Miranda, William E. Fantegrossi, Paul D. Kennedy, Paul Dobrowolski, Anna Radominska-Pandya, Keith R. McCain, Laura P. James, Gregory W. Endres & Jeffery H. Moran. (2013) Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology. Analytical Chemistry 85:19, pages 9390-9399.
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Samuel D. Banister, Shane M. Wilkinson, Mitchell Longworth, Jordyn Stuart, Nadine Apetz, Katrina English, Lance Brooker, Catrin Goebel, David E. Hibbs, Michelle Glass, Mark Connor, Iain S. McGregor & Michael Kassiou. (2013) The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse. ACS Chemical Neuroscience 4:7, pages 1081-1092.
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Laura M. Borgelt, Kari L. Franson, Abraham M. Nussbaum & George S. Wang. (2013) The P harmacologic and C linical E ffects of M edical C annabis . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 33:2, pages 195-209.
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David A. Gorelick, Robert S. Goodwin, Eugene Schwilke, David M. Schwope, William D. Darwin, Deanna L. Kelly, Robert P. McMahon, Fang Liu, Catherine Ortemann-Renon, Denis Bonnet & Marilyn A. Huestis. (2013) Tolerance to Effects of High-Dose Oral Δ9-Tetrahydrocannabinol and Plasma Cannabinoid Concentrations in Male Daily Cannabis Smokers. Journal of Analytical Toxicology 37:1, pages 11-16.
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E. J. GILBERT & C. A. LUNN. 2012. Anti-Inflammatory Drug Discovery. Anti-Inflammatory Drug Discovery 391 413 .
Daniel W. Bowles, Cindy L. O’Bryant, D. Ross Camidge & Antonio Jimeno. (2012) The intersection between cannabis and cancer in the United States. Critical Reviews in Oncology/Hematology 83:1, pages 1-10.
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Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu & Li Zhang. (2012) Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine 209:6, pages 1121-1134.
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Zhongyong Wei, Hua Yang, Ziping Liu, Maxime Tremblay, Shawn Johnstone, Sara Béha, Shi Yi Yue, Sanjay Srivastava, Miroslaw J. Tomaszewski, William Brown, Christopher Walpole, Stéphane St-Onge, Etienne Lessard, Anne-Julie Archambault, Thierry Groblewski & Daniel Pagé. (2012) N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. Bioorganic & Medicinal Chemistry Letters 22:12, pages 3884-3889.
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J. Michael Bostwick. (2012) Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana. Mayo Clinic Proceedings 87:2, pages 172-186.
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Jan M. Keppel Hesselink & David J. Kopsky. (2012) Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%. Journal of Clinical Anesthesia 24:1, pages 78-79.
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Serena Deiana, Akihito Watanabe, Yuki Yamasaki, Naoki Amada, Marlene Arthur, Shona Fleming, Hilary Woodcock, Patricia Dorward, Barbara Pigliacampo, Steve Close, Bettina Platt & Gernot Riedel. (2011) Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour. Psychopharmacology 219:3, pages 859-873.
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M.-C. Li, J. E. Brady, C. J. DiMaggio, A. R. Lusardi, K. Y. Tzong & G. Li. (2011) Marijuana Use and Motor Vehicle Crashes. Epidemiologic Reviews 34:1, pages 65-72.
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Aoife Gowran, Janis Noonan & Veronica A. Campbell. (2011) The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration. CNS Neuroscience & Therapeutics 17:6, pages 637-644.
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Pradip K. Sasmal, Rashmi Talwar, J. Swetha, D. Balasubrahmanyam, B. Venkatesham, Khaji Abdul Rawoof, B. Neelima Devi, Vikram P. Jadhav, Sanjoy K. Khan, Priya Mohan, D. Srinivasa Reddy, Vijay Kumar Nyavanandi, Srinivas Nanduri, K. Shiva Kumar, M. Kannan, P. Srinivas, Prabhakar Nadipalli, Hira Chaudhury & V.J. Sebastian. (2011) Structure–activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists. Bioorganic & Medicinal Chemistry Letters 21:16, pages 4913-4918.
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Marat Fudim, Gabriel Wagman, Rebecca Altschul, Evin Yucel, Michelle Bloom & Timothy J. Vittorio. (2011) Pathophysiology and Treatment Options for Cardiac Anorexia. Current Heart Failure Reports 8:2, pages 147-153.
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Takao Kiyoi, Julia M. Adam, John K. Clark, Keneth Davies, Anna-Marie Easson, Darren Edwards, Helen Feilden, Ruth Fields, Stuart Francis, Fiona Jeremiah, Duncan McArthur, Angus J. Morrison, Alan Prosser, Paul D. Ratcliffe, Jurgen Schulz, Grant Wishart, James Baker, Robert Campbell, Jean E. Cottney, Maureen Deehan, Ola Epemolu & Louise Evans. (2011) Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists. Bioorganic & Medicinal Chemistry Letters 21:6, pages 1748-1753.
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Shuangsong Hong, Gen Zheng, Xiaoyin Wu, Natasha T. Snider, Chung Owyang & John W. Wiley. (2011) Corticosterone Mediates Reciprocal Changes in CB 1 and TRPV1 Receptors in Primary Sensory Neurons in the Chronically Stressed Rat. Gastroenterology 140:2, pages 627-637.e4.
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CJ Ledgerwood, SM Greenwood, RR Brett, JA Pratt & TJ Bushell. (2010) Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways. British Journal of Pharmacology 162:1, pages 286-294.
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Pradip K. Sasmal, D. Srinivasa Reddy, Rashmi Talwar, B. Venkatesham, D. Balasubrahmanyam, M. Kannan, P. Srinivas, K. Shiva Kumar, B. Neelima Devi, Vikram P. Jadhav, Sanjoy K. Khan, Priya Mohan, Hira Chaudhury, Debnath Bhuniya, Javed Iqbal & Ranjan Chakrabarti. (2011) Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides. Bioorganic & Medicinal Chemistry Letters 21:1, pages 562-568.
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Gillian Burgess & Dic Williams. (2010) The discovery and development of analgesics: new mechanisms, new modalities. Journal of Clinical Investigation 120:11, pages 3753-3759.
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Sue Peat. (2010) Using cannabinoids in pain and palliative care. International Journal of Palliative Nursing 16:10, pages 481-485.
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Gregory T. CarterMary E. Abood, Sunil K. Aggarwal & Michael D. Weiss. (2010) Cannabis and Amyotrophic Lateral Sclerosis: Hypothetical and Practical Applications, and a Call for Clinical Trials. American Journal of Hospice and Palliative Medicine® 27:5, pages 347-356.
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