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Expert Opinion on Pharmacotherapy Volume 10, 2009 - Issue 18
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Drug Evaluations

Pazopanib: therapeutic developments

Suwicha Limvorasak University of Chicago, Department of Pharmaceutical Services, 5841 S. Maryland Avenue, MC2115, Chicago, IL 60637, USA +1 773 834 5137; +1 773 702 3163
&
Edwin M Posadas University of Chicago, Department of Medicine, Hematology and Oncology, 5841 S. Maryland Avenue, MC2115, Chicago, IL 60637, USA [email protected]
, MD
Pages 3091-3102 | Published online: 02 Dec 2009

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Carmen Criscitiello, Lucia Gelao, Giulia Viale, Angela Esposito & Giuseppe Curigliano. (2014) Investigational platelet-derived growth factor receptor kinase inhibitors in breast cancer therapy. Expert Opinion on Investigational Drugs 23:5, pages 599-610.
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Brian Rini & Mhd Yaser Al-Marrawi. (2011) Pazopanib for the treatment of renal cancer. Expert Opinion on Pharmacotherapy 12:7, pages 1171-1189.
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Elena Geuna, Andrea Milani, Stefania Redana, Valentina Rossi, Giorgio Valabrega, Massimo Aglietta & Filippo Montemurro. (2011) Hitting multiple targets in HER2-positive breast cancer: proof of principle or therapeutic opportunity?. Expert Opinion on Pharmacotherapy 12:4, pages 549-565.
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Peter E Clark. (2010) Rationale for targeted therapies and potential role of pazopanib in advanced renal cell carcinoma. Biologics: Targets and Therapy 4, pages 187-197.
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Articles from other publishers (17)

Ping Yu, Yaru Wang, Dahai Yuan, Yunqin Sun, Shuang Qin & Tianye Li. (2023) Vascular normalization: reshaping the tumor microenvironment and augmenting antitumor immunity for ovarian cancer. Frontiers in Immunology 14.
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Hong-yang Sun, Jin Wu, Rui Wang, Shun Zhang, Hao Xu, Еlena Kaznacheyeva, Xiao-jun Lu, Hai-gang Ren & Guang-hui Wang. (2022) Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway. Acta Pharmacologica Sinica 44:6, pages 1135-1148.
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Paul Dent. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 250 261 .
Jun Akatsuka, Go Kimura, Kotaro Obayashi, Kotaro Tsutsumi, Masato Yanagi, Yuki Endo, Hayato Takeda, Tatsuro Hayashi, Yuka Toyama, Yasutomo Suzuki, Tsutomu Hamasaki, Yoichiro Yamamoto & Yukihiro Kondo. (2021) Outcomes of starting low-dose pazopanib in patients with metastatic renal cell carcinoma who do not meet eligibility criteria for clinical trials. Urological Science 32:3, pages 104.
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Paul Dent. 2021. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 237 283 .
Lingling Zhang, Huanan Wang, Wei Li, Juchang Zhong, Rongcheng Yu, Xinfeng Huang, Honghui Wang, Zhikai Tan, Jiangang Wang & Yingjie Zhang. (2016) Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis. Oncotarget 8:2, pages 3289-3303.
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Yuping Jia, Jian Zhang, Jinhong Feng, Fuming Xu, Huili Pan & Wenfang Xu. (2014) Design, Synthesis and Biological Evaluation of Pazopanib Derivatives as Antitumor Agents. Chemical Biology & Drug Design 83:3, pages 306-316.
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Dana Faingold, Silvin Bakalian & Dawn S. Russell-Hermanns. 2013. Experimental and Clinical Metastasis. Experimental and Clinical Metastasis 445 469 .
Amy M. Pick & Kelly K. Nystrom. (2012) Pazopanib for the Treatment of Metastatic Renal Cell Carcinoma. Clinical Therapeutics 34:3, pages 511-520.
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Alexander Kutikov, Peter Makhov, Konstantin Golovine, Daniel J. Canter, Mohit Sirohi, Ryan Street, Jay Simhan, Robert G. Uzzo & Vladimir M. Kolenko. (2011) Interleukin-6: A Potential Biomarker of Resistance to Multitargeted Receptor Tyrosine Kinase Inhibitors in Castration-resistant Prostate Cancer. Urology 78:4, pages 968.e7-968.e11.
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Sushil Kumar, Reza Bayat Mokhtari, Reihaneh Sheikh, Bing Wu, Libo Zhang, Ping Xu, Shan Man, Indhira Dias Oliveira, Herman Yeger, Robert S. Kerbel & Sylvain Baruchel. (2011) Metronomic Oral Topotecan with Pazopanib Is an Active Antiangiogenic Regimen in Mouse Models of Aggressive Pediatric Solid Tumor. Clinical Cancer Research 17:17, pages 5656-5667.
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Michael R. Harrison. (2011) Pharmacotherapy Options in Advanced Renal Cell Carcinoma: What Role for Pazopanib?. Clinical Medicine Insights: Oncology 5, pages CMO.S6087.
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Brunilde Gril, Diane Palmieri, Yong Qian, DeeDee Smart, Lilia Ileva, David J. Liewehr, Seth M. Steinberg & Patricia S. Steeg. (2011) Pazopanib Reveals a Role for Tumor Cell B-Raf in the Prevention of HER2+ Breast Cancer Brain Metastasis. Clinical Cancer Research 17:1, pages 142-153.
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Ioannis S. Vizirianakis, Maria Chatzopoulou, Ioannis D. Bonovolias, Ioannis Nicolaou, Vassilis J. Demopoulos & Asterios S. Tsiftsoglou. (2010) Toward the Development of Innovative Bifunctional Agents To Induce Differentiation and To Promote Apoptosis in Leukemia: Clinical Candidates and Perspectives. Journal of Medicinal Chemistry 53:19, pages 6779-6810.
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Joshua M. LangMichael R. Harrison. (2010) Pazopanib for the Treatment of Patients with Advanced Renal Cell Carcinoma. Clinical Medicine Insights: Oncology 4, pages CMO.S4088.
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Shridhar Hegde & Michelle Schmidt. 2010. 466 537 .

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